Growth-Factor Stimulation Reveals Two Mechanisms of Retinoblastoma Gene Inactivation in Human Myelogenous Leukemia Cells

References

• Murphree A. L., Benedict W. F. Retinoblastoma: clues to human oncogenesis. Science 1984; 223: 1028–1033
   PubMed Web of Science ®Google Scholar
• Buchkovich K., Duffy L. A., Harlow E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 1989; 58: 1097–1105
   PubMed Web of Science ®Google Scholar
• Ludlow J. W., Shon J., Pipas J. M., Livingston D. M., DeCaprio J. A. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 1990; 60: 387–396
   PubMed Web of Science ®Google Scholar
• Xu H. J., Hu S.-X., Benedict W. F. Lack of nuclear RB protein staining in GO/middle G1 cells: correlation to changes in total RB protein level. Oncogene 1991; 6: 1139–1144
   PubMed Web of Science ®Google Scholar
• Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins J. R. The E2F transcription factor is a cellular target for the RB protein. Cell 1991; 65: 1053–1061
   PubMed Web of Science ®Google Scholar
• Shew J., Chen Y. P.-L., Bookstein R., Lee E. Y.-H. P., Lee W.-H. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen. Cell Growth Differ. 1990; 1: 17–25
   PubMedGoogle Scholar
• Templeton D. J., Park S. H., Lanier L., Weinberg R. A. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein associaton, and nuclear tethering. Proc. Natl. Acad. Sci. USA 1991; 88: 3033–3037
   PubMed Web of Science ®Google Scholar
• Sakai T., Ohtani N., McGee T. L., Robbins P. D., Dryja T. P. Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene. Nature (London) 1991; 353: 83–86
   PubMed Web of Science ®Google Scholar
• Ohtani-Fujita N., Fujita T., Aoike A., Osifchin N. E., Robbins P. D., Sakai T. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 1993; 8: 1063–1067
   PubMed Web of Science ®Google Scholar
• Cavenee W. K., Dryja T. P., Phillips R. A., Benedict W. F., Godbout R., Gallie B. L., Murphree A. L., Strong L. C., White R. L. Genetic origin of mutations predisposing to retinoblastoma. Nature (London) 1983; 305: 779–784
   PubMed Web of Science ®Google Scholar
• Friend S. H., Bernards R., Rogelj S., Weinberg R. A., Rapaport J. M., Albert D. M., Dryja T. P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (London) 1986; 323: 643–646
   PubMed Web of Science ®Google Scholar
• Lee W.-H., Bookstein R., Hong F., Young L.-J., Shew J. Y., Lee E. Y.-H. P. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 1987; 235: 1394–1399
   PubMed Web of Science ®Google Scholar
• Fung Y.-K. T., Murphree A. L., T'Ang A., Qian J., Hin-Richs S. H., Benedict W. F. Structural evidence for the authenticity of the human retinoblastoma gene. Science 1987; 236: 1657–1661
   PubMed Web of Science ®Google Scholar
• Toguchida J., Ishizaki K., Sasaki M. S., Nakamura Y., Ikenaga M., Kato M., Sugimoto M., Kotoura Y., Ya-Mamuro T. Preferential mutation of paternally derived RB gene as the initial event in sporadic retinoblastoma. Nature (London) 1989; 338: 156–158
   PubMed Web of Science ®Google Scholar
• Cance W. G., Brennan M. F., Dudas M. E., Huang C-M., Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcoma. N. Engl. J. Med. 1990; 323: 1457–1462
   PubMed Web of Science ®Google Scholar
• Lee E. Y., To H., Shew J. Y., Bookstein R., Scully P., Lee W.-H. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 1988; 241: 218–221
   PubMed Web of Science ®Google Scholar
• T'Ang A., Varley J. M., Chakraborty S., Murphree A. L., Fung Y.-K. T. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 1988; 242: 263–266
   PubMed Web of Science ®Google Scholar
• Harbour J. W., Lai S.-L., Whang-Peng J., Gazdar A. F., Minna J. D., Kaye F. J. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 1988; 241: 353–357
   PubMed Web of Science ®Google Scholar
• Yokota J., Akiyama T., Fung Y.-K. T., Benedict W. F., Namba Y., Hanaoka M., Wada M., Terasaki T., Shimo-Sato Y., Sugimura T., Terada M. Altered expression of the retinoblastoma (Rb) gene in small-cell car-cino of the lung. Oncogene 1988; 3: 471–475
   PubMed Web of Science ®Google Scholar
• Xu H.-J., Hu S.-X., Cagle P. T., Moore G. F., Benedict W. F. Absence of retinoblastoma protein expression in primary non-small cell lung carcinoma. Cancer Res. 1991; 51: 2735–2739
   PubMed Web of Science ®Google Scholar
• Horowitz J. M., Tandell D. W., Park S. H., Canning S., Whyte P., Buchkovich K., Harlow E., Weinberg R. A., Dryja T. P. Point mutational inactivation of the retinoblastoma antioncogene. Science 1989; 243: 937–940
   PubMed Web of Science ®Google Scholar
• Logothetis C. J., Xu H.-J., Ro J. Y., Hu S. X., Sahin A., Ordonez N., Benedict W. Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. JNCI 1992; 84: 1256–1261
   PubMed Web of Science ®Google Scholar
• Furukawa Y., DeCaprio J. A., Belvin M., Griffin J. D. Heterogenous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. Oncogene 1991; 6: 1343–1346
   PubMed Web of Science ®Google Scholar
• Kornblau S., Xu H.-J., del Giglio A., Hu S., Zhang X. W., Smallwood L., Beran M., Estey E., Andreeff M., Trujillo J., Cork M. A., Smith T. L., Benedict W. F., Deisseroth A. B. Clinical implications of decreased retinoblastoma protein expression in acute myelogenous leukemia. Cancer Res. 1992; 52: 4587–4590
   PubMed Web of Science ®Google Scholar
• Huang H.-J. S., Yee J.-K., Shew J.-Y., Chen P. L., Bookstein R., Friedmann T., Lee E. Y.-H. P., Lee W.-H. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988; 242: 1563–1566
   PubMed Web of Science ®Google Scholar
• Xu H., Sumegi J. J., Hu S. X., Banerjee A., Uzvolgyi E., Klein G., Benedict W. F. Intraocular tumor formation of RB reconstituted retinoblastoma cells. Cancer Res. 1991; 51: 4481–4485
   PubMed Web of Science ®Google Scholar
• Brookstein R., Shew J.-Y., Chen P. L., Scully P., Lee W.-H. Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Science 1990; 247: 712–715
   PubMed Web of Science ®Google Scholar
• Sawyers C. L., Denny C. T., Witte O. N. Leukemia and the disruption of normal hematopoiesis. Cell 1991; 64: 337–350
   PubMed Web of Science ®Google Scholar
• Andreeff M., Darzynkiewicz Z., Sharpless T. K., Clark-Son B. D., Melamed M. R. Discrimination of human leukemia subtype by flow cytometric analysis of cellular DNA and RNA. Blood 1980; 55: 282–293
   PubMed Web of Science ®Google Scholar
• Tafuri A., Andreeff M. Kinetic rationale for cy-tokine-induced recruitment of myeloblasts leukemia followed by cycle-specific chemotherapy in vitro. Leukemia 1990; 4: 826–834
   PubMed Web of Science ®Google Scholar