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Leukemia & Lymphoma Volume 18, 1995 - Issue 1-2
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Original Article

Growth Factors Can Protect B-Chronic Lymphocytic Leukaemia Cells Against Programmed Cell Death Without Stimulating Proliferation

A. P. Jewell Department of Haematology, University College London Medical School, London, UK
,
P. M. Lydyard Immunology, University College London Medical School, London, UK
,
C. P. Worman Department of Haematology, University College London Medical School, London, UK
,
F. J. Giles Department of Haematology, University College London Medical School, London, UK
&
A. H. Goldstone Department of Haematology, University College London Medical School, London, UK
Pages 159-162 | Received 04 Aug 1994, Published online: 01 Jul 2009

References

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  • Hoffbrand A. V., Panayiotidis P., Reittie J., Ganeshaguru K. Autocrine and paracrine growth loops in chronic lymphocytic leukemia. Sem. Hematol 1993; 30: 306–317
  • Cohen J. J., Duke R. C., Fadok V. A., Sellins K. S. Apoptosis and programmed cell death in immunity. Ann. Rev. Immunol 1992; 10: 267–293
  • Pangalis G. A., Griva E. Recombinant alfa 2b interferon therapy in untreated stages A and B chronic lymphocytic leukaemia. Cancer 1988; 61: 869–872
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  • Heslop H. E., Bianchi A. C. M., Cordingely F. T., Turner M., De Mel C. P., Hoffbrand A. V., Brenner M. K. Effects of interferon alpha on autocrine growth factor loops in B lymphopro-liferative disorders. J Exper. Med 1990; 172: 1729–1734
  • Drexler H. G. Which cells respond during in vitro stimulation of B-CLL and HCL cultures?. Leukaemia 1988; 4: 240–241
  • Cordingley F. T., Bianchi A., Hoffbrand A. V., Reittie J. E., Heslop H. E., Vyakarnam A., Turner M., Meager M., Brenner M. K. Tumour necrosis factor as an autocrine growth factor for chronic B-cell malignancies. Lancet 1988; ii: 969–970
  • Schiller J. H., Bittner G., Spriggs D. R. Tumour necrosis factor, but not other haemopoietic growth factors, prolongs the survival of hairy cell leukaemia cells. Leukdemia Res 1992; 16: 337–346
  • Jewell A. P., Worman C. P., Giles F. J., Goldstone A. H. Levels of circulating cytokines in patients with chronic lymphocytic leukaemia receiving interferon-alpha therapy. Br. J. Haematol 1994; 86: S1, 73

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