MicroRNAs expressed in hematopoietic stem/progenitor cells are deregulated in acute myeloid leukemias

References

• Doulatov S, Notta F, Eppert K, et al. Revised map of the human progenitors hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol 2010;11:585–593.
   PubMed Web of Science ®Google Scholar
• Gorgens A, Radtke S, Mollmann M, et al. Revision of the human hematopoietic tree:granulocytes subtypes derive from distinct hematopoietic lineages. Cell Rep 2013;3:1539–1552.
   PubMed Web of Science ®Google Scholar
• Notta F, Doulatov S, Laurenti E, et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011;333:218–221.
   PubMed Web of Science ®Google Scholar
• Goardon N, Marchi E, Atzerberger A, et al. Coexistence of LMMP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell 2011;19:138–152.
   PubMed Web of Science ®Google Scholar
• Anjos-Afonso F, Currie E, Palmer HG, et al. CD34- cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell 2013;13:161–174.
   PubMed Web of Science ®Google Scholar
• Yamamoto R, Morita Y, Oehara J, et al. Clonal analysis unveils self-renewing lineage-restricted progenitors directly generated from hematopoietic stem cells. Cell 2013;154:1112–1126.
   PubMed Web of Science ®Google Scholar
• Sanjuan-Pla A, Maculay IC, Jensen CT, et al. Platelet-biased stem cells at the apex of the hematopoietic stem cell hierarchy. Nature 2013;502:232–236.
   PubMed Web of Science ®Google Scholar
• Grover A, Mancini E, Moore S, et al. Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. J Exp Med 2014;211:181–188.
   PubMed Web of Science ®Google Scholar
• Marcucci G, Mzorek K, Radmacher M, et al. The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood 2011;117:1121–1129.
   PubMed Web of Science ®Google Scholar
• Ling H, Fabbri M, Calin G. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discovery 2013;12:847–865.
   PubMed Web of Science ®Google Scholar
• Undi RB, Kandi R, Gutti RK. MicroRNAs as hematopoiesis regulators. Adv Hematol 2013;e695754.
   Google Scholar
• Batmagar B, Garzon R. The use of molecular genetics to refine prognosis in acute myeloid leukemia. Curr Hematol Malig Rep 2014;9:148–157.
   PubMed Web of Science ®Google Scholar
• Georgantas R III, Hildreth R, Morisot S, et al. CD34 + hematopoietic stem/progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci USA 2007;104:2750–2755.
   PubMed Web of Science ®Google Scholar
• O’Connell R, Chaudhuri A, Rao D, et al. MicroRNAs regulate long-term hematopoietic output. Proc Natl Acad Sci USA 2010; 107:14235–14240.
   PubMed Web of Science ®Google Scholar
• Liao R, Sun J, Zhang L, et al. MicroRNA play a role in the development of human hematopoietic stem cells. J Cell Biochem 2008;104:805–817.
   PubMed Web of Science ®Google Scholar
• Merkerova M, Vasikova A, Belickova M, et al. MicroRNA expression profiles in umbilical cord blood lineages. Stem Cell Dev 2010;19:17–25.
   PubMed Web of Science ®Google Scholar
• Jin P, Wang E, Ren J, et al. Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis. J Transl Med 2008;6:39.
   PubMed Web of Science ®Google Scholar
• Gentner B, Visigalli I, Hiramatsu H, et al. Identification of a hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci Transl Med 2010;2:58ra84.
   Web of Science ®Google Scholar
• Lechman F, Gentner B, van Galen P, et al. Attenuation of miR-126 activity expands HSC in vivo without exhaustion. Cell Stem Cell 2012;11:799–811.
   PubMed Web of Science ®Google Scholar
• Li Z, Lu J, Sun M, et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 2008;105:15535–15540.
   PubMed Web of Science ®Google Scholar
• Schurhuis G, Meel M, Wouters F, et al. Normal hematopoietic stem cells within the AML bone marrow have a distinct and higher ALDH activity level than co-existing leukemic-stem cells. PLoS One 2013;8:e78897.
   Web of Science ®Google Scholar
• De Leeuw D, Deukers F, Olthof M, et al. Attenuation of microRNA-126 expression that drives CD34 + CD38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication. Cancer Res 2014;74:2094–2105.
   PubMed Web of Science ®Google Scholar
• Gerrits A, Walasek MA, Olthof S, et al. Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells. Blood 2012;119:377–387.
