Defects in Signal Transduction Pathways in Chronic B Lymphocytic Leukemia Cells

References

• Carlsson M., Totterman T. H., Matsson P., Nilsson K. Cell cycle progression of B chronic lymphocytic leukernia cells induced to differentiate by TPA. Blood 1988; 71: 415–421
   PubMed Web of Science ®Google Scholar
• Drexler H. G., Brenner M. K., Coustan-Smith E., Gignac S. M., Hoffbrand A. V. Analysis of signal transduction in B-chronic lymphocytic leukemia. Blood 1988; 71: 1461–1469
   PubMed Web of Science ®Google Scholar
• Drexler H. G., Janssen J. W. G., Brenner M. K., Hoffbrand A. V., Bartram C. R. Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore. Blood 1989; 73: 1656–1663
   PubMed Web of Science ®Google Scholar
• Gignac S. M., Buschle M., Petit G. R., Hoffbrand A. V., Drexler H. G. Expression of proto-oncogene c-jun during differentiation of B chronic lymphocytic leukemia. Leukemia 1989; 4: 441–446
   Web of Science ®Google Scholar
• Murphy J. J., Norton J. D. Phorbol ester induction of early response gene expression in lymphocytic leukaemia and normal human B cells. Leuk. Res 1993; 17: 657–662
   PubMed Web of Science ®Google Scholar
• Carlsson M., Totterman T. H., Matsson P., Nilsson K. Cell cycle progression of B-chronic lymphocytic leukemia cells induced to differentiate by TPA. Blood 1985; 71: 415–421
   Google Scholar
• Drexler H. G., Brenner M. K., Coustan-Smith E., Wickremasinghe R. G., Hoffbrand A. V. Synergistic action of calcium ionophore A23187 and phorbol ester TPA on B-chronic lymphocytic leukemia cells. Blood 1987; 70: 1536–1542
   PubMed Web of Science ®Google Scholar
• Zucali J. R., Elfenbein G. J., Barth K. C., Dinarello C. A. Effect of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation. J. Clin. Invest 1987; 80: 772–777
   PubMed Web of Science ®Google Scholar
• Kehrl J. H., Miller A., Fauci A. S. Effect of tumor necrosis factor α on mitogen activated human B cells. J. Exp. Med 1987; 166: 786–790
   PubMed Web of Science ®Google Scholar
• Vilcek J., Palombella V. J., Heniksen-Destefano D., Swenson C., Feinman R., Hirai M., Tsujimoto M. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J. Exp. Med 1986; 163: 632–643
   PubMed Web of Science ®Google Scholar
• Waage A., Liabakk N., Lien E., Lamvik J., Espevik T. p55 and p75 tumor necrosis factor receptors in pateints with chronic lymphocytic leukemia. Blood 1992; 80: 2577–2583
   PubMed Web of Science ®Google Scholar
• Cordingley F. T., Bianchi A., Hoffbrand A. V., Reittie J. E., Heslop H. E., Vyakarnam A., Turner M., Meager A., Brenner M. K. Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies. Lancet 1988; 1: 969–971
   PubMed Web of Science ®Google Scholar
• Digel W., Stefanic M., Schoniger W., Buck C., Raghavachar A., Frickhofen N., Heimpel H., Porszolt F. Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukemia. Blood 1989; 73: 1242–1246
   PubMed Web of Science ®Google Scholar
• Foa R., Massaia M., Cardona S., Tos A. G., Bianchi A., Attisano C., Guarini A., Francia De Celle P., Fierro M. T. Production of tumor necrosis factor-α by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the production of the disease. Blood 1991; 76: 393–400
   Web of Science ®Google Scholar
• Karin M. The AP-1 complex and its role in transcriptional control. The Hormonal Control of Gene Expression, J. G. Foulkes, P. Cohen. Elsevier Publications., Oxford 1991; 235–253
   Google Scholar
• Curran T. Fos and Jun: intermediary transcription factors. The Hormonal Control of Gene Expression, J. G. Foulkes, P. Cohen. Elsevier Publications., Oxford 1991; 295–308
   Google Scholar
• Vilcek J., Lee T. H. Tumor necrosis factor. New insights into the molecular mechanism of its multiple actions. J. Biol. Chem 1991; 266: 7313–7316
