Interleukin 3 Stimulation Enhances Tyrosine Phosphorylation and Proliferative Activity of Human Fetal Thymocytes and Leukemic T-cell Precursors at Multiple Developmental Stages of T-Cell Ontogeny

References

• Haynes B. F., Denning S. M., Singer K. H., Kurtzberg J. Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunol. Today 1989; 10: 87
   PubMedGoogle Scholar
• Haynes B. F., Martin M. E., Kay H. H., Kurtzberg J. Early events in human T cell ontogeny. Phenotypic characterization and immunohistological localization of T cell precursors in early human fetal tissues. J. Exp. Med 1988; 168: 1061
   PubMed Web of Science ®Google Scholar
• Groh V., Fabbi M., Strominger J. L. Maturation or differentiation of human thymocyte precursors in vitro. Proc. Natl. Acad Sci. USA 1990; 87: 5973
   PubMed Web of Science ®Google Scholar
• Yang Y. C., Clark S. C. Interleukin-3: molecular biology and biologic activities. Hematol/Oncol. Clinics of North America 1989; 3: 441
   Web of Science ®Google Scholar
• Ihle J. N., Weinstein Y. Immunological regulation of hematopoietic/lymphoid stem cell differentiation by interleukin 3. Advances in Immunology 1986; 39: 1
   PubMed Web of Science ®Google Scholar
• Sieff C. A. Hematopoietic growth factors. J. Clin. Invest 1987; 79: 1549
   PubMed Web of Science ®Google Scholar
• Yang Y. C., Ciarletta A. B., Temple P. A., Chung M. P., Kovaci S., Witek-Giannotti J. S., Leary A. C., Kriz R., Donahue R. E., Wong G. G., Clark S. C. Human IL-3: Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 1986; 47: 3
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Gesner T. G., Song C. W., Myers D. E., Mufson A. Leukemic B-cell precursors express functional receptors for human interleukin-3. Blood 1989; 73: 533
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Muraguchi A., Ledbetter J. A., Kishimoto T., O'Brien R. T., Roloff J. S., Gajl-Peczalska K. J., Provisor A., Koller B. Biphenotypic leukemia lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues. Blood 1989; 73: 1000
   PubMed Web of Science ®Google Scholar
• Chen B. D., Clark C. R. Interleukin 3 regulates the in vitro proliferation of both blood monocytes and peritoneal exudate macrophages: Synergism between a macrophage lineage specific colony stimulating factor CSF1 and IL-3. J. Immunol 1986; 137: 563
   PubMed Web of Science ®Google Scholar
• Donahue R. E., Seehra J., Metzger M., Lefebvre D., Rock B., Carbone S., Nathan D., Garnick M., Sehgal P. K., Laston D., LaVallie E., McCoy J., Schendel P. F., Norton C., Turner K., Yang Y. C., Clark S. C. Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science 1988; 241: 1820
   PubMed Web of Science ®Google Scholar
• Lopez A. F., To L. B., Yang Y. C., Gamble J. R., Shannon M. F., Burns G. F., Dyson P. G., Juttner C. A., Clark S., Vadas M. A. Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proc. Natl. Acad. Sci. USA 1987; 84: 2761
   PubMed Web of Science ®Google Scholar
• Griesinger F., Arthur D. C., Brunning R., Parkin J. L., Ochoa A. C., Miller W. J., Wilkowski C. W., Greenberg J. M., Hurvitz C., Kersey J. H. Mature T-lineage leukemia with growth factor-induced multilineage differentiation. J. Exp. Med 1989; 169: 1101
   PubMed Web of Science ®Google Scholar
• Schneider E. M., Lorenz I., Lcippold S., Zischler H., Clark S. C., Wernet P. Generation of mature CD3+ and T cell receptor (TCR)+ T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF. Leukemia 1988; 2: 282
   PubMed Web of Science ®Google Scholar
• Santoli D., Clark S. C., Kreider B. L., Maslin P. A., Rovera G. Amplification of IL-2-driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor. J. Immunol 1988; 141: 519
