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Leukemia & Lymphoma Volume 56, 2015 - Issue 6
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Commentary on selected article in this issue

Bortezomib followed by autologous stem cell transplant for patients with hepatitis B positive multiple myeloma: a cautionary note

Deborah RundHebrew University Hadassah Medical Organization, Ein Kerem, Jerusalem, IsraelCorrespondence[email protected]
Pages 1579-1580 | Published online: 19 Feb 2015

References

  • Li J, Huang B, Li Y, et al. Hepatitis B virus reactivation in patients with multiple myeloma receiving bortezomib-containing regimens followed by autologous stem cell transplant. Leuk Lymphoma 2015;56:1710–1717.
  • Lalazar G, Rund D, Shouval D. Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol 2007;136:699–712.
  • Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000;191:1269–1280.
  • Busca A, Kumar A. Innate immune responses in hepatitis B virus (HBV) infection. Virol J 2014;11:22.
  • Blanco B, Pérez-Simón JA, Sánchez-Abarca LI, et al. Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines. Blood 2006;107:3575–3583.
  • Nencioni A, Schwarzenberg K, Brauer KM, et al. Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation. Blood 2006;108:551–558.
  • World Health Organization. Hepatitis B fact sheet number 204. Geneva: WHO; 2008.
  • Becker N, Schnitzler P, Boffetta P, et al. Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph. J Cancer Res Clin Oncol 2012;138:1993–2001.
  • Kim K, Lee JH, Kim JS, et al. Clinical profiles of multiple myeloma in Asia-an Asian Myeloma Network study. Am J Hematol 2014; 89:751–756.

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