24
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Pharmacokinetics of Mitoxantrone in Plasma and Leukemic Cells During Treatment of Patients with Acute Non-Lymphocytic Leukemia

, , , , , , , & show all
Pages 493-496 | Received 08 Sep 1991, Published online: 01 Jul 2009

References

  • Ho A., Seither E., Ma D., Prentice H. Mitoxantrone-induced toxicity and DNA strand breaks in leukaemic cells. Br. J. Haematol. 1987; 65: 51–55
  • Alberts D., Peng Y., Bowden G., Mackel C., Dalton W. Mechanism of action and pharmacokinetics of Novantrone in intravenous and intraperitoneal therapy. Proceedings of the symposium on the current status of Novantrone. 1985; 21–24, 15-21
  • Ehninger G., Schuler U., Proksch B., Zeller K., Blanz J. Pharmacokinetics and metabolism of mitoxantrone, a review. Clin. Pharmacokinet. 1990; 18: 365–380
  • Savaraj N., Lu K., Manuel V., Loo T. Pharmacology of mitoxantrone in cancer patients. Cancer Chemother. Pharmacol 1982; 8: 113–117
  • Stewart D., Green R., Mikhael N., Montpetit V., Thibault M., Maroun J. Human autopsy tissue concentrations of mitoxantrone. Cancer Treat. Rep. 1986; 70: 1255–1261
  • Bjorkholm M., Bjornsdottir J., Stenke L., Grimfors G. Mitoxantrone, etoposide and cytarabine in the treatment of acute nonlymphocytic leukemia. Oncology 1990; 47: 112–114
  • Larson R., Daly K., Choi K., Han D., Sinkule J. A clinical and pharmacokinetic study of mitoxantrone in acute nonlymphocytic leukemia. J. Clin. Oncol 1987; 5: 391–397
  • Dunne A. JANA: A new iterative polyexponential curve stripping program. Comput. Methods Programs Biomed. 1985; 20: 269–275
  • Eksborg S., Strandler H., Edsmyr F., Naslund I., Tahvanainen P. Pharmacokinetic study of iv infusions of adriamycin. Eur. J. Clin. Pharmacol. 1985; 28: 205–212
  • Tidefelt U., Sundman-Engberg B., Paul C. Comparison of the intracellular pharmacokinetics of doxorubicin and 4′-epi-doxorubicin in patients with acute leukemia. Cancer Chemother. Pharmacol 1989; 24: 225–229
  • Paul C., Liliemark J., Tidefelt U., Gahrton G., Peterson C. Pharmacokinetics of daunorubicin and doxorubicin in plasma and leukemic cells from patients with acute nonlymphoblastic leukemia. Ther. Drug Monit. 1989; 11: 140–148
  • Faulds D., Balfour J., Chrisp P., Langtry H. Mitoxantrone—A review of its pharmacodynamic properties, and therapeutic potential in the chemotherapy of cancer. Drugs 1991; 41: 400–449
  • Kaminer L., Choi K., Daley K., Larson R. Continuous infusion of mitoxantrone in relapsed acute nonlymphocytic leukemia. Cancer 1989; 65: 2619–2623
  • Deuchars K., Ling V. P-glycoprotein and multidrug resistance in cancer chemotherapy. Semin. Oncol. 1989; 16: 156–165
  • Plunkett W., Iacoboni S., Estey E., Danhauser L., Liliemark J., Keating M. Pharmacologically directed ara-C therapy for refractory leukemia. Semin. Oncol. 1985; 12(suppl. 3)20–30

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.