References
- Green JL, Kuntz SG, Sternberg PW. Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol 2008;18:536–544.
- Minami Y, Oishi I, Endo M, . Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev Dyn 2010;239:1–15.
- Robinson DR. The protein tyrosine kinase family of the human genome. Oncogene 2000;19:5548–5557.
- Reilly JT. Receptor tyrosine kinases in normal and malignant haematopoiesis. Blood Rev 2003;17:241–248.
- Forrester WC. The Ror receptor tyrosine kinase family. Cell Mol Life Sci 2002;59:83–96.
- Masiakowski P, Carroll RD. A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem 1992;267:26181–26190.
- Al-Shawi R, Ashton SV, Underwood C, . Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev Genes Evol 2001;211:161–171.
- Oishi I, Takeuchi S, Hashimoto R, . Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 1999;4:41–56.
- DeChiara TM, Kimble RB, Poueymirou WT, . Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet 2000;24:271–274.
- MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005;7:591–600.
- Klein U, Tu Y, Stolovitzky GA, . Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001;194:1625–1638.
- Rosenwald A, Alizadeh AA, Widhopf G, . Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194:1639–1647.
- Baskar S, Kwong KY, Hofer T, . Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin Cancer Res 2008;14:396–404.
- Daneshmanesh AH, Mikaelsson E, Jeddi-Tehrani M, . Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. Int J Cancer 2008;123:1190–1195.
- Fukuda T, Chen L, Endo T, . Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci USA 2008;105: 3047–3052.
- Barna G, Mihalik R, Timar B, . ROR1 expression is not a unique marker of CLL. Hematol Oncol 2011;29:17–21.
- Uhrmacher S, Schmidt C, Erdfelder F, . Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL). Leuk Res 2011;35:1360–1366.
- Broome HE, Rassenti LZ, Wang HY, . ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia. Leuk Res 2011;35:1390–1394.
- Kobayashi M, Shibuya Y, Takeuchi J, . Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:398–406.
- O’Connell MP, Fiori JL, Xu M, . The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 2010;29:34–44.
- Morioka K, Tanikawa C, Ochi K, . Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci 2009;100:1227–1233.
- Wright TM, Brannon AR, Gordan JD, . Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene 2009;28:2513–2523.
- Yamamoto H, Oue N, Sato A, . Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene 2010;29:2036–2046.
- Kubo T, Kuroda Y, Shimizu H, . Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis 2009;30:1857–1864.
- Swerdlow SH, Campo E, Harris NL, . WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.
- Daneshmanesh AH, Hojjat-Farsangi M, Khan AS, . Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells. Leukemia 2012;26:1348–1355.
- Hudecek M, Schmitt TM, Baskar S, . The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood 2010;116: 4532–4541.
- Yang J, Baskar S, Kwong KY, . Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS One 2011;6:e21018.
- Widhopf GF, Cui B, Avery E, . ROR1 expression accelerates leukemia development in RORxTCL1 transgenic mice. Blood 2011; 118(Suppl. 1): Abstract 3905.
- Zhang S, Chen L, Cui B, . ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One 2012;7:e31127.
- Mellstedt H, Hojjat-Farsangi M, Mansouri L, . ROR1 isoforms are constitutively phosphorylated in chronic lymphocytic leukemia (CLL) - a survival factor for CLL cells. Blood 2011;118(Suppl. 1): Abstract 1778.
- Gentile A, Lazzari L, Benvenuti S, . Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res 2011;71: 3132–3141.
- Rabbani H, Ostadkarampour M, Danesh Manesh AH, . Expression of ROR1 in patients with renal cancer--a potential diagnostic marker. Iran Biomed J 2010;14:77–82.
- Yamaguchi T, Yanagisawa K, Sugiyama R, . NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 2012;21:348–361.
- Li P, Harris D, Liu Z, . Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells. PLoS One 2010;5:e11859.
- Choudhury A, Derkow K, Daneshmanesh AH, . Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells. Br J Haematol 2010;151:327–335.