197
Views
21
CrossRef citations to date
0
Altmetric
Reviews

Double umbilical cord blood transplant: more than a cell dose?

, , &
Pages 975-982 | Received 30 Jan 2010, Accepted 13 Feb 2010, Published online: 31 Mar 2010

References

  • Gluckman E, Broxmeyer HA, Auerbah AD, et al Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling. N Engl J Med 1989;321:1174–1178.
  • Rubinstein P, Carrier C, Scaradavou A, et al Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New Engl J Med 1997;339:1565–1577.
  • Gluckman E, Rocha V, Boyer-Chammard A, et al Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplantation Group and the European Blood and Marrow Transplantation Group. New Engl J Med 1997;337:373–381.
  • Nitsche A, Zhang M, Clauss T, Siegert W, Brune K, Pahl A. Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors. BMC Immunol 2007;31:8–18.
  • Garderet L, Dulphy N, Douay C, et al The umbilical cord blood alpha beta T-cell repertoire: characteristics of a polyclonal and naive but completely formed repertoire. Blood 1998;91:340–346.
  • Mohty M, Gaugler B. Inflammatory cytokines and dendritic cells in acute graft-versus-host disease after allogeneic stem cell transplantation. Cytokine Growth Factor Rev 2008;19:53–63.
  • Verneris MR, Miller JS. The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells. Br J Haematol 2009;147:185–191.
  • Dalle JH, Menezes J, Wagner E, et al Characterization of cord blood natural killer cells: IMPLICATION for transplantation and neonatal infections. Pediatr Res 2005;57:649–655.
  • Condiotti R, Zakai YB, Nagler A. Ex vivo expansion of CD56 + cytotoxic cells from human umbilical cord blood. Exp Hematol 2001;29:104–113.
  • Bone Marrow Donors Worldwide. Annual report 2008. Available from: http://www.bmdw.org/uploads/media/BMDW2008.pdf.
  • Sullivan M.J. Banking on cord blood stem cells. Nat Rev Cancer 2008;8:555–563.
  • Rocha V, Gluckman E. Improving outcomes of cord transplantation-related factors. Br J Haematol 2009;147:262–274.
  • Smith A, Wagner J. Alternative hematopoietic stem cell sources for transplantation: place of umbilical cord blood. Br J Haematol 2009;147:246–261.
  • Wagner J, Barker J, DeFor T, et al Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002;100:1611–1618.
  • Sanz J, Saavedra S, Montesinos P, Sanz G. Unrelated donor umbilical cord blood transplantation (UD-UCBT) for adult patients with high-risk acute myeloid leukemia (AML). Blood 2008;112: 4401.
  • Rocha V, Labopin M, Sanz G, et al Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004;351:2276–2285.
  • Laughlin MJ, Eapen M, Rubinstein P, et al Outcome after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004;351:2265–2275.
  • Takahashi S, Ooi J, Iseki T, et al Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004;104:3813–3820.
  • Takahashi S, Ooi J, Tomonari A, et al Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 2007;109:1322–1330.
  • Rocha V, Eapen M, Scaradavou E, et al Effect of stem cell source on transplant outcomes in adults with acute leukemia: a comparison of bone marrow, peripheral blood and cord blood. Bone Marrow Transplant 2009;43:S5.
  • Eapen M, Rubinstein P, Zhang MJ, et al Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukemia: a comparison study. Lancet 2007;369:1947–1954.
  • Gluckman E, Rocha V, EBMT Pediatric, Acute Leukemia Working Parties; Eurocord. Indications and results of cord blood transplant in children with leukemia. Bone Marrow Transplant 2008;41:80–82.
  • US General Accounting Office. Bone marrow transplants: despite recruitment successes, national programs may be underutilized. GAO-03-182. Washington, DC: General Accounting Office; 2002. pp 19–20.
  • Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Wagner JE. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005;105:1343–1347.
  • Tse W, Bunting K, Laughlin M. New insights into cord blood stem cell transplantation. Curr Opin Hematol 2008;15:279–284.
  • Delaney C, Gutman G, Appelbaum F. Cord blood transplantation for hematological malignancies: conditioning regimens, double cord transplant and infectious complications. Br J Haematol 2009;147:207–216.
  • Verneris M, Brunstein C, DeFor T, et al Risk of relapse after umbilical cord blood transplantation in patients with acute leukemia – marked reduction in recipients of two units. Biol Blood Marrow Transplant 2006;12:1219–1219.
  • Brunstein CG, Macmillan ML, Barker J, et al Relapse risk after umbilical cord blood transplantation: enhanced graft versus leukemia effect in recipients of two units. Blood 2009;114:4293–4299.
  • Willemze R, Rodrigues CA, Labopin M, et al KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia 2009;3:492–500.
  • Sorror ML, Sandmaier BM, Storer BE, et al Co-morbidity and disease status based risk stratification of outcomes among patients with acute myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic cell transplantation. J Clin Oncol 2007;25:4246–4254.
  • Brunstein CG, Cantero S, Cao Q, et al Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant 2009;15:214–222.
  • Matsuno N, Wake A, Uchida N, et al Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation. Blood 2009;114:1689–1695.
  • Rocha V, Mohty M, Gluckman E, Rio B. Reduced intensity conditioning regimens before unrelated cord blood transplantation in adults with acute leukemia and other hematological malignancies. Curr Opin Oncol 2009;21(Suppl. 1):S31–S34.
