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Original Article

The Modulatory Hematopoietic Activities of Leukemia Inhibitory Factor

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Pages 1-7 | Received 20 Feb 1992, Published online: 01 Jul 2009

References

  • Gearing D. P., Gough N. M., King J. A., Hilton D. J., Nicola N. A., Simpson R. J., Nice E. C., Kelso A., Metcalf D. Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO Journal 1987; 6: 3995–4002
  • Moreau J. F., Donaldson D. D., Bennett F., Witek-Giannotti J., Clark S. C., Wong G. G. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 1988; 336: 690–692
  • Williams R. L., Hilton D. J., Pease S., Willson T. A., Stewart C. L., Gearing D. P., Wagner E. F., Metcalf D., Nicola N. A., Gough N. M. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem celts. Nature 1988; 336: 684–687
  • Smith A. G., Heath J. K., Donaldson D. D., Wong G. G., Moreau J., Stahl M., Rogers D. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988; 336: 688–690
  • Mori M., Yamaguchi K., Abe K. Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia. Biochemical and Biophysical Research Communications 1989; 160: 1085–1092
  • Baumann H., Wong G. G. Hepatocyte-stimulating factor-Ill shares structural and functional identity with leukemia-inhibitory factor. Journal of Immunology 1989; 143: 1163–1167
  • Yamamori T., Fukada K., Aebersold R., Korsching S., Fann M.-J., Patterson P. H. The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Science 1989; 246: 1412–1416
  • Abe E., Tanaka H., Ishimi Y., Miyaura C., Hayashi T., Nagasawa H., Tomida M., Yamaguchi Y., Hozumi M., Suda T. Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption. Proceedings of the National Academy of Sciences, U.S.A. 1986; 83: 5958–5962
  • Smith A. G., Hooper M. L. Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells. Developmental Biology 1987; 121: 1–9
  • Koopman P., Cotton R. G. H. A factor produced by feeder cells which inhibits embryonal carcinoma cell differentiation: characterization and partial purification. Experimental Celt Research 1984; 154: 233–242
  • Rathjen P. D., Toth S., Willis A., Heath J. K., Smith A. G. Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage. Cell 1990; 62: 1105–1114
  • Kurzrock R., Estrov Z., Wetzler M., Gutterman J. U., Talpaz M. LIF: Not just a leukemia inhibitory factor. Endocrine Reviews 1991; 12: 208–217
  • Hilton D. J., Nicola N. A., Metcalf D. Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells. Proceedings of the National Academy of Sciences, U.S.A. 1988; 85: 5971–5975
  • Yamamoto-Yamaguchi Y., Tomida M., Hozumi M. Specific binding of a factor inducing differentiation to mouse myeloid leukemic Ml cells. Experimental Cell Research 1986; 164: 97–102
  • Lowe D. G., Nunes W., Bombara M., McCabe S., Ranges G. E., Henzel W., Tomida M., Yamamoto-Yamaguchi Y., Hozumi M., Goeddel D. V. Genomics of cloning and heterologous expression of human differentiation-stimulating factor (leukemic inhibitory factor, human interleukin DA). DNA 1989; 8: 351–354
  • Moreau J.-F., Bonneville M., Godard A., Gascan H., Gruart V., Moore M. A., Soulillou J. P. Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activities. Journal of Immunology 1987; 138: 3844–3849
  • Godard A., Gascan H., Naulet J., Peyrat M.-A., Jacques Y., Soulillou J.-P., Moreau J.-F. Biochemical characterization and purification of HILDA, a human lymphokine active on eosinophils and bone marrow cells. Blood 1988; 71: 1618–1623
  • Conquet F., Brulet P. Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos. Molecular and Cellular Biology 1990; 10: 3801–3805
  • Rathjen P. D., Nichols J., Toth S., Edward D. R., Heath J. K., Smith A. G. Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations. Genes and Development 1990; 4: 2308–2318
  • Evans M. J., Kaufman M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154–156
  • Pease S., Williams R. L. Formation of germ-line chimeras from embryonic stem cells maintained with recombinant leukemia inhibitory factor. Experimental Cell Research 1990; 190: 209–211
  • Burgess A. W. Life after LIF?. Bio Essays 1989; 10: 166–169
  • Murphy M., Reid K., Hilton D. J., Bartlett P. F. Generation of sensory neurons is stimulated by leukemia inhibitory factor. Proceedings of the National Academy of Sciences, U.S.A. 1991; 88: 3498–3501
  • Freidin M., Kesler J. A. Cytokine regulation of substance P expression in sympathetic neurons. Proceedings of the National Academy of Sciences, U.S.A. 1991; 88: 3200–3203