   PubMed Web of Science ®Google Scholar
• Brenner D. A., O'Hara M., Angel P., Chojkier M., Karin M. Prolonged activation of c-jun and collagenase genes by tumour necrosis factor-α. Nature 1989; 337: 661–663
   PubMed Web of Science ®Google Scholar
• Brach M. A., Gruss H. J., Sott C., Herrmann F. The mitogenic response to tumor necrosis factor requires c-jun/AP-1. Molec. Cell. Biol 1993; 13: 4284–4290
   PubMed Web of Science ®Google Scholar
• Lowenthal J. W., Ballard D. W., Bogerd H., Bohnlein E., Greene W. C. Tumor necrosis factor-α activation of the IL-2 receptor-α gene involves the induction of kB-specific DNA binding protein. J. Immunol 1989; 142: 3121–3128
   PubMed Web of Science ®Google Scholar
• Osborn L., Kunkel S., Nabel G. J. Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kB. Proc. Natl. Acad. Sci. USA 1989; 86: 2336–2340
   PubMed Web of Science ®Google Scholar
• Kronke M., Schutze S., Scheurich P., Meichle A., Hensel H., Thoma B., Kruppa G., Pfiznmaier K. Tumour necrosis factor signal transduction. Cell. Signalling 1990; 2: 1–8
   PubMed Web of Science ®Google Scholar
• Duyao M. P., Buckler A. J., Sonenshein G. E. Interaction of an NF-kB- like factor with a site upstream of the c-myc promoter. Proc Natl. Acad. Sci. USA 1990; 87: 4727–4731
   PubMed Web of Science ®Google Scholar
• Baldwin A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. Induction of NF-kB DNA binding activity during the G0-to-G1 transition in mouse fibroblasts. Molec. Cell. Biol 1991; 11: 4943–4951
   PubMed Web of Science ®Google Scholar
• Sen R., Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986; 46: 705–706
   PubMed Web of Science ®Google Scholar
• Grilli M., Chiu J. J.-S., Lenardo M. J. NF-kB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol 1993; 143: 1–62
   PubMed Web of Science ®Google Scholar
• Grimm S., Bauerle P. A. The inducible transcription factor NF-kB: structure-function relationship of its protein subunits. Biochem. J 1993; 290: 297–308
   PubMed Web of Science ®Google Scholar
• Liou H.-C., Sha W., Scott M. L., Baltimore D. Sequential induction of NF-kB/Rel family proteins during B-cell terminal differentiation. Molec. Cell. Biol 1994; 14: 5349–5359
   PubMed Web of Science ®Google Scholar
• Inoue J.-I., Takahara T., Akizawa T., Hino O. Bcl-3, a member of the IkB proteins, has distinct specificity towards the Rel family of proteins. Oncogene 1993; 8: 2067–2073
   PubMed Web of Science ®Google Scholar
• Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 1984; 334: 661–665
   Web of Science ®Google Scholar
• Ghosh S., Baltimore D. Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB. Nature 1990; 344: 678–682
   PubMed Web of Science ®Google Scholar
• Kruppa G., Thoma B., Machleidt T., Wiegmann W., Kronke M. Inhibition of tumour necrosis factor (TNF)-mediated NF-kB activation by selective blockade of the human 55-kDa TNF receptor. J. Immunol 1992; 148: 3152–3157
   PubMed Web of Science ®Google Scholar
• Schutze S., Potthoff K., Machleidt T., Berkovic D., Weigmann K., Kronke M. TNF activates NF-kB by phosphatidyl-choline-specific phospholipase C- induced “acidic” sphingomyelin breakdown. Cell 1992; 71: 765–776
   PubMed Web of Science ®Google Scholar
• Kolesnick R., Golde D. W. The sphingomyelin pathway in tumor necrosis factor and IL-1 signaling. Cell 1994; 77: 325–328
   PubMed Web of Science ®Google Scholar
• Schreck R., Rieber P., Bauerle P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV. EMBO J 1991; 10: 2247–2258
   PubMed Web of Science ®Google Scholar
