Significance of the Detection of Epstein—Barr Virus DNA In Lymph Nodes in Patients with Hodgkin's Disease

References

• Brinker M. G. L., Poppema S., Buys C. H. C. M., Timens W., Osinga J., Visser L. Clonal immunoglobulin gene arrangements in tissues involved by Hodgkin's disease. Blood 1987; 70: 186–91
   PubMed Web of Science ®Google Scholar
• O'Connor N. T. J., Crick J. A., Gatter K. C., Mason D. Y., Falini B., Stein H. S. Cell lineage in Hodgkin's disease. Lancer 1987; i: 58–59
   Google Scholar
• Casey T. T., Olson S. J., Cousar J. B., Collins R. D. Immunophenotypes of Reed-Sternberg cells: A study of 19 cases of Hodgkin's disease in plastic embedded sections. Blood 1989; 74: 2624–28
   PubMed Web of Science ®Google Scholar
• Herbst H., Tippelmann G., Anagnostopoulos I., Gerdes J., Schwarting R., Boehm T., Pileri S., Jones D. B., Stein H. Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-l -positive anaplastic large cell lymphoma: dissociation between phenotype and genotype. Leuk. Res. 1989; 13: 103–16
   PubMed Web of Science ®Google Scholar
• Anagnostopoulos I., Herbst H., Niedobitek G., Stein H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-l-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization. Blood 1989; 74: 810–16
   PubMed Web of Science ®Google Scholar
• Weiss L. M., Movahed L. A., Warnke R. A., Sklar J. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N. Engl. J. Med. 1989; 320: 502–06
   PubMed Web of Science ®Google Scholar
• Brousset P., Chittal S., Schlaifer D., Icart J., Payen C., Rigal-Huguet F., Voigt J. J., Delsol G. Detection of Epstein-Barr virus messenger RNA in Reed-Sternberg cells of Hodgkin's disease by in situ hybridization with biotinylated probes on specially processed modified acetone methyl benzoate xylene (ModAMeX) sections. Blood 1991; 77: 1781–86
   PubMed Web of Science ®Google Scholar
• Pallesen G., Hamilton-Dutoit S. J., Rowe M., Young L. S. Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet 1991; i: 320–22
   Web of Science ®Google Scholar
• Mueller N., Evans A., Harris N. L., Comstock G. W., Jellum E., Magnus K., Ortenreich N., Polk F., Vogelman J. Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis. N. Engl. J. Med. 1989; 320: 689–95
   PubMed Web of Science ®Google Scholar
• Raab-Traub N., Flynn K., Pearson G., Huang A., Levine P., Lanier A., Pagano J. S. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int. J. Cancer 1987; 39: 25–29
   PubMed Web of Science ®Google Scholar
• Raab-Traub N., Rajadurai O., Flynn K., Lanier A. P. Epstein-Barr virus infection carcinoma of the salivary gland. J. Virol. 1991; 65: 7032–36
   PubMed Web of Science ®Google Scholar
• Epstein M. A., Achong B. G., Barr Y. M. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 1964; i: 702–03
   Web of Science ®Google Scholar
• Cleary M. L., Nalesnik M. A., Shearer W. T., Sklar J. Clonal analysis of transplant associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood 1988; 72: 349–52
   PubMed Web of Science ®Google Scholar
• Katz B. Z., Raab-Traub N., Miller G. Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative disorders. J. Infect. Dis. 1989; 160: 589–98
   PubMed Web of Science ®Google Scholar
• Fischer A., Blanche S., Le Bidois J., Bordigoni P., Garnier J. L., Niaudet P., Morinet F., Le Deist F., Fischer A. M., Griscelli C., Hirn M. Anti-B-cell monoclonal antibodies in the treatment of severe B-cell lymphoproliferative syndrome following bone marrow and organ transplantation. N. Engl. J. Med. 1991; 324: 1451–56
   PubMed Web of Science ®Google Scholar
