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Letter to the Editor

Methylenetetrahydrofolate reductase polymorphism has no differential effect on the outcome of allogeneic hematopoietic stem cell transplant

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Pages 2473-2475 | Received 16 Oct 2014, Accepted 06 Jan 2015, Published online: 09 Feb 2015

References

  • Chien JW, Zhang XC, Fan W, et al. Evaluation of published single nucleotide polymorphisms associated with acute GVHD. Blood 2012;119:5311–5319.
  • Robien K, Bigler J, Yasui Y, et al. Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia. Biol Blood Marrow Transplant 2006;12:973–980.
  • Kim I, Lee K-H, Kim JH, et al. Polymorphims of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation. Ann Hematol 2007;86:41–48.
  • Murphy N, Diviney M, Szer J, et al. Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate. Bone Marrow Transplant 2006;37:773–779.
  • Sugimoto K, Murata M, Onizuka M, et al. Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype. Int J Hematol 2008; 87:451–458.
  • Nakamura S, Aoshima T, Ikeda M, et al. Simultaneous detection of methylenetetrahydrofolate reductase gene polymorphisms, C677T and A1298C, by melting curve analysis with LightCycler. Anal Biochem 2002;306:340–343.
  • Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies:a HuGE minireview. Am J Epidemiol 2000;151:862–877.
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  • Beelen DW, Elmaagacli A, Muller KD, et al. Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and long-term follow-up of an open-label prospective randomized trial. Blood 1999;93:3267–3275.

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