Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60

References

• Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604–616.
   PubMed Web of Science ®Google Scholar
• Kolesnick R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 2002. 110:3–8.
   PubMed Web of Science ®Google Scholar
• Perry DK, Hannun YA. The role of ceramide in cell signaling. Biochim Biophys Acta 1998;1436:233–243.
   PubMed Web of Science ®Google Scholar
• Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 2000;10:73–80.
   PubMed Web of Science ®Google Scholar
• Pettus BJ, Chalfant CE, Hannun YA. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 2002;1585:114–125.
   PubMed Web of Science ®Google Scholar
• Cuvillier O. Sphingosine in apoptosis signaling. Biochim Biophys Acta 2002;1585:153–162.
   PubMed Web of Science ®Google Scholar
• Cuvillier O, Pirianov G, Kleuser B, et al Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996;381:800–803.
   PubMed Web of Science ®Google Scholar
• Spiegel S, Milstien S. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 2000;476:55–57.
   PubMed Web of Science ®Google Scholar
• Cuvillier O, Levade T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001;98:2828–2836.
   PubMed Web of Science ®Google Scholar
• Edsall LC, Cuvillier O, Twitty S, Spiegel S, Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem 2001. 76:1573–1584.
   PubMed Web of Science ®Google Scholar
• Olivera A, Kohama T, Edsall L, et al Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999;147:545–558.
   PubMed Web of Science ®Google Scholar
• Bonhoure E, Pchejetski D, Aouali N, et al Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 2006;20:95–102.
   PubMedGoogle Scholar
• Park MT, Kang JA, Choi JA, et al Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. Clin Cancer Res 2003;9:878–885.
   PubMed Web of Science ®Google Scholar
• Park MT, Choi JA, Kim MJ, et al Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J Biol Chem 2003;278:50624–50634.
   PubMed Web of Science ®Google Scholar
• Sakakura C, Sweeney EA, Shirahama T, et al Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. Biochem Biophys Res Commun 1998;246:827–830.
   PubMed Web of Science ®Google Scholar
• Lunghi P, Tabilio A, Dall'Aglio PP, et al Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 2003;17:1783–1793.
   PubMed Web of Science ®Google Scholar
• Milella M, Kornblau SM, Estrov Z, et al Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001;108:851–859.
   PubMed Web of Science ®Google Scholar
• Mas VM, Hernandez H, Plo I, et al Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. Blood 2003;101:1543–1550.
   PubMed Web of Science ®Google Scholar
• Scudiero DA, Shoemaker RH, Paull KD, et al Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988;48:4827–4833.
   PubMed Web of Science ®Google Scholar
• Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27–55.
   PubMedGoogle Scholar
• Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 1997;411:77–82.
   PubMed Web of Science ®Google Scholar
• Walczak H, Krammer PH. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 2000. 256:58–66.
   PubMed Web of Science ®Google Scholar
• Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008;9:47–59.
   PubMed Web of Science ®Google Scholar
• Nagahara Y, Shinomiya T, Kuroda S, Kaneko N, Nishio R, Ikekita M. Phytosphingosine induced mitochondria-involved apoptosis. Cancer Sci 2005;96:83–92.
   PubMed Web of Science ®Google Scholar
• Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309–1312.
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 1997;91:627–637.
   PubMed Web of Science ®Google Scholar
• Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998;94:491–501.
   PubMed Web of Science ®Google Scholar
• Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004;18:189–218.
   PubMed Web of Science ®Google Scholar
• Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee WJ. Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1. Blood 1999;93:3893–3899.
   PubMed Web of Science ®Google Scholar
• Towatari M, Iida H, Tanimoto M, Iwata H, Hamaguchi M, Saito H. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997. 11:479–484.
   PubMed Web of Science ®Google Scholar
• Jaffrezou JP, Levade T, Bettaieb A, et al Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 1996;15:2417–2424.
   PubMed Web of Science ®Google Scholar