Differential Expression of Receptors for Hemopoietic Growth Factors on Subsets of CD34⁺ Hemopoietic Cells

References

• Civin C. I., Strauss L. C., Brovall C., Fackler M. J., Schwartz J. F., Shaper J. H. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J. Immunol 1984; 133: 157
   PubMed Web of Science ®Google Scholar
• Strauss L. C., Rowley S. D., LaRussa V. F., Sharkis S. J., Stuart R. K., Civin C. I. Antigenic analysis of hematopoiesis. V. Characterization of My-10 antigen expression by normal lymphohematopoietic progenitor cells. Exp. Hematol. 1986; 14: 878–886
   PubMed Web of Science ®Google Scholar
• Berenson R. J., Andrews R. G., Bensinger W. I., Kalamasz D., Knitter G., Buckner C. D., Bernstein I. D. Antigen CD34+ cells engraft lethally irradiated baboons. J. Clin. invest. 1988; 81: 951–955
   PubMed Web of Science ®Google Scholar
• Andrews R. G., Bryant E. M., Bartelmez S. H., Muirhead D. Y., Knitter G. H., Bensinger W., Strong D. M., Bernstein I. D. CD34+ Marrow Cells, Devoid of Lymphocyte-T and Lymphocyte-B, Reconstitute Stable Lymphopoiesis and Myelopoiesis in Lethally Irradiated Allogeneic Baboons. Blood 1992; 80: 1693–1701
   PubMed Web of Science ®Google Scholar
• Andrews R. G., Singer J. W., Bernstein I. D. Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties. J. Exp. Med. 1989; 169: 1721–1731
   PubMed Web of Science ®Google Scholar
• Sutherland H., Eaves C., Eaves A., Dragowska W., Lansdorp P. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 1989; 74: 1563–1570
   PubMed Web of Science ®Google Scholar
• Terstappen L. W. M. M., Huang S., Safford M., Lansdorp P. M., Loken M. R. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood 1991; 77: 1218–1227
   PubMed Web of Science ®Google Scholar
• Craig W., Kay R., Cutler R., Lansdorp P. Expression of Thy on human hematopoietic progenitor cells. J. Exp. Med. 1993; 177: 1331–1342
   PubMed Web of Science ®Google Scholar
• Loken M. R., Shah V. O., Dattilio K. L., Civin C. I. Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood 1987; 69: 255–263
   PubMed Web of Science ®Google Scholar
• Loken M. R., Shah V. O., Dattilio K. L., Civin C. I. Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development. Blood 1987; 70: 1316–1324
   PubMed Web of Science ®Google Scholar
• Park L. S., Waldron P. E., Friend D., Sassenfeld H. M., Prie V., Anderson D., Cosman D., Andrews R. G., Bernstein I. D., Urdal D. L. GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: Receptor heterogeneity and relationship to growth factor responsiveness. Blood 1989; 74: 56–65
   PubMed Web of Science ®Google Scholar
• Budel L., Touw I., Delwel H., Clark S., Löwenberg B. IL-3 and GM-CSF receptors on human acute myelocytic leukemia cells and relationship to the proliferative response. Blood 1989; 74: 565–571
   PubMed Web of Science ®Google Scholar
• Broudy V. C., Smith F. O., Lin N., Zsebo K. M., Egrie J., Bernstein I. D. Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor. Blood 1992; 80: 60–67
   PubMed Web of Science ®Google Scholar
• Lopez A., Eglinton J., Gillis D., Park L., Vadas M. Reciprocal inhibition of binding between interleukin-3 and granulocyte-macrophage colony-stimulating factor to human eosinophils. Proc. Natl. Acad. Sci. USA 1989; 86: 7022–7026
   PubMed Web of Science ®Google Scholar
• Lopez A., Vadas M., Woodcock J., Milton S., Lewis A., Elliott M., Gillis D., Ireland R., Park L. Interleukin-5, interleukin-3 and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell-surface receptors on human eosinophils. J. Biol. Chem. 1991; 266: 24741–24747
