Chronic lymphocytic leukemia specific T-cell subset alterations are clone-size dependent and not present in monoclonal B lymphocytosis

References

• Ghia P, Prato G, Scielzo C, . Monoclonal CD5 + and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004;103:2337–2342.
   PubMed Web of Science ®Google Scholar
• Nieto WG, Almeida J, Romero A, . Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 2009;114:33–37.
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Bennett FL, O’Connor SJ, . Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008;359:575–583.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Kay NE, Rabe KG, . Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol 2009;27:3959–3963.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Ghia P, Lanasa MC, . Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 2010;24:512–520.
   PubMed Web of Science ®Google Scholar
• Fazi C, Scarfo L, Pecciarini L, . General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood 2011;118:6618–6625.
   PubMed Web of Science ®Google Scholar
• Kern W, Bacher U, Haferlach C, . Monoclonal B-cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early-stage CLL. Br J Haematol 2012 Jan 9. [Epub ahead of print]
   Web of Science ®Google Scholar
• Hallek M, Cheson BD, Catovsky D, . Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446–5456.
   PubMed Web of Science ®Google Scholar
• Porakishvili N, Roschupkina T, Kalber T, . Expansion of CD4 + T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL). Clin Exp Immunol 2001;126:29–36.
   PubMed Web of Science ®Google Scholar
• Serrano D, Monteiro J, Allen SL, . Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic lymphocytic leukemia. J Immunol 1997;158:1482–1489.
   PubMed Web of Science ®Google Scholar
• Goolsby CL, Kuchnio M, Finn WG, . Expansions of clonal and oligoclonal T cells in B-cell chronic lymphocytic leukemia are primarily restricted to the CD3(+)CD8(+) T-cell population. Cytometry 2000;42:188–195.
   PubMedGoogle Scholar
• Van den Hove LE, Vandenberghe P, Van Gool SW, . Peripheral blood lymphocyte subset shifts in patients with untreated hematological tumors: evidence for systemic activation of the T cell compartment. Leuk Res 1998;22:175–184.
   PubMed Web of Science ®Google Scholar
• Briggs PG, Kraft N, Atkins RC. T cells and CD45R expression in B-chronic lymphocytic leukemia. Leuk Res 1990;14:155–159.
   PubMed Web of Science ®Google Scholar
• Farace F, Orlanducci F, Dietrich PY, . T cell repertoire in patients with B chronic lymphocytic leukemia. Evidence for multiple in vivo T cell clonal expansions. J Immunol 1994;153:4281–4290.
   PubMed Web of Science ®Google Scholar
• Rezvany MR, Jeddi-Tehrani M, Osterborg A, et al H. Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: major perturbations are preferentially seen within the CD4 T-cell subset. Blood 1999;94:1063–1069.
   PubMed Web of Science ®Google Scholar
• Gorgun G, Holderried TA, Zahrieh D, . Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest 2005;115:1797–1805.
   PubMed Web of Science ®Google Scholar
• Ramsay AG, Johnson AJ, Lee AM, . Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008;118:2427–2437.
   PubMed Web of Science ®Google Scholar
• Christopoulos P, Pfeifer D, Bartholome K, . Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL. Blood 2011;117: 3836–3846.
   PubMed Web of Science ®Google Scholar
• Lanasa MC, Allgood SD, Bond KM, . Oligoclonal TRBV gene usage among CD8(+) T cells in monoclonal B lymphocytosis and CLL. Br J Haematol 2009;145:535–537.
   PubMed Web of Science ®Google Scholar
• te Raa GD, Fischer K, Verweij W, . Use of the CD19 count in a primary care laboratory as a screening method for B-cell chronic lymphoproliferative disorders in asymptomatic patients with lymphocytosis. Clin Chem Lab Med 2011;49:115–120.
   PubMed Web of Science ®Google Scholar
• Hallaert DY, Jaspers A, van Noesel CJ, . c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches. Blood 2008;112:5141–5149.
   PubMed Web of Science ®Google Scholar
• Tonino SH, van de, Berg PJ, Yong SL, . Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia. Leuk Lymphoma 2012 April 19. [Epub ahead of print]
   Google Scholar
• Jak M, Mous R, Remmerswaal EB, . Enhanced formation and survival of CD4 + CD25hi Foxp3 + T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 2009;50:788–801.
   PubMed Web of Science ®Google Scholar
• Mackus WJ, Frakking FN, Grummels A, . Expansion of CMV-specific CD8 + CD45RA +. Blood 2003;102:1057–1063.
   PubMed Web of Science ®Google Scholar
• Buhmann R, Nolte A, Westhaus D, . CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells. Blood 1999;93:1992–2002.
   PubMed Web of Science ®Google Scholar
• Pourgheysari B, Bruton R, Parry H, . The number of cytomegalovirus-specific CD4 + T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4 + T-cell repertoire. Blood 2010;116: 2968–2974.
   PubMed Web of Science ®Google Scholar
• Bichi R, Shinton SA, Martin ES, . Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA 2002;99:6955–6960.
   PubMed Web of Science ®Google Scholar
• Hofbauer JP, Heyder C, Denk U, . Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL. Leukemia 2011;25:1452–1458.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Kay NE, Jenkins G, . B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. Blood 2009;113: 4188–4196.
   PubMed Web of Science ®Google Scholar