Interleukin-4—a Dual Regulatory Factor in Hematopoiesis

References

• Metcalf D. The molecular control of cell division, differentiation commitment and maturation in haematopoietic cells. Nature 1989; 339: 27–30
   PubMed Web of Science ®Google Scholar
• Clark S. C., Kamen R. The human hematopoietic colony-stimulating factors. Science 1987; 236: 1229–1237
   PubMed Web of Science ®Google Scholar
• Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993; 81: 2844–2853
   PubMed Web of Science ®Google Scholar
• Sonoda Y., Yang Y.-C, Wong G. G., Clark S. C., Ogawa M. Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: In-terleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages. Proc. Natl. Acad. Sci. USA 1988; 85: 4360–4364
   PubMed Web of Science ®Google Scholar
• Sonoda Y., Arai N., Ogawa M. Humoral regulation of eosinophilopoiesis in vitro: Analysis of the targets of interleukin-3, granulocyte/macrophage colony-stimulating factor (GM-CSF), and interleukin-5. Leukemia 1989; 3: 14–18
   PubMed Web of Science ®Google Scholar
• Bischoff S. C., Week A. L. D., Dahinden C. A. lnterleukin-3 and granulocyte/macrophage-colony-stimulating factor render human basophils responsive to low concentration of complement component C3a. Proc. Natl. Acad. Sci. USA 1990; 87: 6813–6817
   PubMed Web of Science ®Google Scholar
• Ashman R. I., Jarboe D. L., Conrad D. H., Huff T. F. The mast cell-committed progenitor. J. Immunol. 1991; 146: 211–216
   PubMed Web of Science ®Google Scholar
• Howard M., Farrar J., Hilfiker M., Johnson B., Takatsu K., Hamaoka T., Paul W. E. Identification of a T cell-derived B cell growth factor distinct from interleukin-2. J. Exp. Med. 1982; 155: 914–923
   PubMed Web of Science ®Google Scholar
• Rabin E. M., Ohara J., Paul W. E. B-cell stimulatory factor 1 activates resting B cells. Proc. Natl. Acad. Sci. USA 1985; 82: 2935–2939
   PubMed Web of Science ®Google Scholar
• Lee F., Yokota T., Otsuka T., Meyrson P., Villaret D., Coffman R., Mosmann T., Rennick D., Roehm N., Smith C., Zlotnik A., Arai K. Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc. Natl. Acad. Sci. USA 1986; 83: 2061–2065
   PubMed Web of Science ®Google Scholar
• Noma Y., Sideras P., Naito T., Bergstedt-Lindquist S., Azuma C., Severinson E., Tanabe T., Kinashi T., Matsuda F., Yaoita Y., Honjo T. Cloning of cDNA encoding the murine IgGl induction factor by a novel strategy using SP6 promoter. Nature 1986; 319: 640–646
   PubMed Web of Science ®Google Scholar
• Yokota T., Otsuka T., Mosmann T., Banchereau J., De France T., Blanchard D., Vries J. E. D., Lee F., Arai K. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. USA 1986; 83: 5894–5898
   PubMed Web of Science ®Google Scholar
• Ohara J., Paul W. E. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 1987; 325: 537–540
   PubMed Web of Science ®Google Scholar
• Lowenthal J. W., Castle B. E., Christiansen J., Schreurs J., Rennick D., Arai N., Hoy P., Takebe Y., Howard M. Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hematopoietic and nonhematopoietic cells. J. Immunol. 1988; 140: 456–464
   PubMed Web of Science ®Google Scholar
• Hamaguchi Y., Kanakura Y., Fujita J., Takeda S., Nak-Ano T, Tarui S., Honjo T., Kitamura Y. Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells. J. Exp. Med. 1987; 165: 268–273
   PubMed Web of Science ®Google Scholar
• Peschel C., Paul W. E., Ohara J., Green I. Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells. Blood 1987; 70: 254–263
   PubMed Web of Science ®Google Scholar
