56
Views
29
CrossRef citations to date
0
Altmetric
Original Article

Influence of Interferon-α on Cytokine Expression by the Bone Marrow Microenvironment—Impact on Treatment of Myeloproliferative Disorders

, &
Pages 129-134 | Received 18 Mar 1996, Published online: 01 Jul 2009

References

  • Rowley J. D. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243: 290
  • Ben-Neriah Y., Daley G. Q., Mes-Masson A. M., Witte O. N., Baltimore D. The chronic myelogenous leukemia-specific p210 protein is the product of the bcr-abl hybrid gene. Science 1986; 233: 212
  • de Klein A., van Kessel A. G., Grosfeld G., Bartram C. R., Hagemeijer A., Bootsma D., Spurr N. K., Heisterkamp N., Groffen J., Stephenson J. R. A cellular oncogene (c-abl) is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 1982; 294: 765
  • Konopka J. B., Watanabe S. M., Witte O. N. An alteration of the human c-abl protein in K562 cells unmasks associated tyrosine kinase activity. Cell 1984; 37: 1035
  • McWhirter J. R., Wang J. Y. An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of philadelphia chromosome-positive human leukemias. EMBO J. 1991; 12: 1533
  • Sirard C., Laneuville P., Dick J. E. Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism. Blood 1994; 83: 1575
  • Daley G. Q., Baltimore D. Tranformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific p210 bcr/abl protein. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 9312
  • Elefanty A. G., Hariharan I. K., Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J. 1990; 9: 1069
  • Kelliher M. A., McLaughlin J., Witte O. N., Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 6649
  • Heisterkamp N., Jenster G., ten Hoeve J., Zovich D., Pattengale P. K., Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature 1990; 344: 251
  • Goldman J. M., Th'ng K. H., Lowenthal R. M. In vitro colony forming cells and colony stimulating factor in chronic granulocytic leukemia. Br. J. Cancer 1974; 30: 1
  • Lepine J., Messner H. A. Pluripotent hemopoietic progenitors (CFU-GEMM) in chronic myelogenous leukemia. Int. J. Cell Cloning 1983; 1: 230
  • Emanuel P. D., Bates L. J., Castleberry R. P., Gualtieri R. J., Zuckerman K. S. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood 1991; 77: 925
  • Bedi A., Zehnbauer B. A., Barber J. P., Sharkis S. J., Jones R. J. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 1994; 83: 2038
  • McGahon A., Bissonnette R., Schmitt M., Cotter K. M., Green D. R., Cotter T. G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 1994; 83: 1179
  • Bedi A., Barber J. P., Bedi G. C., El-Deiry W. S., Sidransky D., Vala M. S., Akhtar A. J., Hilton J., Jones R. J. BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents. Blood 1995; 86: 1148
  • Schwab R., Peschel C., Derigs G., Fischer T., Huber C., Aulitzky W. E. Deficient cell cycle control upon gamma irradiation and growth factor starvation in immature myeloid cells from chronic phase CML patients Cytokines and Molecular Therapy. 1995
  • Eaves A. C., Cashman J. D., Gaboury L. A., Kalousek D. K., Eaves C. J. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells. Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 5306
  • Cashman J. D., Eaves A. C., Eaves C. J. The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism. Blood 1994; 84: 1534
  • Gordon M. Y., Dowding C. R., Riley G. P., Goldman J. M., Greaves M. F. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukemia. Nature 1987; 328: 342
  • Gordon M. Y., Atkinson J., Clarke D., Dowding C. R., Goldman J. M., Grimsley P. G., Siczkowski M., Greaves M. F. Deficiency of a phosphatidylinositol-anchored cell adhesion molecule influences haemopoietic progenitor binding to marrow stroma in chronic myeloid leukaemia. Leukemia 1991; 5: 693
