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Original Articles: Research

Epigenetic alterations of p15INK4B and p16INK4A genes in pediatric primary myelodysplastic syndrome

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Pages 1887-1894 | Received 01 Apr 2010, Accepted 27 Jun 2010, Published online: 27 Jul 2010

References

  • Nimer SD. Myelodysplastic syndromes. Blood 2008;111:4841–4851.
  • Niemeyer CM, Baumann I. Myelodysplastic syndrome in children and adolescents. Semin Hematol 2008;45:60–70.
  • Elghetany MT. Myelodysplastic syndromes in children: a critical review of issues in the diagnosis and classification of 887 cases from 13 published series. Arch Pathol Lab Med 2007;131:1110–1116.
  • Hasle H, Niemeyer CM, Chessels JM, et al A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia 2003;17:277–282.
  • Polychronopoulou S, Panagiotou JP, Kossiva L, Mavrou A, Anagnostou D, Haidas S. Clinical and morphological features of paediatric myelodysplastic syndromes: a review of 34 cases. Acta Paediatr 2004;93:1015–1023.
  • Paluszczak J, Baer-Dubowska W. Epigenetic diagnostics of cancer - the application of DNA methylation markers. J Appl Genet 2006;47:365–375.
  • Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hematol 2008;68:1–11.
  • Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 1997;57:837–841.
  • Toyota M, Kopecky KJ, Toyota MO, Jair KW, Willman CL, Issa JP. Methylation profiling in acute myeloid leukemia. Blood 2001;97:2823–2829.
  • Shimamoto T, Ohyashiki JH, Ohyashiki K. Methylation of p15INK4B and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Leuk Res 2005;29:653–659.
  • Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996;85:27–37.
  • Quesnel B, Guillerm G, Vereecque R, et al Methylation of the p15INK4B gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 1998;8:2985–2990.
  • Tien HF, Tang JL, Tsay W, et al Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early or during disease progression and is highly associated with leukaemic transformation. Br J Haematol 2001;112:148–154.
  • Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1 and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 2006;76:23–32.
  • Hasegawa D, Manabe A, Kubota T, et al Methylation status of the p15 and p16 genes in paedriatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia. Br J Haematol 2005;128:805–812.
  • Vidal DO, Paixão VA, Brait M, et al Aberrant methylation in pediatric myelodysplastic syndrome. Leuk Res 2007;31:175–181.
  • Herman J, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821–9826.
  • Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997;25:2532–2534.
  • Brakensiek K, Länger F, Schlegelberger B, Kreipe H, Lehmann U. Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome. Br J Haematol 2005;130:209–217.
  • Uchida T, Kinoshita T, Nagai H, et al Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood 1997;90:1403–1409.
  • Solomon PR, Munirajan AK, Tsuchida N, et al Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic and prognostic implications. Indian J Med Res 2008;127:52–57.
  • Flotho C. Is childhood MDS an epigenetic disease? Leuk Res 2007;31:743.
  • Sheng XM, Kawamura M, Ohnishi H, et al Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia. Leuk Res 1997;21:697–701.
  • Fernandez TS, Menezes J, Silva MLM, Tabak D, Abdelhay E. Correlation of N-ras point mutations with specific chromosomal abnormalities in primary myelodysplastic syndrome. Leuk Res 1998;22:125–134.
  • Jeki B, Novakovic I, Lukovic L, et al Low frequency of NRAS and KRAS2 gene mutations in childhood myelodysplastic syndromes. Cancer Genet Cytogenet 2004;154:180–182.
  • Jiang Y, Dunbar A, Lukasz P, et al Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009;113:1315–1325.

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