• Saito I., Servenius B., Compton T., Fox R. I. Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjögren's syndrome. J. Exp. Med. 1989; 169: 2191–98
   PubMed Web of Science ®Google Scholar
• Knecht H., Odermatt B. F., Bachmann E., Teixeira S., Sahli R., Hayoz D., Heitz P., Bachmann F. Frequent detection of Epstein-Barr virus DNA by the polymerase chain reaction in lymph node biopsies from patients with Hodgkin's disease without genomic evidence of B or T cell clonality. Blood 1991; 78: 760–67
   PubMed Web of Science ®Google Scholar
• Herbst H., Niedobitek G., Kneba M., Hummel M., Finn T., Anagnostopoulos I., Bergholz M., Krieger G., Stein H. High incidence of Epstein-Barr virus genomes in Hodgkin's disease. Am. J. Pathol. 1990; 137: 13–18
   PubMed Web of Science ®Google Scholar
• Knecht H., Sahli R., Shaw P., Meyer C., Bachmann E., Odermatt B. F., Bachmann F. Detection of Epstein-Barr virus DNA by polymerase chain reaction in lymph node biopsies from patients with angioimmunoblastic lymphadenopathy. Br. J. Haematol. 1990; 75: 610–14
   PubMed Web of Science ®Google Scholar
• Katzenstein A. L., Peiper S. Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases using the polymerase chain reaction technique. Mod. Pathol. 1990; 3: 435–41
   PubMed Web of Science ®Google Scholar
• Wolf B. C., Martin A. W., Neiman R. S., Janckila A. J., Yam L. T., Caracansi A., Leav B. A., Winpenny R., Schultz D. S., Wolfe H. J. The detection of Epstein-Barr virus in hairy cell leukemia cells by in situ hybridization. Am. J. Pathol. 1990; 136: 717–23
   PubMed Web of Science ®Google Scholar
• Weiss L. M., Chen Y. Y., Liu X. F., Shibata D. Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study. Am. J. Pathol. 1991; 139: 1259–65
   PubMed Web of Science ®Google Scholar
• Jones J. F., Shurin S., Abramowsky C., Tubbs R. R., Sciotto C. G., Wahl R., Sands J., Gottman D., Katz B. Z., Sklar J. T-cell lymphomas containing Epstein Barr viral DNA in patients with chronic Epstein- Barr virus infections. N. Engl. J. Med. 1988; 318: 733–41
   PubMed Web of Science ®Google Scholar
• Kawa-Ha K., Ishihara S., Ninomiya T., Yumura-Yagi K., Hara J., Murayama F., Tawa A., Hirai K. CD-3 negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. J. Clin. Invest. 1989; 84: 51–55
   PubMed Web of Science ®Google Scholar
• Su I. J., Hsieh H. C., Lin K. H., Uen W. C., Kao C. L., Chen C. J., Cheng A. L., Kadin M. E., Chen J. Y. Aggressive peripheral T-cell lymphomas containing Epstein-Barr viral DNA: a clinicopathologic and molecular analysis. Blood 1991; 77: 799–808
   PubMed Web of Science ®Google Scholar
• Kikuta H., Taguchi Y., Tomizawa K., Ishizaka A., Sakiyama Y., Matsumoto S., Imai S., Kinoshita T., Koizumi S., Osato T., Kobayashi I., Hamada I., Hirai K. Epstein-Barr virus genome-positive lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease. Nature 1988; 333: 455–57
   PubMed Web of Science ®Google Scholar
• Yoneda N., Tatsumi E., Kawanishi M., Teshigawara K., Masuda S., Yamamura Y., Inui A., Yoshino G., Oimomi M., Baba S., Yamaguchi N. Detection of Epstein-Barr virus genome in benign polyclonal proliferative T-cells of a young male patient. Blood 1990; 76: 172–77
   PubMed Web of Science ®Google Scholar
• McGuire L. J., Huang D. P., Teoh R., Arnold M., Wong K., Lee J. C. K. Epstein-Barr virus genome in thymoma and thymic lymphoid hyperplasia. Am. J. Pathol. 1988; 131: 385–90
   PubMed Web of Science ®Google Scholar
• Wu T. C., Mann R. B., Charache P., Hayward D., Staal S., Lambe B. C., Ambinder R. F. Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease. Int. J. Cancer 1990; 46: 801–04
   PubMed Web of Science ®Google Scholar
