Apoptotic cells in allogeneic hematopoietic stem cell transplantations: “turning trash into gold”

References

• Ferrara JL, Deeg HJ. Graft-versus-host disease. N Engl J Med 1991;324: 667–674.
   PubMed Web of Science ®Google Scholar
• Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275–284.
   PubMed Web of Science ®Google Scholar
• Bleakley M, Riddell SR. Molecules and mechanisms of the graft versus leukaemia effect. Nat Rev Cancer 2004;4:371–380.
   PubMed Web of Science ®Google Scholar
• Erlich HA, Opelz G, Hansen J. HLA DNA typing and transplantation. Immunity 2001;14:347–356.
   PubMed Web of Science ®Google Scholar
• Welniak LA, Blazar BR, Murphy WJ. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol 2007;25:139–170.
   PubMed Web of Science ®Google Scholar
• Appelbaum FR. Haematopoietic cell transplantation as immunotherapy. Nature 2001;411:385–389.
   PubMed Web of Science ®Google Scholar
• Slavin S, Nagler A, Naparstek E, . Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998;91: 756–763.
   PubMed Web of Science ®Google Scholar
• Sykes M, Preffer F, McAfee S, . Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet 1999;353:1755–1759.
   PubMed Web of Science ®Google Scholar
• Khouri IF, Saliba RM, Giralt SA, . Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft versus host disease, and treatment-related mortality. Blood 2001;98:3595–3599.
   PubMed Web of Science ®Google Scholar
• McSweeney PA, Niederwieser D, Shizuru JA, . Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft versus tumor effects. Blood 2001;97:3390–3400.
   PubMed Web of Science ®Google Scholar
• Loiseau P, Busson M, Balere ML, . HLA association with hematopoietic stem cell transplantation outcome: the number of mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 is strongly associated with overall survival. Biol Blood Marrow Transplant 2007;13:965–974.
   PubMed Web of Science ®Google Scholar
• Hahn T, McCarthy PL Jr, Zhang MJ, . Risk factors for acute graft versus host disease after human leukocyte antigen-identical sibling transplants for adults with leukemia. J Clin Oncol 2008;26:5728–5734.
   PubMed Web of Science ®Google Scholar
• Kernan NA, Bartsch G, Ash RC, . Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 1993;328:593–602.
   PubMed Web of Science ®Google Scholar
• Flomenberg N, Baxter-Lowe LA, Confer D, . Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004;104:1923–1930.
   PubMed Web of Science ®Google Scholar
• Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med 2006;354:1813–1826.
   PubMed Web of Science ®Google Scholar
• Koreth J, Matsuoka K, Kim HT, . Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 2011;365:2055–2066.
   PubMed Web of Science ®Google Scholar
• Yoo EK, Rook AH, Elenitsas R, . Apoptosis induction of ultraviolet light A and photochemotherapy in cutaneous T-cell lymphoma: relevance to mechanism of therapeutic action. J Invest Dermatol 1996;107:235–242.
   PubMed Web of Science ®Google Scholar
• Lucas M, Stuart LM, Savill J, . Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol 2003;171:2610–2615.
   PubMed Web of Science ®Google Scholar
• Huynh ML, Fadok VA, Henson PM. Phosphatidylserine dependent ingestion of apoptotic cells promotes TGF-beta 1 secretion and the resolution of inflammation. J Clin Invest 2002;109:41–50.
   PubMed Web of Science ®Google Scholar
• Barker RN, Erwig L, Pearce WP, . Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages. Pathobiology 1999;67:302–305.
   PubMed Web of Science ®Google Scholar
• Steinman RM, Turley S, Mellman I, . The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000;191:411–416.
   PubMed Web of Science ®Google Scholar
• Maeda A, Schwarz A, Kernebeck K, . Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen specific regulatory T cells. J Immunol 2005;174:5968–5976.
   PubMed Web of Science ®Google Scholar
• Gatza E, Rogers CE, Clouthier SG, . Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 2008;112:1515–1521.
   PubMed Web of Science ®Google Scholar
• Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999; 17:2941–2953.