• Sonoda Y., Okuda T., Yokota S., Maekawa T., Shizumi Y., Nishigaki H., Misawa S., Fujii H., Abe T. Actions of human interleukin-4/B-cell stimulatory factor-1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture. Blood 1990; 75: 1615–1621
   PubMed Web of Science ®Google Scholar
• Sonoda Y., Kuzuyama Y., Tanaka S., Yokota S., Maekawa T., Clark S. C., Abe T. Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture. Blood 1993; 81: 624–630
   PubMed Web of Science ®Google Scholar
• Rennick D., Yang G., Muller-Sieburg C., Smith C., Arai N., Takabe Y., Gemmell L. Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells. Proc. Natl. Acad. Sci. USA 1987; 84: 6889–6893
   PubMed Web of Science ®Google Scholar
• Broxmeyer H. E., Lu L., Cooper S., Tushinski R., Mochizuki D., Rubin B. Y., Gillis S., Williams D. E. Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. J. Immunol. 1988; 141: 3852–3862
   PubMed Web of Science ®Google Scholar
• London L., McKearn J. P. The dual regulatory role of interleukin 4 is mediated through a direct effect on the target cell. Exp. Hematol. 1990; 18: 1059–1063
   PubMed Web of Science ®Google Scholar
• Vellenga E., de Wolf J. T. M., Beentjes J. A. M., Esselink M. T., Smit J. W., Halie R. Divergent effects of interleukin-4 (IL-4) on the granulocyte colony-stimulating factor and IL-3-supported myeloid colony formation from normal and leukemic bone marrow cells. Blood 1990; 75: 633–637
   PubMed Web of Science ®Google Scholar
• Migliaccio A. R., Migliaccio G., Shimada Y., Adamson J. W. Direct effects of IL-4 on the in vitro differentiation and proliferation of hematopoietic progenitor cells. Biotechnol. Therap. 1989-1990; 1: 347–360
   PubMedGoogle Scholar
• Snooeck H.-W., Lardon F. L., Bockstaele D. R. V., Peetermans M. E. Effects of interleukin-4 (IL-4) on myelopoiesis: Studies on highly purified CD34+ hematopoietic progenitor cells. Leukemia 1993; 7: 625–629
   PubMed Web of Science ®Google Scholar
• Snoeck H.-W., Lardon F., Bockstaele D. R. V., Peetermans M. E. Effects of interleukin-4 on myelopoiesis: Localization of the action of IL-4 in the CD34+HLA-DR++ subset and distinction between direct and indirect effects of IL-4. Exp. Hematol., 21: 635–639
   PubMed Web of Science ®Google Scholar
• Jansen J. H., Wientjens G.-J. H. M., Fibbe W. E., Willemze R., Kluin-Nelemans H. C. Inhibition of human macrophage colony formation by interleukin 4. J. Exp. Med. 1989; 170: 577–582
   PubMed Web of Science ®Google Scholar
• Snoeck H.-W., Lardon F., Lenjou M., Nys G., Bockstaele D. R. V., Peetermans M. E. Interferon-and interleukin-4 reciprocally regulate the production of monocyte/macrophages and neutrophils through a direct effect on committed monopotential bone marrow progenitor cells. Eur. J. Immunol. 1993; 23: 1072–1077
   PubMed Web of Science ®Google Scholar
• Akashi K. The role of interleukin-4 in the negative regulation of leukemia cell growth. Leukemia and Lymphoma 1993; 9: 205–209
   PubMed Web of Science ®Google Scholar
• Caux C., Favre C., Saeland S., Duvert V., Mannoni P., Durand I., Aubry J.-P., de Vries J. E. Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3: Characterization of CD34−, HLA-DR+ cells. Blood 1989; 74: 1287–1294
   PubMed Web of Science ®Google Scholar
• De Wolf J. T. M., Hendriks D. W., Beentjes J. A. M., Esselink M. T., Smit J. W., Halie M. R., Vellenga E. Erythroid progenitors in polycythemia vera demonstrate a different response pattern to IL-4 compared to the normal BFU-E from peripheral blood. Exp. Hematol. 1991; 19: 888–892
   PubMed Web of Science ®Google Scholar