• Herbst H., Dallenhach F., Hummel M., Niedobitek G., Finn T., Young L. S., Rowe M., Müller-Lantzsch N., Stein H. Epstein-Barr virus DNA and latent gene products in Ki-l (CD30)-positive anaplastic large cell lymphomas. Blood 1991; 78: 2666–73
   PubMed Web of Science ®Google Scholar
• Pallesen G., Hamilton-Dutoit S. J., Rowe M., Lisse I., Ralfkiaer E., Sandvej K., Young L. S. Expression of Epstein-Barr virus replicative proteins in AIDS-related Non-Hodgkin's lymphoma cells. J. Pathol. 1991; 165: 289–99
   PubMed Web of Science ®Google Scholar
• Coates P. J., Slavin G., D'Ardenne A. J. Persistence of Epstein-Barr virus in Reed-Sternberg cells throughout the course of Hodgkin's disease. J. Pathol. 1991; 164: 291–97
   PubMed Web of Science ®Google Scholar
• Kieff E, Liebowitz D. Epstein-Barr virus and its replication. Fundamental Virology, 2nd edn., B. N. Fields, D. M. Knipe. Raven Press, Ltd., New York 1991; 897–928
   Google Scholar
• Countryman J., Jenson H., Seibl R., Wolf H., Miller G. Polymorphic proteins encoded within BZLFl of defective and standard Epstein-Barr viruses disrupt latency. J. Virol 1987; 61: 3672, 79.
   PubMed Web of Science ®Google Scholar
• Jenson H. B., Miller G. Polymorphisms of the region of the Epstein-Barr virus genome which disrupts latency. Virology 1988; 165: 549–64
   PubMed Web of Science ®Google Scholar
• Biggin M., Farrell P. J., Barrell B. G. Transcription and DNA sequence of the BamHl L fragment of B95–8 Epstein-Barr virus. EMBO J. 1984; 3: 1083–90
   PubMed Web of Science ®Google Scholar
• Murray P. G., Young L. S., Rowe M., Crocker J. Immunohistochemical demonstration of the Epstein-Barr virus encoded latent membrane protein in paraffin sections of Hodgkin's disease. J. Pathol. 1992; 166: 1–5
   PubMed Web of Science ®Google Scholar
• Herbst H., Dallenbach F., Hummel M., Nidobitek G., Pileri S., Müller-Lantzsch N., Stein H. Epstein Barr virus latent membrane protein expression in Hodgkin and Reed—Sternberg cells. Proc. Natl. Acad. Sci. USA 1991; 88: 4166–70
   PubMed Web of Science ®Google Scholar
• Joske D. J. L., Emery-Goodman A., Odermatt B. F., Bachmann E., Bachmann F., Knecht H. Epstein -Barr virus gene expression in Hodgkin's disease (HD): Analysis by reverse transcriptase-polymerase chain reaction suggests that the virus is not actively replicating in HD. 1992, submitted).
   Google Scholar
• Pallesen G., Sandvej K., Hamilton-Dutoit S. J., Rowe M., Young L. S. Activation of Epstein-Barr virus replication in Hodgkin and Reed-Sternberg cells. Blood 1991; 78: 1162–65
   PubMed Web of Science ®Google Scholar
• Fennewald S., Van Santen V., Kieff E. Nucleotide sequence of a mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein. J. Virol. 1984; 51: 411–19
   PubMed Web of Science ®Google Scholar
• Bankier A. T., Deininger P. L., Satchwell S. C., Baer R., Farrell P. J., Barrell G. B. DNA sequence analysis of the EcoRl Dhet fragment of 895–8 Epstein-Barr virus containing the terminal repeat sequences. Mol. Biol. Med. 1983; 1: 425–45
   PubMedGoogle Scholar
• Hudson G. S., Farrell P. J., Barrell B. G. Two related but differently expressed potential membrane proteins encoded by the EcoRl Dhet region of Epstein- Barr virus B95–8. J. Virol. 1985; 53: 528–35
   PubMed Web of Science ®Google Scholar
• Wang D., Liebowitz D., Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 1985; 43: 831–40
   PubMed Web of Science ®Google Scholar
• Wilson J. B., Weinberg W., Johnson R., Yuspa S., Levine A. J. Expression of the BNLF-l oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell 1990; 61: 1315–27
   PubMed Web of Science ®Google Scholar
