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Original Article

Hematopoietic Stem Cell Transplants for Multiple Myeloma

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Pages 25-36 | Received 20 Sep 1995, Published online: 01 Jul 2009

References

  • Barlogie B., Alexanian R., Jagannath S. Plasma cell dyscrasias. JAMA 1992; 268: 2946–2951
  • Barlogie B., Epstein J., Selvanayagam P., Alexanian R. Plasma cell myeloma—New biological insights and advances in therapy. Blood 1989; 73: 865–879
  • Kyle R.A. Long-term survival in multiple myeloma. N. Engl. J. Med. 1983; 308: 314–316
  • Gregory W.M., Richards M.A., Malpas J.S. Combination chemotherapy versus melphalan and prednisone in the treatment of multiple myeloma: An overview of published trials. J. Clin. Oncol. 1992; 10: 334–342
  • Durie B. G. M., Stock-Novack D., Salmon S.E., Finley P., Beckord J., Crowley J., Coltman C.A. Prognostic value of pretreatment serum β2 microglobulin in myeloma: A Southwest Oncology Group study. Blood 1990; 75: 823–830
  • Bataille R., Boccadoro M., Klein B., Durie B., Piled A. C-reactive protein and β-2 microglobulin produce a simple and powerful myeloma staging system. Blood 1992; 80: 733–737
  • Greipp P.R., Lust J.A., O'Fallon W.M., Katemann J.A., Witzig T.E., Kyle R.A. Plasma cell labeling index and β2-mi-croglobulin predict survival independent of thymidine kinase and c-reactive protein in multiple myeloma. Blood 1993; 81: 3382–3387
  • San Miguel J.F., Garcia-Sanz R., Gonzalez M., Moro M.J., Hernandez J.M., Ortega F., Borrego D., Carnera M., Casanova F., Jimenez R., Portero J.A., Orfao A. A new staging system for multiple myeloma based on the number of S-phase plasma cells. Blood 1995; 85: 448–455
  • Ffrench M., Ffrench P., Remy F., Chapuis-Cellier C., Wolowiec D., Ville D., Bryon P.A. Plasma cell proliferation in monoclonal gammopathy: Relations with other biologic variables—diagnostic and prognostic significance. Am. J. Med. 1995; 98: 60–66
  • Dewald G.W., Kyle R.A., Hicks G.A., Greipp P.R. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis. Blood 1985; 66: 380–390
  • Lai J.L., Zandecki M., Mary J.Y., Bernardi F., Izydorczyk V., Flactif M., Moret P., Jouet J.P., Bauters F., Facon T. Improved cytogenetics in multiple myeloma: A study of 151 patients including 117 patients at diagnosis. Blood 1995; 85: 2490–2497
  • Dimopoulos M.A., Barlogie B., Smith T.L., Alexanian R. High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma. Ann. Intern. Med. 1991; 115: 931–935
  • Greipp P.R., Raymond N.M., Kyle R.A., O'Fallon W.M. Multiple myeloma: Significance of plasmablastic subtype in morphological classification. Blood 1985; 65: 305–310
  • Salmon S.E., Tesh D., Crowley J., Saeed S., Finley P., Milder M.S., Hutchins L.F., Coltman C.A., Bonnet J.D., Cheson B., Knost J.A., Samhouri A., Beckord J., Stock-Novack D. Chemotherapy is superior to sequential hemibody irradiation for remission consolidation in multiple myeloma: A Southwest Oncology Group study. J. Clin. Oncol. 1990; 8: 1575–1584
  • Cooper M.R., Dear K., McLntyre O.R., Ozer H., Ellerton J., Canellos G., Bemhardt B., Duggan D., Faragher D., Schiffer C. A randomized clinical trial comparing melphalan/pred-nisolone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: A cancer and leukemia group B study. J. Clin. Oncol. 1993; 11: 155–160
  • Blade J., Lopez-Guillermo A., Bosch F., Cervantes F., Reverter J.-C., Montserrat E., Rozman C. Impact of response to treatment on survival in multiple myeloma: Results in a series of 243 patients. Br. J. Haematol. 1994; 88: 117–121