   PubMed Web of Science ®Google Scholar
• Budel L., Hoogerbrugge H., Pouwels K., van Buitenen C., Delwel R., Löwenberg B., Touw I. Granulocyte-macrophage colony-stimulating factor receptors alter their binding characteristics during myeloid maturation through upregulation of the affinity converting β subunit (KH97). J. Biol. Chem. 1993; 268: 10154–10159
   PubMed Web of Science ®Google Scholar
• Elbaz O., Budel L., Hoogerbrugge H., Touw I., Delwel R., Mahmoud L., Löwenberg B. Tumor necrosis factor regulates the expression of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells. Blood 1991; 77: 989–995
   PubMed Web of Science ®Google Scholar
• Testa U., Pelosi E., Gabbianelli M., Fossati C., Campisi S., Isacchi G., Peschle C. Cascade transactivation of growth factor receptors in early human hematopoiesis. Blood 1993; 81: 1442–1456
   PubMed Web of Science ®Google Scholar
• Sawada K., Krantz S., Sawyer S., Civin C. Quantitation of specific binding of erythropoietin to human erythroid colony-forming cells. J. Cell Physiol. 1988; 137: 337–345
   PubMed Web of Science ®Google Scholar
• Blechman J. M., Yarden Y. Structural aspects of receptor dimerization. c-Kit as an example. Ann. N.Y. Acad. Sci. 1995; 766: 344–362
   PubMed Web of Science ®Google Scholar
• Lev S. E., Yarden Y., Givol D. Dimerization and activation of the Kit receptor by monovalent and bivalent binding of the stem cell factor. J. Biol. Chem. 1993; 267: 15970–15977
   Web of Science ®Google Scholar
• Blechman J. M., Lev S., Barg J., Eisenstein M., Vaks B., Vogel Z., Givol D., Yarden Y. The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell 1995; 80: 103–113
   PubMed Web of Science ®Google Scholar
• Itoh N., Yonehara S., Schreurs J., Gorman D., Maruyama K., Ishii A., Yahara I., Arai K., Miyajima A. Cloning of an interleukin-3 receptor: a member of a distinct receptor gene family. Science 1990; 247: 324–327
   PubMed Web of Science ®Google Scholar
• Kitamura T., Sato N., Arai K.-I., Miyajima A. Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors. Cell 1991; 66: 1165–1174
   PubMed Web of Science ®Google Scholar
• Hayashida K., Kitamura T., Gorman D. M., Arai K.-I., Yokota T., Miyajima A. Molecular cloning of a second subunit of the human GM-CSF receptor: Reconstitution of a high affinity GM-CSF receptor. Proc. Natl. Acad. Sci. USA 1990; 87: 9655–9659
   PubMed Web of Science ®Google Scholar
• Ward L. D., Howlett G. J., Discolo G., Yasukawa K., Hammacher A., Moritz R. L., Simpson R. J. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 1994; 269: 23286–23289
   PubMed Web of Science ®Google Scholar
• Paonessa G., Graziani R., Serio A. D., Savino R., Ciapponi L., Lahm A., Salvati A. L., Toniatti C., Cilibert G. Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling. EMBO J. 1995; 14: 1942–1951
   PubMed Web of Science ®Google Scholar
• de Jong M. O., Rozemüller H., Bauman J. G. J., Visser J. W. M. Biotinylation of interleukin-2 (IL-2) for flow cytometric analysis of IL-2 receptor expression. J. Immunol. Meth. 1995; 184: 101–112
   PubMed Web of Science ®Google Scholar
• Wognum A. W., Visser T. P., de Jong M. O., Egeland T., Wagemaker G. Differential expression of receptors for interleukin-3 on subsets of CD34-expressing cells of rhesus monkeys. Blood 1995; 86: 581–591
   PubMed Web of Science ®Google Scholar
• Wognum A. W., van Gils F. C. J. M., Wagemaker G. Flow cytometric detection of receptors for interleukin-6 on bone marrow and peripheral blood cells of humans and rhesus monkeys. Blood 1993; 81: 2036–2043
