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Original Article

Interferon-alpha in the Treatment of Essential Thrombocythemia

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Pages 135-142 | Received 18 Mar 1996, Published online: 01 Jul 2009

References

  • Fialkow J. P., Faguet G. B., Jacobson R. J., Vaidya K., Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 1981; 58: 916–919
  • Schafer A. Bleeding and thrombosis in the myeloproliferative disorders. Blood 1984; 64: 69–96
  • van Genderen P. J., Michiels J. J. Primary thrombocythemia: diagnosis, clinical manifestations and management. Ann. Hematol. 1993; 67: 57–62
  • Griesshammer M., Selfried E., Heimpel H. Essentielle Thrombozythämie. Klinische Bedeutung, Diagnostik und Therapie. Dtsch. Med. Wschr. 1993; 118: 1412–1417
  • Hehlmann R., Jahn M., Baumann B., Köpcke W. Essential thrombocythemia. Clinical characteristics and course of 61 cases. Cancer 1988; 61: 2487–2496
  • Michiels J. J., Abels J., Stecketee J., van Vliet H. D., Vuzevsky V. D. Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Ann. Intern. Med. 1985; 102: 466–471
  • van Genderen P. J., Michiels J. J. Erythromelalgic, thrombotic and haemorrhagic manifestations of thrombocythemia. Presse. Med. 1994; 23: 73–77
  • Belluci S., Janvier M., Tobelem G., Flandrin G., Charpak Y., Berger R., Bolton M. Essential thrombocythemias. Clinical evolutionary and biological data. Cancer 1986; 58: 2440–2447
  • Fenaux P., Simon M., Caulier M. T., Lai J. L., Goudemand J., Bauters F. Clinical course of essential thrombocythemia in 147 cases. Cancer 1990; 66: 549–556
  • Cortelazzo S., Viero P., Finazzi G., D'Emilio A., Rodeghiero F., Barbui T. Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J. Clin. Oncol. 1990; 8: 556–562
  • Millard F. E., Hunter C. S., Anderson M., Edelman M. J., Kosty M. P., Luiken G. A., Martino G. G. Clinical manifestations of essential thrombocythemia in young adults. Am. J. Hematol. 1990; 33: 27–31
  • Mitus A. J., Barbui T., Shulman L. N., Rosenthal D. S., Viero P., Cortelazzo S., Schafer A. I. Hemostatic complications in young patients with essential thrombocythemia. Am. J. Med. 1990; 88: 371–375
  • Randi M. L., Fabris F., Girolami A. Thrombocytosis in young people: Evaluation of 57 cases diagnosed before the age of 40. Blut 1990; 60: 233–237
  • Cortelazzo S., Finazzi G., Ruggeri M., Vestri O., Galli M., Rhodeghiero F., Barbui T. Hydroxyurea for patients with essential thrombocythemia and high risk of thrombosis. N. Engl. J. Med. 1995; 332: 1132–1136
  • Murphy S., Iiiand H., Rosenthal D., Laszlo J. Essential thrombocythemia: An interim report from the polycythemia vera study group. Semin. Hematol. 1986; 23: 177–182
  • Berk P. D., Goldberg J. D., Donovan P. B., Fruchtman S. M., Berlin N. I., Wasserman L. R. Therapeutic recommendations in polycythemia vera based on polycythemia vera study group protocols. Sem. Hematol. 1986; 23: 132–143
  • Giles F. J. Maintenance therapy in the myeloproliferative disorders: The current options. Brit. J. Haematol. 1991; 79(Suppl. 1)92–95
  • Kasparau H., Bernhard M., Krieger O., Lutz D. Remission may continue after termination of rIFN alpha-2b treatment for essential thrombocythemia. Eur. J. Haematol. 1992; 48: 33–36
  • Middelhoff G., Boil I. A long-term clinical trial of interferon alpha-therapy in essential thrombocythemia. Ann. Haematol. 1992; 64: 207–209
  • Sacchi S., Tabilio A., Leoni P., Riccardi A., Vecchi A., Messora C., Bensi L., Falzetti F., Rupoli S., Ucci G., Martelli F. Sustained complete hematological remission in essential thrombocythemia after discontinuation of long-term aIFN treatment. Ann. Hematol. 1993; 66: 245–246
