Recent Results on the Biology of Hodgkin and Reed-Sternberg Cells. I. Biopsy Material

References

• Hodgkin T. On some morbid appearances of the absorbent glands and spleen. Med. Chir. Trans. 1832; 17: 68–114
   PubMedGoogle Scholar
• Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relationship to tuberculosis. J. Hopkins Hosp. Rep. 1902; 10: 133–196
   Google Scholar
• Sternberg C. Über eine eigenartige unter dem Bilde der Pseudoleukämie verlaufende Tuberkulose des lymphatischen Apparates. Z. Heilkunde 1898; 19: 21–90
   Google Scholar
• Anastasi J., Variakojis D. Heterogeneity in Hodgkin's disease: No simple answer for a complex disorder. Human Pathol. 1988; 19: 1251–1254
   PubMed Web of Science ®Google Scholar
• Bucsky P. Hodgkin's disease: The Sternberg-Reed cell. Blut 1987; 55: 413–420
   PubMedGoogle Scholar
• Collins R. H., Jr. The pathogenesis of Hodgkin's disease. Blood Reviews 1990; 4: 61–68
   PubMed Web of Science ®Google Scholar
• Diehl V. Kalle, Von C., Fonatsch C., Tesch H., Jüecker M., Schaadt M. The cell of origin in Hodgkin's disease. Semin. Oncol. 1990; 17: 660–672
   PubMed Web of Science ®Google Scholar
• Drexler H. G., Amlot P. L., Minowada J. Hodgkin's disease-derived cell lines—Conflicting clues for the origin of Hodgkin's disease?. Leukemia 1987; 1: 629–637
   PubMed Web of Science ®Google Scholar
• Drexler H. G., Jones D. B., Diehl V., Minowada J. Is the Hodgkin cell a T- or B-lymphocyte?—Recent evidence from geno- and immunophenotypic analysis and in-vitro cell lines. Hematol. Oncol. 1989; 7: 95–113
   PubMed Web of Science ®Google Scholar
• Ford R. J. Hodgkin's disease in 1987—-Is history repeating itself?. Hematol Oncol. 1988; 6: 201–204
   PubMed Web of Science ®Google Scholar
• Jaffe E. S. The elusive Reed-Sternberg cell. N. Engl. J. Med. 1989; 320: 529–531
   PubMed Web of Science ®Google Scholar
• Jones D. B. The histogenesis of the Reed-Sternberg cell and its mononuclear counterparts. J Pathol. 1987; 151: 191–195
   PubMed Web of Science ®Google Scholar
• Jones E. L. Reticulum cells: Characterization and immune functions and the nature of Hodgkin and Reed-Sternberg cells. J Pathol 1984; 144: 227–232
   PubMed Web of Science ®Google Scholar
• Sinkovics J. G. Hodgkin's disease revisted. Reed-Sternberg cells as natural hybridomas. Crit. Rev. Immunol. 1991; 11: 33–63
   PubMed Web of Science ®Google Scholar
• Kadin M. E. Histogenesis of Hodgkin's disease: Possible insights from a comparison with lymphomatoid papulosis. Human Pathol. 1987; 18: 1085–1088
   PubMed Web of Science ®Google Scholar
• Kadin M. E. The Reed-Sternberg cell, an activated T-cell? The evidence has come full circle. Leukemia Lymphoma 1990; 2: 279–286
   PubMed Web of Science ®Google Scholar
• Lee F. D. Hodgkin's disease. Histopathol 1987; 11: 1211–1217
   PubMed Web of Science ®Google Scholar
• Pileri S., Sabattini E., Tazzari P. L., Gherlinzoni F., Zucchini L., Bigerna B., Leoncini L., Rosso R., Stein H., Falini B. Hodgkin's disease: Update of findings. Huematologica 1991; 76: 175–182
   PubMed Web of Science ®Google Scholar
• Schaadt M., Burrichter H., Stein H., Pfreundschuh M., Fonatsch C., Diehl V. The cell of origin in Hodgkin's disease: Conclusions from in vivo and in vitro studies. Int. Rev. Exp. Pathol. 1985; 27: 185–202
   PubMedGoogle Scholar
• Schwarz O., Dormont D., Lesser J., Andrieu J. M. The origin of the Sternberg cell. Nouv. Rev. Fr. Hematol. 1988; 30: 183–189
   PubMedGoogle Scholar
• Slivnick D. J., Nawrocki J. F., Fisher R. I. Immunology and cellular biology of Hodgkin's disease. Hematol. Oncol. Clin. North Am. 1989; 3: 205–220
   PubMed Web of Science ®Google Scholar
• Stein H., Gerdes J., Falini B. Phenotypic and genotypic markers in malignant lymphomas: Cellular origin of Hodgkin and Sternberg-Reed cells and implications for the classification of T-cell and B-cell lymphomas. Pathology of cell receptors and tumor markers. Application of immunocytochemistry and hybridization in tumor diagnosis, G. Seifert, K. Hübner. Gustav Fischer, Stuttgart 1987; 121–144
   Google Scholar
• Stein H., Schwarting R., Dallenbach F., Dienemann D. lmmunology of Hodgkin and Reed-Sternberg cells. 1989; 14–26, in Diehl V., Pfreundschuh, M., Loeffler, M. (eds): New Aspects in the Diagnosis and Treatment of Hodgkin's Disease. Recent Results in Cancer Research 117. Berlin, Springer
   Google Scholar
• Forni M., Hofman F. M., Parker J. W., Lukes R. J., Taylor C. R. B- and T-lymphocytes in Hodgkin's disease. An immunohistochemical study utilizing heterologous and monoclonal antibodies. Cancer 1985; 55: 728–737
   PubMed Web of Science ®Google Scholar
• Taylor C. R. Upon the enigma of Hodgkin's disease and the Reed-Sternberg cells. Controversies in the Management of lymphomas, J. M. Bennett. Martinus Nijhoff, Boston 1983; 91
   Google Scholar
• Wright D. H. Pathology of Hodgkin's disease: Anything new?. New Aspects in the Diagnosis and Treatment of Hodgkin's Disease. Recent Results in Cancer Research 117, V. Diehl, M. Pfreundschuh, M. Loeffler. Springer, Berlin 1989; 3–13
   Google Scholar
• Miller T. P., Byrne G. E., Jones S. E. Mistaken clinical and pathologic diagnosis of Hodgkin's disease: A Southwest Oncology Group study. Cancer Treat Rep. 1982; 66: 645–651
   PubMedGoogle Scholar
• Kant J. A., Hubbard S. M., Longo D. L., Simon R. M., De Vita V. T., Jr, Jaffe E. S. The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin's disease. J. Clin. Oncol. 1986; 4: 284–294
   PubMed Web of Science ®Google Scholar
• Woodruff D. Reviewing histologic diagnosis of lymphoma. Arch. Pathol. Lab. Med. 1981; 105: 573–576
   PubMed Web of Science ®Google Scholar
• Holman C. D. J., Matz L. R., Finlay-Jones L. R., Waters E. D., Blackwell J. B., Joyce P. R., Kelsall G. R. H., Shilkin K. B., Cullity G. J., Williams K. E., Matthews M. L. V., Armstrong B. K. Inter-observer variation in the histopathological reporting of Hodgkin's disease: An analysis of diagnostic subcomponents using kappa statistics. Histopathol. 1983; 7: 399–407
   PubMed Web of Science ®Google Scholar
• Angel C. A., Warford A., Day S. J., Lauder I. Comparative quality assessment in immunocytochemistry: Pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin's disease. J. Clin. Pathol. 1989; 42: 1096–1100
   PubMed Web of Science ®Google Scholar
• Norton A. J., Isaacson P. G. The diagnosis of malignant lymphoma using monoclonal antibodies reactive in routinely fixed wax embedded tissue. J. Pathol. 1987; 151: 183–184
   PubMed Web of Science ®Google Scholar
• Schmid C., Pan L., Diss T., Isaacson P. G. Expression of B-cell antigens in Hodgkin's and Reed-Sternberg cells. Am. J. Pathol. 1991; 139: 701–708
   PubMed Web of Science ®Google Scholar
• Dallenbach F. E., Stein H. Expression of T-cell-receptor β chain in Reed-Sternberg cells. Lancet 1989; ii: 828–830
   Google Scholar
• Abdulaziz Z., Mason D. Y., Stein H., Gatter K. C., Nash J. R. G. An immunohistological study of the cellular constituents of Hodgkin's disease using a monoclonal antibody panel. Histopathol. 1984; 8: 1–25
   PubMed Web of Science ®Google Scholar
• Agnarsson B. A., Kadin M. E. The immunophenotype of Reed-Sternberg cells. A study of 50 cases of Hodgkin's disease using fixed frozen tissues. Cancer 1989; 63: 2083–2087
   PubMed Web of Science ®Google Scholar
• Angel C. A., Warford A., Campbell A. C., Pringle J. H., Lauder I. The immunohistology of Hodgkin's disease—Reed-Sternberg cells and their variants. J. Pathol. 1987; 153: 21–30
   PubMed Web of Science ®Google Scholar
• Bhoopat L., Turner R. R., Stathopoulos E., Meyer P. R., Taylor C. R., Marder R. J., Epstein A. L. lmmunohistochemical characterization of two new monoclonal antibodies (LN-4, LN-5) reactive with human macrophage subsets and derived malignancies in B5-fixed, paraffin-embedded tissues. Blood 1988; 71: 1079–1085
   PubMed Web of Science ®Google Scholar
• Bishop P. W., Harris M., Smith A. P., Elsam K. J. Immunophenotypic study of lymphocyte predominance Hodgkin's disease. Histopathol. 1991; 18: 19–24
   PubMed Web of Science ®Google Scholar
• Carbone A., Poletti A., Manconi R., Volpe R., Betta P. G. Reliability of anti-Leu-M 1 immunostaining in Hodgkin's disease. Arch. Pathol. Lab. Med. 1986; 110: 465–466
   PubMed Web of Science ®Google Scholar
• Carbone A., Manconi R., Poletti A., Sulfaro S., Menin A., Tirelli U., Betta P. G., Volpe R. Reed-Sternberg cells and their cell microenvironment in Hodgkin's disease with reference to macrophage-histiocytes and interdigitating reticulum cells. Cancer 1987; 60: 2662–2668
   PubMed Web of Science ®Google Scholar
• Carbone A., Gloghini A., Volpe R., Boiocchi M. Anti-vimentin antibody reactivity with Reed-Sternberg cells of Hodgkin's disease. Virchows Archiv. [Pathol. Anat.] 1990; 417: 43–48
