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Original Article

The Role of the CD40 Antigen on Malignant B Cells

, &
Pages 229-235 | Received 26 Sep 1995, Published online: 01 Jul 2009

References

  • Banchereau J., Bazan F., Blanchard D., Brière F., Galizzi J.P., Van Kooten C., Liu Y.J., Rousset F., Saeland S. The CD40 antigen and its ligand. Annual Review of Immunology 1994; 12: 881–922
  • McLennan I. C. M. Germinal Centers. Annual Review of Immunology 1994; 12: 117–139
  • Van den Eertwegh A. J. M., Noelle R.J., Roy M., Shepherd D.M., Aruffo A., Ledbetter J.A., Boersma W. J. A., Claassen E. In vivo CD40-gp39 interactions are essential forthymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J Exp. Med. 1993; 178: 1555–1565
  • Foy T.M., Shepherd D.M., Durie F.H., Aruffo A., Ledbetter J.A., Noelle R.J. In vivo CD40-gp39 interactions are essential for thymus- dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 1993; 178: 1567–1575
  • Blanchard D., Gaillard C., Hermann P., Banchereau J. Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth. Eur. J. Immunol 1994; 24: 330–335
  • Lederman S., Yellin M.J., Cleary A.M., Pernis A., Inghirami G., Cohn L.E., Covey L.R., Lee J.J., Rothman P., Chess L. T-BAM/CD40-L on helper T lymphocytes augments lym-phokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J. Immunol 1994; 152: 2163–2171
  • Spriggs M.K., Armitage R.J., Strockbine L., Clifford K.N., Macduff B.M., Sato T.A., Maliszewski C.R., Fanslow W.C. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 1992; 176: 1543–1550
  • Nishioka Y., Lipsky P.E. The role of CD40-CD40 lig-and interaction in human T cell-B cell collaboration. J. Immunol. 1994; 153: 1027–1036
  • Aruffo A., Farrington M., Hollenbaugh D., Li X., Milatovich A., Nonoyama S., Bajorath J., Grosmaire L.S., Stenkamp R., Neubauer M., Roberts R.L., Noelle R.J., Ledbetter J.A., Francke U., Ochs H.D. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 1993; 72: 291–300
  • Ledbetter J.A., Shu G., Gallagher M., Clark E.A. Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDw40). J. Immunol. 1987; 138: 788–794
  • Banchereau J., Rousset F. Growing human B lymphocytes in the CD40 system. Nature 1991; 353: 678–679
  • Banchereau J., de Paoli P., Valle A., Garcia E., Rousset F. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 1991; 251: 70–72
  • Fluckiger A.C., Rossi J.F., Bussel A., Bryon P., Banchereau J., Defrance T. Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. Blood 1992; 80: 3173–3181
  • Crawford D.H., Catovsky D. In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40. Immunology 1993; 80: 40–44
  • Kluin-Nelemans J.C., Beverstock G.C., Mollevanger P., Wessels H.W., Hoogendoorn E., Willemze R., Falkenburg J. H. F. Proliferation and cytogenetic analysis of hairy cell leukemia upon stimulation via the CD40 antigen. Blood 1994; 84: 3134–3141
  • Stamenkovic I., Clark E.A., Seed B. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO. 1989; 8: 1403–1410
  • Gruss H.-J., Dower S.K. Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lym-phomas. Blood 1995; 85: 3378–3404
  • Holder M.J., Wang H., Milner A.E., Casamayor M., Armitage R., Spriggs M.K., Fanslow W.C., Maclennan I. C. M., Gregory C.D., Gordon J. Suppression of apoptosis in normal and neoplasiic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 1993; 23: 2368–2371
  • Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata D. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314–316
  • Inui S., Kaisho T., Stamenkovic I., Seed B., Clark E.A., Kishimoto T. Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40. Eur. J. Immunol 1990; 20: 1747–1753
