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Original Article

Immunoglobulin Gene Rearrangement in Plasma Cell Dyscrasias: Detection of Small Clonal Cell Populations in Peripheral Blood and Bone Marrow

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Pages 223-229 | Received 24 Oct 1992, Published online: 01 Jul 2009

References

  • Cleary M. L., Chao J., Warnke R., Sklar J. lmmunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc. Nalt. Acad. Sci. USA 1984; 81: 593–7
  • Anderson K. C., Barut B. A., Ritz J., Freedman A. S., Takvonan T., Rabinowe S. N., Soiffer R., Heflin L., Coral F., Dear K., Mauch P., Nadler L. M. Monoclonal antibody-purged autologous bone marrow transplantation therapy for multiple myeloma. Blood 1991; 77: 712–20
  • Kubagawa H., Vogler L. B., Capra J. D., Conrad M. E., Lawton A. R., Cooper M. D. Studies on the clonal origin of multiple myeloma. J. Exp. Med. 1979; 150: 792–807
  • Caligaris-Cappio F., Bergui L., Tesio L., Pizzolo G., Malavasi F., Chilosi M., Campana D., van Camp B., Janossy G. Identification of malignant plasma cell precursors in the bone marrow of multiple myeloma. J. Clin. Invest. 1985; 76: 1243–51
  • Grogan T. M., Durie B. G. M., Lomen C., Spier C., Wirt D. P., Nagle R., Wilson G. S., Richter L., Vela E., Maxey V., McDaniel K., Rangel C. Delineation of a novel pre-B cell component in plasma cell myeloma: Immunochemical, immuno-phenotypic, genotypic, cytologic, cell culture, and kinetic features. Blood 1987; 70: 93242
  • Epstein J., Barlogie B., Katzmann J., Alexanian J. Phenotypic heterogeneity in aneuploid multiple myeloma indicates pre-B cell involvement. Blood 1988; 71: 861–5
  • Warburton P., Joshua D. E., Gibson J., Brown R. D. CDlO-(CALLA) positive lymphocytes in myeloma: evidence that they are a malignant precursor population and are of germinal Centre origin. Leukemia and Lymphoma 1989; 1: 11–20
  • Mellstedt H., Hammarstrom S., Holm G. Monoclonal lymphocyte population in human plasma cell myeloma. Clin. Exp. Immunol. 1974; 17: 371–84
  • Warner T. F. C. S., Krueger R. G. Circulating lymphocytes and the spread of myeloma. Lancer 1978; 1174–6
  • Gobbi M., Caligaris-Cappio F., Campana D., Tazzari P. L., Bergui L., Cavo M., Tura S. Functional behaviour and immunological phenotype of circulating B lymphocytes in multiple myeloma. Studies with pokeweed mitogen. Clin. Exp. Immunol. 1984; 58: 625–30
  • Pilarski L. M., Mant M. J., Ruether B. A., Belch A. Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients. J. Clin. Invest. 1984; 74: 1301–6
  • King M. A., Nelson D. S. Tumor cell heterogeneity in multiple myeloma: antigenic, morphologic and functional studies of cells from blood and bone marrow. Blood 1989; 73: 1925–35
  • King M. A., Wells J. V. Cell bound immunoglobulin on peripheral blood mononuclear cells of patients with myeloma. Clin. Exp. Immunol. 1981; 45: 552–6
  • Berenson J., Wong R., Kim K., Brown N., Lichtenstein A. Evidence for peripheral blood B lymphocyte and not T lymphocyte involvement in multiple myeloma. Blood 1987; 70: 1550–3
  • Chiu E. K. W., Ganeshaguru K., Hoffbrand A. V., Mehta A. B. Circulating monoclonal B-lymphocytes in multiple myeloma. Brit. J. Haematol 1989; 72: 28–31
  • Van Riet I., Heirman C., Lacor P., De Waele M., Thielemans K., van Camp B. Detection of monoclonal B lymphocytes in bone marrow and peripheral blood of multiple myeloma patients by immunoglobulin gene rearrangement studies. Brit. J. Haematol 1989; 73: 289–95
  • Oster W., Lindemann A., Mertelsmann R., Herrmann F. Minimal peripheral blood cells carrying clonal markers of B cell disorders: Evidence for monoclonality of circulating lymphocytes in patients with multiple myeloma. Int. J. Cell Cloning 1989; 7: 111–9
  • Cassel A., Leibovitz N., Hornstein L., Quitt M., Aghai E. Evidence for the existence of circulating monoclonal B-lymphocytes in multiple myeloma patients. Exp. Haematol 1990; 18: 1171–3
  • Bagg A., Becker P., Bezwoda W., van Rensburg L., Mendelow B. Circulating monotypic B-cells in multiple myeloma: Association with lambda paraproteins. Brit. J. Haematol 1989; 11: 167–72
