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Review Article

Mechanisms of Interaction Between Interferon Gamma and Antineoplastic Agents on Growth and Differentiation of Leukemic Cells: A Review

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Pages 469-477 | Received 12 Sep 1991, Published online: 01 Jul 2009

References

  • Gresser I. How does interferon inhibit tumor growth. Interferon 6, I. Gresser. Academic Press, New York 1985; 1–12
  • Brunda M. J., Wright R. B. Differential antiproliferative effects of recombinant interferon α and γ on two murine cell lines. Int. J. Cancer 1986; 37: 287–291
  • Denz H., Lechleitner M., Marth C., Daxenbichler G., Gastl G., Braunsteiner H. Effect of human recombinant α2 and γ interferon on the growth of human cell lines from solid tumor and hematologic malignancies. J. Interferon Res. 1985; 5: 147–157
  • Ball E. D., Guyre P. M., Shen L., Glynn J. M., Maliszewski C. R., Baker P. E., Fanger M. W. Gamma interferon induces monocytoid differentiation in the HL-60 cell line. J. Clin. Invest. 1984; 73: 1072–1077
  • Takei M., Takeda K., Konno K. The role of interferon y in induction of differentiation of human myeloid leukemia cell lines, ML-1 and HL-60. Biochem. Biophys. Res. Comm. 1984; 124: 100–105
  • Pfeffernkorn L. C., Guyre P. M., Fanger M. W. Functional comparison of the inductions of NADPH oxidase activity and Fe gamma RI in IFN gamma-treated U937 cells. Mol. Immunol. 1990; 27: 263–272
  • Fisher P. B., Grant S. Effects of interferon on differentiation of normal tumor cells. Pharmacol. Ther. 1985; 11: 143–166
  • Sariban E., Mitchell T., Griffin J., Kufe D. W. Effects of interferon-y on proto-oncogene expression during induction. J. Immunol. 1987; 138: 1954–1958
  • Iwanami M., Takeda K., Konno K. Enhancement of interferon-γ induced differentiation of human monoblastic leukemia U937 cells by cAMP-inducing agents. J. Interferon Res. 1990; 10: 477–485
  • Craig R. W., Buchan H. L. Differentiation-inducing and cytotoxic effects of tumor necrosis factor and interferon-gammain myeloblasts ML-1 cells. J. Cell. Physiol. 1989; 141: 46–52
  • Faltynek C. R., Finch L. R., Miller P., Overton W. R. Treatment with recombinant I FN-y decreases cell surface CDH levels on peripheral blood monocytes and on myelomonocytic cell lines. J. Immunol. 1989; 142: 500–508
  • Delforge A., Vandenplas B., Lagneaux L., Loos M., Bron D., Debusscher L., Strykmans P. Influence of recombinant alpha and gamma interferons on the in vitro proliferation of myeloid leukemic progenitors. Eur. J. Haematol. 1990; 44: 307–311
  • Cassatella M. A., Hartman L., Perussia B., Trinchieri G. Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy chain gene expression and nicotinamideadenine dinucleotide phosphate hydrogenase oxidase in human leukemia myeloid cells. J. Clin. Invest. 1989; 83: 1570–1579
  • McGlave P., Mamus S., Vilen B., Dewald G. Effect of recombinant gamma interferon on chronic myelogenous leukemia bone marrow progenitors. Exp. Hematol 1987; 15: 331–335
  • Geissler K., Tricot G., Leemhuis T., Walker E., Broxmeyer H. E. Differentiation-inducing effect of recombinant human tumor necrosis factor α and γ-interferon in vitro on blast cells from patients with acute myeloid leukemia and myeloid blast crisis of chronic myeloid leukemia. Cancer Res. 1989; 49: 3057–3062
  • Tanabe Y., Dan K., Kuriya S., Nomura T. Effects of recombinant human alpha-2b and gamma interferons on bone marrow megakaryocyte progenitors (CFU-Meg) from patients with chronic myelocytic leukemia. Rinsho Ketsveki 1989; 30: 1800–1805
  • Novick D., Orchansky P., Revel M., Rubinstein M. The human interferon-y receptor: Purification, characterization and preparation of antibodies. J. Biol. Chem. 1987; 262: 8483–8487
  • Auget M. The interferon-gamma receptor: a comparison with other cytokine receptors. J. Interferon Res. 1990; 10: 551–558
  • Watson R. B., Galvani D. W., Nash J. R., Cawley J. C. Gamma interferon receptor expression in haemic malignancies. Leuk. Res. 1990; 14: 657–660