  • Talpaz M., Mavligit G., Keating M., Walters R. S., Gutterman J. U. Human leukocyte interferon to control thrombocytosis in chronic myelogenous leukemia. Ann. Intern. Med. 1983; 99: 789–792
  • Ludwig H., Linkesch W., Gisslinger H., Fritz E., Sinzinger H., Radaskiewicz T., Chott A., Flehner R., Micksche M. Interferon-alfa corrects thrombocytosis in patients with myeloproliferative disorders. Cancer Immunol. Immunother. 1987; 25: 266–273
  • Gisslinger H., Linkesch W., Fritz E., Ludwig H., Chott A., Radaskiewicz T. Long-term interferon therapy for thrombocytosis in myeloproliferative diseases. Lancet 1989; 2: 634–637
  • Tichelli A., Gratwohl A., Berger C., Lori A., Würsch A., Dieterle A., Thomssen C., Nissen C., Holdener E., Speck B. Treatment of thrombocytosis in myeloproliferative disorders with interferon alpha-2a. Blut 1989; 58: 15–19
  • Talpaz M., Kurzrock R., Kantarjian H., O'Brien S., Gutterman J. U. Recombinant interferon-alpha therapy of Philadelphia chromosome-negative myeloproliferative disorders with thrombocytosis. Am. J. Med. 1989; 86: 554–558
  • Ganser A., Carlo-Stella C., Greher J., Völkers B., Hölzer D. Effect of interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells. Blood 1987; 70: 1173–1179
  • Gugliotta L., Bagnara G. P., Catani L., Gaggiol L., Guarni A., Zauli G. In vivo and in vitro inhibitory effect of interferon on megakaryocyte colony growth in essential thrombocythemia. Brit. J. Haematol. 1989; 71: 177–181
  • Chott A., Gisslinger H., Thiele J., Fritz E., Linkesch W. Interferon-alpha-induced morphological changes of megakaryocytes: A histomorphometrical study on bone marrow biopsies in chronic myeloproliferative disorders with excessive thrombocytosis. Brit. J. Haematol. 1990; 74: 10–16
  • Wadenvik H., Kutti J., Ridell B., Revesz P., Jacobsson S., Magnusson B., Westin J., Vilen L. The effect of alpha-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia. Blood 1991; 77: 2103–2108
  • Lazzarino M., Vitale A., Morra E., Gagliardi A., Bernasconi P., Torromeo C., Inverardi D., Burgio V., Castello A., Bernasconi C., Mandelli F. Interferon alpha-2b as treatment for Philadelphia-negative chronic myeloproliferative disorders with excessive thrombocytosis. Brit. J. Haematol. 1989; 72: 173–177
  • Scheithauer W., Gisslinger H., Temsch E., Linkesch N., Linkesch W., Ludwig H. Effekt of recombinant interferon-a2c on reticuloendothelial function in patients with thrombocytosis. Journal of Interferon Research 1990; 10: 237–242
  • Catani L., Gugliotta L., Cascione M. L., Mattioli Belmonte M., Vianelli N., Belardinelli A. R., Tufa S. Platelet function and interferon alpha-2a treatment in essential thrombocythemia. Eur. J. Haematol. 1991; 46: 158–162
  • Legrand C., Belluci S., Disdier M., Edelman L., Tobelem G. Platelet thrombospondin and glycoprotein VI abnormalities in patients with essential thrombocythemia: Effect of alpha-interferon treatment. Am. J. Hematol. 1991; 38: 307–313
  • Bellucci S., Harousseau L. J., Brice P., Tobelem G. Treatment Of essential thrombocytaemia by alpha 2a Interferon. Lancet 1988; 2((8617))960–961
  • Giles F. J., Gray A. G., Brozovic M., Grant I. R., Machin S. J., Richards J. D., Venutas S., Singer C. R., Yong K. L., Davies S. C., Hoffbrand A. V., Mehta A. B., Thomas M. J., Goldstone A. H. Alpha-interferon therapy for essential thrombocythemia. Lancet 1988; 1: 70–72
  • Giralt M., Rubio D., Cortes M. T., San Miguel J., Steegmann J. L., Fernandes-Ranada J. M., Lopez-Borrasca A. Alpha interferon in the management of essential thrombocythemia. Eur. J. Cancer 1991; 27(Suppl 14)72–74