• De Wolf J. T. M., Beentjes J. A. M., Esselink M. T., Smit J. W., Halie M. R., Vellenga E. Interleukin-4 suppresses the interleukin-3 dependent erythroid colony formation from normal human bone marrow cells. Br. J. Haematol. 1990; 74: 246–250
   PubMed Web of Science ®Google Scholar
• Ishibashi T., Kimura H., Uchida T., Kariyone S., Friese P., Burstein S. A. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc. Natl. Acad. Sci. USA 1989; 86: 5953–5957
   PubMed Web of Science ®Google Scholar
• Paul S. R., Bennett F., Calvetti J. A., Kelleher K., Wood C. R., O'Hara R M, Jr., Leary A. C., Sibley B., Clark S. C., Williams D. A., Yang Y.-C. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 1990; 87: 7512–7516
   PubMed Web of Science ®Google Scholar
• Teramura M., Kobayashi S., Hoshino S., Oshimi K., Mizoguchi H. Interleukin-11 enhances human megakaryocytopoiesis in vitro. Blood 1992; 79: 327–331
   PubMed Web of Science ®Google Scholar
• Ikebuchi K., Wong G. G., Clark S. C., Ihle J. N., Hirai Y., Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA 1987; 84: 9035–9039
   PubMed Web of Science ®Google Scholar
• Musashi M., Yand Y.-C, Paul S. R., Clark S. C., Sudo T., Ogawa M. Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture. Proc. Natl. Acad. Sci. USA 1991; 88: 765–769
   PubMed Web of Science ®Google Scholar
• Ishibashi T., Miller S. L., Burstein S. A. Type β transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro. Blood 1987; 69: 1737–1741
   PubMed Web of Science ®Google Scholar
• Backy B., Breeders L., Bot F. J., Lowenberg B. Positive and negative effects of tumor necrosis factor on colony growth from highly purified normal marrow progenitors. Leukemia 1991; 5: 66–70
   PubMed Web of Science ®Google Scholar
• Murphy M., Pemssia B., Trinchieri G. Effects of recombinant tumor necrosis factor, lymphotoxin, and immune interferon on proliferation and differentiation of enriched hematopoietic precursor cells. Exp. Hematol. 1988; 16: 131–138
   PubMed Web of Science ®Google Scholar
• Ganser A., Carlo-Stella C., Greher J., Volkers B., Hoelzer D. Effects of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocyte progenitor cells. Blood 1987; 70: 1173–1179
   PubMed Web of Science ®Google Scholar
• Carlo-Stella C., Cazzola M., Ganser A., Bergamaschi G., Pedrazzoli P., Hoelzer D., Ascari E. Synergistic antiproliferative effect of recombinant interferon-γ with recombinant interferon-α on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM). Blood 1988; 72: 1293–1299
   PubMed Web of Science ®Google Scholar
• Bruno E., Miller M. E., Hoffman R. Interacting cytokines regulate in vitro human megakaryocytopoiesis. Blood 1989; 73: 671–677
   PubMed Web of Science ®Google Scholar
• Briddle R. A., Hoffman R. Cytokine regulation of the human burst-forming unit-megakaryocyte. Blood 1990; 76: 516–522
   PubMed Web of Science ®Google Scholar
• Kishi K., Ihle J. N., Urdal D. L., Ogawa M. Murine B-cell stimulatory factor-1 (BSF-1)/interleukin-4 (IL-4) is a multilineage colony-stimulating factor that acts directly on primitive hemopoietic progenitors. J. Cell. Physiol. 1989; 139: 463–468
   PubMed Web of Science ®Google Scholar
• Musashi M., Clark S. C., Sudo T., Urdal D. L., Ogawa M. Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice. Blood 1991; 78: 1448–1451
   PubMed Web of Science ®Google Scholar
• Ikebuchi K., Clark S. C., Ihle J. N., Souza L. M., Ogawa M. Granulocyte colony-stimulating factor enhances interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA 1988; 85: 3445–3449