  • Verfaille C. M., McCarthy J. B., McGlave P. B. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J. Clin. Invest. 1992; 90: 1992
  • Eaves C. J., Cashman J. D., Wolpe S. D., Eaves A. C. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein I alpha, an inhibitor of primitive normal hematopoietic cells. Proc. Natl. Acad. Sci. U. S. A. 1993; 90: 12015
  • Estrov Z., Kurzrock R., Wetzler M., Kantarjian H., BlakeHarris M., Gutterman J. U., Talpaz M. Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: A novel application for inhibitors of IL-1 activity. Blood 1991; 78: 1476
  • Wetzler M., Kurzrock R., Lowe D. G., Kantarjian H., Gutterman J. U., Talpaz M. Alteration in bone marrow adherent layer growth factor expression: No novel mechanism of chronic myelogenous leukemia progression. Blood 1991; 78: 2400
  • Klein H., Becher R., Lübbert M., Oster W., Schleiermacher E., Brach M. A., Souza L., Lindemann A., Mertelsmann R., Herrmann F. Synthesis of granulocyte colony-stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia progression. J. Exp. Med. 1990; 171: 1785
  • Herrmann F., Helfrich S. G., Lindemann A., Schleiermacher E., Huber C., Mertelsmann R. Elevated circulating levels of tumor necrosis factor predict unresponsiveness to treatment with interferon alpha-2b in chronic myelogenous leukemia. J. Clin. Oncol. 1992; 10: 631
  • Casadevall B., Vainchenker W., Lacombe C. Erythroid progenitors in polycythemia vera: Demonstration of their hypersensitivity to erythropoietin using serum free cultures. Blood 1982; 59: 447
  • Zanjani E. D., Lutton J. D., Hoffman R., Wasserman L. R. Erythroid colony formation by polycythemia vera bone marrow in vitro: Dependence on erythropoietin. J. Clin. Invest. 1977; 59: 841
  • Fisher M. J., Prchal J. F., Prchal J. T., D'Andrea A. D. Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera. Blood 1994; 84: 1982
  • de Wolf J. T., Hendriks D. W., Esselink M. T., Halie M. R., Vellenga E. The effects of IL-1 and IL-4 on the Epo-independent erythroid progenitor in polycythemia vera. Br. J. Haematol. 1994; 88: 12
  • Dai C. H., Krantz S. B., Dessypris E. N., Means R. T., Horn S. T., Gilbert H. S. Polycythemia vera II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony stimulating factor. Blood 1992; 80: 891
  • de Wolf J. T., Beentjes J. A., Esselink M. T. In polycythemia vera human interleukin 3 and granulocyte-macrophage colony-stimulating factor enhance erythroid colony growth in the absence of erythropoietin. Exp. Hematol. 1989; 17: 981
  • Dai C. H., Krantz S. B., Green W. F., Gilbert H. S. Polycythemia vera III. Burst forming units erythroid (BFU-E) response to stem cell factor and c-kit receptor expression. Br. J. Haematol. 1994; 86: 12
  • Muller E. W., de Wolf J. T., Hendriks D. W., Esselink M. T., Halie M. R., Vellenga E. Recombinant human mast cell growth factor supports erythroid colony formation in polycythemia vera in the presence and absence of erythropoietin and serum. Exp. Hematol. 1995; 21: 1353
  • Correa P. N., Eskinazi D., Axelrad A. A. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: Studies in an improved serum-free medium. Blood 1994; 83: 99
  • Mirza A. M., Correa P. N., Axelrad A. A. Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor-1 receptor β subunit in circulating mononuclear cells of patients with polycythemia vera. Blood, 86: 877
  • Hehlmann R., Heimpel H. Current aspects of drug therapy in Philadelphia-positive CML: Correlation of tumor burden with survival. Leuk. Lymphoma. 1995
  • Reilly J. T., Vellenga E., de Wolff J. T. M. Interferon treatment in polycythemia vera. Leuk. Lymphoma. 1995
  • Lengfelder E., Griesshammer M., Hehlmann R. Interferon-alpha in the treatment of essential thrombocythemia. Leuk. Lymphoma. 1995