• Wang D., Liebowitz D., Wang F., Gregory C., Rickinson A., Larson R., Springer T., Kieff E. Epstein-Barr latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. J. Virol. 1988; 62: 4173–84
   PubMed Web of Science ®Google Scholar
• Henderson S., Rowe M., Gregory C., Croom-Carter D., Wang F., Longnecker R., Kieff E., Rickinson A. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 1991; 65: 1107–15
   PubMed Web of Science ®Google Scholar
• Thorley-Lawson D. A., Israelsohn E. S. Generation of specific cytotoxic T-cells with a fragment of the Epstein-Barr virus-encoded P63/latent membrane protein. Proc. Natl. Acad. Sci. USA 1987; 88: 5384–88
   Web of Science ®Google Scholar
• Wallace L. E., Murray R. J. Immunological aspects of the Epstein-Barr virus system. Advances in viral oncology, G. Klein. Raven Press, Ltd., New York 1989; Vol 8: 219–36
   Google Scholar
• Liebowitz D., Wang D, Kieff E. Orientation and patching of the latent infection membrane protein encoded by Epstein Barr virus. J. Virol. 1986; 58: 233–37
   PubMed Web of Science ®Google Scholar
• Martin J, Sugden B. Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association. J. Virol. 1991; 65: 3246–58
   PubMed Web of Science ®Google Scholar
• Knecht H., Bachmann E., Joske D. J. L., Sahli R., Emery-Goodman A., Bachmann F., Odermatt B. F. Molecular analysis of the LMP (latent membrane protein) oncogene in Hodgkin's disease. 1992, submitted).
   Google Scholar
• Knecht H., Sahli R., Joske D. J. L., Bachmann E., Bachmann F., Hayoz D., Odermatt B. F., Shaw P. Semiquantitative analysis of Epstein-Barr virus DNA by polymerase chain reaction in clinical samples of lymphoproliferative disorders. Frontiers in Virology 1992; 1: 157–70
   Google Scholar
• Rowe M., Evans H. S., Young L. S., Hennessy K., Kieff E., Rickinson A. B. Monoclonal antibodies to the latent membrane protein of Epstein-barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells. J. Gen. Virol. 1987; 68: 1575–86
   PubMed Web of Science ®Google Scholar
• Henderson A., Ripley S., Heller M., Kieff E. Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line and in lymphocytes growth-transformed in vitro. Proc. Natl. Acad. Sci. USA 1983; 80: 1987–91
   PubMed Web of Science ®Google Scholar
• Matsuo T., Heller M., Petti L., O'Shiro E., Kieff E. Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA. Science 1984; 226: 1322–24
   PubMed Web of Science ®Google Scholar
• Lawrence J. B., Villnave C. A., Singer R. H. Sensitive, High-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line. Cell 1988; 52: 51–61
   PubMed Web of Science ®Google Scholar
• Hurley E. A., Agger S., McNeil J. A., Lawrence J. B., Calendar A., Lenoir G., Thorley-Lawson D. A. When Epstein-Barr virus presistently infects B-cell lines, it frequently integrates. J. Virol. 1991; 65: 1245–54
   PubMed Web of Science ®Google Scholar
• Vos J. M. H., Wauthier E. L., Hanawalt P. C. DNA damage stimulates human cell transformation by integrative but not episomal Epstein-Barr virus-derived plasmid. Mol. Carcinogenesis 1989; 2: 237–44
   PubMed Web of Science ®Google Scholar
• Raab-Traub N., Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 1986; 47: 883–89
   PubMed Web of Science ®Google Scholar
• Sugden B., Phelps M., Domoradzki J. Epstein-Barr virus DNA is amplified in transformed lymphocytes. J. Virol. 1979; 3: 590–95
   Google Scholar
• Sundeen J., Lipford E., Uppenkamp M., Sussman E., Wahl L., Raffeld M., Cossman J. Rearranged antigen receptor genes in Hodgkin's disease. Blood 1987; 70: 96–103
   PubMed Web of Science ®Google Scholar
• Sitar G., Brusamolino E., Bernasconi C., Ascari E. Isolation of Reed-Sternberg cells from lymph nodes of Hodgkin's disease patients. Blood 1989; 73: 222–29
