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Original Article

Expression of MDR1 by Normal Bone Marrow Cells and its Implication for Leukemic Hematopoiesis

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Pages 419-424 | Received 01 May 1994, Published online: 01 Jul 2009

References

  • Roninson I.B. Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells. Plenum Press, New York, NY 1991
  • Moscow J.A., Cowan K.H. Multidrug resistance. J. Natl. Cancer Inst. 1988; 80: 14–20
  • Pastan I., Gottesmann M. Multiple-drug resistance in human cancer. N. Engl. J. Med. 1987; 316: 1388–1393
  • Marie J.P., Zittoun R., Sikic B.I. Multidrug-resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity. Blood 1991; 78: 586–592
  • Pirker R., Wallner J., Geissler K., Linkesch W., Haas O.A., Bettelheim P., Hopfner M., Scherrer R., Valent P., Havelec L., Ludwig H., Lechner K. MDR1 gene expression and treatment outcome in acute myeloid leukemia. J. Natl. Cancer Inst. 1991; 83: 708–712
  • Campos L., Guyotat D., Archimbaud E., Calmard-Oriol P., Tsuruo T., Trancy J., Treille D., Fiere D. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 1992; 79: 473–476
  • Zhou D.-C, Marie J.-P., Suberville A.-M., Zittoun R. Relevance of mdr1 gene expression in acute myeloid leukemia and comparison of different diagnostic methods. Leukemia 1992; 6: 879–885
  • Pileri S.A., Sabattini E., Falini B., Tazzari P.L., Gherlinzoni F., Michieli M., Damiani D., Zucchini L., Gobbi M., Tsuruo T., Baccarani M. Immunohistochemical detection of the multidrug transport protein PI70 in human normal tissues and malignant lymphomas. Histopathology 1991; 19: 131–140
  • Cheng A.-L., Su I.-J., Chen Y.-C., et al. Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: The possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors. J. Clin. Oncol. 1993; 11: 109–115
  • Epstein J., Xiao H., Oba B. P-glycoprotein expression in plasma cell myeloma is associated with resistance to VAD. Blood 1989; 74: 913–916
  • Dalton W.S., Grogan T.M., Meltzer P.S., Scheper R.J., Durie B.G., Taylor C.W., Miller T.P., Salmon S.E. Drug resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J. Clin. Oncol. 1989; 7: 415–424
  • Miller T.P., Grogan T.M., Dalton W.S., et al. P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. J. Clin. Oncol. 1991; 9: 17–24
  • Salmon S.E., Dalton W.S., Grogan T.M., et al. Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer. Blood 1991; 78: 44–50
  • Yahanda A.M., Adler K.M., Fisher GA., Brophy N.A., Halsey J., Hardy R.I., Gosland M.P., Lum B.L., Sikic B.I. Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J. Clin. Oncol. 1992; 10: 1624–1633
  • Sonneveld P., Durie B.G.M., Lokhorst H.M., Marie J.-P., Solbu G., Suciu S., Zittoun R., Loöwenberg B., Nooter K. Modulation of multidrug-resistant multiple myeloma by cyclosporin. Lancet 1992; 340: 255–259
  • Marie J.P., Bastie J.N., Coloma F., Suberville A.M.F., Delmer A., Rio B., Delmas-Marsalet B., Leroux G., Casassus P., Baumelou E., Catalin J., Zittoun R. Cyclosporin A as a modifier agent in the salvage treatment of acute leukemia. Leukemia 1993; 7: 821–824
  • List A.F., Spier C., Greer J., Wolff S., Hutter J., Dorr J., Salmon S., Futscher B., Baier M., Dalton W. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J. Clin. Oncol. 1993; 11: 1652–1660
  • Chaudary P.M., Roninson I.B. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991; 66: 85–94
  • Drach D., Zhao S., Drach J., Mahadevia R., Gattringer C., Huber H., Andreeff M. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 1992; 80: 2729–2734
  • Chaudary P.M., Mechetner E.B., Roninson I.B. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992; 80: 2735–2739
  • Marie J.P., Brophy N.A., Ehsan M.N., Aihara Y., Mohamed N.A., Cornbleet J., Chao N.J., Sikic B.I. Expression of multidrug resistance gene mdr 1 mRNA in a subset of normal bone marrow cells. Br. J. Haematol. 1992; 81: 145–152
  • Ludescher C., Thaler J., Drach D., Drach J., Spitaler M., Gattringer C., Huber H., Hofmann J. Detection of activity of P-glycoprotein in human tumour samples using rhodamine 123. Br. J. Haematol 1992; 82: 161–168
  • Körbling M., Drach J., Champlin R.E., Engel H., Huyen L., Kleine H.D., Berenson R., Deisseroth A.B., Andreeff M. Large-scale preparation of highly purified, frozen/thawed CD34+, HLA-DR- hematopoietic progenitor cells by sequential immunoadsorption (CEPRATE SC) and fluorescence-activated cell sorting: implications for gene transduction and/or transplantation. Bone Marrow Transplantion 1994, in press
  • Chin K.-V., Ueda K., Pastan I., Gottesmann M.M. Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Science 1991; 255: 459–462
  • Zhao S., Drach D., Hu G., Squires J., Drach J., Deisseroth A., Andreeff M. Absence of regulation of mdr1 by p53 in normal hematopoiesis and acute myelogenous leukemia. Blood 1992; 80: 202a, Suppl. 1
  • Andreeff M., Zhao S., Drach D., Hegewisch-Becker S., Rees J.H.K., Liu Y., Hanania E.G., Körbling M., Deisseroth A.B., Drach J. Expression of multidrug resistance (mdr-1) and p53 genes in hematologic cell systems: Implications for biology and gene therapy. Cancer Bulletin 1993; 45: 131–138
  • Chaudhary P.M., Roninson I.B. Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncology Res. 1992; 4: 281–290
  • Farrar W.L., Thomas T.P., Anderson W.B. Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C. Nature 1985; 315: 235–237
  • Morla A.O., Schreurs J., Miyajima A., Wang J.Y.J. Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines. Mol. Cell. Biol. 1988; 8: 2214–2219
  • Andreeff M., Drach J., Zhao S., Consoli U., Escudier S., Sanchez-Williams G., Liu Y., Goodacre A., Drach D., Dunne C., Tafuri A., Estey E., Deisseroth A. Cell kinetic, molecular and clinical analysis of growth factor sensitization of myeloid leukemia. Hemopoietic growth factors, oncogenes and cytokines in clinical hematology, E. Cacciola, A.B. Deisseroth, R. Giustolisi. Karger, Basel 1994; 112–136
  • Drach D., Zhao S., Drach J., Andreeff M. Low incidence of MDR1 expression in acute promyelocytic leukemia. 1994, Submitted for publication
  • te Boekhorst P.A.W., de Leeuw K., Schoester M., Wittebol S., Nooter K., Hagemeijer A., Lowenberg B., Sonneveld P. Predominance of functional multidrug resistance (MDR1) phenotype in CD34+ acute myeloid leukemia cells. Blood 1993; 82: 3157–3162

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