  • Kantarjian H. M., Deisseroth A., Kurzrock R., Estrov Z., Talpaz M. Chronic myelogenous leukemia: A concise update. Blood 1993; 82: 691
  • Aulitzky W. E., Peschel C., Schneller F., Huber C. Biotherapy of chronic myelogenous leukemia. Ann. Hematol., 70: 113
  • Allan N. C., Shepherd P. C. A., Richards S. M. UK Medical Research Council randomised multicentre trial of interferon alpha n1 for chronic myeloid leukemia: Improved survival irrespective of cytogenetic response. Lancet 1995; 345: 1392
  • The Italian Cooperative Study Group on Chronic Myeloid Leukaemia. Interferon alpha-2a as compared with conventional chemotherapy for the treatment od chronic myeloid leukemia. N. Engl. J. Med. 1994; 330: 820
  • Messora C., Bensi L., Vecchi A., Longo R., Giacobbi F., Temperani P., Bevini M., Emilia G., Sacchi S. Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha. Brit. J. Haematol. 1994; 86: 402
  • Broxmeyer H. E., Lu L., Platzer E., Felt C., Juliano L., Rubin B. Y. Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-e) and granulocyte-macrophage (CFU-GM) progenitor cells. J. Immunol. 1983; 131: 1300
  • Raefsky E. L., Platanias L. C., Zoumbos N. C., Young N. S. Studies of interferon as a regulator of hematopoietic cell proliferation. J. Immunol. 1985; 135: 2507
  • Ganser A., Carlo-Stella C., Greher J., Völkers B., Hoelzer D. Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells. Blood 1987; 70: 1173
  • Geissler D., Gastl G., Aulitzky W. E., Tilg H., Gaggl S., Kon-Walinka G., Huber C. Recombinant interferon alpha-2c in chronic myelogenous leukemia: relationship of sensitivity of committed haematopoietic precursor cells in vitro. Leuk. Res. 1990; 14: 629
  • Dowding C., Guo A. P., Maisin D., Gordon M. Y., Goldman J. M. The effects of interferon-alpha on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M-BCR breakpoint. Brit. J. Haematol. 1991; 77: 165
  • Mazur E. M., Richtsmeier W. J., South K. Alpha-interferon: differential suppression of colony growth from human erythroid, myeloid, and megakaryocytic hemopoietic progenitor cells. J. Interferon. Res. 1986; 6: 199
  • Galvani D. W., Cawley J. C. Mechanism of action of alpha interferon in chronic granulocytic leukaemia: evidence for preferential inhibition of late progenitors. Brit. J. Haematol. 1989; 73: 475
  • Després D, Goldschmitt J, Aulitzky W. E., Huber C., Peschel C. Differential effect of type 1 interferons on hematopoietic progenitor cells: Failure of IFNs to inhibit immature myeloid progenitor cells from normal bone marrow and chronic myelogeneous leukemia. [In Press. Exp. Hematol. 1995
  • Lotem J., Sachs L. Selective regulation of the activity of different hematopoietic regulatory proteins by transforming growth factor beta 1 in normal and leukemic myeloid cells. Blood 1990; 76: 1315
  • Moore S. C., Theus S. A., Barnett J. B., Soderberg L. S. Bone marrow natural suppressor cells inhibits the growth of myeloid progenitor cells and the synthesis of colony-stimulating factors. Exp. Hematol. 1992; 20: 1178
  • Keller J. R., Bartelmez S. H., Sitnicka E., Ruscetti F. W., Ortiz M., Gooya J. M., Jacobsen S. E. Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth. Blood 1994; 84: 2175
  • Dowding C., Guo A. P., Osterholz J., Siczkowski M., Goldman J. M., Gordon M. Y. Interferon-alpha overrides the deficient adhesion of chronic myeloid primitive progenitor cells to bone marrow stromal cells. Blood 1991; 78: 499
  • Upadhyaya G., Cuba S. C., Sih S. A., Feinberg A. P., Talpaz M., Kantarjian H. M., Deisseroth A. B., Emerson S. G. Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells. J. Clin. Invest. 1991; 88: 2131
  • Bhatia R., Wayner E. A., McGlave P. B., Verfaillie C. M. Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function [see comments]. J. Clin. Invest. 1994; 94: 384