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Gajl-Peczalska K. J., Myers D. E., Ramsay N. K. C., Kersey J. H., Colvin M., Vallera D. A. Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: Efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclopho-sphamide against fresh leukemic marrow progenitor cells. Blood 1987; 69: 361
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Myers D. E., Ledbetter J. A., Swaim S. E., Gajl-Peczalska K. J., Vallera D. A. Use of colony assays and highly potent anti-T cell immunotoxins to elucidate the immunobiological features of leukemic lymphoid progenitor cells in T-lineage acute lymphoblastic leukemia. J. Immunol 1988; 140: 103
   Google Scholar
• Uckun F. M., Tuel-Ahlgren L., Obuz V., Smith R., Dibirdik I., Hanson M., Chandan-Langlie M., Ledbetter J. A. Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, phosphoinositide turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes. Proc. Natl. Acad. Sci. U.S.A 1991; 88: 6323, 1991
   PubMed Web of Science ®Google Scholar
• Hollander Z., Shah V. O., Civin C. I., Loken M. R. Assessment of proliferation during maturation of the B-lymphoid lineage in normal human bone marrow. Blood 1988; 71: 528
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Dibirdik I., Smith R., Tuel-Ahlgren L., Chandan-Langlie M., Schieven G. L., Waddick K. G., Hanson M., Ledbetter J. A. Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human B-cell precursors. Proc. Natl. Acad. Sci. USA 1991; 88: 3589
   PubMed Web of Science ®Google Scholar
• Ledbetter J. A., Schieven G. L., Kuelbelbeck V. M., Uckun F. M. Accessory receptors regulate coupling of the T cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T-lineage acute lymphoblastic fluctuations. Blood 1991; 77: 1271
   PubMed Web of Science ®Google Scholar
• Reinherz E. L., Kung P. C., Goldstein G., Levey R. H., Schlossman S. F. Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T cell lineage. Proc. Natl. Acad. Sci. USA 1980; 77: 1588
   PubMed Web of Science ®Google Scholar
• Greaves M. F. Differentiation-linked leukemogenesis in lymphocytes. Science 1980; 234: 697
   Web of Science ®Google Scholar
• Cleveland J. L., Dean M., Rosenberg N., Wang J. Y. J., Rapp U. R. Tyrosine kinase oncogenes abrogate Interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc conditional regulation of c-myc transcription by temperature-sensitive v-abl. Molecular and Cellular Biology 1989; 9: 5685
   PubMed Web of Science ®Google Scholar
• Kanakura Y., Druker B., Cannistra S. A., Furukawa Y., Torimoto Y., Griffin J. D. Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins. Blood 1990; 76: 706
   PubMed Web of Science ®Google Scholar
• Garland J. M., Ferris D. K., Farrar W. L. Novel characteristics of a 33 KDa protein (pp33) rapidly phosphor-ylated in IL3 dependent cells by stimulation with IL3. Biochemical and Biophysical Res. Comm 1989; 164: 520
   Google Scholar
• Pelech S. L., Paddon H. B., Charest D. L., Federsppiel B. S. IL-3-induced activation of protein kinases in the mast cell/megakaryocyte R6-XE.4 line. J. Immunol 1990; 144: 1759
   PubMed Web of Science ®Google Scholar
• Sorenson P., Mui A. L.-F., Krystal G. Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor. J. Biol. Chem 1989; 264: 19253
   PubMed Web of Science ®Google Scholar
• Koyasu S., Tojo A., Miyajima A., Akiyama T., Kasuga M., Urabe A., Schreurs J., Arai K.-I., Takaku F., Yahara I. Interleukin 3 specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multifactor dependent myeloid cell lines. EMBO J 1987; 6: 3979
   PubMed Web of Science ®Google Scholar
• Isfort R. J., Huhn R. D., Frackelton A. F., Jr., Ihle J. M. Stimulation of factor dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates. J. Biol. Chem 1988; 263: 19203
   PubMed Web of Science ®Google Scholar
• Ledbetter J. A., Rose L. M., Spooner C. E., Beatty P. G., Martin P. J., Clark E. A. Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL2 receptor expression. J. Immunol 1985; 135: 1819