   PubMed Web of Science ®Google Scholar
• Fadok VA, Voelker DR, Campbell PA, . Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992;148: 2207–2216.
   PubMed Web of Science ®Google Scholar
• Henson PM, Bratton DL, Fadok VA. Apoptotic cell removal. Curr Biol 2001;11:R795–R805.
   PubMed Web of Science ®Google Scholar
• Mevorach D. Opsonization of apoptotic cells. Implications for uptake and autoimmunity. Ann NY Acad Sci 2000;926:226–235.
   PubMed Web of Science ®Google Scholar
• Fadok VA, Bratton DL, Konowal A, . Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998;101:890–898.
   PubMed Web of Science ®Google Scholar
• Verbovetski I, Bychkov H, Trahtemberg U, . Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. J Exp Med 2002;196:1553–1561.
   PubMed Web of Science ®Google Scholar
• Skoberne M, Beignon AS, Larsson M, . Apoptotic cells at the crossroads of tolerance and immunity. Curr Top Microbiol Immunol 2005;289:259–292.
   PubMed Web of Science ®Google Scholar
• Skoberne M, Somersan S, Almodovar W, . The apoptotic cell receptor CR3, but not {alpha}v{beta}5, is a regulator of human dendritic cell immunostimulatory function. Blood 2006;108:947–955.
   PubMed Web of Science ®Google Scholar
• Ronchetti A, Rovere P, Iezzi G, . Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. J Immunol 1999;163:130–136.
   PubMed Web of Science ®Google Scholar
• Chen W, Frank ME, Jin W, . TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14:715–725.
   PubMed Web of Science ®Google Scholar
• Feng H, Zeng Y, Graner MW, . Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood 2003;101:245–252.
   PubMed Web of Science ®Google Scholar
• Steinman RM, Turley S, Mellman I, . The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000;191:411–416.
   PubMed Web of Science ®Google Scholar
• Bittencourt MC, Perruche S, Contassot E, . Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood 2001;98:224–230.
   PubMed Web of Science ®Google Scholar
• Mevorach D, Zhou JL, Song X, . Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 1998;188:387–392.
   PubMed Web of Science ®Google Scholar
• Perruche S, Kleinclauss F, Angonin R, . A single intravenous infusion of apoptotic cells, an alternative cell-based therapy approach facilitating hematopoietic cell engraftment, did not induce autoimmunity. Hematother Stem Cell Res 2003;12:451–459.
   PubMedGoogle Scholar
• Gallucci S, Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 2001;13:114–119.
   PubMed Web of Science ®Google Scholar
• Sawalha AH, Harley JB. Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol 2004;16:534–540.
   PubMed Web of Science ®Google Scholar
• Perniok A, Wedekind F, Herrmann M, . High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus 1998;7:113–118.
   PubMed Web of Science ®Google Scholar
• Munoz LE, Lauber K, Schiller M, . The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol 2010;6:280–289.
   PubMed Web of Science ®Google Scholar
• Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 2010;10:36–46.
   PubMed Web of Science ®Google Scholar
• Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124:263–266.
   PubMed Web of Science ®Google Scholar
• Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004;104:2224–2234.
   PubMed Web of Science ®Google Scholar
• Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994;73:2013–2026.
   PubMed Web of Science ®Google Scholar
• Perruche S, Kleinclauss F, Bittencourt Mde C, . Intravenous infusion of apoptotic cells simultaneously with allogeneic hematopoietic grafts alters anti-donor humoral immune responses. Am J Transplant 2004;4:1361–1365.
   PubMed Web of Science ®Google Scholar
• Kleinclauss F, Perruche S, Masson E, . Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion. Cell Death Differ 2006;13:41–52.
   PubMed Web of Science ®Google Scholar
• Qiu CH, Miyake Y, Kaise H, . Novel subset of CD8alpha + dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol 2009;182: 4127–4136.
   PubMed Web of Science ®Google Scholar
• Swiecki M, Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev 2010;234:142–162.
   PubMedGoogle Scholar
• Bonnefoy F, Perruche S, Couturier M, . Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation. J Immunol 2011;186;5696–5705.
   PubMed Web of Science ®Google Scholar