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Leukemia & Lymphoma Volume 22, 1996 - Issue sup1
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Original Article

Feasibility of Randomised Clinical Trials in Rare Diseases: The Case of Polycythemia Vera

Roberto Marchioli Department of Clinical Pharmacology and Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud—Via Nazionale—66030S, Maria Imbaro, Chieti
,
Raffaele Landolfi Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore. Largo Agostino Gemelli, 8, Roma
,
Tiziano Barbui Division of Hematology, Ospedali Riuniti. Largo Barozzi 1, Bergamo
&
Gianni Tognoni Department of Clinical Pharmacology and Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud—Via Nazionale—66030S, Maria Imbaro, Chieti
Pages 121-127 | Received 18 Mar 1996, Published online: 01 Jul 2009

References

  • Anderson D. R. Second Thoughts. Umbrellas and lions. J. Clin. Epidemiol. 1991; 44: 335–7
  • Evidence-based Medicine Working Group. Evidence-based medicine: A new approach to teaching the practice of medicine. JAMA 1992; 268: 2420–2425
  • Sackett K. D. L. Applying overviews and meta-analyses at the bedside. J. Clin. Epidemiol. 1995; 48: 61–66
  • Chalmers I. The Cochrane Collaboration: preparing, maintaining and disseminating systematic reviews of the effects of health care. Ann. N.Y. Acad. Sci. 1993; 703: 156–165
  • Tognoni G., Bonati M. Second-generation clinical pharmacology. Lancet. 1986; 2: 1028–29
  • Tognoni G., Franzosi M. G., Garattini S., Maggioni A., Lotto A., Mauri F., et al. The case of GISSI in changing the attitudes and practice of Italian Cardiologists. Stat. Med. 1990; 9: 17–27
  • Gruppo Italiano per lo Studio della Streptokinasi nell'Infarto Miocardico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986; 1: 397–402
  • Antman E. M., Lau J., Kupelnick B., Mosteller F., Chalmers T. C. A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction. JAMA 1992; 268: 240–48
  • Marchioli R. Easy Meta-analysis?. J. Nephrol. 1993; 6: 193–201
  • Thompson S. G., Pocock S. J. Can meta-analysis be trusted?. Lancet. 1991; 338: 1127–30
  • Miettinen O. S. The clinical trial as a paradigm for epidemiologic research. J. Clin. Epidemiol. 1989; 42: 491–6
  • Pocock S. J. Clinical trials: A practical approach. Wiley, Chichester 1983
  • Peto R., Pike M. C., Armitage P., Breslow N., Cox D. R., Howard S. W., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part I: Introduction and design. Br. J. Cancer 1976–1977; 34: 585–612
  • Yusuf S., Collins R., Peto R. Why do we need some large, simple randomized trials?. Stat. Med. 1984; 3: 409–420
  • Yusuf S., Held P., Teo K. K., Toretsky E. R. Selection of patients for randomized controlled trials: implications of wide or narrow elegibility criteria. Stat. Med. 1990; 9: 73–86
  • Marchioli R., Prieto J. C., Tognoni G. Surrogate end-points: the case of trials on coronary atherosclerotic plaque regression. Clin. Trials and Meta-Analysis 1994; 29: 139–176
  • Hennekens C. H., Buring J. E. Epidemiology in medicine, S. L. Mayrent. Little, Brown and Company, Boston, Massachusetts 1987
  • Sackett K. D. L., Haynes R. B., Guyatt G. H., Tugwell P. Clinical Epidemiology: A basic science for clinical Medicine. Brown, Boston 1991

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