   PubMed Web of Science ®Google Scholar
• Wognum A. W., Westerman Y., Visser T. P., Wagemaker G. Distribution of receptors for granulocyte/macrophage colony stimulating factor on immature CD34-positive bone marrow cells, differentiating monomyeloid progenitors and mature blood cell subsets. Blood 1994; 84: 764–774
   PubMed Web of Science ®Google Scholar
• Shimoda K., Okamura S., Harada N., Niho Y. Detection of the granulocyte colony-stimulating factor receptor using biotinylated granulocyte colony-stimulating factor: presence of granulocyte colony-stimulating factor receptor on CD34-positive hematopoietic progenitor cells. Res. Exp. Med. 1992; 192: 245–255
   PubMedGoogle Scholar
• de Jong M. O., Wagemaker G., Wognum A. W. Separation of myeloid and erythroid progenitors based on expression of CD34 and c-kit. Blood 1995; 86: 4076–4085
   PubMed Web of Science ®Google Scholar
• Wognum A. W., Krystal G., Eaves C. J., Eaves A. C., Lansdorp P. M. Increased Erythropoietin-Receptor Expression on CD34-Positive Bone Marrow Cells from Patients with Chronic Myeloid Leukemia. Blood 1992; 79: 642–649
   PubMed Web of Science ®Google Scholar
• Gleizes P. E., Noaillac D. J., Gas N. Labeling of basic fibroblast growth factor with digoxigenin: a nonradioactive probe for biochemical and cytological applications. Anal. Biochem. 1994; 219: 360–367
   PubMed Web of Science ®Google Scholar
• Taga T., Kawanishi Y., Hardy R., Hirano T., Kishimoto T. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution and regulation of their expression. J. Exp. Med. 1987; 166: 967–981
   PubMed Web of Science ®Google Scholar
• Munck-Petersen C., Davidsen O., Moestrup S., Sonne O., Nykjaer A. Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages. Eur. J. Clin. Invest. 1990; 20: 377–384
   PubMed Web of Science ®Google Scholar
• Gasson J., Kaufman S., Weisbart R., Tomonaga M., Golde D. High-affinity binding of granulocyte-macrophage colony-stimulating factor to normal and leukemic human myeloid cells. Proc. Natl. Acad. Sci. USA 1986; 83: 669–673
   PubMed Web of Science ®Google Scholar
• Park L., Waldron P., Friend D., Sassenfeld H., Price V., Anderson D., Cosman D., Andrews R., Bernstein I., Urdal D. Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood 1989; 74: 56–65
   PubMed Web of Science ®Google Scholar
• Brandt J., Baird N., Lu L., Srour E., Hoffman R. Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro. J. Clin. Invest. 1988; 82: 1017–1027
   PubMed Web of Science ®Google Scholar
• Leary A., Zeng H., Clark S., Ogawa M. Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors. Proc. Natl. Acad. Sri. USA 1992; 89: 4013–4017
   PubMed Web of Science ®Google Scholar
• Elliott M., Vadas M., Eglinton J., Park L., Bik-To L., Cleland L., Clark S., Lopez A. Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. Blood 1989; 74: 2349–2359
   PubMed Web of Science ®Google Scholar
• Budel L., Elbaz O., Hoogerbrugge H., Delwel R., Mahmoud L., Löwenberg B., Touw I. Common binding structure for granulocyte macrophage colony-stimulating factor and interleukin-3 on human acute myeloid leukemia cells and monocytes. Blood 1990; 75: 1439–1445
   PubMed Web of Science ®Google Scholar
• Elliott M., Moss J., Dottore M., Park L., Vadas M., Lopez A. Differential binding of IL-3 and GM-CSF to human monocytes. Growth Factors 1992; 6: 15–29
   PubMedGoogle Scholar