  • Metcalf D., Nicola N. A., Gearing D. P. Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood 1990; 76: 50–56
  • Metcalf D., Gearing D. P. Fatal syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor. Proceedings of the National Academy of Sciences, U.S.A. 1989; 86: 5948–5952
  • Allan E. H., Hilton D. J., Brown M. A., Evely R. S., Yumita S., Metcalf D., Gough N. M., Ng K. W., Nicola N. A., Martin T. J. Osteoblasts display receptors for and responses to leukemia-inhibitory factor. Journal of Cellular Physiology US 1990; 110–119
  • Metcalf D., Gearing D. P. A myelosclerotic syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor (LIF). Leukemia 1989; 3: 847–852
  • Allan E. H., Gough N. M., Gelehrter T. D., Zeheb R., Martin T. J. Transforming growth factor β and leukemia inhibitory factor increase mRNA and protein for plasminogen activator inhibitor-1 in osteoblasts. Journal of Bone and Mineral Research 1989; 4(Suppl. 1)5324
  • Noda M., Vogel R. L., Hasson D. M., Rodan G. A. Leukemia inhibitory factor suppresses proliferation, alkaline phosphatase activity, and type 1 collagen messenger ribonucleic acid level and enhances osteopontin mRNA level in murine osteoblast-like (MC3T3E1) cells. Endocrinology 1990; 127: 185–190
  • Rodan S. B., Wesolowski G., Hilton D. J., Nicola N. A., Rodan G. A. Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT-1 cells and potentiates the retinoic acid induction of alkaline phosphatase. Endocrinology 1990; 127: 1602–1608
  • Reid I. R., Lowe G., Cornish J., Skinner S. J. M., Hilton D. J., Willson T. A., Gearing D. P., Martin T. J. Leukemia inhibitory factor: a novel bone-active cytokine. Endocrinology 1990; 126: 1416–1420
  • Simpson R. J., Hilton D. J., Nice E. C., Rubira M. R., Metcalf D., Gearing D. P., Gough N. M., Nicola N. A. Structural characterization of a murine myeloid leukaemia inhibitory factor. European Journal of Biochemistry 1988; 175: 541–547
  • Hilton D. J., Nicola N. A., Metcalf D. Purification of a murine leukemia inhibitory factor from Krebs ascites cells. Analytical Biochemistry 1988; 173: 359–367
  • Tomida M., Vamamoto-Yamaguchi Y., Hozumi M., Okabe T., Takaku F. Induction by recombinant human granulocyte colony-stimulating factor of differentiation of mouse myeloid leukemic M1 cells. FEBS Letters 1986; 207: 271–275
  • Hozumi M., Takenaga K., Tomida M., Okabe J. Role of leucocytes in ascites in the production of factor(s) stimulating differentiation of mouse myeloid leukemia cells. Japanese Journal of Cancer Research 1977; 68: 643–646
  • Abe E., Ishimi Y., Takahashi N., Akatsu T., Ozawa H., Yamana H., Yoshiki S., Suda T. A differentiation-inducing factor produced by the osteoblastic cell line MC3T3E1 stimulates bone resorption by promoting osteoclast formation. Journal of Bone and Mineral Research 1988; 3: 635–645
  • Hozumi M., Umezawa T., Takenaga K., Ohno T., Shikita M., Yamane I. Characterization of factors stimulating differentiation of mouse myeloid leukemia cells from a Yoshida sarcoma cell line cultured in serum-free medium. Cancer Research 1979; 39: 5127–5131
  • Gascan H., Anegon I., Praloran V., Naulet J., Godard A., Soulillou J.-P., Jacques Y. Constitutive production of human interleukin for DA cells/leukemia inhibitory factor by human tumor cell lines derived from various tissues. Journal of Immunology 1990; 144: 2592–2598
  • Abe T., Murakami M., Sato T., Kajiki M., Ohno M., Kodaira R. Macrophage differentiation incuding factor from human monocytic cells is equivalent to murine leukemia inhibitory factor. Journal of Biological Chemistry 1989; 264: 8941–8945
  • Anegon L., Moreau J. F., Godard A., Jacques Y., Peyrat M. A., Hallet M. M., Wong G., Soulillou J. P. Production on human interleukin for DA cells (HILDA)/leukemia inhibitory factor (LIF) by activated monocytes. Cellular Immunology 1990; 130: 50–65
  • Baumann J., Jahreis G. P., Sauder D. N., Koj A. Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse. Journal of Biological Chemistry 1984; 259: 7331–7342
  • Le P. T., Lazorick S., Whichard L. P., Yang Y.-C, Clark S. C., Haynes B. F., Singer K. H. Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor. Journal of Immunology 1990; 145: 3310–3315
  • Wetzler M. M., Talpaz M., Lowe D. G., Baiocchi G., Gutterman J. U., Kurzrock R. Constitutive expression of leukemia inhibitory factor RNA by human bone marrow stromal cells and modulation by IL-1, TNF-a and TGF-α. Experimental Hematology 1991; 19: 347–351
  • Gearing D. P., King J. A., Gough N. M. Complete sequence of murine myeloid leukaemia inhibitory factor (LIF). Nucleic Acids Research 1988; 16: 9857–9862