   PubMed Web of Science ®Google Scholar
• Patton D. F., Shirley P., Raab-Traub N., Resnick L., Sixbey J. W. Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia. J. Virol 1990; 64: 397–400
   PubMed Web of Science ®Google Scholar
• Masih A., Weisenburger D., Duggan M., Armitage J., Bashir R., Mitchell D., Wickert R., Purtilo D. T. Epstein-Barr viral genome in lymph nodes from patients with Hodgkin's disease may not be specific to Reed-Sternberg cells. Am. J. Pathol. 1991; 139: 37–43
   PubMed Web of Science ®Google Scholar
• Mosier D. E., Gulizia R. J., Baird S. M., Wilson D. B. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256–59
   PubMed Web of Science ®Google Scholar
• Pisa P., Cannon M. J., Pisa E. K., Cooper N. R., Fox R. I. Epstein-Barr virus induced lymphoproliferative tumours in severe combined immunodeficient mice are oligoclonal. Blood 1992; 79: 173–179
   PubMed Web of Science ®Google Scholar
• Knowles II D. M., Neri A., Pelicci P. G., Burke J. S., Wu A., Winberg C. D., Sheibani K., Dalla-Favera R. Immunoglobulin and T-cell receptor β-chain gene rearrangement analysis of Hodgkin's disease: implications for lineage determination and differential diagnosis. Proc. Natl. Acad, Sci. USA 1986; 83: 7942–46
   PubMed Web of Science ®Google Scholar
• Falk M. H., Tesch H., Stein H., Diehl V., Jones D. B., Fonatsch C., Bornkamm G. W. Phenotype versus immunoglobulin and T-cell receptor genotype of Hodgkin-derived cell lines: Activation of immature lymphoid cells in Hodgkin's disease. Int. J. Cancer 1987; 40: 262–69
   PubMed Web of Science ®Google Scholar
• Katamine S., Otsu M., Tada K., Tsuchiya S., Sato T., Ishida N., Honjo T., Ono Y. Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements. Nature 1984; 309: 369–72
   PubMed Web of Science ®Google Scholar
• Gregory C. D., Kirchgens C., Edwards C. F., Young L. S., Rowe M., Forster A., Rabbitts T. H., Rickinson A. B. Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germline or rearranged but nonexpressed heavy chain genes. Eur. J. Immunol. 1987; 17: 1199–207
   PubMed Web of Science ®Google Scholar
• Stein H., Herbst H., Anagnostopoulos I., Niedobitek G., Dallenbach F., Kratzsch H. C. The nature of Hodgkin and Reed-Sternberg cells, their association with EBV and their relationship to anaplastic large-cell lymphoma. Ann. Oncol. 1991; 2: 33–38, suppl 2.
   PubMed Web of Science ®Google Scholar
• Schatz D. G., Oettinger M. A., Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989; 59: 1035–48
   PubMed Web of Science ®Google Scholar
• Oettinger M. A., Schatz D. G., Gorka C., Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990; 248: 1517–23
   PubMed Web of Science ®Google Scholar
• Knecht H., Joske D. J. L., Emery-Goodman A., Bachmann E., Bachmann F., Odermatt B. F. Expression of human recombination of activating genes (RAG-1 and RAG-2) in Hodgkin's disease. 1992, submitted).
   Google Scholar
• Turka L. A., Schatz D. G., Oettinger M. A., Chun J. J. M., Gorka C., Lee K., McCormack W. T., Thompson C. B. Thymocyte expression of RAG-1 and RAG-2: Termination by T-cell receptor cross. linking. Science 1991; 253: 778–81
   PubMed Web of Science ®Google Scholar
• Bories J. C., Cayuela J. M., Loiseau P., Sigaux F. Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression. Blood 1991; 78: 2053–61
   PubMed Web of Science ®Google Scholar
• Stein H., Mason D. Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H., Schwarting R., Lennert K. The expression of Hodgkin's disease associated antigen Ki-l in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 1985; 66: 848–58
   PubMed Web of Science ®Google Scholar