Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML–RARα negative human myeloblastic leukemia cells

References

• Waxman S, Anderson KC. History of the development of arsenic derivatives in cancer therapy. Oncologist 2001;6:3–10.
   PubMed Web of Science ®Google Scholar
• Evens AM, Tallman MS, Gartenhaus RB. The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future. Leuk Res 2004;28:891–900.
   PubMed Web of Science ®Google Scholar
• Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008;111:2505–2515.
   PubMed Web of Science ®Google Scholar
• Niu C, Yan H, Yu T, et al Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood 1999;94:3315–3324.
   PubMed Web of Science ®Google Scholar
• Shen ZX, Chen GQ, Ni JH, et al Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997;89:3354–3360.
   PubMed Web of Science ®Google Scholar
• Mathews V, George B, Lakshmi KM, et al Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood 2006;107:2627–2632.
   PubMed Web of Science ®Google Scholar
• Breitman T, Collins S, Keene B. Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood 1981;57:1000–1004.
   PubMed Web of Science ®Google Scholar
• Huang M, Ye Y, Chen S, et al Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988;72:567–572.
   PubMed Web of Science ®Google Scholar
• Asou N, Kishimoto Y, Kiyoi H, et al A randomized study with or without intensified maintenance chemo- therapy in patients with acute promyelocytic leukemia who have become negative for PML-RARalpha transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. Blood 2007;110:59–66.
   PubMed Web of Science ®Google Scholar
• Shen ZX, Shi ZZ, Fang J, et al All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 2004;101:5328–5335.
   PubMed Web of Science ®Google Scholar
• Zhang XW, Yan XJ, Zhou ZR, et al Arsenic trioxide controls the fate of the PML–RARα oncoprotein by directly binding PML. Science 2010;328:240–243.
   PubMed Web of Science ®Google Scholar
• Yen A, Roberson MS, Varvayanis S, Lee AT. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res 1998;58:3163–3172.
   PubMed Web of Science ®Google Scholar
• Wang J, Yen A. A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation and cell cycle arrest. J Biol Chem 2008;283:4375–4386.
   PubMed Web of Science ®Google Scholar
• Perkins C, Kim C, Fang G, Bhalla K. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL. Blood 2000;95:1014–1022.
   PubMed Web of Science ®Google Scholar
• Herst P, Hesketh E, Ritchie D, Berridge M. Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. Leuk Res 2008;32:327–333.
   PubMed Web of Science ®Google Scholar
• Jiang G, Albihn A, Tang T, Tian Z, Henriksson M. Role of Myc in differentiation and apoptosis in HL60 cells after exposure to arsenic trioxide or all-trans retinoic acid. Leuk Res 2008;32:297–307.
   PubMed Web of Science ®Google Scholar
• Chen GQ, Zhu J, Shi XG, et al In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood 1996;88:1052–1061.
   PubMed Web of Science ®Google Scholar
• Fernandez C, Ramos AM, Sancho P, Amran D, de Blas E, Aller P. 12-O-Tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. J Biol Chem 2004;279:3877–3884.
   PubMed Web of Science ®Google Scholar
• Huang C, Ma W, Li J, Dong Z. Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res 1999;59:3053–3058.
   PubMed Web of Science ®Google Scholar
• Kishimoto H, Hoshino S, Ohori M, et al Molecular mechanism of human CD38 gene expression by retinoic acid identification of retinoic acid response element in the first intron. J Biol Chem 1998;273:15429–15434.
   PubMed Web of Science ®Google Scholar
• Shen M, Yen A. c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells. Cancer Res 2008;68:8761–8769.
   PubMed Web of Science ®Google Scholar
• Reiterer G, Bunaciu RP, Smith JL, Yen A. Inhibiting the platelet derived growth factor receptor increases signs of retinoic acid syndrome in myeloid differentiated HL-60 cells. FEBS Lett 2008;582:2508–2514.
   PubMed Web of Science ®Google Scholar
• Shen M, Yen A. Nicotinamide cooperates with retinoic acid and 1,25-dihydroxyvitamin D3 to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells. Oncology 2009;76:91–100.
   PubMed Web of Science ®Google Scholar
• Muscarella DE, Rachlinski MK, Sotiriadis J, Bloom SE. contribution of gene-specific lesions, DNA-replication-associated damage, and subsequent transcriptional inhibition-mediated apoptosis in lymphoma cells. Exp Cell Res 1998;238:155–167.
   PubMed Web of Science ®Google Scholar
• Lamkin TJ, Chin V, Varvayanis S, et al Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation of viability depending on expression levels. J Cell Biochem 2006;97:1328–1338.
   PubMed Web of Science ®Google Scholar
• Shao W. Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst 1998;90:124–133.
   PubMed Web of Science ®Google Scholar
• Jing Y, Dai J, Chalmers-Redman RME, Tatton WG, Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 1999;94:2102–2111.
   PubMed Web of Science ®Google Scholar
• Davison K, Mann KK, Waxman S, Miller WH. JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. Blood 2004;103:3496–3502.
   PubMed Web of Science ®Google Scholar
• Dai J, Weinberg RS, Waxman S, Jing Y. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood 1999;93:268–277.
   PubMed Web of Science ®Google Scholar
• Ramos AM, Fernandez C, Amran D, Sancho P, de Blas E, Aller P. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 2005;105:4013–4020.
   PubMed Web of Science ®Google Scholar
• Chen GQ, Shi XG, Tang W, et al Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 1997;89:3345–3353.
   PubMed Web of Science ®Google Scholar
• Verma A, Mohindru M, Deb DK, et al Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. J Biol Chem 2002;277:44988–44995.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Tao J, Zhu Q, et al Rapid induction of cAMP/ PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia 2003;18:285–292.
   Web of Science ®Google Scholar
• Zheng PZ, Wang KK, Zhang QY, et al Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci USA 2005;102:7653–7658.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Zhang JW, Zhu HQ, et al Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood 2002;99:1014–1022.
   PubMed Web of Science ®Google Scholar