The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies

References

• Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 1999;68:821–861.
   PubMed Web of Science ®Google Scholar
• Zhang X, Odom DT, Koo SH, . Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 200522;102:4459–4464.
   Web of Science ®Google Scholar
• Johannessen M, Delghandi MP, Moens U. What turns CREB on? Cell Signal 2004;16:1211–1227.
   PubMed Web of Science ®Google Scholar
• Montminy MR, Gonzalez GA, Yamamoto KK. Regulation of cAMP-inducible genes by CREB. Trends Neurosci 1990;13:184–188.
   PubMed Web of Science ®Google Scholar
• Montminy MR, Bilezikijan LM. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 1987;328:175–178.
   PubMed Web of Science ®Google Scholar
• Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001;2:599–609.
   PubMed Web of Science ®Google Scholar
• Siu YT, Jin DY. CREB – a real culprit in oncogenesis. FEBS J 2007; 274:3224–3232.
   PubMed Web of Science ®Google Scholar
• Yamamoto KK, Gonzalez GA, Menzel P, Rivier J, Montminy MR. Characterization of a bipartite activator domain in transcription factor CREB. Cell 1990;60:611–617.
   PubMed Web of Science ®Google Scholar
• Felinski EA, Kim J, Lu J, Quinn PG. Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation. Mol Cell Biol 2001;21:1001–1010.
   PubMed Web of Science ®Google Scholar
• Wu X, Spiro C, Owen WG, McMurray CT. cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA. J Biol Chem 1998;273:20820–20807.
   PubMed Web of Science ®Google Scholar
• Impey S, McCorkle SR, Cha-Molstad H, . Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 2004;119:1041–1054.
   PubMed Web of Science ®Google Scholar
• Kohler JJ, Metallo SJ, Schneider TL, Schepartz A. DNA specificity enhanced by sequential binding of protein monomers. Proc Natl Acad Sci USA 1999;96:11735–11739.
   PubMed Web of Science ®Google Scholar
• Craig JC, Schumacher MA, Mansoor SE, Farrens DL, Brennan RG, Goodman RH. Consensus and variant cAMP-regulated enhancers have distinct CREB binding properties. J Biol Chem 2001;276:11719–11728.
   PubMed Web of Science ®Google Scholar
• Mora-Garcia P, Cheng J, Crans-Vargas HN, Countouriotis A, Shankar D, Sakamoto KM. Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling. Stem Cells 2003;21:123–130.
   PubMed Web of Science ®Google Scholar
• Asahara H, Santoso B, Guzman E, . Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol Cell Biol 2001;21:7892–7900.
   PubMed Web of Science ®Google Scholar
• Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993;365:855–859.
   PubMed Web of Science ®Google Scholar
• Kim J, Lu J, Quinn PG. Distinct cAMP response element-binding protein (CREB) domains stimulate different steps in a concerted mechanism of transcription activation Proc Natl Acad Sci USA 2000;97:11292–11296.
   PubMed Web of Science ®Google Scholar
• Quinn PG. Mechanisms of basal and kinase-inducible transcription activation by CREB. Prog Nucleic Acid Res Mol Biol 2002;72:269–305.
   PubMed Web of Science ®Google Scholar
• Ferreri K, Gill G, Montminy M. The cAMP-regulated transcription factor CREB interacts with acomponent of the TFIID complex. Proc Natl Acad Sci USA 1994;91:1210–1213.
   PubMed Web of Science ®Google Scholar
• Foulkes NS, Borrelli E, Sassone-Corsi P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 1991;64:739–749.
   PubMed Web of Science ®Google Scholar
• Walker WH, Girardet C, Habener JF. Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. J Biol Chem 1996;271:20145–20150.
   PubMed Web of Science ®Google Scholar
• Fimia GM, De Cesare D, Sassone-Corsi P. CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 1999;398:165–169.
   PubMed Web of Science ®Google Scholar
• Fimia GM, De Cesare D, Sassone-Corsi P. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Mol Cell Biol 2000;20:8613–8622.