   PubMed Web of Science ®Google Scholar
• Casey T. T., Olson S. J., Cousar J. B., Collins R. D. Immunophenotypes of Reed-Sternberg cells: A study of 19 cases of Hodgkin's disease in plastic-embedded sections. Blood 1989; 14: 2624–2628
   Google Scholar
• Chittal S. M., Caveriviere P., Schwarting R., Gerdes J. A1, Saati T., Rigal-Huguet F., Stein H., Delsol G. Monoclonal antibodies in the diagnosis of Hodgkin's disease. The search for a rational panel. Am. J. Surg. Pathol. 1988; 12: 9–21
   PubMed Web of Science ®Google Scholar
• Chittal S. M., Alard C., Rossi J. F. A1, Saati T. L. e, Tourneau A., Diebold J., Delsol G. Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin's disease is a large B-cell lymphoma in evolution. Am. J. Surg. Pathol. 1990; 14: 1024–1035
   PubMed Web of Science ®Google Scholar
• Cibull M. L., Stein H., Gatter K. C., Mason D. Y. The expression of the CD3 antigen in Hodgkin's disease. Histopathol 1989; 15: 597–605
   Web of Science ®Google Scholar
• Crocker J., Skilbeck N., Brown G., Bunce C. Presence of 3-fucosyl-N-acetyllactosamine shown by monoclonal antibody AGF 4.48 in Reed-Sternberg cells. J. Clin. Pathol. 1986; 39: 564–568
   PubMed Web of Science ®Google Scholar
• Dorfman R. F., Gatter K. C., Pulford K. A. F., Mason D. Y. An evaluation of the utility of anti-granulocyte and anti-leukocyte monoclonal antibodies in the diagnosis of Hodgkin's disease. Am. J. Pathol. 1986; 123: 508–519
   PubMed Web of Science ®Google Scholar
• Dorreen M. S., Habeshaw J. A., Stansfeld A. G., Wrigley P. F. M., Lister T. A. Characteristics of Sternberg-Reed, and related cells in Hodgkin's disease: an immunohistological study. Br. J. Cancer 1984; 49: 465–476
   PubMed Web of Science ®Google Scholar
• Falini B., Stein H., Pileri S., Canino S., Farabbi R., Martelli M. F., Grignani F., Fagioli M., Minelli O., Ciani C., Flenghi L. Expression of lymphoid-associated antigens on Hodgkin's and Reed-Sternberg cells of Hodgkin's disease. An immuno-cytochemical study on lymph node cytospins using monoclonal antibodies. Histopathol. 1987; 11: 1229–1242
   PubMed Web of Science ®Google Scholar
• Fellbaum C., Hansmann M. L., Parwaresch M. R., Lennert K. Monoclonal antibodies Ki-B3 and Leu-Ml discriminate giant cells of infectious mononucleous and of Hodgkin's disease. Hum. Pathol. 1988; 19: 1168–1173
   PubMed Web of Science ®Google Scholar
• Frierson H. F., Innes D. J., Jr. Sensitivity of anti-Leu-Ml as a marker in Hodgkin's disease. Arch. Pathol. Lab. Med. 1985; 109: 1024–1028
   PubMed Web of Science ®Google Scholar
• Hall P. A., D'Ardenne A. J., Stansfeld A. G. Paraffin section immunohistochemistry. II. Hodgkin's disease and large cell anaplastic (Kil) lymphoma. Histopathol. 1988; 13: 161–169
   PubMed Web of Science ®Google Scholar
• Hansmann M. L., Wacker H. H., Radzun H. J. Paragranuloma is a variant of Hodgkin's disease with predominance of B-cells. Virchows Arch. [ Pathol. Anat.] 1986; 409: 171–181
   PubMed Web of Science ®Google Scholar
• Hansmann M. L., Radzun H. J., Nebendahl C., Parwaresch M. R. Immunoelectron-microscopic investigation of Hodgkin's disease with monoclonal antibodies against histiocytes. Eur. J. Haematol. 1988; 40: 25–30
   PubMedGoogle Scholar
• Herbst H., Tippelmann G., Anagnostopoulos I., Gerdes J., Schwarting R., Boehm T., Pileri S., Jones D. B., Stein H. Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-l-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype. Leuk. Res. 1989; 13: 103–116
   PubMed Web of Science ®Google Scholar
• Herbst H., Dallenbach F., Hummel M., Niedobitek G., Pileri S., Müller-Lantzsch N., Stein H. Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells. Proc. Natl. Acad. Sci. USA 1991; 88: 4766–4770
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Jaffe E. S. Leu Ml and peanut agglutinin stain the neoplastic cells of Hodgkin's disease. Am. J, Clin. Pathol. 1984; 82: 29–32
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Yang K., Jaffe E. S. Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. Am. J. Pathol. 1985; 118: 209–217
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Ho Y. S., Li P. J., Monheit J., Ree H. J., Sheibani K., Winberg C. D. L&H variants of Reed-Sternberg cells express sialylated Leu Ml antigen. Am. J. Pathol. 1986; 122: 199–203
   PubMed Web of Science ®Google Scholar
• Hyder D. M., Schnitzer B. Utility of Leu Ml monoclonal antibody in the differential diagnosis of Hodgkin's disease. Arch. Pathol. Lab. Med. 1986; 110: 416–419
   PubMed Web of Science ®Google Scholar
• Jack A. S., Cunningham D., Soukop M., Liddle C. N., Lee F. D. Use of Leu Ml and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease. J. Clin. Pathol. 1986; 39: 267–270
   PubMed Web of Science ®Google Scholar
• Kadin M. E. Possible origin of the Reed-Sternberg cell from an interdigitating reticulum cell. Cancer Treat. Rep. 1982; 66: 601–608
   PubMedGoogle Scholar
• Kadin M. E., Muramoto L., Said J. Expression of T-cell antigens on Reed-Sternberg cells in a subset of patients with nodular sclerosing and mixed cellularity Hodgkin's disease. Am. J. Puthol. 1988; 130: 345–353
   PubMed Web of Science ®Google Scholar
• Kennedy I. C. S., Hart D. N. J., Colls B. M., Nimmo J. C., Willis D. A., Angus H. B. Nodular sclerosing, mixed cellularity and lymphocyte-depleted variants of Hodgkin's disease are probably dendritic cell malignancies. Clin. Exp. Immunol. 1989; 76: 324–331
   PubMed Web of Science ®Google Scholar
• Kornstein M. J., Bonner H., Gee B., Cohen R., Brooks J. J. Leu MI and S100 in Hodgkin's disease and non-Hodgkin's lymphomas. Am. J. Clin. Pathol. 1986; 85: 433–437
   PubMed Web of Science ®Google Scholar
• Medeiros L. J., Weiss L. M., Warnke R. A., Dorfman R. F. Utility of combining antigranulocyte with antileukocyte antibodies in differentiating Hodgkin's disease from non-Hodgkin's lymphoma. Cancer 1988; 62: 2475–2481
   PubMed Web of Science ®Google Scholar
• Meis J. M., Osborne B. M., Butler J. J. A comparative marker study of large cell lymphoma, Hodgkin's disease, and true histiocytic lymphoma in paraffin-embedded tissue. Am. J. Clin. Pathol 1986; 86: 591–599
   PubMed Web of Science ®Google Scholar
• Myskow M. W., Krajewski A. S. Immunoreactivity of Reed-Sternberg cells in paraffin and frozen sections. J. Clin. Pathol. 1986; 39: 1043–1045
   PubMed Web of Science ®Google Scholar
• Nicholas D. S., Harris S., Wright D. H. Lymphocyte predominance Hodgkin's disease—an immunohistochemical study. Histopathol. 1990; 16: 157–165
   PubMed Web of Science ®Google Scholar
• Norton A. J., Isaacson P. G. Granulocyte and HLA-D region specific monoclonal antibodies in the diagnosis of Hodgkin's disease. J. Clin. Pathol. 1985; 38: 1241–1246
   PubMed Web of Science ®Google Scholar
• Norton A. J., Isaacson P. G. Monoclonal antibody L26: An antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J. Clin. Pathol. 1987; 40: 1405–1412
   PubMed Web of Science ®Google Scholar
• Oka K., Mori N., Kojima M. Anti-Leu-3a antibody reactivity with Reed-Sternberg cells of Hodgkin's disease. Arch. Pathol. Lab. Med. 1988; 112: 139–142
   PubMed Web of Science ®Google Scholar
• Pastuszak W. T., Cartun M. S., Coles F. B. L26 immunoreactivity in LP Hodgkin's disease. Lab. Invest. 1988; 58: 71A
   Web of Science ®Google Scholar
• Patsouris E., Noel H., Lennert K. Cytohistologic and immunohistochemical findings in Hodgkin's disease, mixed cellularity type, with a high content of epithelioid cells. Am. J. Surg. Pathol. 1989; 13: 1014–1022
   PubMed Web of Science ®Google Scholar
• Pinkus G. S., Said J. W. Hodgkin's disease, lymphocyte predominance type, nodular—A distinct entity?. Am. J. Pathol. 1985; 118: 1–6
   PubMed Web of Science ®Google Scholar
• Pinkus G. S., Thomas P., Said J. W. Leu-Ml—A marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am. J. Pathol. 1985; 119: 244–252
   PubMed Web of Science ®Google Scholar
• Pinkus G. S., Said J. W. Hodgkin's disease, lymphocyte predominance type, nodular—Further evidence for a B cell derivation. Am. J. Pathol. 1988; 133: 211–217
   PubMed Web of Science ®Google Scholar
• Pizzolo G., Chilosi M., Semenzato G., Caligaris-Cappio F., Fiore-Donati L., Perona G., Janossy G. Immunohistological analysis of Tac antigen expression in tissues involved by Hodgkin's disease. Br. J. Cancer 1984; 50: 415–417
   PubMed Web of Science ®Google Scholar
• Poppema S. The diversity of the immunohistological staining pattern of Sternberg-Reed cells. J. Histochem. Cytochem. 1980; 28: 788–791
   PubMed Web of Science ®Google Scholar