  • Clofent G., Klein B., Commes T., Ghanem N., Lefranc M. P., Bataille R. No detectable malignant B cells in the peripheral blood of patients with multiple myeloma. Brit. J. Haematol 1989; 71: 357–61
  • Baldini L., Cro L., Delia D., Chiorboli O., Neri A., Maiolo A. T. Analysis of tumor-specific immunoglobulin gene rearrangement in peripheral blood B-cells of multiple myeloma patients. Am. J. Hematol 1991; 37: 1–5
  • Durie B. G. M., Salmon S. E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer 1975; 36: 842–54
  • Lichtman M. A. Essential and secondary monoclonal gammopathies. Hematology, W. J. Williams, E. Beutler, A. J. Erslev, M. A. Lichtman. McGraw-Hill Inc, New York 1990; 1109–14
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1989
  • Griinewald K., Lyons J., Hansen-Hagge T. E., Janssen J. W. G., Feichtinger H., Bartram C. R. Molecular genetic analysis of DNA obtained from fixed, air dried or paraffin embedded sources. Ann. Hematol 1991; 62: 108–14
  • Bakhshi A., Minowada J., Arnold A., Cossman J., Jensen J. P., Whang-Peng J., Waldmann T. A., Korsmeyer S. J. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. N. Engl J. Med. 1983; 309: 826–31
  • Feinberg A. B., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 1984; 137: 266–7
  • Boehm T., Baer R., Lavenir I., Forster A., Waters J. J., Nacheva E., Rabbitts T. H. The mechanism of chromosomal translocation t(ll;14) involving the T-cell receptor C<5 on human chromosome 14qll and a transcribed region of chromosome llpl5. EMBO J 1988; 7: 385–94
  • Selvanayagam P., Blick M., Narni F., van Tuinen P., Ledbetter D. H., Alexanian R., Saunders G. F., Barlogie B. Alteration and abnormal expression of the c-myc oncogene in human multiple myeloma. Blood 1988; 71: 30–5
  • Zaccaria A., Tassinari A., Saglio G., Guerrasio A., Tura S. Immunoglobulin gene rearrangements in multiple myeloma. Brit. J. Haematol 1989; 73: 425
  • Humphries J. E., Dressman H. K., Williams M. E. Immunoglobulin gene rearrangement in multiple myeloma: limitations of Southern blot analysis. Hum. Pathol 1991; 22: 966–71
  • Fey M. F., Pilkington S. P., Summers C., Wainscoat J. S. Molecular diagnosis of haematological disorders using DNA from stored bone marrow slides. Brit. J. Haematol 1987; 67: 489–92
  • Bartl R., Frisch B., Fateh-Moghadam A., Kettner G., Jaeger K., Sommerfeld W. Histologic classification and staging of multiple myeloma. A retrospective and prospective study of 674 cases. Am. J. Clin. Pathol 1987; 87: 342–55
  • Berenson J. R., Lichtenstein A. K. Clonal rearrangement of immunoglobulin genes in the peripheral blood of multiple myeloma patients. Brit. J. Haematol 1989; 73: 425–7
  • Ruiz-Argiielles G. J., Katzmann J. A., Greipp P. R., Gonchoroft N. J., Garton J. P., Kyle R. A. Multiple myeloma: circulating lymphocytes that express plasma cell antigens. Blood 1984; 64: 352–6
  • Omede P., Boccadoro M., Gallone G., Frieri R., Battaglio S., Redoglia V., Pileri A. Multiple myeloma: increased circulating lymphocytes carrying plasma cell-associated antigens as indicators of poor survival. Blood 1990; 76: 1375–9
  • Clofent G., Klein B., Commes T., Vincent C., Ghanem N., Lenoir G., Lefranc M. P., Bataille R. Limiting dilution cloning of B cells from patients with multiple myeloma: emergence of non-malignant B-cell lines. Int. J. Cancer 1989; 43: 578–86
  • Wright J. J., Poplack D. G., Bakhshi A., Reaman G., Cole D., Jensen J. P., Korsmeyer S. J. Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia. J. Clin. Oncol 1987; 5: 735–11
  • Kyle R. A. “Benign” monoclonal gammopathy. A misnomer?. Am. J. Med. 1984; 251: 1849–54
  • Radl J. Age-related monoclonal gammopathies: clinical lessons from the aging C56BL mouse. Immunol Today 1990; 11: 234–6
  • Morell A., Maurer W., Skavril F., Barandun S. Differentiation between benign and malignant monoclonal gammopathies by discriminant analysis on serum and bone marrow parameters. Acta Haematol-Basel 1978; 60: 129–36
  • Greipp P. R., Kyle R. A. Clinical, morphological, and cell kinetic differences among multiple myeloma, monoclonal gammopathy of undetermined significance, and smouldering multiple myeloma. Blood 1983; 62: 166–71

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