Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity

References

• Moe PJ, Holen A. High-dose methotrexate in childhood ALL. Pediatr Hematol Oncol 2000;17:615–622.
   PubMed Web of Science ®Google Scholar
• Fujita N, Kobayashi R, Takimoto T, et al. Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. Leuk Lymphoma 2011;52:223–229.
   PubMed Web of Science ®Google Scholar
• Mahoney DH Jr, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy—a Pediatric Oncology Group study. J Clin Oncol 1998;16:1712–1722.
   PubMed Web of Science ®Google Scholar
• Rask C, Albertioni F, Bentzen SM, et al. Clinical and pharmacokinetic risk factors for high-dose methotrexate-induced toxicity in children with acute lymphoblastic leukemia—a logistic regression analysis. Acta Oncol 1998;37:277–284.
   PubMed Web of Science ®Google Scholar
• Cheng KK. Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer. Eur J Cancer Care (Engl) 2008;17:306–311.
   PubMed Web of Science ®Google Scholar
• Holmboe L, Andersen AM, Mørkrid L, et al. High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients. Br J Clin Pharmacol 2012;73:106–114.
   PubMed Web of Science ®Google Scholar
• Csordas K, Hegyi M, Eipel OT, et al. Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia. Anticancer Drugs 2013;24:189–197.
   PubMed Web of Science ®Google Scholar
• Goldman ID, Matherly LH. The cellular pharmacology of methotrexate. Pharmacol Ther 1985;28:77–102.
   PubMed Web of Science ®Google Scholar
• Jackson RC. Biological effects of folic acid antagonists with antineoplastic activity. Pharmacol Ther 1984;25:61–82.
   PubMed Web of Science ®Google Scholar
• Broxson EH Jr, Stork LC, Allen RH, et al. Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions. Cancer Res 1989;49:5879–5883.
   PubMed Web of Science ®Google Scholar
• Refsum H, Wesenberg F, Ueland PM. Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate. Cancer Res 1991;51:828–835.
   PubMed Web of Science ®Google Scholar
• Kishi S, Griener J, Cheng C, et al. Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 2003;21: 3084–3091.
   PubMed Web of Science ®Google Scholar
• Valik D, Sterba J, Bajciova V, et al. Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. Oncology 2005; 69:269–272.
   PubMed Web of Science ®Google Scholar
• Kishi T, Tanaka Y, Ueda K. Evidence for hypomethylation in two children with acute lymphoblastic leukemia and leukoencephalopathy. Cancer 2000;89:925–931.
   PubMed Web of Science ®Google Scholar
• Cole PD, Beckwith KA, Vijayanathan V, et al. Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatr Neurol 2009;40:34–41.
   PubMed Web of Science ®Google Scholar
• Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43–52.
   PubMed Web of Science ®Google Scholar
• She QB, Nagao I, Hayakawa T, et al. A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver. Biochem Biophys Res Commun 1994:205; 1748–1754.
   PubMed Web of Science ®Google Scholar
• Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukaemia. Lancet Oncol 2008;9:257–268.
   PubMed Web of Science ®Google Scholar
• Schmiegelow K. Advances in individual prediction of methotrexate toxicity: a review. Br J Haematol 2009;146:489–503.
   PubMed Web of Science ®Google Scholar
• Widemann BC, Adamson PC. Understanding and managing methotrexate nephrotoxicity. Oncologist 2006;11:694–703.
   PubMed Web of Science ®Google Scholar
• Hegyi M, Gulácsi A, Cságoly E, et al. Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. J Cancer Res Clin Oncol 2012;138:1697–1702.
   PubMed Web of Science ®Google Scholar
• Kim YI. 5,10-Methylenetetrahydrofolate reductase polymorphism and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease. Nutr Rev 2005;63:398–407.
   PubMed Web of Science ®Google Scholar
• Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr 2006;136(6 Suppl.):1636S–1640S.
   Web of Science ®Google Scholar
• Roubenoff R, Dellaripa P, Nadeau MR, et al. Abnormal homocysteine metabolism in rheumatoid arthritis. Arthritis Rheum 1997;40:718–722.
   PubMed Web of Science ®Google Scholar
• Toffoli G, Russo A, Innocenti F, et al. Effect of methylenetetrahydrofolate reductase 677C→T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. Int J Cancer 2003;103: 294–299.
   PubMed Web of Science ®Google Scholar
• Jabs K, Koury MJ, Dupont WD, et al. Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in children. Metabolism 2006;55:252–257.
   PubMed Web of Science ®Google Scholar
• Liu C, Wang Q, Guo H, et al. plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr 2008;138:311–315.
   Web of Science ®Google Scholar
• Hagleitner MM, Coenen MJ, Aplenc R, et al. The role of the MTHFR 677C> T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer. Pharmacogenomics J 2013 May 7. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Kantar M, Kosova B, Cetingul N, et al. Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphism and therapy- related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. Leuk Lymphoma 2009;50:912–917.
   PubMed Web of Science ®Google Scholar
• Kharbanda KK. Alcoholic liver disease and methionine metabolism. Semin Liver Dis 2009;29:155–165.
   PubMed Web of Science ®Google Scholar
• Homung N, Ellingsen T, Stengaard-Pedersen K, et al. Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement. J Rheumatol 2004;31:2374–2381.
   PubMed Web of Science ®Google Scholar
• Canellos GP, Haskell CM, Arseneau J, et al. Hypoalbuminemic and hypocholesteroemic effect of L-asparaginase (NSC-109,229) treatment in man—a preliminary report. Cancer Chemother Rep 1969;53:67–69.
   PubMedGoogle Scholar
• Yalçinkaya S, Unlüçerçi Y, Giriş M, et al. Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine. Nutrition 2009;25:436–444.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Kang MH, Min H. Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol. Nutr Res Pract 2011;5:520–526.
   PubMed Web of Science ®Google Scholar
• Cacciapuoti F. Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties. J Thromb Thrombolysis 2011;32:82–88.
   PubMed Web of Science ®Google Scholar