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Original Article

Persistent Clonal Expansions of CD3+TCRγδ+ and CD3+TCRαβ+CD4CD8 Lymphocytes Associated with Neutropenia

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Pages 429-440 | Received 02 Dec 1993, Published online: 01 Jul 2009

References

  • Richards S. J., Scott C. S. Human NK cells in health and disease: Clinical, functional, phenotypic and DNA genotypic characteristics. Leukemia and Lymphoma 1992; 7: 377–399
  • Richards S. J., Sivakumaran M., Parapia L. A., Balfour I., Norfolk D. R., Kaeda J., Scott C. S. A distinct large granular lymphocyte (LGL)/NK-associated (NKa) abnormality characterized by membrane CD4 and CD8 coexpression. Br. J. Haematol. 1992; 82: 494–501
  • Scott C. S., Richards S. I. Classification of large granular lymphocyte (LGL) and NK-associated (NKa) disorders. Blood Rev. 1992; 6: 220–233
  • Scott C. S., Richards S. J., Sivakumaran M., Short M., Child J. A., Hunt K. M., McEvoy M. W., Steed A. J., Balfour I. C., Parapia L. A., McVerry B. A., Bynoe A. G., Galvin M. C., Norfolk D. R., Roberts B. E. Transient and persistent expansions of large granular lymphocytes (LGL) and NK-associated (NKa) cells: The Yorkshire Leukaemia Group study. Br. J. Haematol. 1993; 83: 504–515
  • Wagner L., Base W., Wiesholzer M., Sexl V., Bognar H., Worman C. P. Detection of BLT substrate-specific proteases in individual human peripheral blood leucocytes and bone marrow cells: Application to the classification of leukaemia. J. Immunol. Meth. 1991; 142: 147–155
  • Richards S. J., Scott C. S. Immunophenotypic dissection of normal peripheral blood NK associated (NKa) subpopulations by flow cytometry: Morphological features and relationships between membrane NKa (CDI lb. CD16, CD56 and CD57) and T-cell (CD2. CD3, TCR, CD5, CD7, CD8 and CD38) associated determinant expression. Leukemia and Lymphoma 1990; 2: 111–126
  • Scott C. S., Richards S. J., Roberts B. E. Patterns of membrane TcRαβ and TcRγδ chain expression by normal blood CD4+CD8-, CD4-CD8 +. CD4-CD8dim + and CD4-CD8- lymphocytes. Immunology 1990; 70: 351–356
  • Kung P. T cell antigen receptor antibodies. Nature 1987; 330: 501–502
  • Brenner M. B., McLean J., Dialynis B. P., Strominger J. L., Smith J. A., Owen F. L., Seidman J. G., Ip F., Krangel M. S. Identification of a putative second T cell receptor. Nature 1986; 322: 145–149
  • Raulet D. H. Antigens for γy/β T cells. Nature 1989; 339: 342–343
  • Kyoizumi S., Akiyama M., Hirai Y., Kusunoki Y. Isolation and characterization of human peripheral blood CD4+ T cell clones expressing γδ T cell receptors. Immunol. Lett. 1991; 29: 197–204
  • Morikawa K., Oseko F., Hara J., Kobayashi S., Nakano A., Morikawa S. Functional analysis of clonally expanded CD8, TCRγδ T cells in a patient with chronic T-gamma lymphoproliferative disease. Leuk. Res. 1990; 14: 581–592
  • Koning F., Stingl G., Yokoyama W. M., Yamada H., Maloy W. L., Tschachler E., Shevack E. M., Coligan J. E. Identification of a T3-associated γδ T cell receptor on Thy-1+ dendritic epidermal cell lines. Science 1987; 326: 834–837
  • Stingl G., Koning F., Yamada H., Yokoyama W. M., Tschachler E., Bluestone J. A., Steiner G., Samuelson L. E., Lew A. M., Colligan J. E., Shevach E. M. Thy-1 + dendritic epidermal cells express T3 antigen and the T-cell receptor y chain. Proc. Natl. Acad. Set. USA 1987; 84: 4586–4589
