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Original Article

Induction of Apoptosis by 2-Chloro-2'deoxyadenosine (2-CdA) Alone and In Combination with other Cytotoxic Drugs: Synergistic Effects on Normal and Neoplastic Lymphocytes by Addition of Doxorubicin and Mitoxantrone

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Pages 559-567 | Received 12 Jul 1999, Published online: 01 Jul 2009

References

  • Toft N. J., Arends M. J. Apoptosis and necrosis in tumors. In: Martin SJ (ed.), Apoptosis and cancer. Basel: Karger Landes Systems. 1997; 22–44
  • Rummel M. J., Leimer A., Knuth C, Schadeck-Gressel C, Hossfeld L., Bergmann L., Hoelzer D., Mitrou P. S. 2-chlorodeoxyadenosine (2-CdA) in the treatment of previously untreated low grade Non-Hodgkin's lymphomas. Blood 1997; 90(Suppl. 1)342A
  • Juliusson G., Liliemark J. Complete remission of B-cell chronic lymphocytic leukemia after oral cladribine. Lancet 1993; 341: 54
  • Kay A. C., Saven A., Carrera C. J., Carson D. A., Thurston D., Beutler E., Piro L. D. 2-chlorodeoxyadenosine treatment of low-grade lymphoma. J. Clin. Oncol. 1992; 10: 371–7
  • Saven A., Emanuele S., Kosty M., Koziol J., Ellison D., Piro L. D. 2-chloro-deoxyadenosine activity in patients with untreated, indolent Non-Hodgkin's lymphoma. Blood 1995; 86: 1710–6
  • Piro L. D., Carrera C. J., Beutler E., Carson D. A. 2-chloro-deoxyadenosine, an effective new agent for the treatment of chronic lymphocylic leukemia. Blood 1988; 72: 1069–77
  • Saven A., Piro L. D. Newer purine analogues for the teatment of hairy cell leukemia. New Engl. J. Med. 1994; 330: 691–7
  • Carson D. A., Wasson D. B., Taetle R., Yu A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 1983; 62: 737–43
  • Petersen A. J., Brown R. D., Gibson J., Pope B., Luo X. F., Schutz L., Wiley J. S., Joshua D. E. Nucleoside transporters, bcl-2 and apoptosis in CLL cells exposed to nucleoside analogues in vitro. Eur. J. Haematol. 1996; 56: 213–20
  • Avery T. L., Rehg J. E., Lumm W. C., Harwood F. C., San-tana V. M., Blakley R. L. Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bro-modeoxyadenosine in drug combinations in mice. Cancer Res. 1989; 49: 4972–8
  • Carrera C. J., Saven A., Piro L. D., Beutler E., Terai C., Carson D. A. 2-CdA chemotherapy triggers programmed cell death in normal and malignant lymphocytes. Adv. Exp. Biol 1991; 15: 309A
  • Carson D. A., Carrera C. J., Wasson D. J., Yamanaka H. Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. Adv. Enzyme Regul. 1988; 27: 395
  • Beutler E. Drug profiles. Cladribine (2-chlorodeoxyadenosine). Lancet 1992; 340: 952
  • Carson DA., Wasson D. B., Kaye J., Ullman B., Martin D. W., JR, Robins R. K., Montgomery J. A. Deoxycy-tidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L 1210 leukemia in vivo. Proc. Natl. Acad. Sci. 1980; 77: 6865–9
  • Arner E. S. J. On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment. Leukemia and Lymphnma 1996; 21: 225–31
  • Fabianowska-Majewska K., Tybor K., Duley J., Sim-monds A. The influence of 2-chloro-2'-deoxyade-nosine on metabolism of deoxyadenosine in human primary cns lymphoma. Biochem. Pharm. 1995; 50: 1379–83
  • Kristensen J., Nygren P., Liliemark J., Fridborg H., Kil-lander A., Simonsson B., Öberg G., Larsson R. Interactions between cladribine (2-chlorodeoxyadenosine) and standard antileukemic drugs in primary cultures of human tumor cells from patients with acute myelocytic leukemia. Leukemia 1994; 8: 1712–7
