241
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Clonal heterogeneity in patients with cytogenetically normal acute myeloid leukemia with NPM1 mutations

, , , , , , & show all
Pages 1056-1060 | Received 06 Aug 2012, Accepted 23 Sep 2012, Published online: 16 Oct 2012

References

  • Falini B, Mecucci C, Tiacci E, . Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005;352:254–266.
  • Falini B, Martelli MP, Mecucci C, . Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice. Haematologica 2008;93:775–779.
  • Chou WC, Tang JL, Lin LI, . Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution. Cancer Res 2006;66:3310–3316.
  • Dvorakova D, Racil Z, Jeziskova I, . Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations. Am J Hematol 2010;85:926–929.
  • Chiu RW, Murphy MF, Fidler C, . Determination of RhD zygosity: comparison of a double amplification refractory mutation system approach and a multiplex real-time quantitative PCR approach. Clin Chem 2001;47:667–672.
  • Ishii T, Xu M, Zhao Y, . Recurrence of clonal hematopoiesis after discontinuing pegylated recombinant interferon-alpha 2a in a patient with polycythemia vera. Leukemia 2007;21:373–374.
  • Bellanné-Chantelot C, Chaumarel I, Labopin M, . Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders. Blood 2006;108:346–352.
  • Larsen TS, Christensen JH, Hasselbalch HC, . The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders. Br J Haematol 2007;136:745–751.
  • Li S, Kralovics R, De Libero G, . Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. Blood 2008;111:3863–3866.
  • Delhommeau F, Dupont S, Tonetti C, . Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis. Blood 2007;109:71–77.
  • Miyamoto T, Weissman IL, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci USA 2000;97: 7521–7526.
  • Pasqualucci L, Liso A, Martelli MP, . Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification. Blood 2006;108:4146–4155.
  • Martelli MP, Manes N, Pettirossi V, . Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML. Leukemia 2008;22:195–198.
  • Konoplev S, Huang X, Drabkin HA, . Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. Cancer 2009;115:4737–4744.
  • Taussig DC, Vargaftig J, Miraki-Moud F, . Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(−) fraction. Blood 2010;115: 1976–1984.
  • Schwarz BA, Bhandoola A. Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis. Immunol Rev 2006;209: 47–57.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.