  • Gough N. M., Williams R. L. The pleiotropic actions of leukemia inhibitory factor. Cancer Cells 1989; 1: 77–80
  • Tomida M., Yamamoto-Yamaguchi Y., Hozumi M. Purification of a factor inducing differentiation of mouse myeloid leukaemic M1 cells from conditioned medium of mouse fibroblast L929 cells. Journal of Biological Chemistry 1984; 259: 10978–10982
  • Gough N. M., Gearing D. P., King J. A., Wilson T. A., Hilton D. J., Nicola N. A., Metcalf D. Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukaemia-inhibitory factor. Proceedings of the National Academy of Sciences, U.S.A. 1988; 85: 2623–2627
  • Stahl J., Gearing D. P., Willson T. A., Brown M. A., King J. A., Gough N. M. Structural organization of the genes for murine and human leukemia inhibitory factor. Journal of Biological Chemistry 1990; 265: 8833–8841
  • Sutherland G. R., Baker E., Hyland V. J., Callen D. F., Stahl J., Gough N. M. The gene for human leukemia inhibitory factor (LIF) maps to 22q12. Leukemia 1989; 3: 9–13
  • Kola I., Davey A., Gough N. M. Localization of the murine leukaemia inhibitory factor gene near the centromere on chromosome 11. Growth Factors 1990; 2: 235–240
  • Budarf M., Emanuel B. S., Mohandas T., Goeddel D. V., Lowe D. G. Human differentiation-stimulating factor (leukemia inhibitory factor, human interleukin DA) gene maps distal to the Ewing sarcoma breakpoint on 22q. Cytogenetics and Cell Genetics 1989; 52: 19–22
  • Metcalf K., Hilton D., Nicola N. A. Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro. Blood 1991; 77: 2150–2153
  • Hilton D. J., Nicola N. A., Metcalf D. Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells. Journal of Cellular Physiology 1991; 146: 207–215
  • Hilton D. N., Nicola N. A., Gough N. M., Metcalf D. Resolution and purification of three distinct factors produced by Krebs ascities cells which have differentiation-inducing activity on murine myeloid leukaemic cells lines. Journal of Biological Chemistry 1988; 263: 9238–9243
  • Shabo Y., Lotem J., Rubinstein M., Revel M., Clark S. C., Wolf S. F., Kamen R., Sachs L. The myeloid blood cell differentiation-inducing protein MG1–2A is interleukin-6. Blood 1988; 72: 2070–2073
  • Metcalf D. Suppression of myeloid leukemic cells by normal hemopoietic regulators. Proceedings of the Mochida Memorial Symposium. Recent Progresses in Cytokine Research 1989; 10: 11–19
  • Metcalf D., Hilton D. J., Nicola N. A. Clonal analysis of the actions of the murine leukaemia inhibitory factor on leukaemic and normal murine haemopoietic cells. Leukemia 1988; 2: 216–221
  • Wang C., Lishner M., Minder M. D., McCulloch E. A. The effects of leukemia inhibitory factor (LIF) on the blast stem cells of acute myeloblastic leukemia. Leukemia 1990; 4: 548–552
  • Maekawa T., Metcalf D. Clonal suppression of HL60 and U937 cells by recombinant human leukemia inhibitory factor in combination with GM-CSF or G-CSF. Leukemia 1989; 3: 270–276
  • Maekawa T., Metcalf D., Gearing D. P. Enhanced suppression of human myeloid leukemic cell lines by combinations of IL-6, LIF, GM-CSF and G-CSF. International Journal of Cancer 1990; 45: 353–358
  • Leary A. G., Wong G. G., Clark S. C., Smith A. G., Ogawa M. Leukemia inhibitory factor/differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells. Blood 1990; 75: 960–964
  • Verfaillie C., McGlave P. Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors. Blood 1991; 77: 263–270
  • Wetzler M., Kurzrock R., Taylor K., Spitzer G., Kantarjian H., Ku S., Gutterman J. U., Talpaz M. Constitutive and induced expression of growth factors in normal and chronic phase CML Ph1 bone marrow stroma. Cancer Research 1990; 50: 5801–5805
  • Schaafsma M. R., Falkenburg J. H. F., Duinkerken N., Soulillou J. P., Moreau J. F., Willemze R., Fibbe W. E. Human interleukin for DA cells (HILDA) does not affect the proliferation and differentiation of hematopoietic progenitor cells in human long-term bone marrow cultures. Experimental Hematology 1990; 18: 609, abstract
  • Wetzler M., Kurzrock R., Lowe D. G., Kantarjian H., Gutterman J. U., Talpaz M. Alteration in bone marrow adherent layer growth factor expression: A novel mechanism of chronic myelogenous leukemia progression. Blood 1991; 78: 2400–2406
  • Estrov Z., Kurzrock R., Wetzler M., Kantarjian H., Blake M., Harris D., Gutterman J. U., Talpaz M. Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: A novel application for inhibitors of IL-1 activity. Blood 1991; 78: 1476–1484

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