  • Rabinovitch P. S., Torres R. M., Engel D. Simultaneous cell cycle analysis and two- color surface immunof-luorescence using 7- amino- actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine LY-1 B cells. J. Immunol. 1986; 136: 2769–75
  • Schmid I., Uittenbogaart C. H., Keld B., Giorgi J. V. A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytome-try. J. Immunol. Methods 1994; 170: 145–57
  • Lecoeur; H., Gougeon M. Comparative analysis of How cytometric methods for apoptosis quantitation in murine thymocytes and human peripheral lymphocytes from controls and HIV- infected persons. Evidence for interference by granulocytes and erythroeytes. J. Immunol. Methods 1996; 198: 87–99
  • Vermes I., Haanen C., Steffens-Nakken H., Reuteling-sperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J. Immunol. Methods 1995; 184: 39–51
  • Stein J., Hahn A., Rehner G. High-performance liquid chromatographic determination of nicotinic acid and nicotinamide in biological samples applying post-column derivatization resulting in bathmochrome absorption shifts. J. Chmmatogr: B. 1995; 665: 71–8
  • Saven A., Lee T., Kosty M., Piro L. Cladribine and mitoxantrone dose escalation in indolent Non-Hodgkin's lymphoma. J. Clin. Oncol. 1996; 14: 2139–44
  • Bromidge T. J., Turner D. L., Howe D. J., Johnson S. A., Rule S. A. J. In vitro chemosensitivity of chronic lymphocytic leukemia to purine analogues - correlation with clinical course. Leukemia 1998; 12: 1230–35
  • Castejón R., Vargas J. A., Briz M., Berrocal E., Romero Y., Gea-Banacloche J. C., Fernández M. N., Durántez A. Induction of apoptosis by 2-chlorodeoxyadenosine in B cell chronic lymphocytic leukemia. Leukemia 1997; 11: 1253–57
  • Albertioni F., Lindemalm S., Reichelova V., Petterson B., Eriksson S., Juliusson G., Liliemark J. Pharma-cokinetics of Cladribine in plasma and its 5'monophosphate and 5'triphosphate in leukemic cells of patients with chronic lymphocytic leukemia. Clin. Cancer Res. 1998; 4: 653–8
  • Begleiter A., Verburg L., Ashique A., Lee K., Israels L. G., Mowat M., Johnston J. B. Comparison of antitu-mor activities of 2-chlorodeoxyadenosine and 9-b˜-arabi-nosyl-2-fluoroadenine in chronic lymphocytic leukemia and marrow cells in vitro. Leukemia 1995; 9: 1875–81
  • Kawasaki H., Carrera C. J., Piro L. D., Saven A., Kipps T. J., Carson D. A. Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemothera-peutic efficacy of 2-chlorodeoxyadenosine. Blood 1993; 81: 597–601
  • Betticher D. C., von Rohr A., Ratschiller D., Hsu Schmitz S.F., Egger T., Sonderegger T., Hermann R., Kroner T., Zulian G. B., Cavalli F., Fey M. F., Cerny T. Fewer infections, but maintained antitumor activity with lower-dose versus standard-dose cladribine in pretreated low-grade Non-Hodgkin's lymphoma. J. Clin. Oncol. 1998; 16: 850–8
  • Cummings J., Anderson L., Willmott N., Smyth J. F. The molecular pharmacology of doxorubicin in vivo. Eur. J. Cancer 1991; 27: 532–5
  • Faulds D., Balfour J. A., Chrisp P., Langtry H. D. Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutical potential in the chemotherapy of cancer. Drugs 1991; 41: 400–49
  • Begleiter A., Wang H., Verburg L., Lee L., Israels L. G., Mowat M. R. A., Johnston J. B. In vitro cytoxicity of 2-chlorodeoxyadenosine and chlorambucil in chronic lymphocytic leukemia. Leukemia 1996; 10: 1959–65

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