• Poppema S., Bhan A. K., Reinherz E. L., Posner M. R., Schlossman S. F. In situ immunologic characterization of celllrlar constituents in lymph nodes and spleens involved by Hodgkin's disease. Blood 1982; 59: 226–232
   PubMed Web of Science ®Google Scholar
• Poppema S. The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease. Am. J. Pathol. 1989; 135: 351–357
   PubMed Web of Science ®Google Scholar
• Ree H. J., Neiman R. S., Martin A. W., Dallenbach F., Stein H. Paraffin section markers for Reed-Sternberg cells. A comparative study of peanut agglutinin, Leu-Ml, LN-2, and Ber-H2. Cancer 1989; 63: 2030–2036
   PubMed Web of Science ®Google Scholar
• Regula D. P., Weiss L. M., Warnke R. A., Dorfman R. F. Lymphocyte predominance Hodgkin's disease: a reappraisal based upon histological and immunophenotypical findings in relapsing cases. Histopathol. 1987; 11: 1107–1120
   PubMed Web of Science ®Google Scholar
• Rowlands D. C., Hansel T. T., Crocker J. Immunohistochemical determination of CD23. expression in Hodgkin's disease using paraffin sections. J. Pathol. 1990; 160: 239–243
   PubMed Web of Science ®Google Scholar
• Schwarting R., Gerdes J., Ziegler A., Stein H. Immunoprecipitation of the interleukin-2 receptor from Hodgkin's disease derived cell lines by monoclonal antibodies. Hematol. Oncol. 1987; 5: 57–64
   PubMed Web of Science ®Google Scholar
• Schwarting R., Gerdes J., Dürkop H., Falini B., Pileri S., Stein H. BER-H2, a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood 1989; 74: 1678–1689
   PubMed Web of Science ®Google Scholar
• Sheibani K., Battifora H., Burke J. S., Rappaport H. Leu-Ml antigen in human neoplasms. Am. J. Surg. Pathol. 1986; 10: 227–236
   PubMed Web of Science ®Google Scholar
• Sherrod A. E., Felder B., Levy N., Epstein A., Marder R., Lukes R. J., Taylor C. R. Immunohistologic identification of phenotypic antigens associated with Hodgkin and Reed-Sternberg cells. A paraffin section study. Cancer 1986; 57: 2135–2140
   PubMed Web of Science ®Google Scholar
• Stein H., Uchánska-Ziegler B., Gerdes J., Ziegler A., Wernet P. Hodgkin and Sternberg-Reed cells contain antigens specific to late cells of granulopoiesis. Int. J. Cancer 1982; 29: 283–290
   PubMed Web of Science ®Google Scholar
• Stein H., Gerdes J., Schwab U., Lemke H., Mason D. Y., Ziegler A., Schienle W., Diehl V. Identification of Hodgkin and Reed-Sternberg cells as a unique cell type derived from a newly-detected small-cell population. Int. J. Cancer 1982; 30: 445–459
   PubMed Web of Science ®Google Scholar
• Stein H., Mason D. Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H., Schwarting R., Lennert K. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 1985; 66: 848–858
   PubMed Web of Science ®Google Scholar
• Stein H., Hansmann M. L., Lennert K., Brandtzaeg P., Gatter K. C., Mason D. Y. Reed-Sternberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain. Am. J. Clin. Pathol. 1986; 86: 292–297
   PubMed Web of Science ®Google Scholar
• Strauchen J. A., Dimitriu-Bona A. Immunopathology of Hodgkin's disease. Characterization of Reed-Sternberg cells with monoclonal antibodies. Am. J. Pathol. 1986; 123: 293–300
   PubMed Web of Science ®Google Scholar
• Strauchen J. A., Breakstone B. Leu M-l antigen: Comparative expression in Hodgkin's disease and T cell lymphoma. Hematol. Oncol. 1987; 5: 107–114
   PubMed Web of Science ®Google Scholar
• Strickler J. G., Michie S. A., Warnke R. A., Dorfman R. F. The “syncytial variant” of nodular sclerosing Hodgkin's disease. Am. J. Surg. Pathol. 1986; 10: 470–477
   PubMed Web of Science ®Google Scholar
• Stuart A. E., Volsen S. G., Zola H. The reactivity of Reed-Sternberg cells with monoclonal antisera at thin section and ultrastructural levels. J. Pathol. 1983; 141: 71–82
   PubMed Web of Science ®Google Scholar
• Swerdlow S. H., Wright S. A. The spectrum of Leu-Ml staining in lymphoid and hematopoietic, proliferations. Am. J. Clin. Pathol. 1986; 85: 283–288
   PubMed Web of Science ®Google Scholar
• Timens W., Visser L., Poppema S. Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. Lab. Invest. 1986; 54: 457–461
   PubMed Web of Science ®Google Scholar
• Weiss L. M., Strickler J. G., Hu E., Warnke R. A., Sklar J. Immunoglobulin gene rearrangements in Hodgkin's disease. Hum. Pathol. 1986; 17: 1009–1014
   PubMed Web of Science ®Google Scholar
• Werner M., Georgii A., Bernhards J., Hübner K., Schwarze E. W., Fischer R. Characterization of giant cells in Hodgkin's lymphomas by immunohistochemistry applied to randomly collected diagnostic biopsies from the German Hodgkin trial. Hematol. Oncol. 1990; 8: 241–250
   PubMed Web of Science ®Google Scholar
• Xerri L., Horschowski N., Gabert J., Lejeune C., Dhiver C., Hassoun J. Correlations between gene rearrangements and immunoreactivity of Reed-Sternberg cells in paraffin sections: A genotypic and phenotypic study of 14 cases of Hodgkin's disease. Leukemia Lymphoma 1991; 3: 267–275
   PubMed Web of Science ®Google Scholar
• Zukerberg L. R., Collins A. B., Ferry J. A., Harris N. L. Coexpression of CD15 and CD20 by Reed-Sternberg cells in Hodgkin's disease. Am. J. Pathol. 1991; 139: 475–483
   PubMed Web of Science ®Google Scholar
• Andrade R. E., Wick M. R., Frizzera G., Gajl-Peczalska K. Immunophenotyping of hematopoietic malignancies in paraffin sections. Hum. Pathol. 1988; 19: 394–402
   PubMed Web of Science ®Google Scholar
• Coles F. B., Cartun R. W., Pastuszak W. T. Hodgkin's disease, lymphocyte-predominant type: Immunoreactivity with B-cell antibodies. Mod. Pathol. 1988; 274: 274–278
   Google Scholar
• Della Croce D. R., Imam A., Brynes R. K., Nathwani B. N., Taylor C. R. Anti-BLA. 36 monoclonal antibody shows reactivity with Hodgkin's cells and B lymphocytes in frozen and paraffin-embedded tissues. Hematol. Oncol. 1991; 9: 103–114
   PubMed Web of Science ®Google Scholar
• Linder J., Ye Y., Armitage J. O., Weisenburger D. D. Monoclonal antibodies marking B-cell non-Hodgkin's lymphoma in paraffin-embedded tissue. Mod. Pathol. 1988; 1: 29–34
   PubMed Web of Science ®Google Scholar
• Schmid C., Sargent C., Isaacson P. G. L cells and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction. Am. J. Pathol. 1991; 139: 1281–1290
   PubMed Web of Science ®Google Scholar
• Campana D., Thompson J. S., Amlot P., Brown S., Janossy G. The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. J. Immunol. 1987; 138: 648–655
   PubMed Web of Science ®Google Scholar
• Campana D., Van Dongen J. J. M., Mehta A., Coustan-Smith E., Wolvers-Tettero I. L. M., Ganeshaguru K., Janossy G. Stages of T-cell receptor protein expression in T-cell acute lymphoblastic leukemia. Blood 1991; 77: 1546–1554
   PubMed Web of Science ®Google Scholar
• Poppema S., Hollema H., Visser L., Vos H. Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections. Am. J. Pathol. 1987; 127: 418–429
   PubMed Web of Science ®Google Scholar
• Leech H. Immunoglobulin-positive Reed-Sternberg cells in Hodgkin's disease. Lancet 1973; ii: 265–266
   Google Scholar
• Garvin A. J., Spicer S. S., Parmley R. T., Munster A. M. Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease. J. Exp. Med. 1974; 139: 1077–1083
   PubMed Web of Science ®Google Scholar
• Taylor C. R. The nature of Reed-Sternberg cells and other malignant “reticulum” cells. Lancet 1974; ii: 802–807
   Google Scholar
• Landaas T. O., Godal T., Halvorsen T. B. Characterization of immunoglobulins in Hodgkin's cells. Int. J. Cancer 1977; 20: 717–722
   PubMed Web of Science ®Google Scholar
• Kadin M. E., Stiles D. P., Levy R., Warnke R. Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin's disease. N. Engl. J. Med. 1978; 299: 1208–1214
   PubMed Web of Science ®Google Scholar
• Papadimitriou C. S., Stein H., Lennert K. The complexity of immunohistochemical staining pattern of Hodgkin and Sternberg-Reed cells. Demonstration of immunoglobulin, albumin, α-1-antichymotrypsin and lysozyme. Int. J. Cancer 1978; 21: 531–541
   PubMed Web of Science ®Google Scholar
• Poppema S., Kaiserling E., Lennert K. Nodular paragranuloma and progressivley transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch. [Cell Pathol.] 1979; 31: 211–220
   Google Scholar
• Ruprai A. K., Pringle J. H., Angel C. A., Kind C. N., Lauder I. Localization of immunoglobulin light chain mRNA expression in Hodgkin's disease by in situ hybridization. J. Pathol. 1991; 164: 37–40
   PubMed Web of Science ®Google Scholar
• Brandtzaeg P. Studies on J chain and binding site for secretory component in circulating human B cells. II. The cytoplasm. Clin. Exp. Immunol. 1976; 25: 59–66
   PubMed Web of Science ®Google Scholar
• Campana D., Janossy G., Bofill M., Trejdosiewicz L. K., Ma D., Hoffbrand A. V., Mason D. Y., Lebacq A. M., Forster H. K. Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue. J. Immunol. 1985; 134: 1524–1529