  • Gisslinger H., Chott A., Scheithauer W., Gilly B., Linkesch W., Ludwig H. Interferon in essential thrombocythemia. Brit. J. Haematol. 1991; 79(Suppl. 1)42–47
  • Sacchi S., Tabillo A., Leoni P., Riccardi A., Vecchi A., Messora C., Falzetti F., Rupoli S., Ucci G., Martelli M. F. Interferon alpha-2b in the long-term treatment of essential thrombocythemia. Ann. Hematol. 1991; 63: 206–209
  • Turri D., Mitra M. E., Di-Trapani R., Lipari M. G., Perricone R., Cajozzo A. Alpha-interferon in polycythemia vera and essential thrombocythemia. Haematologica 1991; 76: 75–77
  • Yatanagas X., Meletis J., Plata E., Viniou N., Deligiannis F., Tsekoura C., Voscaridou E., Boussiotis V., Rombos J., Vayopoulos G., Kittas C., Fessas P. Alpha interferon treatment of essential thrombocythemia and other myeloproliferative disorders with excessive thrombocytosis. Eur. J. Cancer 1991; 27(Suppl 4)69–71
  • Seewann H. L. Interferontherapie bei essentiellen Thrombozythämien. Widen. Med. Wochenschr. 1993; 143: 420–424
  • Rametta V., Ferrara F., Marottoli V., Matera C., Mettivier V., Cimino R. Recombinant interferon alpha-2b as treatment of essential thrombocythaemia. Acta. Haematol. 1994; 91: 126–129
  • Törnebohm-Roche E., Merup M., Lockner D., Paul C. Alpha-2a interferon therapy and antibody formation in patients with essential thrombocythemia and polycythemia vera with thrombocytosis. Am. J. Hematol. 1994; 48: 163–167
  • Catani L., Gugliotta L., Zauli G., Bagnara G. P., Antonelli G., Belmonte M. M., Visanelli N., Bonsi L., Brunelli M. A., Tura S. In vitro inhibition of interferon alpha-2a and antiproliferative activity by antibodies developed during treatment for essential thrombocythaemia. Hematologica 1992; 77: 318–321
  • Hehlmann R., Heimpel H., Hasford J., Kolb H. J., Pralle H., Hossfeld D. K., Queisser W., Löffler H., Hochhaus A., Heinze B., Georgii A., Bartram C. R., Grieβhammer M., Bergmann L., Essers U., Falge C., Queisser U., Meyer P., Schmitz N., Eimermacher H., Walter F., Fet T W., Kleeberg U. E., Käbisch A., Nerl C., Zimmermann R., Meuret G., Tichelli A., Kanz L., Tigges F. J., Schmid L., Brockhaus W., Tobler A., Reiter A., Perker M., Emmerich B., Verpoort K., Zankovich R., Wussow P., Prümmer O., Thiele J., Buhr T., Ansari H. and the German CML Study Group. (1994) Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia (CML). Blood, 84: 4064–4077
  • Anger B., Jansson J. W., Schrezenmeier H., Hehlmann R., Heimpel H., Bartram C. R. Clonal analysis of chronic myeloproliferative disorders using X-linked DNA polymorphisms. Leukemia 1990; 4: 258–261
  • El Kassar N., Hetel G., Briere J., Grandchamp B. Clonal analysis of hematopoietic cells in essential thrombocythemia. Brit. J. Haematol. 1995; 90: 131–137
  • Shibata K., Shimamoto Y., Suga K., Sano M., Matsuzaki M., Yamaguchi M. Essential thrombocythemia terminating in acute leukemia with minimal myeloid differentiation- a brief review of recent literature. Acta. Haematol. 1994; 91: 84–88
  • Fruchtman S. M., Kaplan M. E., Peterson P., Mack K., Berk P. D., Wasserman L. R., for the PVSG. Acute leukemia (AL), hydroxyurea (HU) and polycthemia vera (PV): An analysis of risk of the polycythemia vera study group (PVSG). Blood 1994; 84(suppl 1)2058
  • Anagrelide study group. Anagrelide, a therapy for thrombocythemic states. Experience in 577 patients. Am. J. Med. 1992; 92: 69–76
  • Spencer C. M., Brogden R. N. Anagrelide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of thrombocythemia. Drugs 1994; 47: 809–822
  • Mazur E., Rosmarin A. G., Sohl P. A., Newton J. L., Naredran A. Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 1992; 79: 1931–1937

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