  • Goodman T., Lefrancois L. Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 1988; 333: 855
  • Bonneville M., Janeway C. A., Ito K., Haser W., Ishida I., Nakanishi N., Tonegawa S. Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 1988; 336: 479–481
  • Brandtzaeg P., Halstensen T. D., Scott H., Sollid L. M., Valnes K., Bosnes V., Bucy R. P., Vroom T. M., Bos J. D., Borst J., Janeway C. A. Epithelial homing of γδ T cells?. Nature 1989; 341: 113–114
  • Bucy R. P., Chen C.-L. H., Cooper M. D. Tissue localization of CDS accessory molecule expression of Tγδ cells in humans. J. Immunol. 1989; 142.: 3045–3049
  • Spencer J., Isaacson P. G., Janeway C. A. Human T-cell receptor expression. Nature 1989; 337: 416
  • Spencer J., MacDonald T. T., Diss T. C., Walker-Smith J. A., Ciclitira P. J., Isaacson P. G. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 1989; 30: 339–346
  • Hochstenbach F., Brenner M. B. Newly identified γδ and βδ T-cell receptors. J. Clin. Immunol. 1990; 10: 1–18
  • Ferrini S., Zarcone D., Viale M., Cerruti G., Millo R., Moretta A., Grossi C. E. Morphologic and functional characterization of human peripheral blood T cells expressing the T cell receptor γ/δ. Eur. J. Immunol. 1989; 19: 1183–1188
  • Harboe M., Quayle J. Heat shock proteins: friend and foe?. Clin. Exp. Immunol. 1991; 86: 2–5
  • Doherty P. C. The function of γδ T cells. Br. J. Haematol. 1992; 81: 321–324
  • Brennan F. M.M., Jackson A. M., Hercend T., Brenner M. B., Maimi R. N., Feldmann M. T cells expressing γδ chain receptors in rheumatoid arthritis. J. Autoimmunol. 1988; 1: 319–326
  • Holshitz J., Koning F., Coligan J. E., de Bruyn J., Strober S. Isolation of CD4-CD8- mycobacteria-re-active T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 1989; 339: 226–229
  • Kjeldson-Kragh J., Quayle A., Kalvenes C., Foore O., Sorskaar D., Vinje O., Thoen J., Natvig J. N. Tγδ T cells in juvenile rheumatoid arthritis and rheumatoid arthritis. Scand. J. Immunol. 1990; 32: 651–660
  • Smith J. D., Broker B., Moretta L., Ciccone E., Grossi C. E., Edwards J. C. W., Yuksel F., Colaco B., Worman C., MacKenzie L., Kline R., Weseloh G., Gluckert K., Lydyard P. M. Tγδ cells and their subsets in blood and synovial tissue from rheumatoid arthritis patients. Scand. J. Immunol. 1990; 32: 585–593
  • Augustin A., Kubo R. T., Sim G.-K. Resident pulmonary lymphocytes expressing the γ/δ T-cell receptor. Nature 1989; 340: 239–241
  • Uyemura K., Band H., Ohmen J., Brenner M. B., Rea T. H., Modlin R. L. γδ T cells in leprosy lesions. Curr. Top. Microbiol. Immunol. 1991; 173: 41–46
  • Selmaj K., Brownan C. F., Raine C. S. Colo-calisation of lymphocytes bearing γδ T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. USA 1991; 88: 6452–6456
  • Suzuki Y., Hoshi K., Matsuda T., Mizushima Y. Increased peripheral blood γδ+ T cells and Natural Killer cells in Behcets disease. J. Rheumatol. 1992; 19: 588–592
  • Ikushima S., Hibi S., Kataoka Y., Fujita N., Ima-Shuku S. Increase of gamma/delta T cells in a case of typhoid fever. Br. J. Haematol. 1993; 83: 177–178
  • Holcombe R. F., van de Griend R., Ang S.-L., Bolhuis R. L. H., Seidman J. G. Gamma-delta T cells in Chediak-Higashi syndrome. Acta Haematol. 1990; 83: 193–197
