Advanced search
Publication Cover
Leukemia & Lymphoma Volume 56, 2015 - Issue 6
Submit an article Journal homepage
316
Views
27
CrossRef citations to date
0
Altmetric
Original Article: Clinical

Incidence, nature and mortality of cytomegalovirus infection after double-unit cord blood transplant

Parastoo B. DahiAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Miguel A. PeralesAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Sean M. DevlinDepartment of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Amanda OlsonAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Marissa LubinAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Anne Marie GonzalesAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Andromachi ScaradavouDepartment of Pediatric Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Nancy A. KernanDepartment of Pediatric Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Richard J. O’ReillyDepartment of Pediatric Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
,
Sergio GiraltAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Ann JakubowskiAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Guenther KoehneAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Esperanza B. PapadopoulosAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Doris M. PonceAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Craig SauterAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USA
,
Genovefa PapanicolaouAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
&
Juliet N. BarkerAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Weill Cornell Medical College, New York, NY, USACorrespondence[email protected]
 show all
Pages 1799-1805 | Received 12 Jun 2014, Accepted 03 Sep 2014, Published online: 21 Oct 2014

References

  • Szabolcs P. T-lymphocyte recovery and function after cord blood transplantation. Immunol Res 2011;49:56–69.
  • Chiesa R, Gilmour K, Qasim W, et al. Omission of in vivo T-cell depletion promotes rapid expansion of naive CD4 + cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant. Br J Haematol 2012;156: 656–666.
  • Sauter C, Abboud M, Jia X, et al. Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin. Biol Blood Marrow Transplant 2011;17: 1460–1471.
  • van Heijst JW, Ceberio I, Lipuma LB, et al. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med 2013;19:372–377.
  • Tomonari A, Iseki T, Ooi J, et al. Cytomegalovirus infection following unrelated cord blood transplantation for adult patients:a single institute experience in Japan. Br J Haematol 2003;121:304–311.
  • Milano F, Pergam SA, Xie H, et al. Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients. Blood 2011;118:5689–5696.
  • Beck JC, Wagner JE, DeFor TE, et al. Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation. Biol Blood Marrow Transplant 2010;16:215–222.
  • Walker CM, van Burik JA, De For TE, et al. Cytomegalovirus infection after allogeneic transplantation:comparison of cord blood with peripheral blood and marrow graft sources. Biol Blood Marrow Transplant 2007;13:1106–1115.
  • Barker JN, Ponce DM, Devlin SM, et al. Double-unit cord blood transplantation (DCBT) for acute leukemia: high disease-free survival in adults and children with comparable survival in European and minority patients. Biol Blood Marrow Transplant 2013;19:S354.
  • Barker JN, Byam C, Scaradavou A. How I treat: the selection and acquisition of unrelated cord blood grafts. Blood 2011;117:2332–2339.
  • Barker JN, Abboud M, Rice RD, et al. A “no-wash” albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactions. Biol Blood Marrow Transplant 2009;15:1596–1602.
  • Ponce DM, Sauter C, Devlin S, et al. A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation. Biol Blood Marrow Transplant 2013;19: 799–803.
  • Ponce DM, Gonzales A, Lubin M, et al. Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biol Blood Marrow Transplant 2013;19:904–911.
  • van Burik JA, Carter SL, Freifeld AG, et al. Higher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host disease. Biol Blood Marrow Transplant 2007;13:1487–1498.
  • Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002;34:1094–1097.
  • Boeckh M, Ljungman P. How I treat cytomegalovirus in hematopoietic cell transplant recipients. Blood 2009;113:5711–5719.
  • Winston DJ, Young JA, Pullarkat V, et al. Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study. Blood 2008;111:5403–5410.
  • Marty FM, Winston DJ, Rowley Sea. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med 2013;369:1227–1236.
  • Hanley PJ, Cruz CR, Savoldo B, et al. Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood 2009;114:1958–1967.
  • Leen AM, Bollard CM, Mendizabal AM, et al. Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood 2013;121:5113–5123.
  • Brown JA, Stevenson K, Kim HT, et al. Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis. Blood 2010;115:4111–4119.
  • McGoldrick SM, Bleakley ME, Guerrero A, et al. Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo. Blood 2013;121: 2796–2803.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.