  • MacLennan I. C. M., Chapman C., Dunn J., Kelly K. Combined chemotherapy with ABCM versus melphalan for treatment of myelomatosis. Lancet 1992; 339: 200–205
  • Osterborg A., Bjorkholm M., Bjoreman M., Brenning F., Carlson K., Celsing F., Gahrton G., Grimfors G., Gyllenhammar H., Hast R., Johansson B., Juliusson G., Jammark M., Kimby E., Lerner R., Linder O., Merk K., Nilsson B., Ohrling M., Paul C., Simonsson B., Smedmyr B., Svedmyr E., Stalfelt A-M., Strander H., Uden A-M., Osby E., Mellstedt H. Natural inter-feron-a in combination with melphalan/prednisone versus melpha-lan/prednisone in the treatment of multiple myeloma stages II and III: A randomized study from the Myeloma Group of Central Sweden. Blood 1993; 81: 1428–1434
  • Boccadoro M., Marmont F., Tribalto M., Avvisati G., Andriani A., Barbui T., Cantonetti M., Carotenuto M., Camotti B., Dammacco F., Frieri R., Gallamini A., Gallone G., Giovangrossi P., Grignani F., Lauta V.M., Liberati M., Musto P., Neretto G., Petrucci M.T., Resegotti L., Pileri A., Mandelli F. Multiple myeloma: VMCP/VBAP alternating combination chemotherapy is not superior to melphalan and prednisone even in high-risk patients. J. Clin. Oncol. 1991; 9: 444–448
  • Alexanian R., Barlogie B., Tucker S. VAD-based regimens as primary treatment for multiple myeloma. Am. J. Hematol. 1990; 33: 86–89
  • Alexanian R., Dimopoulos M.A., Delasalle K., Barlogie B. Primary dexamethasone treatment of multiple myeloma. Blood 1992; 80: 887–890
  • Hata H., Xiao H., Petrucci M.T., Woodliff J., Chang R., Epstein J. Interleukin-6 gene expression in multiple myeloma: A characteristic of immature tumor cells. Blood 1993; 81: 3357–3364
  • Epstein J., Xiao H., Oba B.K. P-Glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD. Blood 1989; 74: 913–917
  • McElwain T.J., Powles R.L. High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Lancet 1983; 822–824
  • Vesole D.H., Barlogie B., Jagannath S., Cheson B., Tricot G., Alexanian R., Crowley J. High-dose therapy for refractory multiple myeloma: Improved prognosis with better supportive care and double transplants. Blood 1994; 84: 950–956
  • Selby P., McElwain T., Mana A., Nandi A.C. Multiple myeloma treated with high-dose intravenous melphalan. Br. J. Haematoi. 1987; 66: 55–62
  • Cunningham D., Paz-Ares L., Gore M.E., Malpas J., Hickish T., Nicolson M., Meldrum M., Viner C., Milan S., Selby P.J., Normal A., Raymond J., Powles R. High-dose melphalan for multiple myeloma: long-term follow-up data. J. Clin. Oncol. 1994; 12: 764–768
  • Lokhorst H.M., Meuwissen O. J. A. T., Verdonck L.F., Dekker A.W. High-risk multiple myeloma treated with high-dose melphalan. J. Clin. Oncol. 1992; 10: 47–51
  • Cunningham D., Paz-Ares L., Milan S., Powles R., Nicolson M., Hickish T., Selby P., Treleavan J., Viner C., Malpas J., Slevin M., Findlay M., Raymond J., Gore M.E. High-dose melphalan and autologous bone marrow transplantation as consolidation in previously untreated myeloma. J. Clin. Oncol. 1994; 12: 759–763
  • Harousseau J-L., Attal M., Divine M., Mark G., Leblond V., Stoppa A-M., Bourhis J.-H., Caillot D., Boasson M., Abgrall J-F., Facon T., Linassier C., Cahn J-Y., Lamy T., Troussard X., Gratecos N., Pignon B., Auzanneau G., Bataille R. Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: A report of the French Registry on autologous transplantation in multiple myeloma. Blood 1995; 85: 3077–3085