  • Balbi B., Moller D. R., Kurby M., Holroyd K. J., Crystal R. G. Increased numbers of T lymphocytes with γδ-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis. J. Clin. Invest. 1990; 85: 1353–1361
  • Carbonari M., Cherchi M., Paganelli R., Giannini G., Galli E., Gaetano C., Papetti C., Fiorilli M. Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-telangiectasis. A'. Engl. J. Med. 1990; 322: 73–76
  • Hara T., Mizuno Y., Nagata M., Okabe Y., Taniguchi S., Harada M., Niho Y., Oshimi K., Ohga S., Yoshikai Y., Nomoto K., Yumura K., Kawa-Ha K., Ueda K. Human γδ T-cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune postglandular syndrome and pure red cell aplasia. Blood 1990; 75: 941–950
  • Vilmer E., Triebel F., David V., Rabian C., Schumpp M., Leca G., Degos L., Hercend T., Sigaux F., Ben-Sussan A. Prominent expansion of circulating lymphocytes bearing γ T-cell receptors with preferential expression of variable γ genes after allogeneic bone marrow transplantation. Blood 1988; 72: 841–849
  • Lin M.-T., Shen M.-C, Su I.-J., Tien H.-F., Chen Y. C., Hsu P.-N., Chang C.-S., Wang C.-H. Peripheral T-γ/δ lymphoma presenting with idiopathic thrombocytopenic purpura-like picture. Br. J. Haematol. 1991; 78: 280–282
  • Picker L. J., Brenner M. B., Michie S., Warnke R. A. Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations. Am. J. Pathol. 1988; 132: 401–405
  • Pandolfi F., Foa R., de Rossi G., Zambello R., Chisesi T., di Celle P. F., Migone N., Casorati G., Scarseli E., Trentin L., Semenzato G. Clonally expanded CD3+, CD4-, CD8- cells bearing the α/β or the γ/δ T-cell receptor in patients with the lymphoproliferative disease of granular lymphocytes. Clin. Immunol. Immunopathol. 1991; 60: 371–383
  • Vie H., Chevalier S., Garand R., Moisan J.-P., Praloran V., Devilder M.-C, Moreau J.-F., Soilillou J.-P. Clonal expansion of lymphocytes bearing the γδ T-cell receptor in a patient with large granular lymphocyte disorder. Blood 1989; 74: 285–290
  • Oostveen J. W., Breit T. M., de Wolf J. T. M., Brandt R. M. P., Smit J., van Dongen J. J. M., Borst J., Melief C. J. M. Polyclonal expansion of T-cell receptor γδ T lymphocytes associated with neutropenia and thrombocytopenia. Leukemia 1992; 6: 410–418
  • Foroni L., Matutes E., Foldi J., Morella R., Rabbitts Th., Luzatto L., Catovsky D. T-cell leukemias with rearrangement of the γ but not β T-cell receptor. Blood 1988; 71: 356–362
  • Horiuchi T., Yasukawa M., Yanagisawa K., Hato T., Fujita S. Immunological analysis of T-cells bearing T-cell receptor aB or γδ in patients with granular lymphocyte proliferative disorder. Acta Haematol. 1993; 89: 174–179
  • Oshimi K., Hoshino S., Takahashi M., Akahoshi M., Saito H., Kobayashi Y., Hirai H., Takaku F., Yohagi N., Oshimi Y., Horie N., Mizoguchi H. Ti(WT31)-neg-ative, CD3-positive large granular lymphocyte leukemia with nonspecific cytotoxicity. Blood 1988; 71: 923–931
  • Shivakumar S., Tsokos G. C., Datta S. K. T cell receptor α/β expressing double-negative (CD4-CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupis nephritis. J. Immunol. 1989; 143: 103–112
  • Wirt D. P., Brooks E. G., Vaidya S., Klimpel G. R., Waldmann T. A., Goldblum R. M. Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease. N. Engl. J. Med. 1990; 322: 336–337

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