L-Asparaginase-Induced Coagulopathy in Acute Lymphoblastic Leukemia

References

• Oettegen H. F., Stephenson P. A., Schwartz M. K., Leeper R. D., Tallal L., Tan C. C., Clarkson B. D., Golbey R. B., Karkoff I. H., Karaofsky D. A., Murphy M. L., Burchenal J. H. Toxicity of E. ColiL-asparaginase in man. Cancer 1970; 25: 253–78
   PubMedGoogle Scholar
• Whitecarr J. P., Jr, Bodey G. P., Hill C. S., Samaan N. A. Effect of L-asparaginase on carbohydrate metabolism. Metabolism 1970; 19: 581–6
   PubMed Web of Science ®Google Scholar
• Deutsch E., Fischer M., Frischauf H., Honetz N., Lechner K., Pesendorfer F., Stych H., Weissmann A. Blood coagulation changes under L-asparaginase therapy. Recent Advances in Cancer 1970; 33: 331–41
   PubMedGoogle Scholar
• Garnick M. B., Larsen P. R. Acute deficiency of thyroxine-binding globulin during L-asparaginase therapy. New England Journal of Medicine 1979; 301: 252–3
   PubMed Web of Science ®Google Scholar
• Ramsay N. K. C., Coccia P. F., Krivit W., Nesbit M. E., Edson J. R. The effect of L-asparaginase on plasma coagulation factors in acute lymphoblastic leukemia. Cancer 1977; 40: 1398–401
   PubMed Web of Science ®Google Scholar
• Cairo M. S., Lazarus K., Gilmore R. L., Baehner R. L. Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphoblastic leukemia. Journal of Pediatrics 1980; 97: 829–33
   PubMed Web of Science ®Google Scholar
• Urban C., Sager W. D. Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia. European Journal of Pediatrics 1981; 137: 323–7
   PubMed Web of Science ®Google Scholar
• Muntean W. Hemorrhagic complications of L-asparaginase therapy. Journal of Pediatrics 1983; 102: 483–4
   PubMed Web of Science ®Google Scholar
• Priest J. R., Ramsay N. K. C., Steinherz P. G., Tubergen D. G., Cairo M. S., Sitarz A. L., Bishop A. T., White L., Trigg M. E., Levitt C. J., Cich J. A., Coccia P. R. A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia. Journal of Pediatrics 1982; 100: 984–9
   PubMed Web of Science ®Google Scholar
• Pitney W. R., Phadke K. P., Dean S. Antithrombin III deficiency during asparaginase therapy. Lancet 1980; 1: 493–4
   PubMed Web of Science ®Google Scholar
• Vellenga E., Mulder N. H., Niewag H. O. Antithrombin III deficiency during asparaginase therapy. Lancet 1980; 1: 649–50
   PubMed Web of Science ®Google Scholar
• Conard J., Cazenave B., Maury J., Horellou M. H., Samama M. L-asparaginase, antithrombin III and thrombosis. Lancet 1980; 11: 1091
   Google Scholar
• Steinherz P. G., Miller P. L., Ghavimi F., Allen J. C., Miller D. R. Dural sinus thrombosis in children with acute lymphoblastic leukaemia. Journal of American Medical Association 1981; 246: 2837–39
   Web of Science ®Google Scholar
• Tura S., Gugliotta L., Guarini A., Timoncini C, Aieta M. (1981) L-asparaginasi e trombosi nella leucemia acuta linfoblastica dell'adulto. XXVIII Congresso della Societa Italiana di Ematologia, Bari, October, 28–311981, 70, Book of Abstracts
   Google Scholar
• Valori V. M., Traisci G., Leone G., Bizzi B. Trombosi iliaco-femorale dopo terapia con asparaginasi e pillola estro-progestinica: possibile importanza del deficit acquisito di AT-III. Haematologica 1981; 66: 708, abs.
   Google Scholar
• Barbui T., Rodeghiero F., Meli S., Dini E. Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy. Acta Haematologica 1983; 69: 188–91
   PubMed Web of Science ®Google Scholar
• Vellenga E., Broekmans A. W., Kluft C. Thrombotic complications during L-asparaginase related to protein C deficiency?. Thrombosis and Haemostasis 1985; 53: 443
   PubMed Web of Science ®Google Scholar
• Kucuk O., Kwaan H. C., Gunnar W., Vazquez R. M. Thromboembolic complications associated with L-asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma. Cancer 1985; 55: 702–6
   PubMed Web of Science ®Google Scholar
• Gugliotta L., Mazzucconi M. G., Leone G., Mattioli Belmonte M., Defazio D., Annino L., Tura S., Mandelli F. Incidence of thrombotic complications in adult patients with acute lymphoblastic leukaemia receiving L-asparaginase during induction therapy: a GIMEMA retrospective study. European Journal of Haematology, in press.
