30
Views
3
CrossRef citations to date
0
Altmetric
Original Article

Multiple Myeloma: New Evidence and Insights from the Immunoglobulin Heavy Chain Gene and Phenotypes

&
Pages 395-400 | Received 13 Jan 1995, Published online: 01 Jul 2009

References

  • Greipp P. R., Kyle R. A. Clinical, morphological and cell kinetic differences among multiple myeloma, monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Blood 1983; 62: 166–71
  • Boccadoro M., Durie B. G. M., Frutiger Y., Gavarotti P., Redoglia V., Massaia M., D'Alberto M., Marmont F., Gallamini A., Tribalto M., Pileri A. Lack of correlation between plasma cell labeling index and serum beta-2-microglobulin in monoclonal gammopathies. Acta Haemtol. 1987; 78: 239–42
  • Buchsbaum R. J., Schwartz R. S. Cellular origins of hematologic neoplasms. N. Eng. J. Med. 1990; 322: 694–6
  • Bakkus M. H. C., Heirman C., Van Riet I., Van Camp B., Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 1992; 80: 2326–35
  • Billadeau D., Ahlmann G., Greipp P., Van Ness B. The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J. Exp. Med. 1993; 178: 1023–31
  • Corrandini P., Boccadoro M., Voena C., Pileri A. Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to Cμ sequence in immunoglobulin (IgG-) and IgA-secreting multiple myelomas. J. Exp. Med. 1993; 178: 1091–6
  • Bakkus M. H. C., Van Riet I., Van Camp B., Thielemans K. Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. Br. J. Haematol. 1994; 87: 68–74
  • Takishita M., Kosaka M., Goto T., Saito S. Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies. Br. J. Haematol. 1994; 87: 735–42
  • Stewart A. K., Schwartz R. S. Immunoglobulin V region and B cell. Blood 1994; 83: 1717–30
  • Schatz D. G., Oettinger M. A., Schlissel M. S. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 1992; 10: 359–83
  • Kleinfield R., Hardy R. R., Tarlinton D., Dangl J., Herzenberg L. A., Weigert M. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1 + B-cell lymphoma. Nature 1986; 322: 843–6
  • Berek C., Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 1987; 96: 23–41
  • MacLennan I. C. M. Germinal centers. Annu. Rev. Immunol. 1994; 12: 117–39
  • Berek C., Berger A., Apel M. Mutation of the immune response in germinal centers. Cell 1991; 67: 1121–9
  • Gray D. Immunological memory. Annu. Rev. Immunol. 1993; 11: 49–77
  • Harriman W., Volk H., Defranoux N., Wabl M. immunoglobulin class switch recombination. Annu. Rev. Immunol. 1993; 11: 361–84
  • Bird J., Galili N., Link M., Stites D., Sklar J. Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J. Exp. Med. 1988; 168: 229–45
  • Wasserman R., Yamada M., Ito Y., Finger L. R., Reichard B. A., Shane S., Lange B., Rovera G. VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia. Blood 1992; 79: 223–8
  • Bahler D. W., Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc. Natl. Acad. Sci. USA 1992; 89: 6770–4
  • Carroll W. L., Yu M., Link M. P., Korsmeyer S. J. Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma. J. Immunol. 1989; 143: 692–8
  • Pratt L. F., Rassenti L., Lanick J., Robbins B., Banks P. M., Kipps T. J. Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation. J. Immunol. 1989; 143: 699–705
  • Hummel M., Tamaru J., Kalvelage B., Stein H. Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 1994; 84: 403–7
  • Aoki H., Takishita M., Kosaka M., Saito S. Frequent somatic mutations in D and/or JH segments of Ig gene in Waldenström's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome, but not in common CLL. Blood 1995, in press
  • Wagner S. D., Martinelli V., Luzzatto L. Similar patterns of VK gene usage but not different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. Blood 1994; 83: 3647–53
  • Yamada M., Wasserman R., Lange B., Reichard B. A., Womer R. B., Rovera G. Minimal residual disease in childhood B-lineage lymphoblastic leukemia: persistence of leukemic cells during the first 18 months of treatment. N. Engl. J. Med. 1990; 323: 448–55
  • Kiyokawa N., Kokai Y., Ishimoto K., Fujita H., Fujimoto J., Hata J. Characterization of the common ALL antigen (CD10) as an activation molecule on mature human B cells. Clin. Exp. Immunol. 1990; 79: 322–7
  • Baum C. M., Weismann I. L., Tsukamoto A. S., Buckle A. M., Peault B. Isolation of a candidate human hematopoietic stem-cell population. Proc. Natl. Acad. Sci. USA 1992; 89: 2804–8
  • Barlogie B., Epstein J., Selvanayagam P., Alexanian R. Plasma cell myeloma—New biological insights and advances in therapy. Blond 1989; 73: 865–79
  • Epstein J., Xiao H., He X-Y. Markers of multiple hematopoietic-cell lineages in multiple myeloma. N. Eng. J. Med. 1990; 322: 664–8
  • Tarstappen L. W. M.M., Johnsen S., Segers-Nolten I. M. J., Loken M. Identification and characterization of plasma cells in normal human hone marrow by high resolution flow cytometry. Blood 1990; 76: 1739–47
  • Fruehauf S., Haas R., Zeller W. J., Hunstein W. CD34 selection for purging in multiple myeloma and analysis of CD34+ B cell precursors. Stem Cells 1994; 12: 95–102
  • Fearon E. R., Vogelstein B. A genetic model for col-orectal tumorigenesis. Cell 1990; 61: 759–67
  • Shpilberg O., Modan M., Modan B., Chetrit A., Fuchs Z., Ramot B. Familial aggregation of haematological neoplasms: a controlled study. Br. J. Haematol. 1994; 87: 75–80
  • Taniwaki M., Nishida K., Takashima T., Nakagawa H., Fujii H., Tamaki T., Shimazaki C., Horiike S., Misawa S., Abe T., Kashima K. Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood 1994; 84: 2283–90
  • Corradini P., Inghirami G., Astolfi M., Ladetto M., Voena C., Ballerini P., Gu W., Nilsson K., Knowles D. M., Boccadoro M., Pileri A., Dalla-Favera R. Inactivation of tumor sup-presser genes, p53 and Rb1, in plasma cell dyscrasias. Leukemia 1994; 8: 758–67
  • Neri A., Murphy J. P., Cro L., Ferrero D., Tarella C., Baldini L., Dalla-Favera R. Ras oncogene mutation in multiple myeloma. J. Exp. Med. 1989; 170: 1715–25

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.