   PubMed Web of Science ®Google Scholar
• Janossy G., Coustan-Smith E., Campana D. The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: A study of 500 cases. Leukemia 1989; 3: 170–181
   PubMed Web of Science ®Google Scholar
• Pizzolo G., Chilosi M., Vinante F., Dazzi F., Lestani M., Perona G., Benedetti F., Todeschini G., Vincenzi C., Trentin L., Semenzato G. Soluble interleukin-2 receptors in the serum of patients with Hodgkin's disease. Brit. J. Cancer 1987; 55: 427–428
   PubMed Web of Science ®Google Scholar
• Pui C. H., Ip S., Thompson E., Wilimas J., Brown M., Dodge R. K., De Hoyas R. A., Berard C. W., Crist W. M. High serum interleukin-2 levels correlate with a poor prognosis in children with Hodgkin's disease. Leukemia 1989; 3: 481–484
   PubMed Web of Science ®Google Scholar
• Takahashi K., Yamaguchi H., Ishizeki J., Nakajima T., Nakazato Y. Immuno-histochemical and immunoelectron microscope localization of S100 protein in the interdigitating reticulum cells of the human lymph node. Virchows Arch. [Cell Pathol.] 1981; 37: 125–135
   Google Scholar
• Sangster G., Crocker J., Jenkins R., Leyland M. J. Cells which contain S-100 protein in Hodgkin's disease: A qualitative study. J. Clin. Pathol. 1985; 38: 1021–1024
   PubMed Web of Science ®Google Scholar
• Moller P. Peanut lectin: A useful tool for detecting Hodgkin cells in paraffin sections. Virchows Arch. [Pathol. Anat.] 1982; 396: 313–317
   PubMed Web of Science ®Google Scholar
• Ree H. J., Kadin M. E. Macrophage-histiocytes in Hodgkin's disease: The relation of peanut-agglutinin-binding macrophage-histiocytes to clinicopathologic presentation and course of disease. Cancer 1985; 56: 333–338
   PubMed Web of Science ®Google Scholar
• Ree H. J., Hsu S. M. Lectin histochemistry of malignant tumors. I. Peanut agglutinin receptors in follicular lymphoma and follicular hyperplasia. An immunohistochemical study. Cancer 1983; 51: 1631–1638
   PubMed Web of Science ®Google Scholar
• Ree H. J., Kadin M. E. Peanut agglutinin: A useful marker for histiocytosis X and interdigitating reciculum cells. Cancer 1986; 57: 282–287
   PubMed Web of Science ®Google Scholar
• Coles F. B., Cartun R. W., Pastuszak W. T. Hodgkin's disease, lymphocyte-predominant type: Immunoreactivity with B-cell antibodies. Mod. Pathol. 1988; 1: 274–278
   PubMed Web of Science ®Google Scholar
• Lukes R. J., Butler R. J., Hicks E. B. Natural history of Hodgkin's disease as related to its pathologic picture. Cancer 1966; 19: 317–344
   Web of Science ®Google Scholar
• Hsu S. M., Huang L. C., Hsu P. L., Ge Z. H., Ho Y. S., Cuttita F., Mulshine J. Biochemical and ultrastructural study of Leu Ml antigen in Reed-Sternberg cells: Comparison with granulocytes and interdigitating reticulum cells. J. Natl. Cancer Inst. 1986; 77: 363–370
   PubMed Web of Science ®Google Scholar
• Ree H. J., Teplitz C., Khan A. The Lewis X antigen. A new paraffin section marker for Reed-Sternberg cells. Cancer 1991; 67: 1338–1346
   PubMed Web of Science ®Google Scholar
• Warhol M. J., Pinkus G. S., Said J. W. Ultrastructural localization of Leu Ml in Reed-Sternberg cells and normal myeloid cells. Hum. Pathol. 1987; 18: 824–829
   PubMed Web of Science ®Google Scholar
• Hall P. A., D'Ardenne A. J. Value of CD15 immunostaining in diagnosing Hodgkin's disease: A review of published literature. J. Clin. Pathol. 1987; 40: 1298–1304
   PubMed Web of Science ®Google Scholar
• Schwab U., Stein H., Gerdes J., Lemke H., Kirchner H., Schaadt M., Diehl V. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and subset of normal lymphoid cells. Nature 1982; 299: 65–67
   PubMed Web of Science ®Google Scholar
• Andreesen R., Osterholz J., Löhr G. W., Bross K. J. A Hodgkin cell-specific antigen is expressed on a subset of auto- and alloactivated T (helper) lymphoblasts. Blood 1984; 63: 1299–1302
   PubMed Web of Science ®Google Scholar
• Andreesen R., Brugger W., Lohr G. W., Bross K. J. Human macrophages can express the Hodgkin's cell-associated antigen Ki-l (CD30). Am. J. Pathol. 1989; 134: 187–192
   PubMed Web of Science ®Google Scholar
• Pfreundschuh M., Mommertz E., Meissner M., Feller A. C., Hassa R., Krueger G. R. F., Diehl V. Hodgkin and Reed-Sternberg cell associated monoclonal antibodies HRS-1 and HRS-2 react with activated cells of lymphoid and monocytoid origin. Anticancer Res. 1988; 8: 217–224
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Hsu P. L. Aberrant expression of T cell and B cell markers in myelocyte-monocyte-histiocytederived lymphoma and leukemia cells. Is the infrequent expression of T/B cell markers sufficient to establish a lymphoid origin for Hodgkin's Reed-Sternberg cells?. Am. J. Pathol. 1989; 134: 203–212
   PubMed Web of Science ®Google Scholar
• Hecht T. T., Longo D. L., Cossman J., Bolen J. B., Hsu S. M., Israel M., Fisher R. I. Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells. J. Immunol. 1985; 134: 4231–4236
   PubMed Web of Science ®Google Scholar
• Froese P., Lemke H., Gerdes J., Havsteen B., Schwarting R., Hansen H., Stein H. Biochemical characterization and biosynthesis of the Ki-l antigen in Hodgkin-derived and virus-transformed human B and T lymphoid cell lines. J. Immunol. 1987; 139: 2081–2087
   PubMed Web of Science ®Google Scholar
• Nawrocki J. F., Kirsten E. S., Fisher R. I. Biochemical and structural properties of a Hodgkin's disease-related membrane protein. J. Immunol. 1988; 141: 672–680
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Ho Y. S., Hsu P. L. Effect of monoclonal antibodies anti-2H9, anti-IRac, anti-HeFi-l on the surface antigens of Reed-Sternberg cells. J. Natl. Cancer. Inst. 1987; 79: 1091–1099
   PubMed Web of Science ®Google Scholar
• Carde P., Da Costa L., Manil L., Pfreundschuh M., Lumbroso J. D., Saccavini J. C., Caillou B., Ricard M., Boudet F., Hayat M., Diehl V., Parmentier C. Immunoscintigraphy of Hodgkin's disease: In vivo use of radiolabelled monoclonal antibodies derived from Hodgkin cell lines. Eur. J. Cancer 1990; 26: 474–479
   PubMed Web of Science ®Google Scholar
• Engert A., Burrows F., Jung W., Tazzari P. L., Stein H., Pfreundschuh M., Diehl V., Thorpe P. Evaluation of rich A chain-containing immunotoxins directed against the CD30 antigen as potential reagents for the treatment of Hodgkin's disease. Cancer Res 1990; 50: 84–88
   PubMed Web of Science ®Google Scholar
• Josimovic-alasevic O., Dürkop H., Schwarting R., BackÉ E., Stein H., Diamantstein T. Ki-l (CD30) antigen is released by Ki-l-positive tumor cells in vitro and in vivo. Eur. J. Immunol. 1989; 19: 157–162
   PubMed Web of Science ®Google Scholar
• Pfreundschuh M., Pohl C., Berenbeck C., Schroeder J., Jung W., Schmits R., Tschiersch A., Diehl V., Cause A. Detection of a soluble form of the CD30 antigen in the sera of patients with lymphoma, adult T-cell leukemia and infectious mononucleosis. Int. J. Cancer 1990; 45: 869–874
   PubMed Web of Science ®Google Scholar
• Pizzolo G., Vinante F., Chilosi M., Dallenbach F., Josimovic-Alasevic O., Diamantstein T., Stein H. Serum levels of soluble CD30 molecule (Ki-l antigen) in Hodgkin's disease: Relationship with disease activity and clinical stage. Brit. J. Haematol. 1990; 75: 282–284
   PubMed Web of Science ®Google Scholar
• Gause A., Pohl C., Tschiersch A., Da Costa L., Jung W., Diehl V., Hasenclever D., Pfreundschuh M. Clinical significance of soluble CD30 antigen in the sera of patients with untreated Hodgkin's disease. Blood 1991; 77: 1983–1988
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Pescovitz M. D., Hsu P. L. Monoclonal antibodies against SU-DHL-l cells stain the neoplastic cells in true histiocytic lymphoma, malignant histiocytosis, and Hodgkin's disease. Blood 1986; 68: 213–219
   PubMed Web of Science ®Google Scholar
• Hsu P. L., Hsu S. M. Identification of an Mr 70, 000 antigen associated with Reed-Sternberg cells and interdigitating reticulum cells. Cancer Res. 1990; 50: 350–357
   PubMed Web of Science ®Google Scholar
• Imam A., Stathopoulos E., Taylor C. R. BLA. 36: A glycoprotein specifically expressed on the surface of Hodgkin's and B cells. Anticancer Res 1990; 10: 1095–1104
   PubMed Web of Science ®Google Scholar
• Imam A., Stathopoulos E., Holland S. L., Epstein A. L., Taylor C. R. Characterization of a cell surface molecule expressed on B-lymphocytes and Hodgkin's cells. Cancer Res. 1990; 50: 1650–1657
   PubMed Web of Science ®Google Scholar
• Cossman J., Sundeen J., Uppenkamp M., Sussman E., Wahl L., Coupland R., Lipford E., Raffeld M. Rearranging antigen-receptor genes in enriched Reed—Sternberg cell fractions of Hodgkin's disease. Hematol. Oncol. 1988; 6: 205–211
