127
Views
0
CrossRef citations to date
0
Altmetric
Letter to the Editor

Possible implication of IKAROS gene deletion and BCR–ABL1 variants in progression of chronic myeloid leukemia to lymphoid blast crisis in childhood: a single-institution experience

, , , , &
Pages 2460-2462 | Received 01 Dec 2014, Accepted 13 Dec 2014, Published online: 17 Feb 2015

References

  • Scrideli CA, de Oliveira FM, Brassesco MS, et al. Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood? Leuk Res 2009;33:495–499.
  • Faber E, Nausova J, Jarosova M, et al. Intermittent dosage of imatinib mesylate in CML patients with a history of significant hematologic toxicity after standard dosing. Leuk Lymphoma 2006;47:1082–1090.
  • Kuiper RP, Schoenmakers EF, van Reijmersdal SV, et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007;21:1258–1266.
  • Georgopoulos K, Moore DD, Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 1992;258:808–812.
  • Kastner P, Chan S. Role of Ikaros in T-cell acute lymphoblastic leukemia. World J Biol Chem 2011;2:108–114.
  • Mullighan CG, Miller CB, Radtke I, et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008;453:110–114.
  • Meyer C, Zur Stadt U, Escherich G, et al. Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients. Am J Blood Res 2013;3:165–173.
  • van der Sligte NE, Krumbholz M, Pastorczak A et al. DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia. Br J Haematol 2014;166:250–253.
  • Iacobucci I, Storlazzi CT, Cilloni D, et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell’Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 2009;114:2159–2167.
  • Kuiper RP, Waanders E, van der Velden VH, et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010;24:1258–1264.
  • Kirstetter P, Thomas M, Dierich A, et al. Ikaros is critical for B cell differentiation and function. Eur J Immunol 2002;32:720–730.
  • Mullighan CG. Genomic profiling of B-progenitor acute lymphoblastic leukemia. Best Pract Res Clin Haematol 2011;24:489–503.
  • Krentz S, Hof J, Mendioroz A, et al. Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 2013;27:295–304.
  • Pastorczak A, Gorniak P, Sherborne A, et al. Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population. Leuk Res 2011;35:1534–1536.
  • Iacobucci I, Iraci N, Messina M, et al. IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS One 2012;7:e40934.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.