   PubMed Web of Science ®Google Scholar
• Boulon S, Dantonel JC, Binet V, . Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism. Mol Cell Biol 2002;22:7769–7779.
   PubMed Web of Science ®Google Scholar
• Giebler HA, Lemasson I, Nyborg JK. p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol Cell Biol 2000;20:4849–4858.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhuang S, Cassenaer S, . Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol 2003;23:4066–4082.
   PubMed Web of Science ®Google Scholar
• Okoshi R, Kubo N, Nakashima K, Shimozato O, Nakagawara A, Ozaki T. CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. Biochem Biophys Res Commun 2011;406:79–84.
   PubMed Web of Science ®Google Scholar
• Iourgenko V, Zhang W, Mickanin C, . Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci USA 2003;100:12147–12152.
   PubMed Web of Science ®Google Scholar
• Conkright MD, Canettieri G, Screaton R, . TORCs: transducers of regulated CREB activity. Mol Cell 2003;12:413–423.
   PubMed Web of Science ®Google Scholar
• Screaton RA, Conkright MD, Katoh Y, . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 2004;119:61–74.
   PubMed Web of Science ®Google Scholar
• Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989;59:675–680.
   PubMed Web of Science ®Google Scholar
• de Groot RP, Ballou LM, Sassone-Corsi P. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 1994;79:81–91.
   PubMed Web of Science ®Google Scholar
• Parker D, Jhala U, Radhakrishnan I, . Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell 1998;2:353–359.
   PubMed Web of Science ®Google Scholar
• Parker D, Rivera M, Zor T, . Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol 1999;19:5601–5607.
   PubMed Web of Science ®Google Scholar
• Best JL, Amezcua CA, Mayr B, . Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci USA 2004;101:17622–17627.
   PubMed Web of Science ®Google Scholar
• Hagiwara M, Alberts A, Brindle P, . Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 1992;70:105–113.
   PubMed Web of Science ®Google Scholar
• Wadzinski BE, Wheat WH, Jaspers S, . Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol Cell Biol 1993;13:2822–2834.
   PubMed Web of Science ®Google Scholar
• Enselen H, Sun P, Brickey D, Soderling SH, Klamo E, Soderling TR. Characterization of Ca2 + /calmodulin-dependent protein kinase IV. Role in transcriptional regulation. J Biol Chem 1994;269:15520–15527.
   PubMed Web of Science ®Google Scholar
• Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphorylation: a Ca(2 +)- and stimulus duration-dependent switch for hippocampal gene expression. Cell 1996;87:1203–1214.
   PubMed Web of Science ®Google Scholar
• Huang H, Cheville JC, Pan Y, Roche PC, Schmidt LJ, Tindall DJ. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. J Biol Chem 2001;276:38830–38836.
   PubMed Web of Science ®Google Scholar
• Gu T, Zhang Z, Wong AC, . CREB is a novel nuclear target of PTEN phosphatase. Cancer Res 2011;71:2821–2825.
   PubMed Web of Science ®Google Scholar
• Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation? EMBO J 2000;19:1176–1179.
   PubMed Web of Science ®Google Scholar
• Comerford KM, Leonard MO, Karhausen J, Carey R, Colgan SP, Taylor CT. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci USA 2003;100:986–991.
   PubMed Web of Science ®Google Scholar
• Lamarre-Vincent N, Hsieh-Wilson LC. Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation. J Am Chem Soc 2003;125:6612–6613.
   PubMed Web of Science ®Google Scholar
• Sakamoto KM, Fraser JK, Lee HJ, Lehman E, Gasson JC. Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter. Mol Cell Biol 1994;14:5975–5985.
   PubMed Web of Science ®Google Scholar
• Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, . PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation. J Biol Chem 2004;279: 17772–17784.
   Google Scholar
• Ginty DD, Bonni A, Greenberg ME. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 1994;77:713–725.