   PubMed Web of Science ®Google Scholar
• Mosmann T. R., Bond M. W., Coffman R. L., Ohara J., Paul W. E. T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc. Natl. Acad. Sci. USA 1986; 83: 5654–5658
   PubMed Web of Science ®Google Scholar
• Kitamura Y., Yokoyama Y., Matsuda H., Ohno T. Spleen colony-forming cell as common precursor for tissue mast cells and granulocytes. Nature 1981; 291: 159–160
   PubMed Web of Science ®Google Scholar
• Nakano T., Sonoda T., Hayashi A., Yamatodani Y., Kanayama T., Yamamura H., Asai T., Yonezawa Y., Kitamura Y., Galli S. J. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/W” mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J. Exp. Med. 1985; 162: 1025–1043
   PubMed Web of Science ®Google Scholar
• Nakahata T., Kobayashi T., Ishiguro A., Tsuji K., Naganuma K., Ando O., Yagi Y., Tadokoro K., Akabane T. Extensive proliferation of mature connective tissue-type mast cells in vitro. Nature 1986; 324: 65–67
   PubMed Web of Science ®Google Scholar
• Tsuji K., Nakahata T., Takagi M., Kobayashi T., Ishiguro A., Kikuchi T., Naganuma K., Koike K., Miyajima A., Arai K., Akabane T. Effects of interleukin-3 and interleukin-4 on the development of “connective tissue-type” mast cells: Interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3. Blood 1990; 75: 421–427
   PubMed Web of Science ®Google Scholar
• Kirshenbaum A. S., Kessler S. W., Goff J. P., Metcalfe D. D. Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells. J. Immunol. 1991; 146: 1410–1415
   PubMed Web of Science ®Google Scholar
• Favre C., Saeland S., Caux C., Duvert V., De Vries J. E. Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells. Blood 1990; 75: 67–73
   PubMed Web of Science ®Google Scholar
• Smeland E. B., Blomhoff H. K., Funderud S., Shalaby M. R., Espevik T. Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes. J. Exp. Med. 1989; 170: 1463–1468
   PubMed Web of Science ®Google Scholar
• Wiesser M., Bonifer R., Oster W., Lindemann A., Mertelsmann R., Herrmann F. Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes. Blood 1989; 73: 1105–1108
   PubMed Web of Science ®Google Scholar
• Vellenga E., Dokter W., De Wolf J. T. M., De Vinne B. V., Esselink M. T., Halie M. R. Interleukin-4 prevents the induction of G-CSF mRNA in human adherent monocytes in response to endotoxin and IL-1 stimulation. Br. J. Haematol. 1991; 79: 22–26
   PubMed Web of Science ®Google Scholar
• Brantschen S., Gauchat J.-E., De Week A. L., Stadler B. M. Regulatory effect of recombinant interleukin (IL)3 and IL4 on cytokine gene expression of bone marrow and peripheral blood mononuclear cells. Eur. J. Immunol. 1989; 19: 2017–2023
   PubMed Web of Science ®Google Scholar
• Essner R., Rhoades K., McBride W. H., Morton D. L., Economou J. S. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J. Immunol. 1989; 142: 3857–3861
   PubMed Web of Science ®Google Scholar
• Peleman R., Wu J., Fargeas C., Delespesse G. Recombinant interleukin 4 suppresses the production of interferon by human mononuclear cells. J. Exp. Med. 1989; 170: 1751–1756
   PubMed Web of Science ®Google Scholar
• Orino E., Sone S., Nii A., Ogura T. IL-4 up-regulates IL-1 receptor antagonist gene expression and its production in human blood monocytes. J. Immunol. 1992; 149: 925–931
   PubMed Web of Science ®Google Scholar
• Standiford T. J., Strieter R. M., Chensue S. W., West-Wick J, Kasahara K., Kunkel S. L. IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J. Immunol. 1990; 145: 1435–1439
   PubMed Web of Science ®Google Scholar