• van Gils F. C. J. M., van Teeffelen M. E. J. M., Neelis K. J., Hendrikx J., Burger H., van Leen R. W., Knol E., Wagemaker G., Wognum A. W. Interleukin-3 treatment of rhesus monkeys leads to increased production of histamine-releasing cells that express IL-3 receptors at high levels. Blood 1995; 86: 592–597
   PubMed Web of Science ®Google Scholar
• Wagemaker G., Peters M. F., Bol S. J. Induction of erythropoietin responsiveness in vitro by a distinct population of bone marrow cells. Cell Tissue Kinet. 1979; 12: 521–537
   PubMedGoogle Scholar
• Iscove N. N., Roitsch C. A., Williams N., Guilbet L. J. Molecules stimulating early red cell, granulocyte, macrophage, and megakaryocyte precursors in culture: similarity in size. hydrophobicity, and charge. J. Cell Physiol. 1982; 1: 65–78, Suppl
   Google Scholar
• Goodman J., Hall E., Miller K., Shinpock S. interleukin-3 promotes erythroid burst formation in “serum-free” cultures without detectable erythropoietin. Proc. Natl. Acad. Sci. USA 1985; 82: 3291–3295
   PubMed Web of Science ®Google Scholar
• Sieff C., Emerson S. G., Donahue R. E., Nathan D. G., Wang E. A., Wong G. G., Clark S. C. Human recombinant granulocyte-macrophage colony-stimulating factor. a multi-lineage hematopoietin. Science 1985; 230: 1171–1173
   PubMed Web of Science ®Google Scholar
• Ulich T. R., del Castillo J., Yin S. M., Egrie J. C. The erythropoietic effects of interleukin-6 and erythropoietin in vivo. Exp. Hematol. 1991; 19: 29–34
   PubMed Web of Science ®Google Scholar
• Ashman L., Cambareri A., To L. B., Levinsky R., Juttner C. Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood 1991; 78: 30–37
   PubMed Web of Science ®Google Scholar
• Papayannopoulou T., Brice M., Broudy V., Zsebo K. Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood and fetal liver: functional properties and composite antigenic profile. Blood 1991; 78: 1403–1412
   PubMed Web of Science ®Google Scholar
• Broudy V., Lin N., Zsebo K., Birkett N., Smith K., Bernstein I., Papayannopoulou T. Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor. Blood 1992; 79: 338–346
   Google Scholar
• Strobl H., Takimoto M., Majdic O., Höcker P., Knapp W. Antigenic analysis of human hematopoietic progenitor cells expressing the growth factor c-kit. Br. J. Haematol 1992; 82: 287–294
   PubMed Web of Science ®Google Scholar
• Gunji Y., Nakamura M., Ogawa H., Nagayoshi K., Nakauchi H., Miura Y., Yanagisawa M., Suda T. Human primitive hematopoietic progenitor cells are more enriched in kitlow cells than in kithhigh cells. Blood 1993; 82: 3283–3289
   PubMed Web of Science ®Google Scholar
• Simmons P. J., Aylett G. W., Niutta S., To L. B., Juttner C. A., Ashman L. K. C-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture. Exp. Hematol. 1994; 22: 157–165
   PubMed Web of Science ®Google Scholar
• Reisbach G., Bartke I., Kempkes B., Kostka G., Ellwart J., Birner A., Thalmeier K., Mailhammer R., Bornkam G. W., Ullrich A. Characterization of hemopoietic cell populations from cord blood expressing c-kit. Exp. Hematol. 1993; 74–79
   PubMed Web of Science ®Google Scholar
• Sato N., Caux C., Kitamura T., Watanabe Y., Arai K., Banchereau J., Miyajima A. Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Blood 1993; 82: 752–761
   PubMed Web of Science ®Google Scholar
• Palacios R., Henson G., Steinmetz M., McKearn J. Interleukin-3 supports growth of mouse pre-B-cell clones in vitro. Nature 1984; 309: 126–131
   PubMed Web of Science ®Google Scholar
• Tadmori W., Feingersh D., Clark S., Choi Y. Human recombinant IL-3 stimulates B cell differentiation. J. Immunol. 1989; 142: 1950–1955
