331
Views
12
CrossRef citations to date
0
Altmetric
Research Article

5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells

, , , &
Pages 2375-2383 | Received 26 Jul 2013, Accepted 14 Dec 2013, Published online: 24 Feb 2014

References

  • Estey E, Döhner H. Acute myeloid leukaemia. Lancet 2006; 368:1894–1907.
  • Brown G, Hughes P. Retinoid differentiation therapy for common types of acute myeloid leukemia. Leuk Res Treat 2012;2012:939021.
  • Schenk T, Chen WC, Göllner S, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012;18:605–611.
  • Radomska HS, Alberich-Jordà M, Will B, et al. Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα. J Clin Invest 2012;122:2955–2966.
  • Congleton J, MacDonald R, Yen A. Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells. Leukemia 2012;26:1180–1188.
  • Nishioka C, Ikezoe T, Yang J, et al. Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. Int J Cancer 2009;125:1710–1720.
  • Mise J, Dembitz V, Banfic H, et al. Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells. Pathol Oncol Res 2011;17:645–656.
  • Lalic H, Lukinovic-Skudar V, Banfic H, et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma 2012;53:2253–2261.
  • Yang J, Ikezoe T, Nishioka C, et al. Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo. Exp Hematol 2010;38:666–676.
  • Hardie DG. AMP-activated protein kinase:an energy sensor that regulates all aspects of cell function. Genes Dev 2011;25:1895–1908.
  • Del Barco S, Vazquez-Martin A, Cufí S, et al. Metformin:multi-faceted protection against cancer. Oncotarget 2011;2:896–917.
  • Green AS, Chapuis N, Maciel TT, et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 2010;116:4262–4273.
  • Vakana E, Altman JK, Glaser H, et al. Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. Blood 2011;118:6399–6402.
  • Campàs C, Lopez JM, Santidrián AF, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood 2003;101:3674–3680.
  • Campàs C, Santidrián AF, Domingo A, et al. Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma. Leukemia 2005;19:292–294.
  • Rosilio C, Lounnas N, Nebout M, et al. The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells. Cancer Lett 2013;336:114–126.
  • Rattan R, Giri S, Singh AK, et al. 5-Aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 2005;280:39582–39593.
  • Visnjic D, Batinic D, Banfic H. Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. Blood 1997;89:81–91.
  • Miranda MB, McGuire TF, Johnson DE. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiatiation of myeloid cell lines. Leukemia 2002;16:683–692.
  • Ajenjo N, Aaronson DS, Ceballos E, et al. Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation. J Biol Chem 2000;275:7189–7197.
  • Wang X, Studzinski GP. Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells. J Cell Biochem 2001;80: 471–482.
  • Matkovic K, Brugnoli F, Bertagnolo V, et al. The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia 2006;20:941–951.
  • Matkovic K, Lukinovic-Skudar V, Banfic H, et al. The activity of extracellular signal-regulated kinase is required during G2/M phase before metaphase-anaphase transition in synchronized leukemia cell lines. Int J Hematol 2009;89:159–166.
  • Ketley NJ, Allen PD, Kelsey SM, et al. Modulation of idarubicin-induced apoptosis in human acute myeloid leukemia blasts by all-trans retinoic acid, 1,25(OH)2 vitamin D3, and granulocyte-macrophage colony-stimulating factor. Blood 1997;90:4578–4587.
  • Vondracek J, Sheard MA, Krejci P, et al. Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells. J Leukoc Biol 2001;69:794–802.
  • Chae HD, Lee MR, Broxmeyer HE. 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells 2012;30:140–149.
  • Kanazawa I, Yamaguchi T, Yano S, et al. Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. Am J Physiol Endocrinol Metab 2009;296:E139–E146.
  • Zang Y, Yu LF, Pang T, et al. AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. J Biol Chem 2008;283:6201–6208.
  • Kanellis J, Kandane RK, Etemadmoghadam D, et al. Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. Immunol Cell Biol 2006;84:6–12.
  • Bae HB, Zmijewski JW, Deshane JS, et al. AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J 2011;25:4358–4368.
  • Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell 2008;134:405–415.
  • Lanner JT, Georgiou DK, Dagnino-Acosta A, et al. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med 2012;18:244–251.
  • Hawley SA, Ross FA, Chevtzoff C, et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab 2010;11:554–565.
  • Zou MH, Hou XY, Shi CM, et al. Activation of 5’-AMP- activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol Chem 2003;278: 34003–34010.
  • Xie Z, Dong Y, Scholz R, et al. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation 2008;117:952–962.
  • Huai L, Wang C, Zhang C, et al. Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway. Biochem Biophys Res Commun 2012;422:398–404.
  • Kandilci A, Grosveld GC. SET-induced calcium signaling and MAPK/ERK pathway activation mediate dendritic cell-like differentiation of U937 cells. Leukemia 2005;19:1439–1445.
  • Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297–315.
  • Robert G, Ben Sahra I, Puissant A, et al. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 2009;4:e7889.
  • Chakrabarti A, Gupta K, Sharma JP, et al. ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway. J Biol Chem 2012;287:23635–23643.
  • Wampfler J, Tschan MP, Shan D, et al. SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. Br J Haematol 2009;146:337–341.
  • Skrtic M, Sriskanthadevan S, Jhas B, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 2011;20:674–688.
  • Samudio I, Harmancey R, Fiegl M, et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 2010;120:142–156.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.