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Leukemia & Lymphoma Volume 56, 2015 - Issue 1
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Original Article: Clinical

Acute myeloid leukemia in patients older than 75: prognostic impact of FLT3-ITD and NPM1 mutations

Pierre HirschService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, FranceCorrespondence[email protected]
,
Ghazi QassaService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France
,
Christophe MarzacUPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France;Laboratoire d’Immunologie et Hématologie biologique, Hôpital Saint-Antoine, APHP, Paris, France
,
Ruoping TangService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France
,
Jean-Yves PerrotLaboratoire d’Immunologie et Hématologie biologique, Hôpital Saint-Antoine, APHP, Paris, France
,
Françoise IsnardService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France
,
Mohamad MohtyService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France
,
Jean Pierre MarieService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France
&
Ollivier LegrandService d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France;UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France
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Pages 147-150 | Received 08 Jan 2014, Accepted 05 Apr 2014, Published online: 16 Jun 2014

References

  • SEER [internet]. SEER Stat Fact Sheets: Leukemia. 2011. Available from: http://seer.cancer.gov/statfacts/html/leuks.html
  • Amadori S, Suciu S, Jehn U, et al. Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study. Blood 2005;106:27–34.
  • Goldstone AH, Burnett AK, Wheatley K, et al. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial. Blood 2001;98:1302–1311.
  • Estey E, Dohner H. Acute myeloid leukaemia. Lancet 2006;368: 1894–1907.
  • Hirsch P, Tang R, Marzac C, et al. Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC. Haematologica 2012;97:241–245.
  • Oran B, Weisdorf DG. Survival for older patients with acute myeloid leukemia: a population based-study. Haematologica 2012;97: 1916–1924.
  • Kantarjian H, Ravandi F, O’Brien S, et al. Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia. Blood 2010;116:4422–4429.
  • Vey N, Coso D, Bardou VJ, et al. The benefit of induction chemotherapy in patients age > or = 75 years. Cancer 2004;101: 325–331.
  • Juliusson G, Antunovic P, Derolf A, et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 2009;113:4179–4187.
  • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood 2000;96:4075–4083.
  • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003;21:4642–4649.
  • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010;28:562–569.

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