19
Views
11
CrossRef citations to date
0
Altmetric
Original Article

2-Chlorodeoxyadenosine in the Treatment of Hairy Cell Leukemia and Chronic Lymphocytic Leukemia

&
Pages 109-114 | Published online: 01 Jul 2009

References

  • Piro L. D., Carrera C. J., Carson D. A., Beutler E. Lasting remissions in hairy cell leukemia induced by a single infusion of 2–chlorodeoxyadenosine. N. Engl. J. Med. 1990; 322: 1117–1121
  • Piro L. D., Saven A., Ellison D., Thurston D., Carson D. A., Beutler E. Prolonged complete remissions following 2–chlorodeoxyadenosine (2–CdA) in hairy cell leukemia (HCL). Proc. Am. Soc. Clin. Oncol. 1992; 11: 846, Abstract
  • Juliusson G., Liliemark J. Rapid recovery from cytopenia in hairy cell leukemia after treatment with 2–chloro-2′-deoxyadenosine (CdA): Relation to opportunistic infections. Blood 1992; 79: 888–894
  • Estey E. M., Kurzrock R., Kantarjian H. M., O'Brien S., McCredie K., Beran M., Koller C., Keating M., Hirsch-Ginsberg C., Huy Y. O., Stass S., Freireich E. Treatment of hairy cell leukemia with 2–chlorodeoxyadenosine (2–CdA). Blood 1992; 79: 882–887
  • Tallman M. S., Hakimian D., Variakojis D., Koslow D., Sisney G. A., Rademaker A. W., Rose E., Kaul K. A single cycle of 2–chlorodeoxyadenosine results in complete remission in the majority of patients with hairy cell leukemia. Blood 1992; 9: 2203–2209
  • Lauria F., Benfenati D., Zinzani P. L., Raspadori D., Rondelli D., Tura S. 2–Chlorodeoxyadenosine in the treatment of hairy cell leukemia patients relapsed after α-interferon. Blood 1991; 78(Suppl. 1)34a, Abstract
  • Piro L. D., Carrera C. J., Beutler E., Carson D. A. 2–chlorodeoxyadenosine: An effective new agent for the treatment of chronic lymphocytic leukemia. Blood 1988; 72(3)1069–1073
  • Saven A., Camera C. J., Carson D. A., Beutler E., Piro L. D. 2–Chlorodeoxyadenosine treatment of refractory chronic lymphocytic leukemia. Leukemia and Lymphoma 1991; 5(Suppl.)133–138
  • Juliusson G., Elmhorn-Rosenborg A., Liliemark I. Response to 2–chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. N. Engl. J. Med. 1992; 327: 1056–1061
  • Juliusson G., Liliemark J. High complete remission rate from 2–chloro-2′-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: Response predicted by rapid decrease of blood lymphocyte count. J. Clin. Oncol. 1993; 11: 679–689
  • Kay A. C., Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2–Chlorodeoxyadenosine treatment of low-grade lymphomas. J. Clin. Oncol. 1992; 10: 371–377
  • Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2–Chlorodeoxyadenosine: An active agent in the treatment of cutaneous T-cell lymphoma. Blood 1992; 80: 587–592
  • Kuzel T., Samuelson E., Roenigk H., Trop E., Rosen S. Phase II trial of 2–chlorodeoxyadenosine (2–CdA) for the treatment of mycosis fungoides or the Sezary syndrome (MF-SS). Proc. Am. Soc. Clin. Oncol. 1992; 11: 1089, Abstract
  • Giblett E. R., Anderson J. E., Cohen F., Pollara B., Meuwissen H. J. Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 1972; 2: 1067–1069
  • Cohen A., Hirshhorn R., Horowitz S. D., Rubinstein A., Polmar S. H., Hong R., Martin D. W., Jr. Deox-yadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency. Proc. Natl. Acad. Sci. USA 1978; 75: 472–476
  • Carson D. A., Wasson D. B., Kaye J., Ullman B., Martin D. W., Jr., Robins R. K., et al. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs towards malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc. Natl. Acad. Sci. USA 1980; 77: 6865–6869
  • Carson D. A., Wasson D. B., Taetle R., Yu A. Specific toxicity of 2–chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 1983; 62: 737–743
  • Kawasaki H., Camera C. J., Piro L. D., Saven A., Kipps T. J., Carson D. A. Relationship of deoxycytidine kinase and cytoplasmic 5′-nucleotidase to the chemothera-peutic efficacy of 2–chlorodeoxyadenosine. Blood 1993; 81: 597–601
  • Seto S., Camera C. J., Kubota M., Wasson D. B., Carson D. A. Mechanism of deoxyadenosine and 2–chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 1985; 75: 377–383