  • Uckun F.M., Schieven G.L., Dibirdik I., Chandan-Langlie M., Tuel-Ahlgren L., Ledbetter J.A. Stimulation of protein tyrosine phosphorylation, phosphionositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J. Biol. Chem. 1991; 26: 17478–17485
  • Hu H.M., O'Rourke K., Boguski M.S., Dixit V.M. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 1994; 269: 30069–30072
  • Berberich I., Shu G.L., Clark E.A. Cross-linking CD40 on B cells rapidly activates nuclear factor-kappaB. J. Immunol 1994; 153: 4357–4366
  • Ling N.R., Maclennan I. C. M., Mason D.Y. B-cell and plasma cell antigens: new and previously defined clusters. Leucocyte typing 111. White cell differentiation antigens, A.J. McMichael. Oxford University Press, Oxford, New York, Tokyo 1987; 302–335
  • Uckun F.M. Regulation of human B-cell ontogeny. Blood 1990; 76: 1908–1923
  • Uckun F.M., Gajl-Peczalska K., Myers D.E., Jaszcz W., Haissig S., Ledbetter J.A. Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lin-eage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells. Blood 1990; 76: 2449–2456
  • Alderson M.R., Armitage R.J., Tough T.W., Strockbine L., Fanslow W.C., Spriggs M.K. CD40 expression by human monocytes: Regulation by cytokines and activation of mono-cytes by the ligand for CD40. Exp. Med. 1993; 178: 669–674
  • Caux C., Massacrier C., Vanbervliet B., Dubois B., Van Kooten C., Durand I., Banchereau J. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 1994; 180: 1263–1272
  • Saeland S., Duvert B., Caux C., Pandrau D., Favre C., Valle A., Durand I., Charbord P., de Vries J.E., Banchereau J. Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells. Exp. Hematol 1992; 20: 24–33
  • Galy A., Spits H. CD40 is functionally expressed on human thymic epithelial cells. J Immunol 1992; 149: 775–782
  • Karmann K., Hughes C. C. W., Schechner J., Fanslow W.C., Pober J.S. CD40 on human endothelial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression. Proceedings of the National Academy of Sciences, USA 1995; 92: 4342–4346
  • Paulie S., Rosen A., Ehlin-Henriksson B., Braesh-Anderson S., Jakobson E., Koho H., Perlman P. The human B lymphocyte and carcinoma antigen, CDw40, is a phospho-protein involved in growth signal transduction. J. Immunol 1989; 142: 590
  • Carbone A., Gloghini A., Gattei V., Aldinucci D., Degan M., de Paoli P., Zagonel B., Pinto A. Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines. Blood 1995; 85: 780–789
  • Dijkstra N.H., Planken E.V., Bakkus M., Willemze R., Kluin-Nelemans J.C. Proliferation of precursor B-ALL by triggering the CD40 antigen. Blood 1995; 86, (suppll)
  • Castle B.E., Kishimoto K., Stearns C., Brown M.L., Kehry M.R. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol 1993; 151: 1777–1788
  • Casamayor-Palleja M., Khan M., Maclennan I. C. M. A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 1995; 181: 1293–1301
  • Foy T.M., Laman J.D., Ledbetter J.A., Aruffo A., Claassen E., Noelle R.J. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 1994; 180: 157–163
  • Ranheim E.A., Kipps T.J. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Med. 1993; 177: 925–935
  • Yellin M.J., Sippel K., Inghirami G., Covey L.R., Lee J.J., Sinning J., Clark E.A., Chess L., Lederman S. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L: Potential role in regulating helper effector function. J. Immunol 1994; 152: 598–608
  • Van Kooten C., Gaillard C., Galizzi J.-P., Hermann P., Fossiez F., Banchereau J., Blanchard D. B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 1994; 24: 787–792
  • Caux C., Burdin N., Galibert L., Hermann P., Renard N., Servet-Delprat C., Banchereau J. Functional CD40 on B lymphocytes and dendritic cells. Res. Immunol 1994; 145: 235–239
  • Allen R.C., Armitage R.J., Conley M.E., Rosenblatt H., Jenkins N.A., Copeland N.G., Bedell M.A., Edelhoff S., Disteche C.M., Simoneaux D.K., Fanslow W.C., Belmont J., Spriggs M.K. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 1993; 259: 990–993