   PubMed Web of Science ®Google Scholar
• Guo S, Lu J, Schlonger R, et al. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci USA 2010; 107:14229–14234.
   PubMed Web of Science ®Google Scholar
• Oboi AG, Sahoo D, Adorno M, et al. Micro-RNA 125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and the lymphoid-biased subsets. Proc Natl Acad Sci USA 2010;107:21505–21510.
   PubMed Web of Science ®Google Scholar
• Bousquet M, Qualen C, Rosati R, et al. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008;205:2499–1506.
   PubMed Web of Science ®Google Scholar
• Chaudhury AA, So AY, Mehta A, et al. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci USA 2012;13;4233–4238.
   Web of Science ®Google Scholar
• Cheng J, Guo S, Chey S, et al. An extensive network of TET2-targeting microRNAs regulates malignant hematopoiesis. Cell Rep 2013;5:471–481.
   PubMed Web of Science ®Google Scholar
• Klusmann JH, Li Z, Bohmer K, et al. miR-125b-2 is a potential oncomiR on chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010;24:478–490.
   PubMed Web of Science ®Google Scholar
• Song SJ, Ito K, Ala U, et al. The oncogenic microRNA miR-22 targets the TET2-tumor suppressor to promote hematopoietic stem cell-renewal and transformation. Cell Stem Cell 2013;13:87–101.
   PubMed Web of Science ®Google Scholar
• Solary E, Bernard OA, Tefferi A, et al. The ten-eleven translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases. Leukemia 2014;28:485–496.
   PubMed Web of Science ®Google Scholar
• Bissels U, Wild S, Tomiuk S, et al. Combined characterization of microRNA and miRNA profiles delineates early differentiation pathways of CD133 + and CD34 + hematopoietic stem- and progenitor cells. Stem Cells 2011;29:847–857.
   PubMed Web of Science ®Google Scholar
• Wang XS, Gong JN, Yu J, et al. MicroRNA-29a and microRNA 142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood 2012;119:4992–5004.
   PubMed Web of Science ®Google Scholar
• Careccia S, Mainardi S, Pelosi A, et al. A restricted signature distinguishes APL blasts from normal promyelocytes. Oncogene 2009;28:4034–4040.
   PubMed Web of Science ®Google Scholar
• Lu X, Li X, He Q, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res 2013;23:1356–1368.
   PubMed Web of Science ®Google Scholar
• Nimmo R, Ciau-Vitz A, Ruiz-Herguido C, et al. miR-142-3p controls the specification of definitive hemangioblasts during ontogeny. Dev Cell 2013;26:237–249.
   PubMed Web of Science ®Google Scholar
• Dahlaus M, Roolf C, Ruck S, et al. Expression and prognostic significance of has-miR-142-3p in acute leukemia. Neoplasma 2013;60:432–438.
   PubMed Web of Science ®Google Scholar
• Wang F, Wang XS, Yang GH, et al. miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia. Mol Biol Rep 2012;39:2713–2722.
   PubMed Web of Science ®Google Scholar
• Han JC, Park CY, Bhagat G, et al. MicroRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development and acute myeloid leukemia. J Exp Med 2010;207: 473–489.
   Web of Science ®Google Scholar
• Gong JN, Yu J, Lin HS, et al. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ 2014;21:100–112.
   PubMed Web of Science ®Google Scholar
• Garzon R, Volinia S, Liu CG, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008;111:3183–3189.
   PubMed Web of Science ®Google Scholar
• Garzon R, Garofalo M, Martelli MP, et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 2008;105:3945–3950.
   PubMed Web of Science ®Google Scholar
• Garzon R, Heaphy C, Havalange V, et al. MicroRNA-29b functions in acute myeloid leukemia. Blood 2009;114:5331–5341.
   PubMed Web of Science ®Google Scholar
• Liu S, Wu LC, Pang J, et al. Sp1/NFkB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 2010;17: 333–347.
   PubMed Web of Science ®Google Scholar
• Garzon R, Liu S, Fabbri M, et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009;113:6411–6418.
   PubMed Web of Science ®Google Scholar
• Blum W, Garzon R, Klisovic R, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA 2010;107:7473–7478.
   PubMed Web of Science ®Google Scholar
• Blum W, Schwind S, Tarighat S, et al. Clinical and pharmacodynamics activity of bortezomib and decitabine in acute myeloid leukemia. Blood 2012;119:6025–6031.