   PubMed Web of Science ®Google Scholar
• Wörmann B., Gesner T., Mufson R., LeBien T. Proliferative effect of interleukin-3 on normal and leukemic human B cell precursors. Leukemia 1989; 3: 399–404
   PubMed Web of Science ®Google Scholar
• Cockayne D. A., Bodine D. M., Cline A., Nienhuis A. W., Dunbar C. E. Transgenic mice expressing anti-sense interleukin-3 RNA develop a B-lymphoproliferafive syndrome or neurologic dysfunction. Blood 1994; 84: 2699–2710
   PubMed Web of Science ®Google Scholar
• Coulie P., Stevens M., van Snick J. High- and low-affinity receptors for murine interleukin-6. distribution on B and T cells. Eur. J. Immunol. 1989; 19: 2107–2114
   PubMed Web of Science ®Google Scholar
• Kawano M., Hirano T., Matsuda T., Taga T., Horii Y., Iwato K., Asaoku H., Tang B., Tanabe O., Kuramoto A., Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332: 83–85
   PubMed Web of Science ®Google Scholar
• Hilbert D., Kopf M., Mock B. A., Kohler G., Rudikoff S. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J. Exp. Med. 1995; 182: 243–248
   PubMed Web of Science ®Google Scholar
• Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B-lymphocytes to produce immunoglobulin. Nature 1986; 324: 73
   PubMed Web of Science ®Google Scholar
• Briddell R., Broudy V., Bruno E., Brandt J., Srour E., Hoffman R. Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor. Blood 1992; 79: 3159–3167
   PubMed Web of Science ®Google Scholar
• Okada S., Nakauchi H., Nagayoshi K., Nishikawa S., Miura Y., Suda T. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 1992; 80: 3044–3050
   PubMed Web of Science ®Google Scholar
• Ikuta K., Weissman I. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA 1992; 89: 1502–1506
   PubMed Web of Science ®Google Scholar
• Orlic D., Fischer R., Nashikawa S., Nienhuis A., Bodine D. Purification and characterization of heterogeneous pluripotent hematopoietic cell populations expressing high levels of c-kit receptor. Blood 1993; 82: 762–770
   PubMed Web of Science ®Google Scholar
• Berardi A. C., Wang A., Levine J. D., Lopez P., Scadden D. T. Functional isolation and characterization of human hematopoietic stem cells. Science 1995; 267: 104–108
   PubMed Web of Science ®Google Scholar
• Kopf M., Ramsay A., Brombacher F., Baumann H., Freer G., Galanos C., Gutierrez-Ramos J. C., Köhler G. Pleiotropic effects of IL-6 deficient mice including early hematopoiesis, T and B cell function, and acute phase responses. Ann. N.Y. Acad. Sci. 1995; 762: 308–318
   PubMed Web of Science ®Google Scholar
• Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995; 86: 1243–1254
   PubMed Web of Science ®Google Scholar
• Nishinakamura R., Nakayama N., Hirabayashi Y., Inoue T., Aud D., McNeil T., Azuma S., Yoshida S., Toyoda Y., Arai K., Miyajima A., Murray R. Mice deficient for the IL-3/GM-CSFOIL-5 βc receptor exhibit lung pathology and impaired immune response, while BIL-3 receptor-deficient mice are normal. Immunity 1995; 2: 212–222
   Web of Science ®Google Scholar
• Dranoff G., Mulligan R. Activities of granulocyte-macrophage colony-stimulating factor revealed by gene transfer and gene knockout studies. Stem Cells 1994; 12: 173–182, Suppl 1
   PubMed Web of Science ®Google Scholar
• Hara T., Miyajima A. 2 Distinct Functional High Affinity Receptors for Mouse Interleukin-3 (IL-3). EMBO J 1992; 11: 1875–1884
   PubMed Web of Science ®Google Scholar
