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Leukemia & Lymphoma Volume 1, 1989 - Issue 1
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Original Article

Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia

Jill A. Moormeier Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA
,
Carol A. Westbrook Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA
,
Mark J. Ratain Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA
&
Harvey M. Golomb Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA
Pages 43-45 | Published online: 01 Jul 2009

References

  • Golomb H. M., Jacobs A., Fefer A., Ozer H., Thompson J., Portlock C., Ratain M., Golde D., Vardiman J., Burke J. S., Brady J., Bonnem E., Spiegel R. Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients. Journal of Clinical Oncology 1986; 4: 900–5
  • Ratain M. J., Golomb H. M., Bardawil R. G., Vardiman J. W., Westbrook C. A., Kaminer L. S., Lembersky B. C., Bitter M. A., Daly K. Durability of responses to interferon alfa-2b in advanced hairy cell leukemia. Blood 1987; 69: 872–7
  • Ratain M. J., Golomb H. M., Vardiman J. M., Westbrook C. A., Barker C., Hooberman A., Bitter M. A., Daly K. Relapse after interferon alfa-2b therapy for hairy cell leukemia: analysis of prognostic variables. Journal of Clinical Oncology 1988; 6: 1714–21
  • Itri L. M., Campion M., Dennin R. A., Palleroni A. V., Gutterman J. U., Groopman J. E., Trown P. W. Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection. Cancer. 1987; 59: 668–74, (suppl. 3)
  • Spiegel R. J., Spicehandler J. R., Jacobs S. L., Oden E. M. Low incidence of serum neutralizing factors in patients receiving recombinant alfa-2b interferon (Intron A). American Journal of Medicine 1986; 80: 223–8
  • Quesada J. R., Rios A., Swanson D., Trown P., Gutterman J. U. Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma. Journal of Clinical Oncology 1985; 3: 1522–8
  • VonWussow P, Freund M., Block B., Diedrich H., Poliwoda H., Deicher H. Clinical significance of anti-IFN-alfa antibody titres during interferon therapy. Lancet 1987; ii: 635–6
  • Steis R. G., Smith J. W., Urba W. J., Clark J. W., Itri L. M., Evans L. M., Schoenberger C., Longo D. L. Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralising anti-interferon antibodies. Neu Englund Journal of Medicine 1988; 318: 1409–13
  • Moormeier J., Ratain M., Westbrook C., Vardiman J., Daly K., Golomb H. M. Low dose interferon in the treatment of hairy cell leukemia. Proceedings of the American Association of Cancer Research 1988; 29: 215

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