11
Views
21
CrossRef citations to date
0
Altmetric
Original Article

The 5q- Syndrome: a Scientific and Clinical Update

, &
Pages 375-378 | Received 31 Aug 1993, Published online: 01 Jul 2009

References

  • Noël P., Solberg L. A., Jr. Myelodysplastic syndromes: Pathogenesis, diagnosis and treatment. Crit. Rev. Oncol./Hematol. 1992; 12: 193–215
  • Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C., The French-American-British Co-operative Group. Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol. 1982; 51: 189–199
  • van den Berghe H., Cassiman J.-J., David G., Fryns J.-P., Michaux J.-L., Sokal G. Distinct haema-tological disorder with deletion of long arm of no. 5 chromosome. Nature 1974; 251: 437–438
  • Sokal G., Michaux J. L., Van Den Berghe H., Cordier A., Rodhain J., Ferrant A., Moriau M., De Bruyere M., Sonnet J. A new hematological syndrome with a distinct karyotype: the 5q- chromosome. Blood 1975; 46: 519–533
  • Jenkins R. B., Tefferi A., Solberg L. A., Jr., Dewald G. W. Acute leukemia with abnormal thrombopoiesis and inversions of chromosome 3. Cancer Genet. Cytogenet. 1989; 39: 167–179
  • Dewald G. W., Davis M. P., Pierre R. V., O'Fallon J. R., Hoagland H. C. Clinical characteristics and prognosis of 50 patients with a myeloproliferative syndrome and deletion of part of the long arm of chromosome 5. Blood 1985; 66: 189–197
  • Teerenhovi L. Specificity of haematological indicators for “5q- syndrome” in patients with myelodysplastic syndromes. Eur. J. Haematol. 1987; 39: 326–330
  • Berger R., Bernheim A., Daniel M. T., Valensi F., Flandrin G. Leucemies “induites”: Aspects cy-togenetique et cytologique. Comparison avec des leucemies primitives. Nouv. Rev. Francaise D Hematol. 1981; 23: 275–284
  • Nimer S. D., Golde D. W. The 5q- abnormality. Blood 1987; 70: 1705–1712
  • Mathew P., Tefferi A., Dewald G. W., Goldberg S. L., Su J., Hoagland H. C., Noel P. The 5q- syndrome: a single-institution study of 43 consecutive patients. Blood 1993; 81: 1040–1045
  • Le Beau M. M. Deletions of chromosome 5 in malignant myeloid disorders. Cancer Surv. 1992; 15: 143–159
  • Thangavelu M., Neuman W. L., Espinosa R., III, Naka-Mura Y., Westbrook C. A., Le Beau M. M. A physical and genetic linkage map of the distal long arm of human chromosome 5. Cytogenet. Cell Genet. 1992; 59: 27–30
  • Van den Berghe H., Vermaelen K., Mecucci C., Barbieri D., Tricot G. The 5q- anomaly. Cancer Genet. Cytogenet. 1985; 17: 189–255
  • Willman C. L., Sever C. E., Pallavicini M. G., Harada H., Tanaka M., Slovak M. L., Yamamoto H., Harada K., Meeker T. C., List A. F., Taniguchi T. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 1993; 259: 968–971
  • Pettenati M. J., Le Beau M. M., Lemons R. S., Shima E. A., Kawasaki E. S., Larson R. A., Sherr C. J., Diaz M. O., Rowley J. D. Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc. Natl. Acad. Sci. USA 1987; 84: 2970–2974
  • Wasmuth J. J., Bishop D. T., Westbrook C. A. Report of the Committee on the Genetic Constitution of Chromosome 5. Cytogenet. Cell Genet. 1991; 58: 261–294
  • Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada K., Ishihara M., Taniguchi T. Anti-onco-genic and oncogenic potentials of interferon regulatory factors -1 and -2. Science 1993; 259: 971–974
  • Boultwood J., Rack K., Kelly S., Madden J., Sakaguchi A. Y., Wang L.-M., Oscier D. G., Buckle V. J., Wainscoat J. S. Loss of both CSFIR(FMS alleles in patients with myelodysplasia and a chromosome 5 deletion. Proc. Natl. Acad. Sci. USA 1991; 88: 6176–6180
  • Boultwood J., Rack K., Buckle V. J., Kelly S., Madden J., Oscier D. G., Wainscoat J. S. Homozygous deletion of FMS in a patient with the 5q- syndrome. Br. J. Haematol. 1990; 76: 310–311
  • Bartram C. R., Bohlke J. V., Adolph S., Hameister H., Ganser A., Anger B., Heisterkamp N., Groffen J. Deletion of c-fms sequences in the 5q- syndrome. Leukemia 1987; 1: 146–149
  • Tanaka K., Oshimura M., Kikuchi R., Seki M., Hayashi T., Miyaki M. Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18. Nature 1991; 349: 340–342
  • Carbonell F., Heimpel H., Kubanek B., Fliedner T. M. Growth and cytogenetic characteristics of bone marrow colonies from patients with 5q- syndrome. Blood 1985; 66: 463–465
  • Conneally E., Sherrington P., Fischer P., Lawlor E., Mc Cann S. R. 5q- syndrome: complete response to chemotherapy. Clin. Lab. Haematol. 1990; 12: 101–103
  • Stuart R. K., Mangan K. F. Hematologic and cytogenetic remission of 5q- refractory anemia after syngeneic bone marrow transplantation. Am. J. Med. 1986; 80: 503–507

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.