  • Bartsch H. H., Pfizenmaier K., Hanusch A., Scheurich P., Ucer U., Nagel G. A. Sequential therapy with recombinant interferons gamma and alpha in patients with unfavourable prognosis of chronic myelocytic leukemia: clinical responsiveness to recombinant interferon alpha correlates with the degree of receptor down regulation. Int. J. Cancer 1989; 43: 235–240
  • Carlo-Stella C., Cazzola M., Ganser A., Bergamachi G., Pedrazzoli P., Hoelzer D., Ascari E. Synergistic antiproliferative effect of recombinant interferon-γ with recombinant interferon-α on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM). Blood 1988; 73: 1293–1299
  • Ishii Y., Tsukagoshi S. The synergistic effect of human recombinant interferon alpha 2a in combination with interferon gamma and the induction of interferon alpha 2a receptor by interferon gamma. J. Pharmacobiodyn 1989; 12: 299–304
  • Levy D. E., Lew D. J., Decker T., Kessler D. S., Darnell J. E. Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF 3. EMBO J. 1990; 9: 1105–1111
  • Schiller J. H., Horisberer M. A., Bittner G., Carbin J. M., Storer B., Byrne G. I., Willson J. K., Borden E. C. Effects of combinations of interferon-beta ser and interferon-gamma on interferon-inducible proteins and on the cell cycle. J. Biol. Response Mod. 1990; 9: 368–377
  • Talpaz M., Kantarijan H. M., Kurzrock R., Gutterman J. U. Therapy of chronic myelogenous leukemia: chemotherapy and interferons. Seminars in Hematol. 1988; 25: 62–73
  • Kloke O., Becher R., Niederle N. Response to the combined administration of interferons alpha and gamma after failure of single interferon therapy in chronic myelogenous leukemia. Blut 1987; 55: 453–458
  • Trinchieri G., Kobayashi M., Rosen M., Loudon R., Perussia B., Murphy M. Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. J. Exp. Med. 1986; 164: 1206–1225
  • Murphy M., Perussia B., Trinchieri G. Effects of recombinant tumor necrosis factor, lymphotoxin and immune interferon on proliferation and differentiation of enriched hematopoietic precursor cells. Exp. Hematol 1988; 16: 131–138
  • Nakaya K., Chou Deguchi S. Y., Nakumura Y. Induction of differentiation of human leukemia cells by various combinations of cytokines and low molecular weight inducers. Chem. Pharmac. Bull. Tokyo 1990; 38: 966–970
  • Lydig J., Li W. J., Lopez A. R., Garovoy M., Arlinghaus R., Deiseroth A. The TNF alpha and gamma interferon combination act synergistically to increase class I HLA antigen expression in blast crisis CML patients. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 1989; 8: A715
  • Wietzerbin J., Gaudelet C., Catinot L., Chebath J., Falcoff R. Synergistic effect of interferon -gamma and tumor necrosis factor -alpha on antiviral activity and (2′-5′)oligo A synthetase induction in myelomonocytic cell line. J. Leuc. Biol. 1990; 48: 149–155
  • Salzberg S., Hacohen D., David S., Dovrat S., Ahwan S., Gamliel H., Birnbaum M. Involvement of interferon-system in the regulation of cell growth and differentiation. Scanning Microsc. 1990; 4: 479–489
  • Revel M., Chebath J. Interferon-activated genes. Trends in Biochem. Sci. 1986; 11: 166–170
  • Werner-Felmayer G., Werner E. R., Fuchs D., Hansen A., Reibnegger G., Wachter H. Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment. Cancer Res. 1990; 50: 2863–2867
  • Kim M-Y., Linardic C., Obeid L., Hannon Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor a and γ-interferon. J. Biol. Chem. 1991; 266: 484–489
  • Michishita M., Yoshida Y., Uchino H., Nagata K. Induction of tumor necrosis factor-alpha and its receptor during differentiation in myeloid leukemic cells along the monocytic pathway. A possible regulatory mechanism for TNF-alpha production. J. Biol. Chem. 1990; 265: 8751–8759
  • Raitano A. B., Senderi P, Korc M. Upregulation of interferon-y binding by tumor necrosis factor and lymphotoxin: Disparate potencies of the cytokines and modulation of their effects by phorbol ester. J. Interferon Res. 1991; 11: 61–67
  • Irvine A. E., Berney J. J., Francis G. E. Dissociation of the proliferation and differentiation stimuli of granulocyte colony stimulating factor (G-CSF). Leukemia 1990; 4: 203–209