   PubMed Web of Science ®Google Scholar
• Griesser H., Mak T. W. Immunogenotyping in Hodgkin's disease. Hematol. Oncol. 1988; 6: 239–245
   PubMed Web of Science ®Google Scholar
• Algara P., Martinez P., Sanchez L., Villuendas R., Orradre J. L., Olivia H., Piris M. A. Lymphocyte predominance Hodgkin's disease (nodular paragranuloma)—a bcl-2 negative germinal centre lymphoma. Histopathol. 1991; 19: 69–75
   PubMed Web of Science ®Google Scholar
• Aplin M. S., Duque R. E., Oblon D. J., Smith L. J. Gene rearrangements in Hodgkin's disease. Blood 1988; 72: 238a
   Google Scholar
• Banks R. E., Gledhill S., Ross F. M., Krajewski A., Dewar A. E., Weir-Thompson E. M. Karyotypic abnormalities and immunoglobulin gene rearrangements in Hodgkin's disease. Cancer Genet Cytoyenet 1991; 51: 103–111
   PubMed Web of Science ®Google Scholar
• Boicchi M., Carbone A., De Re V., Dolcetti R. Is the Epstein-Barr virus involved in Hodgkin's disease. Tumori 1989; 75: 345–350
   PubMed Web of Science ®Google Scholar
• Brinker M. G. J., Poppema S., Buys C. H. C. M., Timens W., Osinga J., Visser L. Clonal immunoglobulin gene rearrangements in tissues involved by Hodgkin's disease. Blood 1987; 70: 186–191
   PubMed Web of Science ®Google Scholar
• Daus H., Schwarze G., Kümel G., Scheurlen P. G. Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease. Acta Haematol. 1989; 82: 110–111
   PubMed Web of Science ®Google Scholar
• Ford R. F., Rajaraman C., Lu M., Blick M. In vitro analysis of cell populations involved in Hodgkin's disease lesions and in characteristic T cell immunodeficiency. Hematol. Oncol. 1988; 6: 247–255
   PubMed Web of Science ®Google Scholar
• Gledhill S., Krajewski A. S., Dewar A. E., Onions D. E., Jarrett R. F. Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma. J. Pathol 1990; 161: 245–254
   PubMed Web of Science ®Google Scholar
• Gledhill S., Gallagher A., Jones D. B., Krajewski A. S., Alexander F. E., Klee E., Wright D. H. O., Brien C., Onions D. E., Jarrett R. F. Viral involvement in Hodgkin's disease: Detection of clonal type A Epstein-Barr virus genomes in tumour samples. Brit. J. Cancer 1991; 64: 227–232
   PubMed Web of Science ®Google Scholar
• Griesser H., Feller A. C., Mak T. W., Lennert K. Clonal rearrangements of T-cell receptor and immunoglobulin genes and immunophenotypic antigen expression in different subclasses of Hodgkin's disease. Int. J. Cancer 1987; 40: 157–160
   PubMed Web of Science ®Google Scholar
• Henni T., Gaulard P., Divine M., Le Couedic J. P., Rocha D., Haioun C., Henni Z., Marolleau J. P., Pinaudeau Y., Goossens M., Farcet J. P., Reyes F. Comparison of genetic probe with immunophenotype analysis in lymphoproliferative disorders: A study of 87 cases. Blood 1988; 72: 1937–1943
   PubMed Web of Science ®Google Scholar
• Knecht H., Odermatt B. F., Bachmann E., Teixeira S., Sahli R., Hayoz D., Heitz P., Bachmann F. Frequent detection of Epstein-Barr virus DNA by the polymerase chain reaction in lymph node biopsies from patients with Hodgkin's disease without genomic evidence of B- or T-cell clonality. Blood 1991; 78: 760–767
   PubMed Web of Science ®Google Scholar
• Knowles D. M., II, Neri A., Pelicci P. G., Burke J. S., Wu A., Winberg C. D., Sheibani K., Dalla-Favera R. Immunoglobulin and T-cell receptor β-chain gene rearrangement analysis of Hodgkin's disease: Implications for lineage determination and differential diagnosis. Proc. Natl. Acad. Sci. USA 1986; 83: 7942–7946
   PubMed Web of Science ®Google Scholar
• Koduru P. R. K., Offit K., Filippa D. A., Lieberman P. H., Jhanwar S. C. Cytogenetic and molecular genetic analysis of abnormal cells in Hodgkin's disease. Cancer Genet Cytogenet 1989; 43: 109–118
   PubMed Web of Science ®Google Scholar
• Linden M. D., Fishleder A. J., Katzin W. E., Tubbs R. R. Absence of B-cell or T-cell clonal expansion in nodular, lymphocyte predominant Hodgkin's disease. Hum. Pathol. 1988; 19: 591–594
   PubMed Web of Science ®Google Scholar
• Masih A., Weisenburger D., Duggan M., Armitage J., Bashir R., Mitchell D., Wickert R., Purtilo D. T. Epstein-Barr viral genome in lymph nodes from patients with Hodgkin's disease may not be specific to Reed-Sternberg cells. Am. J. Pathol. 1991; 139: 37–43
   PubMed Web of Science ®Google Scholar
• O'Connor N. T. J. Genotypic analysis of lymph node biopsies. J. Pathol. 1987; 151: 185–190
   PubMed Web of Science ®Google Scholar
• O'Connor N. T. J., Crick J. A., Gatter K. C., Mason D. Y., Falini B., Stein H. S. Cell lineage in Hodgkin's disease. Lancet 1987, i, 158.
   Web of Science ®Google Scholar
• Pastuszak W. T., Kosciol C. M., Rezuke W. N. T and B cell gene rearrangements in Hodgkin's disease. Blood 1991; 78: 122a
   Google Scholar
• Raghavachar A., Binder T., Bartram C. R. Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease. Cancer Res. 1988; 48: 3591–3594
   PubMed Web of Science ®Google Scholar
• Roth M. S., Schnitzer B., Bingham E. L., Harnden C. E., Hyder D. M., Ginsburg D. Rearrangement of immunoglobulin and T-cell receptor genes in Hodgkin's disease. Am. J. Pathol. 1988; 131: 331–338
   PubMed Web of Science ®Google Scholar
• Said J. W., Sassoon A. F., Shintaku I. P., Kurtin P. J., Pinkus G. S. Absence of bcl-2 major breakpoint region and JH gene rearrangement in lymphocyte predominance Hodgkin's disease. Am. J. Pathol. 1991; 138: 261–264
   PubMed Web of Science ®Google Scholar
• Sundeen J., Lipford E., Uppenkamp M., Sussman E., Wahl L., Raffeld M., Cossman J. Rearranged antigen receptor genes in Hodgkin's disease. Blood 1987; 70: 96–103
   PubMed Web of Science ®Google Scholar
• Tesch H., May P., Krueger G. R. F., Fischer R., Diehl V. Analysis of immunoglobulin, T cell receptor and ber rearrangements in human malignant lymphoma and Hodgkin's disease. Oncology 1990; 47: 215–223
   PubMed Web of Science ®Google Scholar
• Villa A., Cairo G., Pozzi M. R., Schiaffonati L., Bardella L., Lucchini R., Delia D., Besana C., Biunno I., Vezzoni P. Lack of TdT and immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease. Int. J. Biol. Markers 1987; 2: 65–70
   PubMedGoogle Scholar
• Weiss L. M., Warnke R. A., Sklar J. Clonal antigen receptor gene rearrangements and Epstein-Ban viral DNA in tissues of Hodgkin's disease. Hematol. Oncol. 1988; 6: 233–238
   PubMed Web of Science ®Google Scholar
• Feller A. C., Griesser H. DNA gene rearrangement studies in Hodgkin's disease and related lymphomas: A contribution to their cellular origin. New Aspects in the Diagnosis and Treatment of Hodgkin's Disease, V. Diehl, M. Pfreundschuh, M. Loeffler. Recent Results in Cancer Research 117, Springer, Berlin 1989; 27–34
   Google Scholar
• Cossmann J., Uppenkamp M., Sundeen J., Coupland R., Raffeld M. Molecular genetics and the diagnosis of lymphoma. Arch. Pathol. Lab. Med. 1988; 112: 117–127
   PubMed Web of Science ®Google Scholar
• Griesser H., Feller A., Lennert K., Minden M., Mak T. W. Rearrangement of the β chain of the T cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders. J. Clin. Invest. 1986; 78: 1179–1184
   PubMed Web of Science ®Google Scholar
• Greaves M. F., Chan L. C., Furley A. J. W., Watt S. M., Molgaard H. V. Lineage promiscuity in hemopoietic differentiation and leukemia. Blood 1986; 67: 1–11
   PubMed Web of Science ®Google Scholar
• Hoffbrand A. V., Leber B. F., Browett P. J., Norton J. D. Mixed acute leukaemias. Blood Reviews 1988; 2: 9–15
   PubMed Web of Science ®Google Scholar
• Johansson B., Klein G., Henle W., Henle G. Epstein Barr virus (EBV)-associated patterns in malignant lymphoma and leukemia. Int. J. Cancer 1970; 6: 450–462
   PubMed Web of Science ®Google Scholar
• Levine P. H., Ablashi D. V., Berard C. W., Carbone P. P., Waggoner D. E., Malan L. Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease. Cancer 1971; 27: 416–421
   PubMed Web of Science ®Google Scholar
• Hesse J., Andersen E., Levine P., Ebbesen P., Halberg P., Reisher J. Antibodies to Epstein-Barr virus and cellular immunity in Hodgkin's disease and chronic lymphatic leukemia. Int. J. Cancer 1973; 11: 237–243
   PubMed Web of Science ®Google Scholar
• Mueller N., Evans A., Harris N. L., Comstock G. W., Jellum E., Magnus K., Orentreich N., Polk B. F., Vogelman J. Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis. N. Engl. J. Med. 1989; 320: 689–695
   PubMed Web of Science ®Google Scholar
• Rosdahl N., Larsen S. O., Clemmesen J. Hodgkin's disease in patients with previous infectious mononucleosis: 30 years' experience. Brit. Med. J. 1974; 2: 253–256
   PubMed Web of Science ®Google Scholar
• Munoz N., Davidson R. J. L., Whitthoff B., Ericsson J. E., De The G. Infectious mononucleosis and Hodgkin's disease. Int. J. Cancer 1978; 22: 10–12
