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Leukemia & Lymphoma Volume 52, 2011 - Issue 11
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Letter

Presence of complex t(6;9;22;15) four-way chromosome rearrangement plus rare t(1;6) translocation with favorable response to imatinib therapy in chronic myelogenous leukemia

Chuanyi M. LuDepartment of Laboratory Medicine, University of California;Veterans Affairs Medical Center, San Francisco, CA, USACorrespondence[email protected]
,
Lukun ZhouInstitute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China
,
Sizhou FengInstitute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China
,
Peter H. KohnCytogenetics Department, Quest/Nichols Institute, San Juan Capistrano, CA, USA
,
Zhongxia QiDepartment of Laboratory Medicine, University of California
&
Jingwei YuDepartment of Laboratory Medicine, University of California
Pages 2182-2184 | Received 13 Apr 2011, Accepted 21 Apr 2011, Published online: 30 Jun 2011

References

  • Barnes DJ, Melo JV. Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia. Acta Haematol 2002; 108:180–202.
  • Johansson B, Fioretos T, Mitelman F. Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematol 2002;107:76–94.
  • Valencia A, Cervera J, Such E, . Complex variant t(9;22) chromosome translocations in five cases of chronic myeloid leukemia. Adv Hematol 2009;2009:187125.
  • Stagno F, Vigneri P, Del Fabro V, . Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Acta Oncol 2010;49:506–508.
  • Ikuta K, Torimoto Y, Jimbo J, . A novel five-way chromosomal translocation observed in chronic myelogenous leukemia. Cancer Genet Cytogenet 2008;183:69–71.
  • Tan J, Cang S, Seiter K, . t(3;9;22) 3-way chromosome translocation in chronic myeloid leukemia is associated with poor prognosis. Cancer Invest 2009;27:718–722.
  • Mkrtchyan H, Ghazaryan S, Avetisyan G, . Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome. Oncol Rep 2008;20:99–104.
  • Huret JL. t(1;6)(p36;p21). Atlas Genet Cytogenet Oncol Haematol. December 2008. Available from: http://AtlasGene ticsOncology.org/Anomalies/t0106p36p21ID1530.html
  • Yin CC, Abruzzo LV, Qiu X, . Del(15q) is a recurrent minor-route cytogenetic abnormality in the clonal evolution of chronic myelogenous leukemia. Cancer Genet Cytogenet 2009;192: 18–23.
  • Fitzgerald PH, Morris CM. Complex chromosomal transloca-tions in the Philadelphia chromosome leukemia. Serial translocations or a concerted genomic rearrangement? Cancer Genet Cytogenet 1991;57:143–151.
  • Nacheva E, Holloway T, Brown K, . Philadelphia-negative chronic myeloid leukemia: detection by FISH of BCR-ABL fusion gene localized either to chromosome 9 or chromosome 22. Br J Haematol 1994;87:409–412.
  • Reid AG, Huntly BJP, Grace C, . Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukemia. Br J Haematol 2003;121:419–427.
  • Richebourg S, Eclache V, Perot C, . Mechanisms of genesis of variant translocation in chronic myeloid leukemia are not correlated with ABL1 or BCR deletion status or response to imatinib therapy. Cancer Genet Cytogenet 2008; 182:95–102.

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