  • Pawelec G., Schneider E., Ehninger G., Rehbeim A., Schmidt H. Partial correction of defective generation of lymphokine-activated killer cells in patients with chronic myelogenous leukemia after in vivo treatment with interferon alpha. Cancer Immunol. Immunother. 1989; 29: 63–66
  • Hivroz C., Valle A., Brouer J. C., Banchereau J., Grillot Courvalin C. Regulation by interleukin 2 of CD23 expression of leukemic and normal B cells: comparison with interleukin 4. Eur. J. Immunol. 1989; 19: 1025–1030
  • Barber K. E., Crosier P. S., Purdie K. J., Buchanan J. M., Cattermole J. A., Watson J. D., Gillis S. Human interleukin 3: effects on normal and leukemic cells. Growth Factors 1989; 1: 101–114
  • Yoshifumi K., Yoichi T., Atsushi H., Takanori A., et al. Synergistic effect of recombinant interferon-γ and interleukin-3 on the growth of immature human hematopoietic progenitors. Blood 1991; 77: 2118–2121
  • Kamijo R., Takeda K., Nagumo M., Konno K. Effect of combinations of transforming growth factor-beta 1 and tumor necrosis factor on induction of differentiation of human myelogenous leukemia cell lines. J. Immunol. 1990; 144: 1311–1316
  • De-Benedetti F., Falk L. A., Ellingsworth L. R., Ruscetti F. W., Faltynek C. R. Synergy between transforming growth factor-beta and tumor necrosis factor-alpha in the induction of monocytic differentiation of human leukemic cell lines. Blood 1990; 75: 626–632
  • Cochran F. R., Finch-Arietta M. B. Regulation of interleukin-beta and tumor necrosis factor secretion by the human monocytic leukemia cell line THP-1. Agents Actions 1989; 27: 271–273
  • Gaffney E. V., Stonner C. R., Lingenfelter S. E., Wagner L. A. Demonstration of IL-1 alpha and IL-1 beta secretion by the monocytic leukemia cell line THP-1. J. Immunol. Methods 1989; 122: 211–218
  • Takahashi S., Yamashita T., Eto Y., Shibani H., Miyamoto K., Ogata E. Inducible gene expression of activin A/erythroid differentiation factor in HL60 cells. Biochem. Biophys. Res. Commun. 1990; 167: 654–658
  • Ayroldi E., Blasi E., Varesio L., Wiltrout R. H. Synergistic antiproliferative effects on I FN gamma, ILI and TNF alpha for a retrovirus immortalized mouse myelomonocytic tumor. Proc. Annu. Meet. Am. Assoc. Cancer Res. 1989; 30: A1617
  • Lin J., Sartorelli A. C. Stimulation by interferon of the differentiation of human promyelocytic leukemia (HL-60) cells produced by retinoic acid and actinomycin D. J. Interferon Res. 1987; 7: 379–387
  • Hemmi H., Breitman T. R. Combinations of recombinant human interferons and retinoic acid synergistically induce differentiation of the human promyelocytic leukemia cell line HL-60. Blood 1987; 69: 501–507
  • Trinchieri G., Rosen M., Perussia B. Retinoic acid cooperates with tumor necrosis factor and immune interferon in inducing differentiation and growth inhibition of the human promyelocytic leukemia cell line HL-60. Blood 1987; 69: 1218–1224
  • Gallagher R. E., Lurie K. Y., Leavitt R. D., Wiernik P. H. Effects of interferon and retinoic acid on the growth and differentiation of clonogenic leukemic cells from acute myelogenous leukemia patients treated with recombinant leukocyte-αA interferon. Leukemia Res. 1987; 11: 609–619
  • Kohlepp E. A., Condon M E., Hamburger A. W. Recombinant human interferon α enhancement of retinoic-acid-induced differentiation of HL-60 cells. Exp. Hematol 1987; 15: 414–418
  • Grant S., Bhalla K., Weinstein B., Pestka S., Mileno N., Fisher P. B. Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation. Biochem. Biophys. Res. Comm. 1985; 130: 379–388
  • Langer J. A., Pestka S. Changes in binding of alpha interferon IFN-aA to HL-60 cells during myeloid differentiation. J. Interferon Res. 1985; 5: 637–649
  • Capeillere-Blandin C., Chauvet G., Tresset F., Descamps-Latscha B. Development of cytochrome b558 and oxidative metabolism in human granulocytes, monocytes and during differentiation of HL-60 and U937 cells. Biol. Cell 1990; 69: 73–82
  • Ho C. K., Wang C. Y., Ou B. R., Shiao M. S., Chen N. Y., Kuwata T. Enhancement of interferon induced 2-5 oligo adenylate synthetase activity by retinoic acid in human histiocytic U937 cells and WISH cells. Differentiation 1989; 40: 70–75