   PubMed Web of Science ®Google Scholar
• Evans A. S., Gutensohn N. M. A population-based case control study of EBV and other viral antibodies among persons with Hodgkin's disease and their siblings. Int. J. Cancer 1984; 34: 149–157
   PubMed Web of Science ®Google Scholar
• Ambinder R. F., Wu T. C., Hayward S. D., Mann R. B. EBV is present in a minority of cases of Hodgkin's disease by PCR and EBER in situ hybridization. Blood 1990; 76: 340a
   Google Scholar
• Anagnostopoulos I., Herbst H., Niedobitek G., Stein H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-l-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization. Blood 1989; 74: 810–816
   PubMed Web of Science ®Google Scholar
• Brocksmith D., Angel C. A., Pringle J. H., Lauder I. Epstein-Barr viral DNA in Hodgkin's disease: Amplification and detection using polymerase chain reaction. J. Pathol. 1991; 165: 11–15
   PubMed Web of Science ®Google Scholar
• Brousset P., Chittal S., Schlaifer D., Icart J., Payen C., Rigal-Huguet F., Voigt J. J., Delsol G. Detection of Epstein-Barr virus messenger RNA in Reed—Sternberg cells of Hodgkin's disease by in situ hybridization with biotinylated probes on specially processed modified acetone methyl benzoate xylene (ModAMeX) sections. Blood 1991; 77: 1781–1786
   PubMed Web of Science ®Google Scholar
• Coates P. J., Slavin G., D'Ardenne A. J. Persistence of Epstein-Barr virus in Reed-Sternberg cells throughout the course of Hodgkin's disease. J. Pathol. 1991; 164: 291–297
   PubMed Web of Science ®Google Scholar
• Herbst H., Niedobitek G., Kneba M., Hummel M., Finn T., Anagnostopoulos I., Bergholz M., Krieger G., Stein H. High incidence of Epstein-Barr virus genomes in Hodgkin's disease. Am. J. Pathol. 1990; 137: 13–18
   PubMed Web of Science ®Google Scholar
• Jarrett R. F., Gallagher A., Jones D. B., Alexander F. E., Krajewski A. S., Kelsey A., Adams J., Angus B., Gledhill S., Wright D. H., Cartwright R. A., Onions D. E. Detection of Epstein-Ban virus genomes in Hodgkin's disease: Relation to age. J. Clin. Pathol. 1991; 44: 844–848
   PubMed Web of Science ®Google Scholar
• Libetta C. M., Pringle J. H., Angel C. A., Craft A. W., Malcolm A. J., Lauder I. Demonstration of Epstein-Barr viral DNA in formalin-fixed, paraffin-embedded samples of Hodgkin's disease. J. Pathol. 1990; 161: 255–260
   PubMed Web of Science ®Google Scholar
• Pallesen G., Hamilton-Dutoit S. J., Rowe M., Young L. S. Expression of Epstein-Barr virus latent gene products in tumor cells of Hodgkin's disease. Lancet 1991; 337: 320–322
   PubMed Web of Science ®Google Scholar
• Pallesen G., Sandvej K., Hamilton-Dutoit S. J., Rowe M., Young L. S. Activation of Epstein-Barr virus replication in Hodgkin and Reed-Sternberg cells. Blood 1991; 78: 1162–1165
   PubMed Web of Science ®Google Scholar
• Staal S. P., Ambinder R., Beschorner W. E., Hayward G. S., Mann R. A survey of Epstein-Barr virus DNA in lymphoid tissue. Am. J. Clin. Pathol. 1989; 91: 1–5
   PubMed Web of Science ®Google Scholar
• Uccini S., Monardo F., Ruco L. P., Baroni C. D., Faggioni A., Agliano A. M., Gradilone A., Manzari V., Vago L., Constanzi G., Carbone A., Boiocchi M., De Re V. High frequency of Epstein-Barr virus genome in HIV-positive patients with Hodgkin's disease. Lancet 1989, i, 1458.
   PubMed Web of Science ®Google Scholar
• Uccini S., Monardo F., Stoppacciaro A., Gradilone A., Agliano A. M., Faggioni A., Manzari V., Vago L., Costanzi G., Ruco L. P., Baroni C. D. High frequency of Epstein-Barr virus genome detection in Hodgkin's disease of HIV-positive patients. Int. J. Cancer 1990; 46: 581–585
   PubMed Web of Science ®Google Scholar
• Uhara H., Sato Y., Mukai K., Akao I., Matsuno Y., Furuya S., Hoshikawa T., Shimosato Y., Saida T. Detection of Epstein-Barr virus DNA in Reed-Sternberg cells of Hodgkin's disease using the polymerase chain reaction and in situ hybridization. Jpn. J. Cancer Res. 1990; 81: 272–278
   PubMedGoogle Scholar
• Weiss L. M., Strickler J. G., Warnke R. A., Purtilo D. T., Sklar J. Epstein-Barr viral DNA in tissues of Hodgkin's diseases. Am. J. Pathol. 1987; 124: 86–91
   Google Scholar
• Weiss L. M., Movahed L. A., Warnke R. A., Sklar J. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N. Engl. J. Med. 1989; 320: 502–506
   PubMed Web of Science ®Google Scholar
• Wright C. F., Reid A. H., Tsai M. M., Ventre K. M., Murari P. J., Frizzera G., O'Leary T. J. Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction. Am. J. Pathol. 1991; 139: 393–398
   PubMed Web of Science ®Google Scholar
• Wu T. C., Mann R. B., Charache P., Hayward S. D., Staal S., Lambe B. C., Ambinder R. F. Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease. Int. J. Cancer 1990; 46: 801–804
   PubMed Web of Science ®Google Scholar
• Samoszuk M., Ravel J. Frequent detection of Epstein-Barr viral deoxyribonucleic acid and absence of cytomegalovirus deoxyribonucleic acid in Hodgkin's disease and acquired immunodeficiency syndrome-related Hodgkin's disease. Lab. Invest. 1991; 65: 631–636
   PubMed Web of Science ®Google Scholar
• Shibata D., Hansmann M. L., Weiss L. M., Nathwani B. N. Epstein-Barr virus infections and Hodgkin's disease. A study of fixed tissues using the polymerase chain reaction. Hum. Pathol. 1991; 22: 1262–1267
   PubMed Web of Science ®Google Scholar
• Weiss L. M., Chen Y. Y., Liu X. F., Shibata D. Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study. Am. J. Pathol. 1991; 139: 1259–1265
   PubMed Web of Science ®Google Scholar
• Guarner J., Del Rio C., Hendrix L., Unger E. R. Composite Hodgkin's and non-Hodgkin's lymphoma in a patient with acquired immune deficiency syndrome. In-situ demonstration of Epstein-Barr virus. Cancer 1990; 66: 796–800
   PubMed Web of Science ®Google Scholar
• Jones J. F., Shurin S., Abramowsky C., Tubbs R. R., Sciotto C. G., Wahl R., Sands J., Gottman D., Katz B. Z., Sklar J. T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N. Engl. J. Med. 1988; 318: 723–741
   Web of Science ®Google Scholar
• Haribuchi Y., Yamanaka N., Kataura A., Imai S., Kinoshita T., Mizuno F., Osato T. Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. Lancet 1990; ii: 128–130
   Web of Science ®Google Scholar
• Su I. J., Hsieh H. C., Lin K. H., Uen W. C., Kao C. L., Chen C. J., Cheng A. L., Kadin M. E., Chen J. Y. Aggressive peripheral T-cell lymphomas containing Epstein-Barr viral DNA: A clinicopathological and molecular analysis. Blood 1991; 77: 799–808
   PubMed Web of Science ®Google Scholar
• Katamine S., Otsu M., Tada K., Tsuchiya S., Sato T., Ishida N., Honjo T., Ono Y. Epstein-Barr virus transforms percursor B-cells even before immunoglobulin gene rearrangements. Nature 1984; 309: 369–372
   PubMed Web of Science ®Google Scholar
• Gregory C. D., Kirchgens C., Edwards C. F., Young L. S., Rowe M., Forster A., Rabbitts T. H., Rickinson A. B. Epstein-Barr virus-transformed human precursor B cell lines: Altered growth phenotype of lines with germline or rearranged but nonexpressed heavy chain genes. Eur. J. Immunol. 1987; 17: 1199–1207
   PubMed Web of Science ®Google Scholar
• Krueger G. R. F., Manak M., Bourgeois N., Ablashi D. V., Salahuddin S. Z., Josephs S. S., Buchbinder A., Gallo R. C., Berthold F., Tesch H. Persistent active Herpes virus infection associated with atypical polyclonal lymphoproliferation (APL) and malignant lymphoma. Anticancer Res. 1989; 9: 1457–1476
   PubMed Web of Science ®Google Scholar
• Clark D. A., Alexander F. E., McKinney P. A., Roberts B. E., O'Brien C., Jarrett R. F., Cartwright R. A., Onions D. E. The seroepidemiology of human herpesvirus-6 (HHV-6) from a case-control study of leukaemia and lymphoma. Int. J. Cancer 1990; 45: 829–833
   PubMed Web of Science ®Google Scholar
• Torelli G., Marasca R., Luppi M., Selleri L., Ferrari S., Narni F., Mariano M. T., Federico M., Ceccherini-Nelli L., Bendinelli M., Montagnani G., Montorsi M., Artusi T. Human herpesvirus-6 in human lymphomas: Identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood 1991; 77: 2251–2258
   PubMed Web of Science ®Google Scholar
• Jarrett R. F., Gledhill S., Qureshi F., Crae S. H., Madhok R., Brown I., Evans I., Krajewski A., O'Brien C. J., Cartwright R. A., Venables P., Onions D. E. Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin's lymphoma. Leukemia 1988; 2: 496–502
   PubMed Web of Science ®Google Scholar
• Tesch H., Jücker M., Krönke M., Diehl V. Analysis of HTLV-1 in Hodgkin's disease. Leukemia and Lymphoma 1991; 4: 371–374
   PubMed Web of Science ®Google Scholar
• Cleary M., Rosenberg S. A. The bcl-2 gene, follicular lymphoma, and Hodgkin's disease. J. Natl. Cancer Inst. 1990; 82: 808–809