  • Barlogie B., Jagannath S., Vesole D., Miller L., Cheson B., Bracy D., Tricot G. Total therapy (TT) for 202 newly diagnosed patients (PTS) with multiple myeloma (MM). Blood 1994; 84(Suppl 1)386a, (abstr)
  • Speed D.E., Galton D. A. G., Swan A. Melphalan in the treatment of myelomatosis. Br. Med. J. 1964; 1: 1964–1969
  • Zucchetti M., D'Incalci M., Willems Y., Cavalli F., Serra C. Lack of effect of cisplatin on IV L-PAM plasma pharmaco-kinetics in ovarian cancer patients. Cancer Chemother. Pharmacol. 1988; 22: 87–89
  • Osterborg A., Ehrsson H., Eksborg S., Wallin I., Mellistedt H. Pharmacokinetics of oral melphalan in relation to renal function in multiple myeloma patients. Eur. J. Cancer Clin. Oncol. 1989; 25: 899–903
  • Harousseau J.L., Milpied N., Laporte J.P., Collombat P., Facon T., Tigaud J.D., Casassus P., Guilhot F., Ifrah N., Gandhour C. Double-intensive therapy in high-risk multiple myeloma. Blood 1992; 79: 2827–2833
  • Tricot G., Alberts D.S., Barlogie B., Dorr R.T., Vesole D.H., Jagannath S., Meyers R., Roe D. High-dose melphalan pharmacokinetics in multiple myeloma, (submitted)
  • Tricot G., Sawyer J., Jagannath S., Bracy D., Mattox S., Vesole D., Naucke S., Barlogie B. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities. Blood
  • Tricot G., Jagannath S., Vesole D., Nelson J., Tindle S., Miller L., Cheson B., Crowley J., Barlogie B. Peripheral blood stem cell transplants for multiple myeloma: Identification of favorable variables for rapid engraftment in 225 patients. Blood 1995; 85: 588–596
  • Tricot G., Jagannath S., Vesole D., Crowley J., Barlogie B. Relapse of multiple myeloma after autologous transplantation: Survival after salvage therapy. Bone Marrow Transplant
  • Bell J. B. G., Maitland J.A., Gore M., Millar B.C., et al. Increase in clonogenic tumour cells in bone marrow of patients with multiple myeloma treated with vincristine, doxorubicin, and methyl-prednisolone. Lancet 1988; 2: 931–933
  • Abdou N.I., Abdou N.L. The monoclonal nature of lymphocytes in multiple myeloma. Ann. Intern. Med. 1975; 83: 42–45
  • Mellstedt H., Hammarstrom S., Holm G. Monoclonal lymphocyte population in human plasma cell myeloma. Clin. Exp. Immunol. 1974; 17: 371–384
  • Bast E., Van Camp B., Reynaert P., Wiringa G., et al. Idiotypic peripheral blood lymphocytes in human monoclonal gam-mopathy. Clin. Exp. Immunol. 1982; 47: 677–682
  • Carmagnola A., Boccadoro M., Massaia M., Pileri A. The idiotypic specificities of lymphocytes in human monoclonal gammopathies: Analysis with the fluorescence activated cell sorter. Clin. Exp. Immunol. 1983; 51: 173–177
  • Berenson J., Wong R., Kim K., Brown N., et al. Evidence for peripheral blood B lymphocyte but not T lymphocyte involvement in multiple myeloma. Blood 1987; 70: 1550–1553
  • Vora A.J., Toh C.H., Peel J., Greaves M. Use of gran-ulocyte colony-stimulating factor (G-CSF) for mobilizing peripheral blood stem cells: Risk of mobilizing clonal myeloma cells in patients with bone marrow infiltration. Br. J. Haematol. 1994; 86: 180–182
  • Witzig T.E., Gertz M.A., Pineda A.A., Kyle R.A., Greipp P.R. Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma. Br. J. Haematoi. 1995; 89: 640–642
  • Bird J.M., Bloxham D., Russell N.H., Samson D., Apperley J.F. Detection of clonally rearranged cells in PBSC harvests in multiple myeloma by immunoglobulin gene fingerprinting. Blood 1993; 82(Supp 11)265a
  • Dreyfus F., Ribrag V., Leblond V., Ravaud P., Melle J., Quarre M.C., Pillier C., Boccaccio C., Varet B. Detection of malignant B cells in peripheral blood stem cell collections after chemotherapy in patients with multiple myeloma. Bone Marrow Transplant 1995; 15: 707–711
