21
Views
8
CrossRef citations to date
0
Altmetric
Original Article

In Vitro and in Vivo Anti-Leukemic Efficacy of Cyclic AMP Modulating Agents Against Human Leukemic B-cell Precursors

, , &
Pages 259-264 | Received 08 Oct 1995, Published online: 01 Jul 2009

References

  • Jegasothy B.V., Namba Y., Walksman B.H. Regulatory substances produced by lymphocytes. IDS inhibits stimulated lymphocyte proliferation by activation of membrane adenylate cyclase at a restriction point in late GI. Immunochemistry 1978; 15: 551
  • Wang T., Sheppard R., Foker J.E. Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis. Science 1978; 201: 155
  • Muraguchi A., Miyazaki K., Kehrl J.H., Fauci A.S. Inhibition of human B cell activation by diterpine forskolin: Interference with B cell growth factor induced Gl to S transition of the B cell cycle. J. Immunol. 1984; 133: 1283–1287
  • Baker P.E., Fahey J.V., Munck A. Prostaglandin inhibition of T cell proliferation is mediated at two levels. Cell. Immunol. 1981; 61: 52
  • DosReis G.A., Nobrga A.F., deCarvalho R.P. Purinergic modulation of T lymphocyte activation: differential susceptibility of distinct activation steps and correlation with intracellular 3′,5′ cAMP accumulation. Cell. Immunol. 1986; 101: 213
  • Blomhoff H.K., Smeland E.B., Bfiske K., Blomhoff R., Ruud E., Bjoro T., Pfeifer-Olson S., Watt R., Funderud S., Godal T., Ohlson R. Cyclic AMP mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha-ras protooncogenes. J. Cell. Physiol. 1987; 131: 426
  • McConkey D., Orrenius S., Jondal M. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J. Immunol. 1990; 145: 1227
  • Kizaki H., Suzuki K., Tadakuma T., Ishimura Y. Adenosine receptor-mediated accumulation of cyclic AMP-induced T lymphocyte death through internucleosomal DNA cleavage. J. Biol. Chem. 1990; 265: 5280
  • McConkey D.J., Orrenius S., Okret S., Jondal M. Cyclic AMP potentiates glucocorticoid indued endogenous endonuclease activation in thymocytes. The FASEB J 1993; 7: 580
  • Albert D.A. The effect of cyclic AMP on the regulation of c-myc expression in T lymphomacells. J. Clin. Invest. 1995; 95: 1490–1496
  • Lomo J., Blomhoff H.K., Beiske K., Stokke T., Smeland E.B. TGF beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes. J. Immunol. 1995; 154: 1634–1643
  • Vintermyr O.K., Boe R., Brustugun O.T., Maronde E., Aakvaag A., Doskeland S.O. Cyclic adenosine monophosphate analogs 8-C1 and 8-NH2-CAMP induce cell death independently of cAMP kinase mediated inhibition of the Gl/S transition in mammary carcinoma cells. Endocrinology 1995; 136: 2513–2520
  • Cho-Chung Y.S., Clair T., Tortora G., Yokozaki H. Role of site-selective cAMP analogs in the control and reversal of malignancy. Pharmacol. Ther. 1991; 50: 1–33
  • Hartwell L. cAMP'ing out. Science 1994; 371: 286
  • Roger P.P., Rickaert F., Huez G., Authlet M., Hofmann F., Dumont J.E. Microinjection of catalytic subunit of cyclic AMP-dependent kinases triggers acute morphological changes in thyroid epithelial cells. FEBS Lett. 1988; 232: 409–413
  • Cook S.J., McCormick F. Inhibition by cAMP of ras-de-pendent activation of raf. Science 1993; 262: 1069–1072
  • Tokiwa G., Tyers M., Volpe T., Futcher B. Inhibition of Gl cyclin activity by the ras/cAMP pathway in yeast. Nature 1994; 371: 342–345
  • Vintermyr O.K., Gjertsen B.T., Lanotte M., Doskeland S.O. Microinjected catalytic subunit of cAMP dependent protein kinase induces apoptosis in myeloid leukemia cells. Exp. Cell. Res. 1993; 206: 157–161
  • Tortora G., Tagliaferri P., Clair T., Colamonici O., Neckers L.M., Robins R.K., Cho-Chung Y.S. Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic leukemia cell lines. Blood 1988; 71: 230–233
  • Miller R.P., Lovelance E., Gallo M., Pastan I. Cyclic AMP and cellular growth. Science 1975; 190: 1213–1215
  • Cho-Chung Y.S., Gullino P.M. In vivo inhibition of growth of two hormone-dependent mammary tumors by dibutyryl cyclic AMP. Science 1974; 183: 87–88
  • Uckun F.M., Manivel C., Arthur D., Chelstrom L.M., Finnegan D., Irvin J., Tuel-Ahlgren L., Myers D.E., Gunther R. In vivo efficacy of B43(anti-CD19)-pokeweed antiviral protein im-munotoxin against human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood 1992; 79: 2201
  • Uckun F.M., Stewart C.F., Reaman G., Chelstrom L.M., Jin J., Chandan-Langlie M., Waddick K.G., White J., Evans W.E. In vitro and in vivo activity of topotecan against human -B-lineage acute lymphoblastic leukemia cells. Blood 1995; 85: 2817–2828
  • Uckun F.M., Jaszcz W., Chandan-Langlie M., Waddick K.G., Song C.W. Intrinsic radiation resistance of primary clono-genic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia. J. Clin. Invest. 1993; 91: 1044
  • Uckun F.M., Evans W.E., Forsyth C.J., Waddick K.G., Tuel-Ahlgren L., Chelstrom L., Burkhardt A., Bolen J., Myers D.E. Biotherapy of B cell precursor leukemia by targeting genis-tein to CD19 associated tyrosine kinases. Science 1995; 267: 886

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.