• Yarden Y., Kuang W.-J., Yang-Feng T., Coussens L., Munemitsu S., Dull T. J., Chen E., Schlessinger J., Francke U., Ullrich A. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987; 6: 3341–3351
   PubMed Web of Science ®Google Scholar
• Chabot B., Stephenson D. A., Chapman V. M., Besmer P., Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988; 335: 88–89
   PubMed Web of Science ®Google Scholar
• Ogawa M., Matsuzaki Y., Nishikawa S., Hayashi S., Kunisada T., Sudo T., Kina T., Nakauchi H., Nishikawa S. Expression and function of c-kit in hemopoietic progenitor cells. J. Exp. Med. 1991; 174: 63–71
   PubMed Web of Science ®Google Scholar
• Sillaber C., Strobl H., Bevec D., Ashman L. K., Butter-Field J H, Lechner K., Maurer D., Bettelheim P., Valent P. IL-4 regulates c-kit proto-oncogene product expression in human mast and myeloid progenitor cells. J. Immunol. 1991; 147: 4224–4228
   PubMed Web of Science ®Google Scholar
• Rennick D., Yang G., Gemmell L., Lee F. Control of hemopoiesis by a bone marrow stromal cell clone: Lipopolysaccharide- and interleukin-1 -inducible production of colony-stimulating factors. Blood 1987; 69: 682–691
   PubMed Web of Science ®Google Scholar
• Lipschitz D. A., Udupa K. B., Taylor J. M., Shadduck R. K., Waheed A. Role of colony-stimulating factor in myelopoiesis in murine long-term bone marrow cultures. Blood 1987; 69: 1211–1217
   PubMed Web of Science ®Google Scholar
• Alberico T. A., Ihle J. N., Liang C. M., McGrath H. E., Quesenberry P. J. Stroma growth factor production in irradiated lectin exposed long-term murine bone marrow cultures. Blood 1987; 69: 1120–1127
   PubMed Web of Science ®Google Scholar
• Aggarwal B. B., Eessalu T. E., Hass P. H. Characterization of receptors for human tumor necrosis factor and their regulation by gamma-interferon. Nature 1985; 318: 665–667
   PubMed Web of Science ®Google Scholar
• Peschel C., Green I., Paul W. E. Interleukin-4 induces a substance in bone marrow stromal cells that reversibly inhibits factor-dependent and factor-independent cell proliferation. Blood 1989; 73: 1130–1141
   PubMed Web of Science ®Google Scholar
• Ogo T., Otsuka T., Satoh H., Chifu Y., Nakano T., Niho Y. Effects of interleukin 4 on stromal cell-associated bone marrow culture. Exp. Hematol. 1991; 19: 899–904
   PubMed Web of Science ®Google Scholar
• Kuhn R., Rajewsky K., Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991; 254: 707–710
   PubMed Web of Science ®Google Scholar
• Sullivan L. M., Bober L. A., Grace M. J., Braun S., Macosko H. D., Payvandi F., Sivo C. C., Narula S. K. The in vivo biological activity of murine IL-4 and the role of endogenous cytokines. J. Cell. Biochem. 1992; 16C(Suppl.)103
   Google Scholar
• Lewis D. B., Prickett K. S., Larsen A., Grabstein K., Weaver M., Wilson C. B. Restricted production of interleukin 4 by activated human T cells. Proc. Natl. Acad. Set. USA 1988; 85: 9743–9747
   PubMed Web of Science ®Google Scholar
• Moore M. A. S. Clinical implications of positive and negative hematopoietic stem cell regulators. Blood 1991; 78: 1–19
   PubMed Web of Science ®Google Scholar
• Testa U., Pelosi E., Gabbianelli M., Fossati C., Campisi S., Isacchi G., Peschle C. Cascade transactivation of growth factor receptors in early human hematopoiesis. Blood 1993; 81: 1442–1456
   PubMed Web of Science ®Google Scholar
• Wang L.-M., Keegan A. D., Paul W. E., Heidaran M. A., Gutkind J. S., Pierce J. H. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBOJ. 1992; 11: 4899–4908
   PubMed Web of Science ®Google Scholar