   PubMed Web of Science ®Google Scholar
• Henderson S., Rowe M., Gregory C., Croom-Carter D., Wang F., Longnecker R., Kieff E., Rickinson A. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 1991; 65: 1107–1115
   PubMed Web of Science ®Google Scholar
• Balk Will F. R., Burke F. The cytokine network. Immunol Today 1989; 10: 299–304
   PubMedGoogle Scholar
• Metcalf D. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 1989; 339: 27–30
   PubMed Web of Science ®Google Scholar
• O'Garra A. Peptide regulatory factors. Interleukins and the immune system 2. Lancet 1989; i: 1003–1005
   Google Scholar
• Ford R. J., Mehta S., Davis F., Maizel A. L. Growth factors in Hodgkin's disease. Cancer Treat. Rep. 1982; 66: 633–638
   PubMedGoogle Scholar
• Newcom S. R., O'rourke L. Potentiation of fibroblast growth by nodular sclerosing Hodgkin's disease cell cultures. Blood 1982; 60: 228–237
   PubMed Web of Science ®Google Scholar
• Merz H., Fliedner A., Orscheschek K., Binder T., Sebald W., Müller-Hermelink H. K., Feller A. C. Cytokine expression in T-cell lymphomas and Hodgkin's disease. Its possible implication in autocrine or paracrine production as a potential basis for neoplastic growth. Am. J. Pathol. 1991; 139: 1173–1180
   PubMed Web of Science ®Google Scholar
• Newcom S. R. The Hodgkin's cell in nodular sclerosis does not release interleukin-l. J. Lab. Clin. Med. 1985; 105: 170–177
   PubMedGoogle Scholar
• Hsu S. M., Zhao X. Expression of interleukin-l in Reed-Sternberg cells and neoplastic cells from true histiocytic malignancies. Am. J. Pathol. 1986; 125: 221–225
   PubMed Web of Science ®Google Scholar
• Ruco L. P., Pomponi D., Pigott R., Stoppacciaro A., Monardo F., Uccini S., Boraschi D., Tagliabue A., Santoni A., Dejana E., Mantovani A., Baroni C. D. Cytokine production (IL-l α, IL-l β, and TNF α) and endothelial cell activation (ELAM-l and HLA-DR) in reactive lymphadenitis, Hodgkin's disease, and in non-Hodgkin's lymphomas. An immunocytochemical study. Am. J. Pathol. 1990; 137: 1163–1171
   PubMed Web of Science ®Google Scholar
• Ree H. J., Crowley J. P., Dinarello C. A. Anti-interleukin-l reactive cells in Hodgkin's disease. Cancer 1987; 59: 1717–1720
   PubMed Web of Science ®Google Scholar
• Sappino A. P., Seelentag W., Pelte M. F., Alberto P., Vassalli P. Tumor necrosis factor/cachectin and lymphotoxin gene expression in lymph nodes from lymphoma patients. Blood 1990; 75: 958–962
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Tseng C. K., Hsu P. L. Expression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 II-2R, in cultured H-RS cells and H-RS cells in tissues. Am. J. Pathol. 1990; 136: 735–744
   PubMed Web of Science ®Google Scholar
• Samoszuk M., Nansen L. Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. Blood 1990; 75: 13–16
   PubMed Web of Science ®Google Scholar
• Jücker M., Abts H., Li W., Schindler R., Merz H., Günther A., von Kalle C., Schaadt M., Diamantstein T., Feller A. C., Krueger G. R. F., Diehl V., Blankenstein T., Tesch H. Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease. Blood 1991; 77: 2413–2418
   PubMed Web of Science ®Google Scholar
• Merz H., Houssiau F. A., Orscheschek K., Renauld J. C., Fliedner A., Herin M., Noel H., Kadin M., Mueller-Hermelink H. K., Van Snick J., Feller A. C. Interleukin-9 expression in human malignant lymphomas: Unique assocation with Hodgkin's disease and large cell anaplastic lymphoma. Blood 1991; 78: 1311–1317
   PubMed Web of Science ®Google Scholar
• Hsu P. L., Hsu S. M. Production of tumor necrosis factor-α and lymphotoxin by cells of Hodgkin's neoplastic cell lines HDLM-l and KM-H2. Am. J. Pathol. 1989; 135: 735–745
   PubMed Web of Science ®Google Scholar
• Kadin M. E., Agnarsson B. A., Ellingsworth L. R., Newcom S. R. Immunohistochemical evidence of a role for transforming growth factor beta in the pathogenesis of nodular sclerosing Hodgkin's disease. Am. J. Pathol. 1990; 136: 1209–1214
   PubMed Web of Science ®Google Scholar
• Kretschmer C., Jones D. B., Morrison K., Schlüter C., Feist W., Ulmer A. J., Arnoldi J., Matthes J., Diamantstein T., Flad H. D., Gerdes J. Tumor necrosis factor α and lymphotoxin production in Hodgkin's disease. Am. J. Pathol. 1990; 137: 341–351
   PubMed Web of Science ®Google Scholar
• Tabibzadeh S. S., Poubouridis D., May L. T., Sehgal P. B. Interleukin-6 immunoreactivity in human tumors. Am. J. Pathol. 1989; 135: 427–433
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Hsu P. L., Lo S. S., Wu K. K. Expression of prostaglandin H synthase (cyclooxygenase) in Hodgkin's mononuclear and Reed-Sternberg cells. Functional resemblance between H-RS cells and histiocytes or interdigitating reticulum cells. Am. J. Pathol. 1988; 133: 5–12
   PubMed Web of Science ®Google Scholar
• Zucker-Franklin D., Grusky G., Baez L. Reed-Sternberg cells cultured from morphologically unidentifiable precursors in the blood of patients with Hodgkin's disease. Hematol Oncol. 1983; 1: 127–138
   PubMedGoogle Scholar
• Stuart A. E. The production of abnormal cells and Reed-Sternberg-like cells from normal lymphocytes. Brit. J. Cancer 1983; 47: 713–717
   PubMed Web of Science ®Google Scholar
• Peckham M. J., Cooper E. H. Proliferation characteristics of the various classes of cells in Hodgkin's disease. Cancer 1969; 24: 135–146
   PubMed Web of Science ®Google Scholar
• Peckham M. J. Quantitative cytology and cytochemistry of Hodgkin's tissue labelled in vivo with tritiated thymidine. Br. J. Cancer 1973; 28: 332–339
   PubMed Web of Science ®Google Scholar
• Kadin M. E., Asbury A. K. Long term cultures of Hodgkin's tissue. A morphologic and radioautographic study. Lab. Invest. 1973; 28: 181–184
   PubMed Web of Science ®Google Scholar
• Gerdes J., Schwab U., Lemke H., Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int. J. Cancer 1983; 31: 13–20
   PubMed Web of Science ®Google Scholar
• Gerdes J., Van Baarlen J., Pileri S., Schwarting R., Unnik J. M. van, Stein H. Tumor cell growth fraction in Hodgkin's disease. Am. J. Pathol. 1987; 129: 390–393
   Google Scholar
• Gerdes J., Schwarting R., Stein H. High proliferative activity of Reed-Sternberg associated antigen Ki-l positive cells in normal lymphoid tissue. J. Clin. Pathol. 1986; 39: 993–997
   PubMed Web of Science ®Google Scholar
• Benjamin D. R., Gown A. M. Aberrant cytoplasmic expression of proliferating cell nuclear antigen in Hodgkin's disease. Am. J. Surg. Pathol. 1991; 15: 764–768
   PubMed Web of Science ®Google Scholar
• Kreipe H., Radzun H. J., Rudolph P., Barth J., Hansmann H. L., Heidorn K., Parwaresch M. R. Multinucleated giant cells generated in vitro. Terminally differentiated macrophages with down-regulated c-fms expression. Am. J. Pathol. 1988; 130: 232–243
   PubMed Web of Science ®Google Scholar
• McInnes A., Rennick D. M. Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J. Exp. Med. 1988; 167: 598–611
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res 1989; 49: 3713–3721
   PubMed Web of Science ®Google Scholar
• Butturini P., Gale R. P. Oncogenes and leukemia. Leukemia 1990; 4: 138–160
   PubMed Web of Science ®Google Scholar
• Calabretta B. Inhibitions of protooncogene expression by antisense oligodeoxynucleotides: Biological and therapeutic implications. Cancer Res. 1991; 51: 4505–4510
   PubMed Web of Science ®Google Scholar
• Weiss L. M., Warnke R. A., Sklar J., Cleary M. L. Molecular analysis of the t(14;18) choromosomal translocation in malignant lymphomas. N. Engl. J. Med. 1987; 317: 1185–1189
   PubMed Web of Science ®Google Scholar
• Shibata D., Hu E., Weiss L. M., Brynes R. K., Nathwani B. N. Detection of specific t(14;18) chromosomal translocations in fixed tissues. Hum. Pathol. 1990; 21: 199–203
   PubMed Web of Science ®Google Scholar
• Louie D. C., Kant J. A., Brooks J. J., Reed J. C. Absence of t(14;18) major and minor breakpoints and of bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease. Am. J. Pathol. 1991; 139: 1231–1237
   PubMed Web of Science ®Google Scholar
• Stetler-Stevenson M., Crush-Stanton S., Cossman J. Involvement of the bcl-2 gene in Hodgkin's disease. J. Natl. Cancer Inst. 1990; 82: 855–858
   PubMed Web of Science ®Google Scholar
• Gupta R. K., Thompson I. W., Norton A. J., Young B. D., Bodmer J. G., Lister T. A. The t(14; 18) chromosomal translocation and bcl-2 expression in Hodgkin's disease. Blood 1991; 78: 168a
   Google Scholar
• Zutter M., Hockenberry D., Silverman G. A., Korsmeyer S. J. Immunolocalization of the bcl-2 protein within hematopoietic neoplasms. Blood 1991; 78: 1062–1068
   PubMed Web of Science ®Google Scholar