  • Santucci M. A., Soligo D., Piled S., Zuffa E., Testoni N., Tura S. Interferon-alpha effects on stromal compartment of normal and chronic myeloid leukemia hematopoiesis. Leuk. Lymphoma, 11(Suppl 1)113
  • Beelen D. W., Graeven U., Elmaagacli A. H., Niederle N., Kloke O., Opalka B., Schaefer U. W. Prolonged administration of interferon-alpha in patients with chronic-phase Philadelphia chromosome-positive chronic myelogenous leukemia before allogeneic bone marrow transplantation may adversely affect transplant outcome. Blood 1995; 85: 2981
  • Aman M. J., Keller U., Derigs G., Mohamadzadeh M., Huber C., Peschel C. Regulation of cytokine expression by interferon alpha in human bone marrow stromal cells: Inhibition of hematopoietic growth factors and induction of IL-1 receptor antagonist. Blood 1994; 83: 4142
  • Aman M. J., Rudolf G., Goldschmitt J., Aulitzky W. E., Lam C., Huber C., Peschel C. Type I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells. Blood 1993; 82: 2371
  • Aman M. J., Bug G., Huber C., Peschel C. Inhibition of interleukin-11 by interferon-alpha in human bone marrow stromal cells. 1995
  • Schindler R., Ghezzi P., Dinarello C. A. IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccaride-induced transcription of IL-1. J. Immunol. 1990; 144: 2216
  • Bartelmez S. H., Stanley R. E. Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineag specific HGF: Assay for hemopoietin-1. J. Cell. Physiol. 1985; 122: 370
  • Mochizuki D. Y., Eisenman J. F., Conlon P. J., Larsen A. D., Tushinski R. J. Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc. Natl. Acad. Sci. U. S. A. 1987; 84: 5267
  • Yang Y.-C., Tsai S., Wong G. G., Clark S. C. Interleukin-1 regulation of hematopoietic growth factor production by human stromal fibroblasts. J. Cell. Physiol. 1988; 134: 292
  • Fibbe W. E., Gosenlink H. M., Van Eeden G., Van Damme J., Biliau A., Voogt P. J., Willemze R., Falkenburg J. H. F. Proliferation of myelopid progenitor cells in human longterm bone marrow cultures is stimulated by interleukin-1 beta. Blood 1988; 72: 1242
  • Van Damme J., Opdenakker G., Simpson R. J., Rubira M. R., Cayphas S., Vink A., Biliau A., Van Snick J. Identification of the human 26 kD protein, interferon β2 (IFN-β2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosi. factor. J. Exp. Med. 1987; 165: 914
  • Elias J. A., Zheng T., Whiting N. L., Trow T. K., Merrill W. W., Zitnik R., Ray P., Alderman E. M. IL-1 and transforming growth factor-beta regulation of fibroblast-derived IL-11. J. Immunol. 1994; 152: 2421
  • Yang L., Yang Y. C. Regulation of interleukin (IL)-11 gene expression in IL-1 induced primate bone marrow stromal cells. J. Biol. Chem. 1994; 269: 32732
  • Aye M. T., Hashemi S., Leclair B., Zeibdawi A., Trudel E., Halpenny M., Fuller V., Cheng G. Expression of stem cell factor and c-kit mRNA in cultured endothelial cells, monocytes and cloned human bone marrow cells (CFU-RF). Exp. Hematol. 1992; 20: 523
  • Koenig A., Yakisan E., Reuter M., Huang M., Sykora K. W., Corbacioglu S., Welte K. Differential regulation of stem cell factor mRNA expression in human endothelial cells by bacterial pathogens: an in vitro model of inflammation. Blood 1994; 83: 2836
  • Tilg H., Mier J. W., Vogel W., Aulitzky W. E., Wiedemann C. J., Vannier E., Huber C., Dinarello C. A. Induction of circulating IL-1 receptor antagonist by IFN treatment. J. Immunol. 1993; 150: 4687
  • Peschel C., Bug G., Aman M. J., Huber C. Tissue specific regulation of the expression of macrophage inflammatory protein 1α (MIP-1α). [Abstract. Exp. Hematol. 1995; 23: 93
  • Wadenvik H., Kutti J., Ridell B., Revesz P., Jacobsson S., Magnusson B., Westin J., Vilen L. The effect of α-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia. Blood 1991; 77: 2103

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.