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Letter

Erythroid but not cytogenetic response in a case with 5q− syndrome: a delayed effect of lenalidomide or a consequence of deferasirox treatment?

, , , , &
Pages 1408-1409 | Received 18 Mar 2013, Accepted 07 Aug 2013, Published online: 09 Sep 2013

References

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  • Oliva EN, Cuzzola M, Nobile F, et al. Changes in RPS14 expression levels during lenalidomide treatment in low- and intermediate- 1-risk myelodysplastic syndromes with chromosome 5q deletion. Eur J Haematol 2010;85:231–235.
  • Giagounidis AA, Haase S, Heinsch M, et al: Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q) MDS patients with unexpected responses. Ann Hematol 2007;86:133–137.
  • Breccia M, Cannella L, Latagliata R, et al. Unexpected erythroid and cytogenetic responses after discontinuation of a short course of lenalidomide as a result of severe skin rash in a patient with 5q syndrome. J Clin Oncol 2011;29:e402–e403.
  • Messa E, Carturan S, Maffè C, et al. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging. Haematologica 2010;95: 1308–1316.
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  • Gattermann N, Finelli C, Della Porta M, et al. Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes. Haematologica 2012;97: 1364–1371.
  • Saigo K, Takenokuchi M, Hiramatsu Y, et al. Oxidative stress levels in myelodysplastic syndrome patients: their relationship to serum ferritin and haemoglobin values. J Int Med Res 2011;39: 1941–1945.
  • Choi SO, Cho YS, Kim HL, et al. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res Commun 2007;356:312–317.
  • Ghoti H, Fibach E, Merkel D, et al. Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes. Haematologica 2010;95:1433–1434.

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