  • Belch A.R., Bergsagel P.L., Szczepek A., Lansdorp P., Pilarski L.M. CD34+ B cells in the blood of patients with multiple myeloma express clonotypic IgH sequences. Blood 1994; 84(Supp 11)385a
  • Vescio R.A., Hong C.H., Cao J., Kim A., Schiller G.J., Lichtenstein A.K., Berenson R.J., Berenson J.R. The hematopoietic stem cell antigen CD34, is not expressed on the malignant cells in multiple myeloma. Blood 1994; 84: 3283–3290
  • Gazitt Y., Reading C.C., Hoffman R., Wickrema A., Vesole D., Jagannath S., Condino J., Lee B., Barlogie B., Tricot G. Purified CD34+Lin-Thy+ stem cells do not contain clonal myeloma cells. Blood 1995; 86: 381–389
  • Anderson K.C., Barut B.A., Ritz J., Freedman A.S., Takvorian T., Rabinowe S.N., Soiffer R., Heflin L., Coral F., Dear K., Mauch P., Nadler L.M. Monoclonal antibody-purged autologous bone marrow transplantation therapy for multiple myeloma. Blood 1991; 77: 712–720
  • Reece D.E., Barnett M.J., Connors J.M., Klingemann H-G., O'Reilly S.E., Shepherd J.D., Sutherland H.J., Phillips G.L. Treatment of multiple myeloma with intensive chemotherapy followed by autologous BMT using marrow purged with 4-hy-droperoxycyclophosphamide. Bone Marrow Transplant 1993; 11: 139–146
  • Schiller G., Vescio R., Freytes C., Spitzer G., Sahebi F., Lee M., Wu C.H., Cao J., Lee J.C., Hong C.H., Lichtenstein A., Lill M., Hall J., Berenson R., Berenson J. Transplantation of CD34+ peripheral blood progenitor cells after high-dose chemotherapy for patients with advanced multiple myeloma. Blood 1995; 86: 390–397
  • Takishita M., Kosaka M., Goto T., Saito S. Cellular origin and extent of clonal involvement in multiple myeloma: Genetic and phenotypic studies. Br. J. Haematoi. 1994; 87: 735–742
  • Bergsagel P.L., Belch A.R., Pilarski L.M. The blood B cells and bone marrow plasma cells in a patient with multiple myeloma include cells with the same N-ras mutation. Blood 1994; 84(Supp 11)524a
  • Murray L., Chen B., Galy A., Chen S., Tushinski R., Uchida N., Negrin R., Tricot G., Jagannath S., Vesole D., Barlogie B., Hoffman R., Tsukamoto A. Enrichment of human hematopoietic stem cell activity in the CD34+Thy-1+Lin-subpop-ulation from mobilized peripheral blood. Blood 1995; 85: 368–378
  • Gazitt Y., Tian E., Barlogie B., Reading C.C., Vesole D., Jagannath S., Schnell J., Hoffman R., Tricot G. Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma following treatment with cyclophosphamide and GM-CSF, (submitted)
  • Attal M., Stoppa A.M., Sotto J.J., Fuzibet G., Rossi J.F., Casassus P., Thyss A., Maisonneuve H., Facon T., Ifrah N., Payen C., Bataille R. High dose therapy in multiple myeloma: A prospective randomized study of the “Intergroupe Francais du Myelome” (IFM). Blood 1994; 84(Suppl 1)386a
  • Alexanian R., Dimopoulos M.A., Hester J., Delasalle K., Champlin R. Early myeloablative therapy for multiple myeloma. Blood 1994; 84: 4278–4282
  • Alexanian R., Dimopoulos M., Smith T., Delasalle K., Barlogie B., Champlin R. Limited value of myeloablative therapy for late multiple myeloma. Blood 1994; 83: 512–516
  • Mandelli F., Avvisati G., Amadori S., Boccadoro M., Gernone A., Lauta V.M., Marmont F., Petrucci M.T., Tribalto M., Vegna M.L., Dammacco F., Pileri A. Maintenance treatment with recombinant interferon Alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy. N. Engl. J. Med. 1990; 322: 1430–1434
