Advanced search
Publication Cover
Leukemia & Lymphoma Volume 55, 2014 - Issue 5
Submit an article Journal homepage
100
Views
10
CrossRef citations to date
0
Altmetric
Letter

A safety and feasibility study with platelet lysate expanded bone marrow mesenchymal stromal cells for the treatment of acute graft-versus-host disease in Brazil

Lucia SillaCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil;Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;Hematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, BrazilCorrespondence[email protected]
,
Vanessa ValimCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Bruna AmorinCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil;Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Ana Paula AlegrettiCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Fernanda dos Santos de OliveiraCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Maria Aparecida Lima da SilvaCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Alice DahmerCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Natália Emerim LemosCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Márcia Arthmar Mentz AlbrechtCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Álvaro Macedo LaureanoCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil;Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Carmem BonfimBone Marrow Transplantation, Hospital de Clinicas da Universidade Federal do Paraná, Curitiba, Paraná, Brazil
,
Lauro Moraes JúniorCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Annelise PezziCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil;Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Letícia BaggioCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Cristina Arthmar Mentz AlbrechtCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil
,
Marcelo CapraCellular Therapy Center of Hospital de Clinicas de Porto Alegre, Center for Experimental Research, Porto Alegre, Rio Grande do Sul, Brazil;Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Laura FogliattoHematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
,
Lisandra Della Costa RigoniHematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
,
Gustavo FischerHematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
,
Alessandra PazHematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
&
Liane Esteves DaudtHematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
 show all
Pages 1203-1205 | Received 05 Apr 2013, Accepted 03 Jul 2013, Published online: 28 Aug 2013

References

  • Appelbaum FR. The current status of hematopoietic cell transplantation. Annu Rev Med 2003;54:491–512.
  • Tabbara IA, Zimmerman K, Morgan C, et al. Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med 2002;162:1558–1566.
  • Deeg HJ. How I treat refractory acute GVHD. Blood 2007;109: 4119–4126.
  • Couriel D, Saliba R, Hicks K, et al. Tumor necrosis factor-alpha blockade for the treatment of acute GVHD. Blood 2004;104:649–654.
  • Kebriaei P, Isola L, Bahceci E, et al. Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 2009;15: 804–811.
  • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579–1586.
  • Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81:1390–1397.
  • Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagosis and staging working group report. Biol Blood Marrow Transplant 2005;11:945–956.
  • Devergie A. Graft versus host disease. In: Apperley J, Carreras E, Gluckman E, et al., editors. EBMT-ESH handbook on haematopoietic stem cell transplantation. Paris: ESH; 2008. Ch 11.
  • Minguell JJ, Erices A, Conget P. Mesenchymal stem cells. Exp Biol Med (Maywood) 2001;226:507–520.
  • Blande IS, Bassaneze V, Lavini-Ramos C, et al. Adipose tissue mesenchymal stem cell expansion in animal serum-free medium supplemented with autologous human platelet lysate. Transfusion 2009;49:2680–2685.
  • Schallmoser K, Strunk D. Preparation of pooled human platelet lysate (pHPL) as an efficient supplement for animal serum-free human stem cell cultures. J Vis Exp 2009;(32). pii:. 1523.
  • von Bahr L, Sundberg B, Lonnies L, et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant 2012;18:557–564.
  • Lucchini G, Introna M, Dander E, et al. Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population. Biol Blood Marrow Transplant 2010;16:1293–1301.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.