   PubMedGoogle Scholar
• Wong A, Sakamoto KM. Granulocyte-macrophage colony-stimulating factor induces the transcriptional activation of egr-1 through a protein kinase A-independent signaling pathway. J Biol Chem 1995;270:30271–30273.
   PubMed Web of Science ®Google Scholar
• Deak M, Clifton AD, Lucocq LM, Alessi DR. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J 1998;17:4426–4441.
   PubMed Web of Science ®Google Scholar
• Arthur JS, Cohen P. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett 2000;482:44–48.
   PubMed Web of Science ®Google Scholar
• Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and-independent mechanisms. Science 1999;286:1358–1362.
   PubMed Web of Science ®Google Scholar
• Zauli G, Gibellini D, Vitale M, . The induction of megakaryocyte differentiation is accompanied by selective Ser133 phosphorylation of the transcription factor CREB in both HEL cell line and primary CD34 + cells. Blood 1998;92:472–480.
   PubMed Web of Science ®Google Scholar
• Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood 2001;98:627–635.
   PubMed Web of Science ®Google Scholar
• Park JM, Greten FR, Wong A, . Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis—CREB and NF-kappaB as key regulators. Immunity 2005;23:319–329.
   PubMed Web of Science ®Google Scholar
• Yasuda T, Sanjo H, Pagès G, . Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 2008;28:499–508.
   PubMed Web of Science ®Google Scholar
• Kinjo K, Sandoval S, Sakamoto KM, Shankar DB. The role of CREB as a proto-oncogene in hematopoiesis. Cell Cycle 2005;4:1134–1135.
   PubMed Web of Science ®Google Scholar
• Crans-Vargas HN, Landaw EM, Bhatia S, Sandusky G, Moore TB, Sakamoto KM. Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia. Blood 2002; 99:2617–2619.
   Google Scholar
• Shankar DB, Cheng JC, Kinjo K, . The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell 2005;7:351–362.
   PubMedGoogle Scholar
• Franklin AA, Kubik MF, Uittenbogaard MN, . Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) and cAMP response element-binding protein (CREB). J Biol Chem 1993;268:21225–21231.
   PubMed Web of Science ®Google Scholar
• Perini G, Wagner S, Green MR. Recognition of bZIP proteins by the human T-cell leukemia virus transactivator Tax. Nature 1995;376:602–605.
   PubMed Web of Science ®Google Scholar
• Tie F, Adya N, Greene WC, Giam CZ. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J Virol 1996;70:8368–8374.
   PubMed Web of Science ®Google Scholar
• Cougot D, Wu Y, Cairo S, . The hepatitis B virus X protein functionally interacts with CBP/p300 in the regulation of CREB-mediated transcription. J Biol Chem 2007;282:4277–4287.
   PubMed Web of Science ®Google Scholar
• Perini G, Oetjen E, Green MR. The hepatitis B pX protein promotes dimerization and DNA-binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region. J Biol Chem 1999;274:13970–13977.
   PubMed Web of Science ®Google Scholar
• Ji L, Mochon E, Arcinas M, Boxer LM. CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J Biol Chem 1996;271:22687–22691.
   PubMed Web of Science ®Google Scholar
• Arcinas M, Heckman CA, Mehew JW, Boxer LM. Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma. Cancer Res 2001;61:5202–5206.
   PubMed Web of Science ®Google Scholar
• Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma – association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 2006;12:5356–5362.
   PubMed Web of Science ®Google Scholar
• Zucman J, Delattre O, Desmaze C, . EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 1993;4:341–345.
   PubMed Web of Science ®Google Scholar
• Cheng JC, Kinjo K, Judelson DR, . CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood 2008;111:1182–1192.
   PubMed Web of Science ®Google Scholar
• Mullighan CG, Zhang J, Kasper LH, . CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011;471:235–239.
   PubMed Web of Science ®Google Scholar
• Best JL, Amezcua CA, Mayr B, . Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci USA 2004;101:17622–17627.
   PubMed Web of Science ®Google Scholar