  • Callard R.E., Armitage R.J., Fanslow W.C., Spriggs M.K. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunology Today 1993; 14: 559–564
  • Farrington M., Grosmaire L.S., Nonoyama S., Fischer S.H., Hollenbaugh D., Ledbetter J.A., Noelle R.J., Aruffo A., Ochs H.D. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proceedings of the National Academy of Sciences, USA 1994; 91: 1099–1103
  • Gordon J., Millsum M.J., Guy G.R., Ledbetter J.A. Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. J. Immunol 1988; 140: 1425–1430
  • Arpin C., Dechanet J., Van Kooten C., Merville P., Grouard G., Briere F., Banchereau J., Liu Y.-J. Generation of memory B cells and plasma cells in vitro. Science 1995; 268: 720–722
  • Barrett T.B., Shu G., Clark E.A. CD40 signaling activates CDlla/CD18 (LFA-l)-mediated adhesion in B cells. J. Immunol 1991; 146: 1722–1729
  • Clark E.A., Shu G. Association between IL-6 and CD40 signalling. IL-6 induces phosphorylation of CD40 receptors. J Immunol 1990; 145: 1400–1406
  • Burdin N., Van Kooten C., Galibert L., Abrams J.S., Wijdenes J., Banchereau J., Rousset F. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol 1995; 154: 2533–2544
  • Saeland S., Duvert V., Moreau I., Banchereau J. Human B cell precursors proliferate and express CD23 after CD40 ligation. J Exp. Med 1993; 178: 113–120
  • Renard N., Duvert V., Blanchard D., Banchereau J., Saeland S. Activated CD4+ T cells induce CD40-dependent proliferation of human B cell precursors. J. Immunol 1994; 152: 1693–1701
  • Larson A.W., LeBien T.W. Cross-linking CD40 on human B cell precursors inhibits or enhances growth depending on the stage of development and the IL costimulus. J. Immunol 1994; 153: 584–594
  • Defrance T., Vanbervliet B., Briere F., Durand I., Rousset F., Banchereau J. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 1992; 671–682
  • Defrance T., Fluckiger A.-C., Rossi J.-F., Rousset F., Banchereau J. In vitro activation of B-CLL cells. Leak. Lymph. 1991; 5: 13–19, Suppl.
  • Planken E.V., Dijkstra N., Willemze R., Kluin-Nelemans J.C. Proliferation of B cell malignancies in all stages of differentiation upon stimulation in the “CD40 system”. 1995, submitted
  • Lotz M., Ranheim E., Kipps T.J. Transforming growth factor P as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J. Exp. Med. 1994; 179: 999–1004
  • Johnson P. W. M., Watt S.M., Betts D.R., Davies D., Jordan S., Norton A.J., Lister T.A. Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system. Blood 1993; 82: 1848–1857
  • Kishimoto T. The biology of interleukin-6. Blood 1989; 74: 1–10
  • Pellat-Deceunynck C., Bataille R., Robillard N., Harousseau J.-L., Rapp M.-J., Juge-Morineau N., Wijdenes J., Amiot M. Expression of CD28 and CD40 in human myeloma cells: A comparative study with normal plasma cells. Blood 1994; 84: 2597–2603
  • Kozbor D., Moretta A., Messner H.A., Moretta L., Croce C.M. Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasmacells. J Immunol. 1987; 138: 4128–4132
  • Planken E.V., Falkenburg J. H. F., Willemze R., Kluin-Nelemans J.C. Proliferation of malignant B cells in the CD40 system. Br. J. Haematol. 1994; 87(suppl. 1)232, (abstract)
  • Westendorf J.J., Ahmann G.J., Armitage R.J., Spriggs M.K., Lust J.A., Greipp P.R., Katzmann J.A., Jelinek D.F. CD40 expression in malignant plasma cells. Role in stimulation of autocrine IL-6 secretion by a human myeloma cell line. J. Immunol. 1994; 152: 117–127
  • Tong A.W., Zhang B., Mues G., Solano M., Hanson T., Stone M.J. Anti-CD40 antibody binding modulates human multiple myeloma clonogenicity in vitro. Blood 1994; 84: 3026–3033

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