STAT5 gene polymorphisms are associated with the response of acute myeloid leukemia patients to Ara-C-based chemotherapy

References

• Estey E, Dohner H. Acute myeloid leukaemia. Lancet. 2006;368:1894–1907.
   PubMed Web of Science ®Google Scholar
• Byrne MM, Halman LJ, Koniaris LG, et al. Effects of poverty and race on outcomes in acute myeloid leukemia. Am J Clin Oncol. 2011;34:297–304.
   PubMed Web of Science ®Google Scholar
• Hoggart CJ, Clark TG, De Iorio M, et al. Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol. 2008;32:179–185.
   PubMed Web of Science ®Google Scholar
• Hinds DA, Stuve LL, Nilsen GB, et al. Whole-genome patterns of common DNA variation in three human populations. Science. 2005;307:1072–1079.
   PubMed Web of Science ®Google Scholar
• McCarthy MI, Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diabetes Reports 2009;9:164–171.
   PubMed Web of Science ®Google Scholar
• Hou X, Wang S, Zhou Y, et al. Cyclin D1 gene polymorphism and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population. Int J Hematol. 2005;82:206–209.
   PubMed Web of Science ®Google Scholar
• Ihle JN. STATs: signal transducers and activators of transcription. Cell. 1996;84:331–334.
   PubMed Web of Science ®Google Scholar
• Darnell JE, Jr. STATs and gene regulation. Science. 1997;277:1630–1635.
   PubMed Web of Science ®Google Scholar
• Copeland NG, Gilbert DJ, Schindler C, et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 1995;29:225–228.
   PubMed Web of Science ®Google Scholar
• Wakao H, Gouilleux F, Groner B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 1994;13:2182–2191.
   PubMed Web of Science ®Google Scholar
• Onishi M, Nosaka T, Misawa K, et al. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol. 1998;18:3871–3879.
   PubMed Web of Science ®Google Scholar
• Schwaller J, Parganas E, Wang D, et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell. 2000;6:693–704.
   PubMed Web of Science ®Google Scholar
• Shuai K, Halpern J, ten Hoeve J, et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene. 1996;13:247–254.
   PubMed Web of Science ®Google Scholar
• Xie S, Wang Y, Liu J, et al. Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation. Oncogene. 2001;20:6188–6195.
   PubMed Web of Science ®Google Scholar
• Wang Y, Cai D, Brendel C, et al. Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL + progenitors via JAK-2/STAT-5 pathway activation. Blood. 2007;109:2147–2155.
   PubMed Web of Science ®Google Scholar
• Nelson EA, Walker SR, Weisberg E, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011;117:3421–3429.
   PubMed Web of Science ®Google Scholar
• Xia Z, Baer MR, Block AW, et al. Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts. Cancer Res. 1998;58:3173–3180.
   PubMed Web of Science ®Google Scholar
• Birkenkamp KU, Geugien M, Lemmink HH, et al. Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia. 2001;15:1923–1931.
   PubMed Web of Science ®Google Scholar
• Nogami A, Oshikawa G, Okada K, et al. FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia. Oncotarget. 2015;6:9189–9205.
   PubMed Web of Science ®Google Scholar
• Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, et al. FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood. 2009;114:5034–5043.
   PubMed Web of Science ®Google Scholar
• Harir N, Pecquet C, Kerenyi M, et al. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood. 2007;109:1678–1686.
   PubMed Web of Science ®Google Scholar
• Weber A, Borghouts C, Brendel C, et al. Stat5 exerts distinct, vital functions in the cytoplasm and nucleus of Bcr-Abl + K562 and Jak2(V617F)+ HEL leukemia cells. Cancers (Basel). 2015;7:503–537.
   PubMed Web of Science ®Google Scholar
• Moriggl R, Sexl V, Kenner L, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell. 2005;7:87–99.
   PubMed Web of Science ®Google Scholar
• Haura EB, Turkson J, Jove R. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol. 2005;2:315–324.
   PubMedGoogle Scholar
• Connelly TM, Koltun WA, Berg AS, et al. A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn’s disease. Dis Colon Rectum. 2013;56:1068–1074.
   PubMed Web of Science ®Google Scholar
• de Groot RP, Raaijmakers JA, Lammers JW, et al. STAT5-dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells. Mol Cell Biol Res Commun. 2000;3:299–305.
   PubMedGoogle Scholar
• Matsumoto A, Masuhara M, Mitsui K, et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. 1997;89:3148–3154.
   PubMed Web of Science ®Google Scholar
• Iriyama N, Hatta Y, Takei M. ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via signal transducer and activator of transcription 5 activation in the acute promyelocytic leukemia cell line HT93A. Leuk Lymphoma. 2015;56:2416–2423.
   PubMed Web of Science ®Google Scholar
• Du J, Fq Z, Zuo Y, et al. Study on the correlation between the rs2272087 and rs6503694 polymorphism of STAT5 gene and asthma. J Clin Pulmon Med. 2012;3:32–40.
   Google Scholar
• Liu YL, Liu PF, Liu HE, et al. Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population. Pathol Res Pract. 2014;210:582–585.
   PubMed Web of Science ®Google Scholar
• Sebastiani P, Nolan VG, Baldwin CT, et al. A network model to predict the risk of death in sickle cell disease. Blood. 2007;110:2727–2735.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Wu J, Chen B, et al. Investigation and analysis of single nucleotide polymorphisms in Janus kinase/signal transducer and activator of transcription genes with leukemia. Leuk Lymphoma. 2012;53:1216–1221.
   PubMed Web of Science ®Google Scholar