• Pietsch T., Kyas U., Steffens U., Yakistan E., Hadam M. R., Ludwig W. D., Zsebo K., Welte K. Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors. Blood 1992; 80: 1199–1206
   PubMed Web of Science ®Google Scholar
• Ashman L. K., Roberts M. M., Gadd S. J., Cooper S. J., Juttner C. Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5. B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia. Leak. Res. 1988; 12: 923–928
   PubMed Web of Science ®Google Scholar
• Bühring H. J., Ullrich A., Schaudt K., Muller C. A., Busch F. W. The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic leukemic cells. Leukemia 1991; 5: 854–860
   PubMed Web of Science ®Google Scholar
• Reuss-Borst M. A., Bühring H. J., Schmidt H., Müller C. A. AML: Immunophenotypic heterogeneity and prognostic significance of c-kit expression. Leukemia 1994; 8: 258–263
   PubMed Web of Science ®Google Scholar
• Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Cacares-Cortes J., Minden M., Paterson B., Caliguri M. A., Dick J. E. A cell initiating human acute myeloid leukemia after transplantation into SCID mice. Nature 1994; 367: 645–648
   PubMed Web of Science ®Google Scholar
• Terpstra W., Prins A., Ploemacher R. E., Wognum A. W., Wagemaker G., Löwenberg B., Wielenga J. J. Long-term leukemia-initiating capacity of a CD34 subpopulation of acute meyeloid leukemia. Blood. 1996; 87: 2187–2194
   PubMed Web of Science ®Google Scholar
• Fialkow P. J., Jacobsen R. J., Papayannopoulou T. Chronic myelogenous leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med. 1977; 63: 125–130
   PubMed Web of Science ®Google Scholar
• de Klein A., Geurts van Kessel A., Grosveld G., Bartram C. R., Hagemeijer A., Bootsma D., Spurr N. K., Heisterkamp N., Groffen J., Stephenson J. R. A cellular oncogene (c-abl) is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 1982; 294: 765–767
   Google Scholar
• Groffen J., Stephenson J. R., Heisterkamp N., de Klein A., Bartram C. R., Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984; 36: 93–99
   PubMed Web of Science ®Google Scholar
• Agarwal R., Doren S., Hicks B., Dunbar C. E. Long-term culture of chronic myelogenous leukemia marrow cells on stem cell factor-deficient stroma favors benign progenitors. Blood 1995; 85: 1306–1312
   PubMed Web of Science ®Google Scholar
• Wognum A. W., Cornelissen J. J., Frassoni F., Ploemacher R. E., Löwenberg B., Wagemaker G. Decreased expression of c-kit on immature hemopoietic cells in patients with chronic myeloid leukemma. Exp. Hematol. 1995; 23: 922
   Web of Science ®Google Scholar
• Visani G., Delwel R., Touw I., Bot F., Löwenberg B. Membrane receptors for interleukin 2 on hematopoietic precursors in chronic myeloid leukemia. Blood 1987; 69: 1182–1187
   PubMed Web of Science ®Google Scholar
• Small D., Levenstein M., Kim E., Carow C., Amin S., Rockwell P., Witte L., Burrow C., Ratajczak M., Gewirtz A., Civin C. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc. Natl. Acad. Sci. USA 1994; 91: 459–463
   PubMed Web of Science ®Google Scholar
• Debili N., Wendling F., Cosman D., Titeux M., Florindo C., Dusanter-Fourt I., Schooley K., Methia N., Charon M., Nador R., Bettaieb A., Vainchenker W. The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 1995; 85: 391–401
   PubMed Web of Science ®Google Scholar
• Heaney M. L., Golde D. W. Soluble cytokine receptors. Blood 1996; 87: 847–857
   PubMed Web of Science ®Google Scholar
• Egeland T., Gaudemack G. CD34. The gateway to the study of lymphohematopoietic progenitor and leukemic cells. The Immunologists 1994; 2: 65
   Google Scholar