• Hsu S. M., Xie S. S., El-Okda M. O., Hsu P. L. Correlation of c-fos/c-jun expression with histiocytic differentiation in Hodgkin's Reed-Sternberg cells. Examination in HDLM-l subclones with spontaneous differentiation. Am. J. Pathol. 1992; 140: 155–165
   PubMed Web of Science ®Google Scholar
• Mitani S., Sugawara I., Shiku H., Mori S. Expression of c-myc oncogene product and ras family oncogene products in various human malignant lymphomas defined by immunohistochemical techniques. Cancer 1988; 62: 2085–2093
   PubMed Web of Science ®Google Scholar
• Sklar M. D., Kitchingman G. R. Isolation of activated ras transforming genes from two patients with Hodgkin's disease. Int. J. Rad. Oncol. Biol. Phys. 1985; 11: 49–55
   PubMed Web of Science ®Google Scholar
• Steenvoorden A. C. M., Janssen J. W. G., Drexler H. G., Lyons J., Tesch H., Binder T., Jones D. B., Bartram C. R. Ras mutations in Hodgkin's disease. Leukemia 1988; 2: 325–326
   PubMed Web of Science ®Google Scholar
• Pezzella F., Tse A. G. D., Cordell J. L., Pulford K. A. F., Gatter K. C., Mason D. Y. Expression of the bcl-2 oncogene protein is not specific for the 14; 18 chromosomal translocation. Am. J. Pathol. 1990; 13: 225–232
   Google Scholar
• Bos J. L. Ras oncogenes in human cancer: A review. Cancer Res 1989; 49: 4682–4689
   PubMed Web of Science ®Google Scholar
• Kelly K., Siebenlist U. The regulation and expression of c-myc in normal and malignant cells. Ann. Rev. Immunol. 1986; 4: 317–338
   PubMed Web of Science ®Google Scholar
• Varmus H. E. Oncogenes and transcriptional control. Science 1987; 238: 1337–1339
   PubMed Web of Science ®Google Scholar
• Turner R., Tijian R. Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cfos-cjun heterodimers. Science 1989; 243: 1689–1694
   PubMed Web of Science ®Google Scholar
• Rowley J. D. Nonrandom chromosome changes in hematologic diseases. Atlas of Blood Cells—Function and Pathology, D. Zucker-Franklin, M. F. Greaves, C. E. Grossi, A. M. Marmont, Stuttgart, Fischer 1988; Vol. 2: 695–732
   Google Scholar
• Thangavelu M., Lebeau M. M. Chromosomal abnormalities in Hodgkin's disease. Hematol. Oncol. Clin. North Am. 1989; 3: 221–236
   PubMed Web of Science ®Google Scholar
• Lawler S. D., Swansbury G. J. Hodgkin's Disease. Cytogenetic studies in Hodgkin's disease, P. Selby, T. J. McElwain. Blackwell, Oxford 1987; 43–67
   Google Scholar
• Cabanillas F. A review and interpretation of cytogenetic abnormalities identified in Hodgkin's disease. Hematol. Oncol. 1988; 6: 271–274
   PubMed Web of Science ®Google Scholar
• Cabanillas F., Pathak S., Trujillo J., Grant G., Cork A., Hagemeister F. B., Velasquez W. S., McLaughlin P., Redman J., Katz R., Butler J. J., Freireich E. J. Cytogenetic features of Hodgkin's disease suggest possible origin from a lymphocyte. Blood 1988; 71: 1615–1617
   PubMed Web of Science ®Google Scholar
• Dennis T. R., Stock A. D., Winberg C. D., Sheibani K., Rappaport H. Cytogenetic studies of Hodgkin's disease. Analysis of involved lymph nodes from 12 patients. Cancer Genet. Cytogenet. 1989; 37: 201–208
   PubMed Web of Science ®Google Scholar
• Döhner H., Bloomfield C. D., Frizzera G., Arthur D. C. Recurring chromosome abnormalities in Hodgkin's disease. Blood 1989; 74: 82a
   PubMedGoogle Scholar
• Fleischmann T., Hakansson C. H., Levan A. Chromosomes of malignant lymphomas. Studies in short-term cultures from lymph nodes of twenty cases. Hereditas. 1976; 83: 47–56
   PubMed Web of Science ®Google Scholar
• Fonatsch C., Diehl V., Schaadt M., Burrichter H., Kirchner H. H. Cytogenetic investigations in Hodgkin's disease: I. Involvement of specific chromosomes in marker formation. Cancer Genet. Cytogenet. 1986; 20: 39–52
   PubMed Web of Science ®Google Scholar
• Hansmann M. L., Godde-Salz E., Hui P. K., Müller-Hermelink H. K., Lennert K. Cytogenetic findings in nodular paragranuloma (Hodgkin's disease with lymphocytic predominance; nodular) and in progressively transformed germinal centers. Cancer Genet. Ctyogenet. 1986; 21: 319–325
   PubMed Web of Science ®Google Scholar
• Hossfeld D. K., Schmidt C. G. Chromosome findings in effusions from patients with Hodgkin's disease. Int. J. Cancer 1978; 21: 147–156
   PubMed Web of Science ®Google Scholar
• Kristoffersson U., Heim S., Mandahl N., Olsson H., Akermann M., Mitelman F. Cytogenetic studies in Hodgkin's disease. Acta. Path. Microbiol. Immunol. Scand 1987; 95: 289–295
   Google Scholar
• Nagai M., Abe T., Seki S., Minato K., Watanabe S., Shimoyama M. Karyotype aberrations and surface marker analyses of the tumor cells of Hodgkin's disease: A case report and review of the literature. Jpn. J. Clin. Oncol. 1986; 16: 397–406
   PubMed Web of Science ®Google Scholar
• Reeves B. R., Nash R., Lawler S. D., Fisher C., Treleaven J. G., Wiltshaw E. Serial cytogenetic studies showing persistence of original clone in Hodgkin's disease. Cancer. Genet. Cytogenet. 1990; 50: 1–8
   PubMed Web of Science ®Google Scholar
• Rowley J. D. Chromosomes in Hodgkin's disease. Cancer Treat. Rep. 1982; 66: 639–643
   PubMedGoogle Scholar
• Schouten H. C., Sanger W. G., Duggan M., Weisenburger D. D., Maclennan K. A., Armitage J. O. Chromosomal abnormalities in Hodgkin's disease. Blood 1989; 73: 2149–2154
   PubMed Web of Science ®Google Scholar
• Schouten H. C., Sanger W. G., Armitage J. O. Chromosomal abnormalities in malignant lymphoma and Hodgkin's disease. Leukemia and Lymphoma 1991; 5: 93–100
   PubMed Web of Science ®Google Scholar
• Schwarze E. W., Gödde-Salz E., Lennert K. Cytogenetic findings in Hodgkin's disease, lymphogranulomatosis X, and T-zone lymphoma. Verh. Dtsch. Ges. Pathol. 1982; 66: 127–133
   PubMedGoogle Scholar
• Slavutsky I., De Vinuesa M. L., Estevez M. E., Sen L., De Salum S. B. Cytogenetic and immunologic phenotype findings in Hodgkin's disease. Cancer Genet. Cytogenet 1985; 16: 123–130
   PubMed Web of Science ®Google Scholar
• Teerenhovi L., Lindholm C., Pakkala A., Franssila K., Stein H., Knuutila S. Unique display of a pathologic karyotype in Hodgkin's disease by Reed-Sternberg cells. Cancer Genet. Cytogenet. 1988; 34: 305–311
   PubMed Web of Science ®Google Scholar
• Tilly H., Bastard C., Delastre T., Duval C., Bizet M., Lenormand B., Dauce J. P., Monconduit M., Piguet H. Cytogenetic studies in untreated Hodgkin's disease. Blood 1991; 77: 1298–1304
   PubMed Web of Science ®Google Scholar
• Anastasi J., Bauer K. D., Variakojis D. DNA aneuploidy in Hodgkin's disease. A multiparameter flow-cytometric analysis with cytologic correlation. Am. J. Pathol. 1987; 128: 573–582
   PubMed Web of Science ®Google Scholar
• Erdkamp F., Janssen W., Hoffmann J., Breed W., Schouten H., Schutte B., Wijnen J., Blijham G. DNA aneuploidy and S-phase analysis in Hodgkin's disease. Blood 1991; 78: 118a
   PubMedGoogle Scholar
• Kaplan H. S. Hodgkin's disease 2nd Ed. 1980, Cambridge, MA, Harvard University Press.
   Google Scholar
• Sitar G., Brusamolini E., Bernasconi C., Ascari E. Isolation of Reed-Sternberg cells from lymph nodes of Hodgkin's disease patients. Blood 1989; 73: 222–229
   PubMed Web of Science ®Google Scholar
• Diehl V., Pfreundschuh M., Fonatsch C., Stein H., Falk M., Burrichter H., Schaadt M. Phenotypic and genotypic analysis of Hodgkin's disease derived cell lines: Histopathological and clinical implications. Cancer Surveys 1985; 4: 399–419
   PubMedGoogle Scholar
• Stein H. Comments on Hodgkin's disease: The Reed-Sternberg cell by P. Bucsky. Blut 1989; 57: 143–146, 1988;Bucsky P: Reply. Blut., 58, 89–92.
   Google Scholar
• Hsu S. M. The never-ending controversies in Hodgkin's disease; Naumovski, L., Warnke, R. Smith, S. D. Response. Blood 1990; 75: 1742–1744, 1990;Drexler H. G: Response. Blood, 76, 1665–1666.
   PubMedGoogle Scholar
• Naumovski L., Smith S. D. Origin of Reed-Sternberg cells in Hodgkin's disease; Andreesen, R., Bross, K. J., Brugger, W. and Lohr, G. W. Origin of Reed-Sternberg cells in Hodgkin's disease; Weiss, L. M., Movahed, L. A., Warnke, R. A. Sklar, J. Reply. N. Engl. J. Med. 1989; 321: 543–544
   PubMedGoogle Scholar
• Brousset P., Chittal S., Roya L., Delsol G. Absence of Epstein-Barr virus nuclear antigen 2 in tumour cells of Hodgkin's disease. Lancet 1991; 337: 1107, 1991;Young, L. S., Deacon, E. M., Rowe, M., Crocker, J., Herbst, H., Niedobitek, G., Hamilton-Dutoit, S. J. Pallesen, G.: Reply. Lancet, 337, 1617.
   PubMed Web of Science ®Google Scholar
• Nicdobitek G., Deacon E. M., Young L. S., Herbst H., Hamilton-Dutoit S. J., Pallesen G. Epstein-Barr virus gene expression in Hodgkin's disease. Blood 1991; 78: 1628–1629, 1991;Brousset, P., Chittal, S. Delsol, G.: Reply. Blood, 78, 1629–1630.
   PubMed Web of Science ®Google Scholar
• Drexler H. G., Leber B. F. The nature of the Hodgkin cell. Blut 1988; 56: 135–137
   PubMedGoogle Scholar