   PubMed Web of Science ®Google Scholar
• Martorell J., Vilella R., Borche L., Rojo I., Vives J. A second signal for T cell mitogenesis provided by monoclonal antibodies to CD45 (T200). Eur. J. Immunol 1987; 17: 1447
   PubMed Web of Science ®Google Scholar
• Ledbetter J. A., Tonks N. K., Fischer E. H., Clark E. A. CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proc. Natl. Acad. Sci. USA 1988; 85: 8628
   PubMed Web of Science ®Google Scholar
• Kiener P. A., Mittler R. S. CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells. J. Immunol 1989; 143: 23
   PubMed Web of Science ®Google Scholar
• Ledbetter J. A., Schieven G. L., Uckun F. M., Imboden J. B. CD45 regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Tistimulated cells. J. Immunology 1991; 146: 1577
   PubMed Web of Science ®Google Scholar
• Hunter T., Cooper J. A. Protein-tyrosine kinases. Ann. Rev. Biochem 1985; 54: 897
   PubMed Web of Science ®Google Scholar
• Yarden Y., Ullrich A. Growth factor receptor tyrosine kinases. Ann. Rev. Biochem 1988; 57: 443
   PubMed Web of Science ®Google Scholar
• Evans J. P. M., Mire-Sluis A. R., Hoffbrand A. V., Wickremasinghe R. G. Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma-interferon to cell surface receptors on human myeloid cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein. Blood 1990; 75: 88
   PubMed Web of Science ®Google Scholar
• Meisenhelder J., Suh P. G., Rhee S. G., Hunter T. Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 1989; 57: 1109
   PubMed Web of Science ®Google Scholar
• Saltzman E. M., Luhowskyj S. M., Casnellie J. E. The 75,000-Dalton interleukin-2 receptor transmits a signal for the activation of a tyrosine protein kinase. J. Biol. Chem 1989; 264: 19979
   PubMed Web of Science ®Google Scholar
• Dibirdik I., Chandan-Langlie M., Ledbetter J. A., Tuel-Ahlgren L., Obuz V., Waddick K. G., Gajl-Peczalska K., Schieven G. L., Uckun F. M. Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells. Blood 1991; 78: 564
   PubMed Web of Science ®Google Scholar
• Fowlkes B. J., Schwartz R. H., Pardoll D. M. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature 1988; 334: 620
   PubMed Web of Science ®Google Scholar
• Hengartner H., Odermatt B., Schneider R., Schreyer M., Walle G., MacDonald H. R., Zinkernagel R. M. Deletion of self-reactive T cells before entry into the thymus medulla. Nature 1988; 336: 338
   Web of Science ®Google Scholar
• Kappler J. W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273
   PubMed Web of Science ®Google Scholar
• Nieto M. A., Gonzales A., Lopez-Rivas A., Diaz-Espada F., Gambon F. IL-2 protects against anti-CD3 induced cell death in human medullary thymocytes. J. Immunol 1990; 145: 1364
   PubMed Web of Science ®Google Scholar
• Watson J. D., Le Gros G. S., Park L. W. Induction of growth responsiveness to interleukin 2. Evidence for intracellular control mechanisms shared with interleukin 3. Recombinant Lymphokines and Their Receptors, S. Gilles. Marcel Dekker Inc., New York 1987; 33–52
   Google Scholar
• Watson J. D., Eszes M., Overell R., Conlon P., Widmer M., Gillis S. Effect of infection with murine recombinant retroviruses containing the v-src oncogene on interleukin 2- and interleukin 3-dependent growth states. J. Immunol 1987; 139: 123
   PubMed Web of Science ®Google Scholar
• Le Gros J. E., Jenkins D., Prestidge R. L., Watson J. D. Expression of genes in cloned murine cell lines that can be maintained in both interleukin 2 and interleukin 3 growth-dependent states. Immunol. Cell Biol 1987; 65: 57
   PubMed Web of Science ®Google Scholar
• Isfort R., Huhn R. D., Frackelton A. R., Ihle J. N. Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates. J. of Biol. Chem 1988; 263: 19203
   PubMed Web of Science ®Google Scholar