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Leukemia & Lymphoma Volume 52, 2011 - Issue 2
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Original Articles: Research

In a patient with biclonal Waldenstrom macroglobulinemia only one clone expands in three-dimensional culture and includes putative cancer stem cells

Julia KirshnerDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
,
Kyle J. ThulienDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
,
Jitra KriangkumDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
,
Sarah MotzDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
,
Andrew R. BelchDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
&
Linda M. PilarskiDepartment of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, CanadaCorrespondence[email protected]
Pages 285-289 | Received 21 Sep 2010, Accepted 21 Oct 2010, Published online: 06 Dec 2010

References

  • Kriangkum J, Taylor BJ, Treon SP, Mant MJ, Belch AR, Pilarski LM. Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood. Blood 2004;104:2134–2142.
  • Owen RG, Johnson SA, Morgan GJ. Waldenstrom's macroglobulinaemia: laboratory diagnosis and treatment. Hematol Oncol 2000;18:41–49.
  • Ciric B, VanKeulen V, Rodriguez M, Kyle RA, Gertz MA, Pease LR. Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor. Blood 2001;97:321–323.
  • Kriangkum J, Taylor BJ, Treon SP, et al. Molecular characterization of Waldenstrom's macroglobulinemia reveals frequent occurrence of two B-cell clones having distinct IgH VDJ sequences. Clin Cancer Res 2007;13:2005–2013.
  • Kirshner J, Thulien KJ, Martin LD, et al. A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma. Blood 2008;112:2935–2945.
  • Szczepek AJ, Seeberger K, Wizniak J, Mant MJ, Belch AR, Pilarski LM. A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase-polymerase chain reaction. Blood 1998;92:2844–2855.
  • Kriangkum J, Taylor BJ, Strachan E, et al. Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery. Blood 2006;107:2920–2927.
  • Taylor BJ, Kriangkum J, Strachan ER, Wizniak J, Pilarski LM. Identification of clonotypic IgH VDJ sequences in multiple myeloma. Methods Mol Med 2005;113:121–144.
  • Ocio EM, Mateo G, Vidriales B, et al. Cell cycle analysis of Waldenstrom's macroglobulinemia. Clin Lymphoma 2005;5:250–252.

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