   Web of Science ®Google Scholar
• Conard J., Samama M., Bilski-Pesquier G., Bousser J. Toxicitè in vivo de la L-asparaginase sur les facteurs de la coagulation et en particulier sur I'antithrombine III (à propos de 25 observations). Coagulation 1971; 4: 195–201
   Google Scholar
• Pui C. H., Chesney C. M., Bergum P. W., Jackson C. W., Rapaport S. I. Lack of pathogenetic role of proteins C and S in thrombosis associated with asparaginase-prednisone-vincristine therapy for leukemia. British Journal of Haematology 1986; 64: 283–90
   PubMed Web of Science ®Google Scholar
• Saito M., Asakura H., Jokaji H., Uotani C., Kumabashiri I., Ito K., Matsuda T. Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy. American Journal of Hematology 1989; 32: 20–23
   PubMed Web of Science ®Google Scholar
• Viganò D'Angelo S., Gugliotta L., Mattioli Belmonte M., Cascione L., Bernasconi P., D'Angelo A. L-asparaginase treatment reduces the anticoagulant potential system of the protein C without affecting vitamin K-dependent carboxylation. Thrombosis Research 1990; 59: 985–95
   PubMed Web of Science ®Google Scholar
• Liebman H. A., Wada J. K., Patch M. J., McGehee W. Depression of functional and antigenic plasma antithrombin III (AT III) due to therapy with L-asparaginase. Cancer 1982; 50: 451–6
   PubMed Web of Science ®Google Scholar
• Barbui T., Finazzi G., Viganò S, Mannucci P. M. L-asparaginase lowers protein C antigen. Thrombosis and Haemostasis 1984; 52: 216
   PubMed Web of Science ®Google Scholar
• Conard J., Horellou M. H., Van Dreden P., Potevin F., Zittoun R., Samama M. Decrease in protein C in L-asparaginase-treated patients. British Journal of Haematology 1985; 59: 725–7
   PubMed Web of Science ®Google Scholar
• Gugliotta L., D'Angelo A., Mattioli Belmonte M., Viganò D'Angelo S., Colombo G., Catani L., Gianni L., Lauria F., Tura S. Hypercoagulability during L-asparaginase treatment: the effect of antithrombin III supplementation in vivo. British Journal of Haematology 1990; 74: 465–70
   PubMed Web of Science ®Google Scholar
• Mattioli Belmonte M., Gugliotta L., Delvos U., Catani L., Vianelli N., Cascione M. L., Belardinelli A. R., Mottola L., Tura S. A regimen for antithrombin III substitution in patients with acute lymphoblastic leukemia under treatment with L-asparaginase. Haematologica 1991; 76: 209–14
   PubMed Web of Science ®Google Scholar
• Vellenga E., Kluft C., Mulder N. H., Wijngaards G., Nieweg H. O. The influence of L-asparaginase therapy on the fibrinolytic system. British Journal of Haematology 1984; 57: 247–54
   PubMed Web of Science ®Google Scholar
• Cappellato M. G., Lazzaro A., Rosolen A., Zanesco L., Girolami A. Failure of L-asparaginase to decrease protein C. A possible rebound phenomenon. Thrombosis and Haemostasis 1986; 56: 238
   PubMed Web of Science ®Google Scholar
• Legnani C., Palareti G, Pession A., Poggi M., Vecchi V., Bianchini B., Coccheri S. Intravascular coagulation phenomena associated with prevalent fall in fibrinogen and plasminogen during L-asparaginase treatment in leukemic children. Haemostasis 1988; 18: 179–86
   PubMedGoogle Scholar
• Marra R., Pagano L., De Stefano V., Leone G., Bizzi B. Antithrombin III during high-dose cytosine arabinoside therapy with or without asparaginase. Acta Haematologica 1986; 75: 96–9
   PubMed Web of Science ®Google Scholar
• Leone G., Gugliotta L., Mazzucconi M. G., De Stefano V., Mattioli Belmonte M., Dragoni F., Specchia G., Centra A., Gamba G., Camera A., Mandelli F. Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. Coli L-asparaginase: a GIMEMA study. Thrombosis and Haemostasis, in press.
   Web of Science ®Google Scholar
• Rodeghiero F., Castaman G., Dini E. Fibrinopep-tide A changes during remission induction treatment with L-asparaginase in acute lymphoblastic leukemia: evidence for activation of blood coagulation. Thrombosis Research 1990; 57: 31–8
   PubMed Web of Science ®Google Scholar
• Bauer K. A., Teitel J. M., Rosenberg R. D. L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state. Thrombosis Research 1983; 29: 437–42
   PubMed Web of Science ®Google Scholar
• O'Meara A., Daly M., Hallinan F. H. Increased antithrombin III concentration in children with acute lymphatic leukaemia receiving L-asparaginase therapy. Medical and Pediatric Oncology 1988; 16: 169–74
   PubMedGoogle Scholar