  • Seto S., Carrera C. J., Wasson D. B., Carson D. A. Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. J. Immunol. 1986; 136: 2839–2843
  • Camera C. J., Piro L. D., Miller W. E., Carson D. A., Beutler E. Remission induction in hairy cell leukemia by treatment with 2–chlorodeoxyadenosine: Role of DNA strand breaks and NAD depletion. Clin. Res. 1987; 35: 597A, Abstract
  • Carrera C. J., Terai C., Piro L., Saven A., Beutler E., Carson D. 2–chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. J. Purine Pyrimidine Res. 1991; 2(Suppl. l)15–38
  • Bouroncle B. A., Wiseman B. K., Doan C. A. Leukemic reticuloendotheliosis. Blood 1958; 13: 609–630
  • Golomb H. M., Catovsky D., Golde D. W. Hairy cell leukemia: A clinical review of 71 cases. Ann. Intern. Med. 1978; 89: 677–683
  • Mintz U., Golomb H. M. Splenectomy as initial therapy in twenty-six patients with leukemic reticuloendotheliosis (hairy cell leukemia). Cancer Res. 1979; 39: 2366–2370
  • Jansen J., Hermans J. Splenectomy in hairy cell leukemia: A retrospective multicenter analysis. Cancer 1981; 47: 2066–2076
  • Golomb H. M., Ratain M. J. Recent advances in the treatment of hairy-cell leukemia. N. Engl. J. Med. 1987; 316: 870–872
  • Quesada J. R., Reuben J., Manning J. T., Hersh E. M., Gutterman J. U. Alpha-interferon for induction of remission in hairy cell leukemia. N. Engl. J. Med. 1984; 310: 15–18
  • Spiers A. S. D., Moore D., Cassileth P. A., Harrington D. P., Cummings F. J., Neiman R. S., Bennett J. M., O'Connell M. J. Remissions in hairy-cell leukemia with pentostatin (2′-deoxycoformycin). N. Engl. J. Med. 1987; 316: 825–871
  • Saven A., Piro L. D. Treatment of hairy cell leukemia. Blood 1992; 79: 1111–1120
  • Cassileth P. A., Cheuvant B., Spiers A. S. D., Hanington D. P., Cummings F. J., Neiman R. S., Bennett J. M., O'Connell M. J. Pentostatin induces durable remissions in hairy cell leukemia. J. Clin. Oncol. 1991; 9: 243–246
  • Carrtra C. J., Piro L. D., Saven A., Cox K., Beutler E., Carson D. A., Kipps T. J. Restoration of lymphocyte subsets following 2–chlorodeoxyadenosine remission induction in hairy cell leukemia. Blood 1990; 76(Suppl. 1)260a, Abstract
  • Hoffman M., Rai K., Sawitsky A., Janson D. 2–chlorodeoxyadenosine (2–CdA) in hairy cell leukemia. Blood 1991; 78(Suppl. 1)454a, Abstract
  • Saven A., Piro L. D. Complete remissions in hairy cell leukemia with 2–chlorodeoxyadenosine after failure with 2′-deoxycoformycin. Ann. Intern. Med. 1993; 119: 278–283
  • Liliemark J., Albertioni F., Hassan M., Petterson B., Juliusson G. On the bioavailability of oral and subcutaneous 2–chloro-2′-deoxyadenosine in humans: Alternative routes of administration. J. Clin. Oncol. 1992; 10: 1514–1518
  • Liliemark J., Petterson B., Juliusson G. The relationship between plasma 2–chloro-2′-deoxyadenosine (CdA) and cellular CdA nucleotides (CdAn) after intermittent and continuous i.v. infusion in patients with chronic lymphocytic leukemia. Blood 1991; 78(Suppl.)33a, (Abstract)
  • Cheson B. D., Bennett J. M., Rai K. R., Grever M. R., Kay N. E., Schiffer C. A., Oken M. M., Keating M. J., Boldt D. H., Kempin S. J., Foon K. A. Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored Working Group. Am. J. Hematol. 1988; 29: 152–163
  • Saven A., Lemon R. H., Piro L. D. 2–Chlorodeoxyadenosine for patients with B-cell chronic lymphocytic leukemia (letter). N. Engl. J. Med. 1993; 328: 812–813
  • Urba W. J., Baseler M. W., Kopp W. C., Steis R. G., Clark J. W., Smith J. W., II, Coggin D. L., Longo D. L. Deoxycoformycin-induced immunosuppression in patients with hairy cell leukemia. Blood 1989; 73: 38–46
  • Carson D. A., Wasson D. B., Esparza L. M., Carrera C. J., Kipps T. J., Cottam H. B. Oral anti-lympho-cytic activity and induction of apoptosis by 2–chloro-2′arabino-fluoro-2′-deoxyadenosine (CAFdA). Proc. Natl. Acad. Sci. USA 1992; 89: 2910–2974

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.