   PubMed Web of Science ®Google Scholar
• Bernot KM, Nemer JS, Santhanam R, et al. Eradicating acute myeloid leukemia in a MLL (PTD/wt):FLT3 (ITD/wt) murine model: a path to novel therapeutic approaches for human disease. Blood 2013;122:3778–3783.
   PubMed Web of Science ®Google Scholar
• Mims A, Walker AR, Huang X, et al. Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia. Leukemia 2013;27:871–878.
   PubMed Web of Science ®Google Scholar
• Huang X, Schwind S, Yu B, et al. Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia. Clin Cancer Res 2013;14:2355–2367.
   Google Scholar
• Mintz PJ, Saetram P, Reebye V, et al. MicroRNA-181a targets Nanog in a subpopulation of CD34 + cells isolated from peripheral blood. Mol Ther Nucleic Acids 2012;1:e34.
   PubMedGoogle Scholar
• Marcucci G, Radmacher MD, Maharry K, et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 20087;358:1919–1928.
   Google Scholar
• Schwind S, Maharry K, Radmacher MD, et al. Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2010;28:5257–5264.
   PubMed Web of Science ®Google Scholar
• Li Z, Huang H, Li Y, et al. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patinets with cytogenetically abnormal AML. Blood 2012;119:2314–2324.
   PubMed Web of Science ®Google Scholar
• Hichey C, Schwind S, Radomska A, et al. Lenalidomide-mediated enhanced translation of C/EBPalpha-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. Blood 2013;121:159–169.
   PubMed Web of Science ®Google Scholar
• Senyuk V, Zhang Y, Liu Y, et al. Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc Natl Acad Sci USA 2013;110:5594–5599.
   PubMed Web of Science ®Google Scholar
• Chen P, Price C, Li Z, et al. miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proc Natl Acad Sci USA 2013;110:11511–11516.
   PubMed Web of Science ®Google Scholar
• Adams B, Guo S, Bai H, et al. An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. Cell Rep 2012;2:1048–1060.
   PubMed Web of Science ®Google Scholar
• Lu J, Guo S, Ebert BL, et al. Micro RNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell 2008; 14:843–853.
   PubMed Web of Science ®Google Scholar
• Morris VA, Zhang A, Yang T, et al. MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors. PLoS One 2013;8:e75815.
   PubMed Web of Science ®Google Scholar
• Jang X, Huang H, Li Z, et al. Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell 2012;22:524–535.
   PubMed Web of Science ®Google Scholar
• Bousquet M, Zhuang G, Meng C, et al. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Mol Cancer Res 2013;11:912–922.
   PubMed Web of Science ®Google Scholar
• Rodriguez A, Vigorito E, Clare S, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007;316: 608–611.
   PubMed Web of Science ®Google Scholar
• O’Connell RM, Rao DS, Chaudhuri AA, et al. Sustained expression of microRNA-155 in hematopoietic stem cells cause a myeloproliferative disorder. J Exp Med 2008;205:585–594.
   PubMed Web of Science ®Google Scholar
• Forrest AR, Kanamori-Katayama M, Tomaru Y, et al. Induction of microRNAs, miR-155, miR-222, miR-424 and miR-503, promotes monocytic differentiation through combinatorial regulation. Leukemia 2010;24:460–466.
   PubMed Web of Science ®Google Scholar
• Faraoni I, Laterza S, Ardiri D, et al. MiR-424 and mIR-155 deregulated expression in cytogenetically normal acute myeloid leukemia: correlation with NPM1 and FLT3 mutation status. J Hematol Oncol 2012;5:26.
   PubMed Web of Science ®Google Scholar
• Jongen-Lavrencic M, Sun SM, Dijkstra MK, et al. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008;111:5078–5085.
   PubMed Web of Science ®Google Scholar
• Cammarata G, Angugliaro L, Salemi D. Differential expression of specific microRNA and their targets in acute myeloid leukemia. Am J Hematol 2010;85:331–339.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhang H, Rodriguez S, et al. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kB-dependent manner. Cell Stem Cell 2014;15:51–65.
   PubMed Web of Science ®Google Scholar
• Ooi AG, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci USA 2010;107:21505–21510.
   PubMed Web of Science ®Google Scholar
• Bousquet M, Harris MH, Zhou B, Lodish HF. MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci USA 2010;107:21558–21563.
   PubMed Web of Science ®Google Scholar
• Ghani S, Riemke P, Schonheit J, et al. Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood 2011;118:2275–2284.
   PubMed Web of Science ®Google Scholar