  • Hemmi H., Nakamura T., Goto Y., Sugamura K. Pertusis toxin inhibits differentiation induced by retinoic acid in a human promyelocytic leukemia cell line HL-60. Biochem. Biophys. Res. Commun. 1989; 163: 797–802
  • Kafka M., Nathan I., Dvilansky A. New combination of 5-fluorouracil and interferon γ effective against human myeloid leukemia in vitro. Anticancer Res. 1989; 9: 1037–1040
  • Harrison S. D., Stevens J. J., Wand W. R., Dykes D. J., Schmid S. M., Griswold D. P. Evaluation of combinations of interferons and cytotoxic drugs in murine tumor models in vivo. J. Biol. Response Mod. 1990; 9: 395–400
  • Namba M., Yamamoto S., Tanaka H., Kamamori T., Nobuhara M., Kimoto T. In vitro, in vivo studies on potentiation of cytotoxic effects of anticancer drugs or cobalt gamma ray by interferon on human neoplastic cells. Cancer 1987; 54: 2262–2267
  • Roberts P., Jones M., Gale R., Thomas S., Tidman N., Linch D. The c-myc oncogene is regulated independently of differentiation in myeloid cell lines. Leukemia Res. 1989; 13: 651–659
  • Chiba P., Tihan T., Eher R., Koller U., Wallner C., Gobi R., Linkesch W. Effect of cell growth and differentiation on 1-β-D-arabinofuranosylcytosine metabolism in myeloid cells. Brit. J. Haemal. 1989; 71: 451–455
  • Elias L., Crissman H. A. Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites. Cancer Res. 1988; 48: 4868–4873
  • Kafka M., Dvilansky A., Nathan I. Mechanism of interaction between interferon γ and antineoplastic agents on the differentiation of HL60 promyelocytic cells. Exp. Hematoi 1990; 18: 153–158
  • Danenberg P. V., Lockshin A. Thymidilate synthetase-substrate complex formation. Mol. Cell. Biochem. 1982; 43: 49–57
  • Chu E., Zinn S., Boarman D., Allegra C. J. Interaction of γ-interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res. 1990; 50: 5834–5840
  • Elias L., Sandoval J. M. Interferon effects upon fluorouracil metabolism by HL60 cells. Biochem. Biophys. Res. Comm. 1989; 163: 867–874
  • Pinedo H. M., Peters G. F. J. Fluorouracil: Biochemistry and pharmacology. J. Clin. Oncol. 1988; 6: 1653–1664
  • Elias L., Wood A., Crissman H. A., Rattlif R. Effects on condition medium upon proliferation, deoxynucleotide metabolism and antimetabolite sensitivity of promyelocytic leukemia in vitro. Cancer Res. 1985; 45: 6301–6307
  • Stolfi R. L., Martin D. S. Modulation of chemotherapeutic drug activity with polyribonucleotides or with interferon. J. Biol. Res. Med 1985; 4: 634–639
  • Ligo M., Chapekar M. S., Glazer R. I. Synergistic antitumor effect of fluoropyrimidines and polyinosinicpolycytidylic acid against L1210 leukemia. Cancer Res. 1985; 45: 4039–4042
  • Morikawa K., Fan D., Denkins Y. M., Levin B., Gutterman J. U., Walker S. M., Fidler I. J. Mechanisms of combined effects of γ-interferon and 5-fluorouracil on human colon cancer implanted into nude mice. Cancer Res. 1989; 49: 799–805
  • Yoneda K., Yamamoto T., Osaki T. Enhanced cytotoxicity of antineoplastics by interferon. Nippon Gan Chiryo Gakkui Shi 1990; 25: 77–84
  • Singh G., Renton K. W., Stebbing N. Homogenous interferon from E. coli depresses hepatic cytochrome P-450 drug biotransformation. Biochem. Biophys. Res. Commun. 1982; 106: 1256–1261
  • Balkwill F. R., Mowshowitz S., Seilman S. S., Moodie Griffin E. M., Fantes D. B.K. H., Wolf C. R. Positive interactions between interferon and chemotherapy due to direct tumor action rather than effect on host drug-metabolizing enzymes. Cancer Res. 1984; 44: 5249–5255
  • Moochhala S. M., Renton K. W. Induction and depression of cytochrome P-450-dependent mixed-function oxidase by a cloned consensus a interferon (IFN-αCON1) in the hamster. Biochem. Pharmacol. 1987; 38: 439–447
  • Nichols K. E., Chitneni S. R., Moore J. O., Weinberg J. B. Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL60 cells induced by the glutamine antagonist acivicin. Blood 1989; 74(5)1728–1737
  • Visani G., Lemoli R. M., Tosi P., Verlicchi F., Gamber B., Cenacchi A. R., Columbini R., Fogli M., Russo D., Zuffa E. Sensitivity of chronic myeloid leukemia hemopoietic progenitors to PTT-119 in combination with human recombinant interferon alpha and gamma. Blut 1990; 60: 287–290

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