  • Brunstein CG, Barker JN, Weisdorf DJ, et al Umbilical cord blood transplantation after non myeloablative conditioning: impact on transplantation outcomes in 110 adults with hematological disease. Blood 2007;110:3064–3070.
  • Ballen KK, Spitzer TR, Yeap B, et al Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Blood 2005;106:579A–580A.
  • Goldstein G, Elhasid R, Bielorai B, et al Similar engraftment kinetics of cord blood transplantations of double units in adults, versus single unit in children. Bone Marrow Transplant 2009;43:S109–S110.
  • Tamila L, Kindwall-Keller DO, Laughlin M. Prospective phase II study of biologic assignment one versus two unit umbilical cord blood transplant in the reduced intensity conditioning setting. Blood 2008;112: 1960.
  • Rodrigues CA, Sanz G, Brunstein CG, et al Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and lymphoma working party of the European group for blood and marrow transplantation. J Clin Oncol 2009;27:256–263.
  • Lister J, Gryn JF, McQeen KL. Multiple unit HLA-unmatched sex-mismatched umbilical cord blood transplantation for advanced hematological malignancy. Stem Cells Dev 2007;16:177–186.
  • Haspel RL, Kao G, Yeap BY, Ballen KK. Pre infusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant 2008;41:523–529.
  • Frisch BJ, Calvi LM. Hematopoietic niche. Curr Opin Support Palliat Care 2008;2:211–217.
  • Haspel RL, Ballen KK. Double cord blood transplants filling a niche? Stem Cell Rev 2006;2:81–86.
  • Kolet O, Dar A, Lapidot T. The multiple roles of osteoclasts in host defense: bone remodeling and hematopoetic stem cell mobilization. Ann Rev Immunol 2007;25:51–69.
  • Nauta AJ, Kruisselbrink AB, Lurvink E, et al Enhanced engraftment of umbilical cord blood-derived stem cells in NOD/SCID mice by co transplantation of a second unrelated cord blood unit. Exp Hematol 2005;33:1249–1256.
  • Gutman JA, Turtle CJ, Manley TJ, et al Single-unit dominance following double unit umbilical cord blood transplantation coincides with a specific CD8 + T cell response against the non-engrafted unit. Blood 2010;115:757–765.
  • Avello J, van de Ven C, Fortino W. Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. Biol Blood Marrow Transplant 2006;12:608–622.
  • Miller JS, Brunstein CG, Cooley S. A novel triple umbilical cord blood transplant (UCBT) strategy to promote NK cell immunotherapy (unit 1) with a fully ablative preparative regimen followed by a double UCBT in patients with refractory AML. Blood 2006;108:1403–1403.
  • Shpall EJ, Quinones R, Giller R, et al Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002;8:368–376.
  • Jaroscak J, Goltry K, Smith A, Kurtzberg J. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the Aastrom Replicell System. Blood 2003;101:5061–5067.
  • de Lima M, McMannis J, Gee A, et al Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a print phase I/II clinical trial. Bone Marrow Transplant 2008;41:771–778.
  • Bug G, Gül H, Schwarz K, et al Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res 2005;65:2537–2541.
  • Magro E, Regidor C, Cabrera R, et al Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor. Haematologica 2006;91:640–648.
  • Anker PS, Noort WA, Kruisselbrink AB, Fibbe WE. Non expanded primary lung and bone marrow-derived mesenchymal stem cells promote the engraftment of umbilical cord blood-derived CD34( + ) cells in NOD/SCID mice. Exp Hematol 2003;31:881–889.
  • Kim DW, Chung YJ, Kim TG, Oh IH. Co-transplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 2004;103:1941–1948.
  • Le Blanc K, Samuelsson H, Gustafsson B, et al Transplantation of mesenchymal stem cells to enhance engraftment of hematopoetic stem cells. Leukemia 2007;21:1733–1738.
  • Resnic I, Shimoni A, Nagler A. Treatment of severe GVHD with mesenchymal stromal cells. Blood 2009;114: 2249.
  • Frassoni F, Gualani F, Labopin M, Basigalupo A. Direct intrabone transplant of unrelated cord-blood cells in acute leukemia: a phase I/II study. Lancet Oncol 2008;9:831–839.
  • Frassoni F, Labopin M, Gualani F. Intrabone marrow transplantation of cord blood cells is associated with better platelet recovery and decreased acute GVHD as compared with intravenous transplantation: a Eurocord matched-paired analysis. Bone Marrow Transplant 2009;43:S3.
  • Brunstein CG, Barker JN, Weisdorf DJ, et al Intra-bone marrow injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units. Bone Marrow Transplant 2009;43:935–940.
  • Calvi LM, Adams GB, Weibrecht N. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841–846.
  • Ballen KK, Shpall EJ, Avigan D, Spitzer TR. Phase I trial of parathyroid hormone to facilitate stem cell mobilization. Biol Blood Marrow Transplant 2007;13:838–843.
  • Perruccio K, Tosti A. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005;106:4397–4406.
  • Serrano LM, Pfeiffer T, Olivares S. Differentiation of naïve cord blood T cells into CD19-specific cytolytic effectors for post transplantation adoptive immunotherapy. Blood 2006;107:2643–2652.
  • Nagler A, Volchek Y, Yerushalmi R. Nilotinib treatment post-allogeneic stem cell transplantation in advanced (> CP) chronic myeloid leukemia (CML) and Ph + acute lymphoblastic leukemia (ALL). Blood 2009;114(Suppl. 1): (Abstract 1176).
  • National Institutes of Health. Treatment of imminent haematological relapse in patients with AML and MDS following allogeneic stem cell transplantation with 5-azacitidine (Vidaza®). NCT00422890. Available from: http://clinicaltrials.gov/ct2/show/NCT00422890.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.