• Staal F. J. T., Roederer M., Herzenberg L. A., Herzenberg L. A. Intracellular thiols regulate activation of nuclear kB and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 1990; 87: 9943–9947
   PubMed Web of Science ®Google Scholar
• Riabowol K., Vosatka R. J., Ziff E. B., Lamb N. J., Feramisco J. R. Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells. Molec. Cell. Biol 1988; 8: 1670–1680
   PubMed Web of Science ®Google Scholar
• Holt J. T., Venkat-Gopal T., Moulton A. D., Nienhuis A. W. Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc. Natl. Acad. Sci. USA 1986; 83: 4794–4798
   PubMed Web of Science ®Google Scholar
• Davis R. J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem 1993; 268: 14553–14556
   PubMed Web of Science ®Google Scholar
• Roberts T. M. A signal chain of events. Nature 1992; 360: 534–535
   PubMed Web of Science ®Google Scholar
• Gille H., Sharrocks A. D., Shaw P. E. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at the c-fos promoter. Nature 1992; 358: 414–417
   PubMed Web of Science ®Google Scholar
• Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett J. R., Karin M., Hunter T. Activation of protein kinase C decreases phosphorylation of c-jun at sites that negatively regulate its DNA binding activity. Cell 1992; 64: 573–584
   Web of Science ®Google Scholar
• Smeal T., Binetruy B., Mercola D., Grover-Bardwick A., Heidecker G., Rapp U. R., Karin M. Oncoprotein-mediated signalling cascade stimulates c-jun activity by phosphorylation of serines 63 and 73. Molec. Cell. Biol 1992; 12: 3507–3513
   PubMed Web of Science ®Google Scholar
• Roux P., Blanchard J.-M., Fernandez A., Lamb N., Jeanteur P., Piechaczyk M. Nuclear localization of c-fos but not v-fos proteins is controlled by extracellular signals. Cell 1991; 63: 341–351
   Web of Science ®Google Scholar
• Auwerx J., Sassone-Corsi P. IP-1: a dominant inhibitor of fos/jun whose activity is modulated by phosphorylation. Cell 1991; 64: 983–993
   PubMed Web of Science ®Google Scholar
• Gignac S. M., Buschle M., Heslop H. E., Brenner M. K., Hoffbrand A. V., Drexler H. G. Delayed induction of proto-oncogene expression in B-CLL cells by tumor necrosis factor. Leukemia and Lymphoma 1990; 3: 37–43
   PubMed Web of Science ®Google Scholar
• Jabbar S. A. B., Hoffbrand A. V., Wickremasinghe R. G. regulation of transcription factors NFkB and AP-1 following tumour necrosis factor-α treatment of cells from chronic B cell leukaemia patients. Brit. J. Haematol 1994; 86: 496–504
   PubMed Web of Science ®Google Scholar
• Jabbar S. A. B., Hoffbrand A. V., Wickremasinghe R. G. Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kB following tumor necrosis factor treatment of chronic B leukaemia cells. Leuk. Res 1994; 18: 523–530
   PubMed Web of Science ®Google Scholar
• Zaknoen S. L., Christian S. L., Suen R., Van Ness B., Kay N. E. B-chronic lymphocytic leukaemia cells contain both endogenous k immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors. Leukemia 1992; 6: 675–679
   PubMed Web of Science ®Google Scholar
• Wickremasinghe R. G., Piga A., Campana D., Yaxley J. C., Hoffbrand A. V. Rapid down-regulation of protein kinase C and membrane association in phorbol ester-treated leukemia cells. FEBS Lett 1985; 190: 50–54
   PubMed Web of Science ®Google Scholar
• van Kooten C., Rensink I., Aarden L., van Oers R. Interleukin-4 inhibits both paracrine and autocrine tumor necrosis factor-α-induced proliferation of B chronic lymphocytic leukemia cells. Blood 1992; 80: 1299–1306
   PubMed Web of Science ®Google Scholar
• Rozengurt E., Rodriguez-Pena M., Smith K. A. Phorbol esters, phospholipase C and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells. Proc. Natl. Acad. Sci. USA 1983; 80: 7244–7248
   PubMed Web of Science ®Google Scholar