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Leukemia & Lymphoma Volume 57, 2016 - Issue 9
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Letters to the Editor

Absolute quantification of BCR-ABL1 fusion transcripts in pediatric chronic myeloid leukemia

Yanjing TangDepartment of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
,
Xiaoyuan WeiTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
,
Jing ChenDepartment of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
,
Yunzhi DuTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
,
Huiling ChuTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
,
Louise MaoDepartment of Cognitive Science, University of California Berkeley, Berkeley, CA, USACorrespondence[email protected]
,
Jun ChenTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
,
Qing XuTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
,
Jingyan TangDepartment of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
,
Shuhong ShenDepartment of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence[email protected]
&
Mao MaoTranslational Bioscience and Diagnostics, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China;
show all
Pages 2216-2218 | Received 19 May 2015, Accepted 07 Dec 2015, Published online: 20 Apr 2016

References

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  • Machado MP, Tomaz JP, Lorand-Metze I, et al. Monitoring of BCR-ABL levels in chronic myeloid leukemia patients treated with imatinib in the chronic phase – the importance of a major molecular response. Rev Bras Hematol Hemoter. 2011;33:211–215.
  • Norkin M, Schiffer CA. Molecular monitoring of BCR-ABL transcripts in patients with chronic myelogenous leukemia: is high sensitivity of clinical value? Curr Hematol Malig Rep. 2010;5:88–94.
  • Martinelli G, Iacobucci I, Soverini S, et al. Monitoring minimal residual disease and controlling drug resistance in chronic myeloid leukaemia patients in treatment with imatinib as a guide to clinical management. Hematol Oncol. 2006;24:196–204.
  • Iacobucci I, Galletti L, Amabile M, et al. Monitoring BCR-ABL transcript levels by real-time quantitative polymerase chain reaction: a linear regression equation to convert from BCR-ABL/B2M ratio to estimated BCR-ABL/ABL ratio. Haematologica. 2007;92:429–430.
  • Jennings LJ, Smith FA, Halling KC, et al. Design and analytic validation of BCR-ABL1 quantitative reverse transcription polymerase chain reaction assay for monitoring minimal residual disease. Arch Pathol Lab Med. 2012;136:33–40.
  • van der Velden VH, Hochhaus A, Cazzaniga G, et al. Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects. Leukemia. 2003;17:1013–1034.
  • Hayden RT, Gu Z, Ingersoll J, et al. Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus. J Clin Microbiol. 2013;51:540–546.
  • Goh HG, Lin M, Fukushima T, et al. Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay. Leuk Lymphoma. 2011;52:896–904.
  • Jennings LJ, George D, Czech J, et al. Detection and quantification of BCR-ABL1 fusion transcripts by droplet digital PCR. J Mol Diagn. 2014;16:174–179.

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