  • Cunningham D., Powles R., Malpas J.S., Milan S., Meldrum M., Viner C., Montes A., Hickish T., Nicolson M., Johnson P., Mansi J., Treleaven J., Raymond J., Gore M.E. A randomised trial of maintenance therapy with intron-A following high dose melphalan and ABMT in myeloma. Proc. ASCO 1993; 12: 1232
  • Miller J.S., Arthur D.C., Litz C.E., Neglia J.P., Miller W.J., Weisdorf D.J. Myelodysplastic syndrome after autol-ogous bone marrow transplantation: An additional late complication of curative cancer therapy. Blood 1994; 83: 3780–3786
  • Traweek S.T., Slovak M.L., Nademanee A.P., Brynes R.K., Niland J.C., Forman S.J. Clonal karyotypic hematopoietic cell abnormalities occurring after autologous bone marrow transplantation for Hodgkin's disease and non-Hodgkin's lym-phoma. Blood 1994; 84: 957–963
  • Darrington D.L., Vose J.M., Anderson J.R., Bierman P.J., Bishop M.R., Chan W.C., Morris M.E., Reed E.C., Sanger W.G., Tarantolo S.R., Weisenburger D.D., Kessinger A., Armitage J.O. Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J. Clin. Oncol. 1994; 12: 2527–2534
  • Stone R.M., Neuberg D., Soiffer R., Takvorian T., Whelan M., Rabinowe S.N., Aster J.C., Leavitt P., Mauch P., Freedman A.S., Nadler L.M. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J. Clin. Oncol. 1994; 12: 2535–2542
  • Pedersen-Bjergaard J., Ersboll J., Sorensen H.M., Keiding N., Larsen S.O., Philip P., Larsen M.S., Schultz H., Nissen N.I. Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lym-phomas. Ann. Int. Med. 1985; 103: 195–200
  • Levine E.G., Bloomfield C.D. Leukemias and myelodysplastic syndromes secondary to drug, radiation, and environmental exposure. Sem. Oncol. 1992; 19: 47–84
  • Sharp J.G., Joshi S.S., Armitage J.O., Bierman P., Coccia P.F., Harrington D.S., Kessinger A., Crouse D.A., Mann S.L., Weisenburger D.D. Significance of detection of occult non-Hodgkin's lymphoma in histologically univolved bone marrow by a culture technique. Blood 1992; 79: 1074–1080
  • Brenner M.K., Rill D.R., Moen R.C., Krance R.A., Mirro J., Anderson W.F., Ihle J.N. Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 1993; 341: 85–86
  • Meloni G., Foa R., Vignetti M., Guarini A., Fenu S., Tosti S., Tos A.G., Mandelli F. Interleukin-2 may induce prolonged remissions in advanced acute myelogenous leukemia. Blood 1994; 84: 2158–2163
  • Hoover R.G., Lary C., Page R., et al. Autoregulatory circuits in myeloma: Tumor cell cytotoxicity mediated by soluble CD 16. J. Clin. Invest.
  • Stevenson F.K., Bell A.J., Cusack R., Hamblin T.J., Slade C.J., Spellerberg M.B., Stevenson G.T. Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody. Blood 1991; 77: 1071–1079
  • Grossbard M.L., Gribben J.G., Freedman A.S., Lambert J.M., Kinsella J., Rabinowe S.N., Eliseo L., Taylor J.A., Blattler W.A., Epstein C.L., Nadler L.M. Adjuvant immunotoxin therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with B-cell non-Hodgkin's lymphoma. Blood 1993; 81: 2263–2271
  • Calabretta B. Inhibition of protooncogene expression by an-tisense oligodeoxynucleotides: Biological and therapeutic implications. Cancer Res. 1991; 51: 4505–4510
  • Cuthbert J.A., Lipsky P.E. Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. Cancer Res. 1995; 55: 1732–1740
  • Mizutani Y., Bonavida B., Koishihara Y., Akamatsu K., Ohsugi Y., Yoshida O. Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum (II) by anti-Interleukin 6 monoclonal antibody or anti-Interleukin 6 receptor monoclonal antibody. Cancer Res. 1995; 55: 590–596

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