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Letters to the Editor

RUNX1 amplification in B-cell acute lymphoblastic leukemia

, , , , , & show all
Pages 329-332 | Received 04 Sep 2009, Accepted 30 Oct 2009, Published online: 09 Dec 2009

References

  • Niini T, Kanerva J, Vettenranta K, Saarinen-Pihkala UM, Knuutila S. AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemia. Haematologica 2000;85:362–366.
  • Nordgren A, Heyman M, Sahlen S, et al Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analysis of 70 cases. Eur J Haematol 2002;68:31–41.
  • Soulier J, Trakhtenbrot L, Najfeld V, et al Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup. Leukemia 2003;17:1679–1682.
  • Ma SK, Wan TSK, Cheuk ATC, et al Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study. Leukemia 2001;15:1442–1447.
  • Mikhail FM, Serry KA, Hatem N, et al AML1 gene over-expression in childhood acute lymphoblastic leukemia. Leukemia 2002;16:658–668.
  • Harewood L, Robinson H, Harris R, et al Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases. Leukemia 2003;17:547–553.
  • Attarbaschi A, Mann G, Panzer-Grumayer R, et al Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: the Austrian and German acute lymphoblastic leukemia Berlin-Frankfurt-Munster (ALL-BFM) trials. J Clin Oncol 2008;26:3046–3050.
  • Penther D, Preudhomme C, Talmant P, et al Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 mutation. Leukemia 2002;16:1131–1134.
  • Jabber Al-Obaidi MS, Martineau M, Bennett CF, et al ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukemia. Leukemia 2002;16:669–674.
  • Garcia-Casado Z, Cervera J, Verdeguer A, et al High-level amplification of the RUNX1 gene in two cases of childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet 2006;170:171–174.
  • De Braekeleer E, Ferec C, De Braekeleer M. RUNX1 translocations in malignant hemopathies. Anticancer Res 2009;29:1031–1038.
  • Kurokawa M, Tanaka T, Tanaka K, et al Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies. Oncogene 1996;12:883–892.
  • Moorman AV, Richards SM, Robinson HM, et al Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21). Blood 2007;109:2327–2330.
  • Strefford JC, van Delft FW, Robinson HM, et al Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci USA 2006;103:8167–8172.
  • Robinson HM, Harrison CJ, Moorman AV, Chudoba I, Strefford JC. Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle. Genes Chromosomes Cancer 2007;46:318–326.

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